Rebamipide alleviates radiation-induced colitis through improvement of goblet cell differentiation in mice.

Abstract:

BACKGROUND AND AIM:Radiation-induced colitis is a common clinical problem associated with radiotherapy and accidental exposure to ionizing radiation. Goblet cells play a pivotal role in the intestinal barrier against pathogenic bacteria. Rebamipide, an anti-gastric ulcer drug, has the effects to promote goblet cell proliferation. The aim of this study was to investigate whether radiation-induced colonic injury could be alleviated by rebamipide. METHODS:This study orally administered rebamipide for 6 days to mice, which were subjected to 13 Gy abdominal irradiation, to evaluate the therapeutic effects of rebamipide against radiation-induced colitis. To confirm the effects of rebamipide on irradiated colonic epithelial cells, this study used the HT29 cell line. RESULTS:Rebamipide clearly alleviated the acute radiation-induced colitis, as reflected by the histopathological data, and significantly increased the number of goblet cells. The drug also inhibited intestinal inflammation and protected from bacterial translocation during acute radiation-induced colitis. Furthermore, rebamipide significantly increased mucin 2 expression in both the irradiated mouse colon and human colonic epithelial cells. Additionally, rebamipide accelerated not only the recovery of defective tight junctions but also the differentiation of impaired goblet cells in an irradiated colonic epithelium, which indicates that rebamipide has beneficial effects on the colon. CONCLUSIONS:Rebamipide is a therapeutic candidate for radiation-induced colitis, owing to its ability to inhibit inflammation and protect the colonic epithelial barrier.

authors

Jang H,Park S,Lee J,Myung JK,Jang WS,Lee SJ,Myung H,Lee C,Kim H,Lee SS,Jin YW,Shim S

doi

10.1111/jgh.14021

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

878-886

issue

4

eissn

0815-9319

issn

1440-1746

journal_volume

33

pub_type

杂志文章
  • Reduced risk of hepatocellular carcinoma by achieving a subcirrhotic liver stiffness through antiviral agents in hepatitis B virus-related advanced fibrosis or cirrhosis.

    abstract:BACKGROUND AND AIM:A subcirrhotic range of liver stiffness (sc-LS), assessed by transient elastography, is associated with better outcomes in patients with chronic hepatitis B (CHB). We investigated whether the achievement of sc-LS by antiviral therapy (AVT) reduced the risk of developing hepatocellular carcinoma (HCC)...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13854

    authors: Kim BS,Seo YS,Kim YS,Lee CH,Lee HA,Um SH,Yoo JJ,Kim SG,Suh SJ,Jung YK,Ahn SH,Han KH,Yim HJ,Kim SU,Korean Transient Elastography Study Group.

    更新日期:2018-02-01 00:00:00

  • Primary sclerosing cholangitis in children.

    abstract::Primary sclerosing cholangitis (PSC), a chronic inflammatory process affecting the extrahepatic and/or medium to large bile ducts, is not rare in children. It has features suggesting an autoimmune pathogenesis, although the mechanism of tissue damage remains unknown. The clinical presentation of childhood primary scle...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1746.1999.01919.x

    authors: Roberts EA

    更新日期:1999-06-01 00:00:00

  • What is the clinical significance of stromal angiogenesis in Barrett's esophagus?

    abstract:BACKGROUND:Enriched blood vessels occur in the stroma of Barrett's esophagus and are related to the ease of tumor invasion in the early stage of the cancer. Hypoxia-inducible factor (HIF) is closely related with angiogenesis through expression of vascular endothelial growth factor. The aim of the present study was to d...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05440.x

    authors: Moriyama N,Amano Y,Mishima Y,Okita K,Takahashi Y,Yuki T,Ishimura N,Ishihara S,Kinoshita Y

    更新日期:2008-12-01 00:00:00

  • Long-term outcome of autoimmune hepatitis in children.

    abstract:BACKGROUND AND AIM:Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology, which usually progresses to cirrhosis if not diagnosed and treated promptly. Data on long-term follow up in children with AIH are scant. The aim of this study is to assess the long-term outcome of autoimmune hepatitis in children wi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2001.02615.x

    authors: Saadah OI,Smith AL,Hardikar W

    更新日期:2001-11-01 00:00:00

  • Immunoactivative role of indoleamine 2,3-dioxygenase in human hepatocellular carcinoma.

    abstract:BACKGROUND:Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolic enzyme. Recent studies have focused on the immunoregulatory role of IDO in mononuclear cells. The role of IDO in hepatocellular carcinoma (HCC) cell lines and HCC patients was examined. METHODS:The expression of IDO mRNA in peripheral blood mononuc...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2003.03259.x

    authors: Ishio T,Goto S,Tahara K,Tone S,Kawano K,Kitano S

    更新日期:2004-03-01 00:00:00

  • Predicting the efficacy of proton pump inhibitors in patients with non-erosive reflux disease before therapy using dual-channel 24-h esophageal pH monitoring.

    abstract:BACKGROUND AND AIM:We aimed to determine whether reflux- and symptom-related parameters can predict the efficacy of proton pump inhibitors (PPI) in non-erosive reflux disease (NERD). METHODS:Twenty-seven NERD patients who had experienced heartburn more than once a week within the previous month were enrolled. Intraeso...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1440-1746.2011.06975.x

    authors: Shimatani T,Sugimoto M,Nishino M,Adachi K,Furuta K,Ito M,Kurosawa S,Manabe N,Mannen K,Hongo M,Chiba T,Kinoshita Y,Acid-Related Symptom Research (ARS) Group.

    更新日期:2012-05-01 00:00:00

  • Prevalence of nonalcoholic fatty liver disease in mainland of China: a meta-analysis of published studies.

    abstract:BACKGROUND AND AIM:Nonalcoholic fatty liver disease (NAFLD) is becoming an increasingly important health issue. However, there are no data on the change in prevalence of NAFLD within a population over time, especially in the mainland of China. The goal of this study was to estimate the pooled prevalence of NAFLD in the...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析

    doi:10.1111/jgh.12428

    authors: Li Z,Xue J,Chen P,Chen L,Yan S,Liu L

    更新日期:2014-01-01 00:00:00

  • Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population.

    abstract:BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) is an emerging problem in the Asia-Pacific region. However, its prevalence and risk factors in Asian (especially South Asian) communities is poorly studied. In this study, the aim was to determine the community prevalence and risk factors for NAFLD among adu...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.05831.x

    authors: Dassanayake AS,Kasturiratne A,Rajindrajith S,Kalubowila U,Chakrawarthi S,De Silva AP,Makaya M,Mizoue T,Kato N,Wickremasinghe AR,de Silva HJ

    更新日期:2009-07-01 00:00:00

  • How Helicobacter pylori acquired its name, and how it overcomes gastric defence mechanisms.

    abstract::At Royal Perth Hospital, Western Australia in April 1982, spiral bacteria were first cultured from a gastric biopsy specimen. Several important taxonomic features were identified which indicated that these bacteria represented a new genus. In October 1989 the new genus name Helicobacter was published. Helicobacter pyl...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1440-1746.1994.tb01292.x

    authors: Goodwin CS

    更新日期:1994-01-01 00:00:00

  • Close observation of gastric mucosal pattern by standard endoscopy can predict Helicobacter pylori infection status.

    abstract:BACKGROUND AND AIM:Common endoscopic findings in stomachs with Helicobacter pylori infections include antral nodularity, thickened gastric folds, and visible submucosal vessels. These findings are suggestive but not diagnostic of H. pylori infection. Magnifying endoscopy can reveal more precisely the abnormal mucosal p...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12046

    authors: Cho JH,Chang YW,Jang JY,Shim JJ,Lee CK,Dong SH,Kim HJ,Kim BH,Lee TH,Cho JY

    更新日期:2013-02-01 00:00:00

  • Pertussis toxin-induced redistribution of cortical actomyosin and inhibition of phagocytosis in rat Kupffer cells.

    abstract::The mechanism of phagocytosis by Kupffer cells has been shown to be related to the Ca(2+)-calmodulin and the actomyosin systems. However the role of the transmembrane signal transmitter, G-protein, is still unknown. In this study, a quantitative evaluation of phagocytosis by Kupffer cells of rats in culture and the ef...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1993.tb01526.x

    authors: Hirose M,Watanabe S,Ueno T,Kitami N,Sato N

    更新日期:1993-07-01 00:00:00

  • Meta-analysis: is sequential therapy superior to standard triple therapy for Helicobacter pylori infection in Asian adults?

    abstract:BACKGROUND AND AIM:Although several meta-analyses suggested that sequential therapy (SQT) is superior to standard triple therapy (STT) for the eradication of Helicobacter pylori, these results were mainly based on the studies from Italy. The aim of this study was to assess the efficacy of 10-day SQT for H. pylori infec...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析

    doi:10.1111/jgh.12397

    authors: Yoon H,Lee DH,Kim N,Park YS,Shin CM,Kang KK,Oh DH,Jang DK,Chung JW

    更新日期:2013-12-01 00:00:00

  • Medical treatment of duodenal ulcer: acid inhibition or Helicobacter pylori eradication?

    abstract::To ascertain whether acid inhibition or Helicobacter pylori (HP) colonization is the decisive factor in the healing of duodenal ulcer, we treated 54 patients with famotidine and carried out long-term follow-up. Helicobacter pylori colonization was found in 70.4% of patients before treatment. There were no differences ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1991.tb01454.x

    authors: Lai KH,Chang FY,Tsay SH,Lu LC,Cheng JT,Jeng SS,Wu TC,Ng WW,Jeng JS,Lee SD

    更新日期:1991-03-01 00:00:00

  • Quality of meta-analyses in major leading gastroenterology and hepatology journals: A systematic review.

    abstract:BACKGROUND AND AIM:To appraise the current reporting methodological quality of meta-analyses in five leading gastroenterology and hepatology journals, and to identify the variables associated with the reporting quality. METHODS:We systematically searched the literature of meta-analyses in Gastroenterology, Gut, Hepato...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/jgh.13591

    authors: Liu P,Qiu Y,Qian Y,Chen X,Wang Y,Cui J,Zhai X

    更新日期:2017-01-01 00:00:00

  • Case report: acanthosis nigricans in association with primary biliary cirrhosis: resolution after liver transplantation.

    abstract::A case is described of a 58 year old Caucasian male with primary biliary cirrhosis (PBC) who first presented with acanthosis nigricans of both axillae, skin pigmentation, which was pronounced over the posterior surface of the neck, and generalized pruritus. Following orthotopic liver transplantation for progressive li...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1996.tb00025.x

    authors: Pham TH,Kaushik S,Lin BP,Jones DB

    更新日期:1996-11-01 00:00:00

  • Hepatocellular carcinoma in the Asia pacific region.

    abstract::Primary liver cancer, particularly hepatocellular carcinoma (HCC) remains a significant disease worldwide. It is among the top three causes of cancer death in the Asia Pacific region because of the high prevalence of its main etiological agents, chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. I...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2009.05784.x

    authors: Yuen MF,Hou JL,Chutaputti A,Asia Pacific Working Party on Prevention of Hepatocellular Carcinoma.

    更新日期:2009-03-01 00:00:00

  • Utility of endoscopic ultrasound in the diagnosis of aberrant right subclavian artery.

    abstract:BACKGROUND AND AIMS:Aberrant right subclavian artery (ARSA) is the most common congenital anomaly of the aortic arch occurring in 0.4-2.0% of the general population. Instead of arising from the brachiocephalic artery, the ARSA arises as the last branch from the aortic arch. The aim of this study was to determine the pr...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04622.x

    authors: Yusuf TE,Levy MJ,Wiersema MJ,Clain JE,Harewood GC,Rajan E,Topazian MD,Wang KK

    更新日期:2007-11-01 00:00:00

  • Safety and immunogenicity of hepatitis A vaccine in healthy adult volunteers.

    abstract::The immunogenicity and adverse reaction of an inactivated hepatitis A (HA) vaccine were investigated. Sixty healthy adult volunteers who lacked antibody to HA virus (anti-HAV) received three doses of vaccine containing 720 enzyme-linked immunosorbent assay (ELISA) units (EL.U) according to a 0, 1 and 6 month schedule....

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1993.tb01524.x

    authors: Horng YC,Chang MH,Lee CY,Safary A,Andre FE,Chen DS

    更新日期:1993-07-01 00:00:00

  • Clinical significance of SEN-virus on interferon response in chronic hepatitis C patients.

    abstract:BACKGROUND AND AIM:A novel virus, SEN-virus (SENV), was recently discovered. It has been reported as a candidate for a non-A-E hepatitis virus. However, much is still unknown about the clinical significance of SENV. The aim of the present study was to clarify the clinical significance of SENV in patients coinfected wit...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.02946.x

    authors: Lin JG,Goto T,Nakane K,Miura K,Mikami K,Ohshima S,Yoneyama K,Watanabe S

    更新日期:2003-10-01 00:00:00

  • Extended indication of endoscopic resection for mucosal early gastric cancer: analysis of a single center experience.

    abstract:BACKGROUND:Endoscopic resection (ER) has become an important therapeutic option for early gastric cancer (EGC). Some investigators have suggested that this indication should be extended. We aimed to compare the extended indication of ER for intramucosal EGC based on data from a large, single-center study. METHODS:We a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06611.x

    authors: Chung JW,Jung HY,Choi KD,Song HJ,Lee GH,Jang SJ,Park YS,Yook JH,Oh ST,Kim BS,Kim JH

    更新日期:2011-05-01 00:00:00

  • Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:Exportin 4 (XPO4) is a recently-discovered candidate tumor-suppressor gene identified in a liver cancer mouse model. To investigate the role of XPO4 in hepatocellular carcinoma (HCC) pathogenesis, we determined XPO4 expression and its correlation to prognosis in human primary HCC. METHODS:The XPO4 m...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06434.x

    authors: Liang XT,Pan K,Chen MS,Li JJ,Wang H,Zhao JJ,Sun JC,Chen YB,Ma HQ,Wang QJ,Xia JC

    更新日期:2011-03-01 00:00:00

  • A two year controlled trial examining the effectiveness of ursodeoxycholic acid in primary biliary cirrhosis.

    abstract::Forty-six patients with primary biliary cirrhosis from a single centre were studied in a randomized placebo-controlled trial to determine the effectiveness of ursodeoxycholic acid (UDCA) over a 2 year period. The two groups were well-matched at baseline. For each parameter, by calculating the difference between the me...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1440-1746.1994.tb01237.x

    authors: Turner IB,Myszor M,Mitchison HC,Bennett MK,Burt AD,James OF

    更新日期:1994-03-01 00:00:00

  • Expression of retinoid receptors in multiple cell lineages in the gastric mucosae of mice and humans.

    abstract:BACKGROUND AND AIM:In mice and humans, the gastric epithelial progenitors undergo proliferation and bipolar migration from the isthmus associated with their differentiation into mucus-, acid- and pepsinogen-secreting cell lineages. Little is known about factors that control the dynamics of these isthmal progenitor cell...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.04064.x

    authors: Karam SM,Hassan WM,John R

    更新日期:2005-12-01 00:00:00

  • Immunohistochemical study of microvessel density, CD44 (standard form), p53 protein and c-erbB2 in gallbladder carcinoma.

    abstract:BACKGROUND:The purpose of the present study was to investigate microvessel density (MVD), and the expression of CD44 adhesion molecule, p53 protein and c-erbB2 in gallbladder carcinoma, and their relation to histological grade and tumor invasiveness. METHODS:Immunohistochemical staining with antibodies against factor ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2004.03357.x

    authors: Kalekou H,Miliaras D

    更新日期:2004-07-01 00:00:00

  • Gastric emptying function changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy.

    abstract:BACKGROUND:Hypothyroidism is commonly thought to cause decreased gastric emptying but is mostly associated with autoimmune disease. In the present study the gastric emptying function of thyroid cancer patients with severe hypothyroidism of short duration was evaluated with a radionuclide solid meal gastric emptying stu...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2003.03326.x

    authors: Kao PF,Lin JD,Chiu CT,Hsu HT,See LC,Tzen KY

    更新日期:2004-06-01 00:00:00

  • Safety and efficacy of elbasvir/grazoprevir in Asian participants with hepatitis C virus genotypes 1 and 4 infection.

    abstract:BACKGROUND AND AIM:Estimates suggest that in Asia, more than 31 million individuals have hepatitis C virus infection. The present analysis was conducted to assess the efficacy and safety of elbasvir/grazoprevir in Asian participants enrolled in the elbasvir/grazoprevir phase 2/3 clinical trials. METHODS:This is an int...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14636

    authors: Wei L,Kumada H,Perumalswami PV,Tanwandee T,Cheng W,Heo J,Cheng PN,Hwang P,Mu SM,Zhao XM,Asante-Appiah E,Caro L,Hanna GJ,Robertson MN,Haber BA,Talwani R

    更新日期:2019-09-01 00:00:00

  • Gastrointestinal manifestations of leukemia.

    abstract::Gastrointestinal (GI) manifestations of leukemia occur in up to 25% of patients at autopsy, generally during relapse. Its presence varies with the type of leukemia and has been decreasing over time due to improved chemotherapy. Gross leukemic lesions are most common in the stomach, ileum, and proximal colon. Leukemia ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2011.06908.x

    authors: Ebert EC,Hagspiel KD

    更新日期:2012-03-01 00:00:00

  • Transabdominal gastroesophageal devascularization without transection for bleeding varices: results and indicators of prognosis.

    abstract:BACKGROUND:Esophagogastric devascularization is an operation that can be performed for endoscopically uncontrolled variceal bleeding in hospitals having only basic surgical instruments and is therefore an appropriate procedure for small hospitals in developing countries. The aim of this study was to analyze one hospita...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04330.x

    authors: Goyal N,Singhal D,Gupta S,Soin AS,Nundy S

    更新日期:2007-01-01 00:00:00

  • P21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migration.

    abstract:BACKGROUND AND AIM:Transforming growth factor-β (TGF-β) has been shown to play a central role in the promotion of cell motility, but its functional mechanism has remained unclear. With the aim of investigating the diagnostic and treatment modalities for patients with hepatocellular carcinoma (HCC), the signaling pathwa...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12150

    authors: Sato M,Matsuda Y,Wakai T,Kubota M,Osawa M,Fujimaki S,Sanpei A,Takamura M,Yamagiwa S,Aoyagi Y

    更新日期:2013-06-01 00:00:00

  • Fetal and infant exposure to the Chinese famine increases the risk of fatty liver disease in Chongqing, China.

    abstract:BACKGROUND AND AIM:Early life exposure to the famine may affect the susceptibility to the metabolic disorders. The objective of this study was to examine the associations of early life exposure to the Chinese Famine (1959-1961) with the risk of fatty liver disease, obesity, hypertension, and hyperglycemia in adulthood....

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13044

    authors: Chen JP,Peng B,Tang L,Sun R,Hu S,Wen XY,Que P,Wang YH

    更新日期:2016-01-01 00:00:00