Role of mucosal microcirculation in gastric lesions induced by lateral hypothalamic lesions in rats.

Abstract:

:To evaluate the pathophysiology underlying gastric mucosal lesions induced by lateral hypothalamic (LH) lesions, we investigated the changes in acid secretion, gastric mucosal blood flow, gastric mucus and mucosal integrity in the corpus during the 4 h period and 48 h after the production of bilateral electrolytic LH lesions in male Sprague-Dawley rats. Gastric mucosal lesions were macroscopically produced 24 h (63%) and 48 h (83%) after LH lesions, although there were no visible lesions at 7 h. Gastric acid secretion was significantly increased 48 h after LH lesions, compared with that in the control group. Gastric mucosal blood flow and transmucosal potential difference (PD) in the LH lesion group immediately decreased after LH lesions and did not recover during 4 h and at 48 h. On the contrary, in the control group, gastric mucosal blood flow decreased after the brain surgery but soon recovered, and there was no significant change in PD. LH lesions resulted in the reduction of intramucosal mucus to 50% 3 h after LH lesions. Moreover, we exposed the stomach to 10 mmol/L taurocholic acid (TCA) 3 h after LH lesions to examine the disruption in gastric mucosal defensive function in rats with LH lesions. The recovery of the reduced PD by TCA was slow and gastric mucosal lesions were easily formed in the LH lesion group. These results suggest that gastric mucosal ischaemia after lesioning of LH immediately results in the disruption of mucosal defensive function before the formation of visible gastric lesions, and predisposes to the formation of gastric mucosal lesions by a delayed increase in acid secretion.

authors

Saita H,Murakami M,Kita T

doi

10.1111/j.1440-1746.1995.tb01586.x

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

371-8

issue

4

eissn

0815-9319

issn

1440-1746

journal_volume

10

pub_type

杂志文章
  • Interobserver agreement in contrast harmonic endoscopic ultrasound.

    abstract:BACKGROUND AND AIM:Contrast harmonic endoscopic ultrasound (CH-EUS) was recently introduced to clinical practice; its reproducibility among endosonographers is unknown. Our aim was to assess the interobserver agreement (IA) in CH-EUS. METHODS:Fifteen endosonographers (eight experienced and seven non-experienced) from ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1440-1746.2012.07115.x

    authors: Fusaroli P,Kypraios D,Mancino MG,Spada A,Benini MC,Bianchi M,Bocus P,De Angelis C,De Luca L,Fabbri C,Grillo A,Marzioni M,Reggio D,Togliani T,Zanarini S,Caletti G

    更新日期:2012-06-01 00:00:00

  • Barrett's esophagus: A historical perspective, an update on core practicalities and predictions on future evolutions of management.

    abstract::Interpretation of exploding knowledge about Barrett's esophagus is impaired by use of several conflicting definitions. Because any histological type of esophageal columnar metaplasia carries risk for esophageal adenocarcinoma, the diagnosis of Barrett's esophagus should no longer require demonstration of intestinal-ty...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1440-1746.2010.06535.x

    authors: Dent J

    更新日期:2011-01-01 00:00:00

  • Adverse effects and other safety aspects of the hepatitis C antivirals.

    abstract::The preferred treatment for patients with chronic hepatitis C, either treatment-naive, relapsers or nonresponders to IFN monotherapy, is now IFN-ribavirin combination treatment. The adverse effects of IFN are well established and familiar to hepatologists all over the world. More than 25,000 patients worldwide have be...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1746.2000.02114.x

    authors: Chutaputti A

    更新日期:2000-05-01 00:00:00

  • Use of hepatitis B virus core-related antigen to evaluate natural history of chronic hepatitis B.

    abstract:BACKGROUND AND AIM:Hepatitis B core-related antigen (HBcrAg) has been shown to correlate with various viral markers in chronic hepatitis B, but its role in defining natural history is not well studied. We aimed to investigate the use of HBcrAg to define different phases of chronic hepatitis B. METHODS:Stored residual ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15058

    authors: Chan HLY,Yasuda S,Wong GLH,Tada T,Chan CKM,Kumada T,Tse YK,Wong VWS,Toyoda H

    更新日期:2020-04-15 00:00:00

  • Comparison between modified wet suction and dry suction technique for endoscopic ultrasound-guided fine-needle biopsy in pancreatic solid lesions.

    abstract:BACKGROUND AND AIM:Although endoscopic ultrasound-guided fine-needle biopsy is widely applied, there is no clear consensus on the optimal biopsy technique. We described a modified wet suction technique (MWEST) with the aim to compare the efficacy and safety between MWEST and the dry suction technique (DST). METHODS:In...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15371

    authors: Tong T,Tian L,Deng M,Liu Y,Yang Y,Yin H,Long X,Pan S,Yang Z,Luo W,Nie K,Meng X,Xiao M,Wu X,Zhang C,Wang X

    更新日期:2020-12-08 00:00:00

  • Computed tomography findings of sorafenib-treated hepatic tumors in patients with advanced hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:The purpose of this study was to describe the computed tomography (CT) findings of sorafenib-treated hepatic tumors in patients with advanced hepatocellular carcinoma and to correlate the findings to the overall survival (OS). METHODS:Twenty-eight sorafenib-treated patients who had advanced hepatoce...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2011.06709.x

    authors: Kim MJ,Choi JI,Lee JS,Park JW

    更新日期:2011-07-01 00:00:00

  • Evaluation of the hepatic reduction of a nitroxide radical in rats receiving ascorbic acid, glutathione or ascorbic acid oxidase by in vivo electron spin resonance study.

    abstract:BACKGROUND:A nitroxide radical, 4-hydroxyl-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL), is directly reduced to hydroxylamine by ascorbic acid (AsA). Ascorbic acid is oxidized to dehydroascorbic acid (DHA) by ascorbic acid oxidase (AAOx), and DHA is reduced to AsA by glutathione (GSH). In the present study, in vivo and...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2004.03201.x

    authors: Tada M,Yokoyama H,Ito O,Ohya H,Ogata T

    更新日期:2004-01-01 00:00:00

  • Frequency of complications during EUS-guided drainage of pancreatic fluid collections in 148 consecutive patients.

    abstract:BACKGROUND AND AIM:The aim of the present study was to evaluate the frequency of complications during endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFC), identify contributing factors, and report on management outcomes. METHODS:All patients who underwent EUS-guided PFC drainage over 7 ye...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2011.06771.x

    authors: Varadarajulu S,Christein JD,Wilcox CM

    更新日期:2011-10-01 00:00:00

  • Marked retention of indocyanine green and sulfobromophthalein with chronic persistent hepatitis.

    abstract::A hepatitis B virus (HBV) carrier with marked retention of indocyanine green (ICG) and sulfobromophthalein (BSP) was admitted to our hospital for assessment of liver function. On admission, he was asymptomatic and blood chemistry tests showed normal values for transaminases and bilirubin. Serum hepatitis B surface ant...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1993.tb01554.x

    authors: Ikejima K,Ichikawa S,Kitamura T,Watanabe S,Hirose M,Yokoi Y,Uchida S,Oide H,Suzuki H,Kitami N

    更新日期:1993-09-01 00:00:00

  • Prehepatic portal hypertension produces increased mast cell density in the small bowel and in mesenteric lymph nodes in the rat.

    abstract:BACKGROUND:Because most of the characteristics of the portal hypertensive enteropathy can be explained on the basis of increased levels of mast cell mediators, the purpose of the present paper was to study mast cell splanchnic infiltration. METHODS:Duodenum, jejunum, ileum and mesenteric lymph node complex infiltratio...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.03831.x

    authors: Prieto I,Aller MA,Santamaría L,Nava MP,Madero R,Pérez-Robledo JP,Arias J

    更新日期:2005-07-01 00:00:00

  • Effectiveness of chemical biliary duct embolization for chemical hepatectomy.

    abstract:BACKGROUND AND AIMS:The high recurrence of hepatolithiasis and high operative trauma of hepatectomy necessitate new therapeutic approaches. Thus, this study was designed to (i) investigate the effectiveness of chemical biliary duct embolization (CBDE) for chemical hepatectomy; and (ii) to determine the mechanism of CBD...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.04090.x

    authors: Li FY,Cheng JQ,Li N,He S,Zhang MM,Dong JH,Jiang LS,Cheng NS

    更新日期:2006-05-01 00:00:00

  • Safety and efficacy of elbasvir/grazoprevir in Asian participants with hepatitis C virus genotypes 1 and 4 infection.

    abstract:BACKGROUND AND AIM:Estimates suggest that in Asia, more than 31 million individuals have hepatitis C virus infection. The present analysis was conducted to assess the efficacy and safety of elbasvir/grazoprevir in Asian participants enrolled in the elbasvir/grazoprevir phase 2/3 clinical trials. METHODS:This is an int...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14636

    authors: Wei L,Kumada H,Perumalswami PV,Tanwandee T,Cheng W,Heo J,Cheng PN,Hwang P,Mu SM,Zhao XM,Asante-Appiah E,Caro L,Hanna GJ,Robertson MN,Haber BA,Talwani R

    更新日期:2019-09-01 00:00:00

  • Incidence and risk factors of Pneumocystis jirovecii pneumonia in Korean patients with inflammatory bowel disease.

    abstract:BACKGROUND AND AIM:Little is known whether routine prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is needed in patients with inflammatory bowel disease (IBD) on immunosuppression, especially in Asian populations. We, therefore, sought to investigate the incidence and risk factors of PJP in patients with IBD...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14832

    authors: Nam K,Park SH,Lee J,Jo S,Kim SO,Noh S,Park JC,Kim JY,Kim J,Ham NS,Oh EH,Song EM,Hwang SW,Yang DH,Ye BD,Byeon JS,Myung SJ,Yang SK

    更新日期:2020-02-01 00:00:00

  • Dengue fever related acalculous cholecystitis in a North Indian tertiary care hospital.

    abstract:BACKGROUND AND AIMS:To document the clinical outcome and prognosis of acalculous cholecystitis in dengue fever. METHODS:Prospective analysis of 27 cases of dengue fever presenting to the medical emergency of a tertiary care referral hospital in Chandigarh, India. RESULTS:All patients with dengue fever presenting with...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04295.x

    authors: Sharma N,Mahi S,Bhalla A,Singh V,Varma S,Ratho RK

    更新日期:2006-04-01 00:00:00

  • Immune response after hepatitis A vaccination in haemodialysis patients: comparison with hepatitis B vaccination.

    abstract::This study evaluates the immune response of 20 haemodialysis (HD) patients vaccinated with hepatitis A (HA) vaccine and eight patients vaccinated with hepatitis B (HB) vaccine. Twenty patients and 22 healthy adults were immunized three times (months 0, 1 and 6) intramuscularly with a 0.5 microgram dose. All members of...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1994.tb01714.x

    authors: Kuramoto I,Fujiyama S,Matsushita K,Sato T

    更新日期:1994-05-01 00:00:00

  • Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India.

    abstract:BACKGROUND AND AIM:Epidemiology of Helicobacter pylori infection has regional variation. Effect of eradication of H. pylori on symptoms of functional dyspepsia is uncertain, and the data in Asian scenario are scanty. The study aimed to see H. pylori positivity rate in patients of functional dyspepsia and the effect of ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/jgh.12178

    authors: Sodhi JS,Javid G,Zargar SA,Tufail S,Shah A,Khan BA,Yattoo GN,Gulzar GM,Khan MA,Lone MI,Saif Ru,Parveen S,Shoukat A

    更新日期:2013-05-01 00:00:00

  • Identifying the optimal strategy for screening of advanced colorectal neoplasia.

    abstract:BACKGROUND AND AIM:To guide selection of optimal screening strategies for advanced colorectal neoplasia (ACRN), we evaluated the screening performances of sigmoidoscopy, fecal immunochemical test (FIT), and the Asia-Pacific Colorectal Screening (APCS) system, as well as combinations of these techniques. METHODS:We rev...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13634

    authors: Jung YS,Park CH,Kim NH,Park JH,Park DI,Sohn CI

    更新日期:2017-05-01 00:00:00

  • Serum levels of transforming growth factor beta1 are significantly correlated with venous invasion in patients with gastric cancer.

    abstract:BACKGROUND AND AIM:The significance of serum levels of transforming growth factor (TGF)-beta1 in the development of gastric cancer is unclear. The purpose of this study is to determine whether serum TGF-beta1 correlated with the clinicopathological findings of patients with gastric cancer. METHODS:Transforming growth ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.03939.x

    authors: Lin Y,Kikuchi S,Obata Y,Yagyu K,Tokyo Research Group on Prevention of Gastric Cancer.

    更新日期:2006-02-01 00:00:00

  • Pegylated alpha-interferon-2a plus ribavirin compared with pegylated alpha-interferon-2b plus ribavirin for initial treatment of chronic hepatitis C virus: prospective, non-randomized study.

    abstract:BACKGROUND AND AIM:We assessed whether the two regimens of pegylated alpha-interferon-2b (PEG-IFN-alpha2b) plus ribavirin and pegylated alpha-interferon-2a (PEG-IFN-alpha2a) plus ribavirin showed differences in terms of sustained virological response, withdrawal due to side-effects and dose adjustment requirements in t...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05397.x

    authors: Escudero A,Rodríguez F,Serra MA,Del Olmo JA,Montes F,Rodrigo JM

    更新日期:2008-06-01 00:00:00

  • A prospective randomized double blind trial comparing prednisolone and 4-aminosalicylic acid enemas in acute distal ulcerative colitis.

    abstract::A prospective double blind and randomized study was conducted to compare 4-aminosalicylic acid (4-ASA) and prednisolone-21-phosphate enemas in inducing remission in patients with acute distal ulcerative colitis. Patients with ulcerative colitis distal to the splenic flexure as assessed by flexible colonoscopy, barium ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1440-1746.1992.tb00957.x

    authors: Sharma MP,Duphare HV,Dasarathy S

    更新日期:1992-03-01 00:00:00

  • Urinary abnormalities in children and adolescents with Wilson disease before and during treatment with d-penicillamine.

    abstract:BACKGROUND AND AIM:Renal abnormalities can occur at any time point during the course of Wilson disease (WD). We aimed to fill a literature gap in this respect by studying urinary abnormalities in children and adolescents with WD. METHODS:This study included 60 children with WD presenting to the Pediatric Hepatology Un...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14653

    authors: Helmy H,Fahmy M,Abdel Aziz H,Ghobrial C,Abdel Hameed N,El-Karaksy H

    更新日期:2019-10-01 00:00:00

  • Enhancement of poly-adenosine diphosphate-ribosylation in human hepatocellular carcinoma.

    abstract:BACKGROUND:Poly-adenosine diphosphate (ADP)-ribosylation, catalysed by poly(ADP-ribose) polymerase (PARP), is a post-translational modification of nuclear proteins and is involved in a wide range of biological processes including DNA repair, cell proliferation and malignant transformation. Alteration of this reaction i...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2000.02193.x

    authors: Nomura F,Yaguchi M,Togawa A,Miyazaki M,Isobe K,Miyake M,Noda M,Nakai T

    更新日期:2000-05-01 00:00:00

  • Rebamipide alleviates radiation-induced colitis through improvement of goblet cell differentiation in mice.

    abstract:BACKGROUND AND AIM:Radiation-induced colitis is a common clinical problem associated with radiotherapy and accidental exposure to ionizing radiation. Goblet cells play a pivotal role in the intestinal barrier against pathogenic bacteria. Rebamipide, an anti-gastric ulcer drug, has the effects to promote goblet cell pro...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14021

    authors: Jang H,Park S,Lee J,Myung JK,Jang WS,Lee SJ,Myung H,Lee C,Kim H,Lee SS,Jin YW,Shim S

    更新日期:2018-04-01 00:00:00

  • Fibroscan can avoid liver biopsy in Indian patients with chronic hepatitis B.

    abstract:BACKGROUND AND AIM:Liver fibrosis is an established determinant of prognosis and therapy in chronic hepatitis B (CHB). The role of fibroscan in assessing fibrosis in CHB remains unclear. Present study was designed to correlate fibroscan with liver biopsy and determine whether fibroscan can avoid liver biopsy in patient...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12318

    authors: Goyal R,Mallick SR,Mahanta M,Kedia S,Shalimar,Dhingra R,Sharma H,Das P,Datta Gupta S,Panda S,Acharya SK

    更新日期:2013-11-01 00:00:00

  • Effects of combination treatment with famotidine and methylmethionine sulfonium chloride on the mucus barrier of rat gastric mucosa.

    abstract:BACKGROUND AND AIM:In Japan, peptic ulcer disease (PUD) is treated clinically with a combination of a mucosal protectant and acid suppressants, but there is scant information regarding the effects of these drugs on normal gastric mucus cells. In the present study, the effects of co-administration of methylmethionine su...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05667.x

    authors: Ichikawa T,Ito Y,Saegusa Y,Iwai T,Goso Y,Ikezawa T,Ishihara K

    更新日期:2009-03-01 00:00:00

  • Visceral adiposity is associated with an increased risk of functional dyspepsia.

    abstract:BACKGROUND:The relationship between visceral adiposity and the incidence of functional dyspepsia (FD) has not yet been studied. The purpose of the present study is to evaluate the association between visceral adiposity and the risk of FD. METHODS:This is a case-control study that compares the abdominal adipose tissue ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13146

    authors: Jung JG,Yang JN,Lee CG,Choi SH,Kwack WG,Lee JH,Kang HW

    更新日期:2016-03-01 00:00:00

  • Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer.

    abstract:BACKGROUND AND AIM:The aim of this study was to assess the gastric histopathology and serum gastrin-17 and pepsinogens profiles in patients with duodenal ulcer before and after Helicobacter pylori eradication in a population with a very high prevalence of H. pylori. At the same time we assessed the role of H. pylori de...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1440-1746.2007.04983.x

    authors: Pimanov SI,Makarenko EV,Voropaeva AV,Matveenko ME,Voropaev EV

    更新日期:2008-11-01 00:00:00

  • Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance.

    abstract:BACKGROUND AND AIM:Development of hepatic cirrhosis involves oxidative stress, inflammation, hepatic stellate cells (HSC)s activation and fibrosis. On the other hand, quercetin, a natural flavonoid is a potent antioxidant and activator of superoxide dismutase and catalase. The aim was to determinate the effect of querc...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2012.07262.x

    authors: Hernández-Ortega LD,Alcántar-Díaz BE,Ruiz-Corro LA,Sandoval-Rodriguez A,Bueno-Topete M,Armendariz-Borunda J,Salazar-Montes AM

    更新日期:2012-12-01 00:00:00

  • Epidemiology of hepatitis E: current status.

    abstract::Hepatitis E, caused by infection with hepatitis E virus (HEV), is a common cause of acute hepatitis in areas with poor sanitation. The virus has four genotypes with one serotype: genotypes 1 and 2 exclusively infect humans, whereas genotypes 3 and 4 also infect other animals, particularly pigs. In endemic areas, both ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2009.05933.x

    authors: Aggarwal R,Naik S

    更新日期:2009-09-01 00:00:00

  • Identification of genes with universally upregulated or downregulated expressions in colorectal cancer.

    abstract:BACKGROUND AND AIM:Differentially expressed (DE) genes detected at the population-level through case-control comparison provide no information on the dysregulation frequencies of DE genes in a cancer. In this work, we aimed to identify the genes with universally upregulated or downregulated expressions in colorectal ca...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14529

    authors: Song K,Su W,Liu Y,Zhang J,Liang Q,Li N,Guan Q,He J,Bai X,Zhao W,Guo Z

    更新日期:2019-05-01 00:00:00