Abstract:
BACKGROUND AND AIM:Radiation-induced colitis is a common clinical problem associated with radiotherapy and accidental exposure to ionizing radiation. Goblet cells play a pivotal role in the intestinal barrier against pathogenic bacteria. Rebamipide, an anti-gastric ulcer drug, has the effects to promote goblet cell proliferation. The aim of this study was to investigate whether radiation-induced colonic injury could be alleviated by rebamipide. METHODS:This study orally administered rebamipide for 6 days to mice, which were subjected to 13 Gy abdominal irradiation, to evaluate the therapeutic effects of rebamipide against radiation-induced colitis. To confirm the effects of rebamipide on irradiated colonic epithelial cells, this study used the HT29 cell line. RESULTS:Rebamipide clearly alleviated the acute radiation-induced colitis, as reflected by the histopathological data, and significantly increased the number of goblet cells. The drug also inhibited intestinal inflammation and protected from bacterial translocation during acute radiation-induced colitis. Furthermore, rebamipide significantly increased mucin 2 expression in both the irradiated mouse colon and human colonic epithelial cells. Additionally, rebamipide accelerated not only the recovery of defective tight junctions but also the differentiation of impaired goblet cells in an irradiated colonic epithelium, which indicates that rebamipide has beneficial effects on the colon. CONCLUSIONS:Rebamipide is a therapeutic candidate for radiation-induced colitis, owing to its ability to inhibit inflammation and protect the colonic epithelial barrier.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Jang H,Park S,Lee J,Myung JK,Jang WS,Lee SJ,Myung H,Lee C,Kim H,Lee SS,Jin YW,Shim Sdoi
10.1111/jgh.14021subject
Has Abstractpub_date
2018-04-01 00:00:00pages
878-886issue
4eissn
0815-9319issn
1440-1746journal_volume
33pub_type
杂志文章abstract:BACKGROUND AND AIM:A subcirrhotic range of liver stiffness (sc-LS), assessed by transient elastography, is associated with better outcomes in patients with chronic hepatitis B (CHB). We investigated whether the achievement of sc-LS by antiviral therapy (AVT) reduced the risk of developing hepatocellular carcinoma (HCC)...
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journal_title:Journal of gastroenterology and hepatology
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doi:10.1111/jgh.12046
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journal_title:Journal of gastroenterology and hepatology
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pub_type: 杂志文章,meta分析
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doi:10.1111/j.1440-1746.1996.tb00025.x
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journal_title:Journal of gastroenterology and hepatology
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1111/j.1440-1746.2004.03357.x
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journal_title:Journal of gastroenterology and hepatology
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