Safety and efficacy of elbasvir/grazoprevir in Asian participants with hepatitis C virus genotypes 1 and 4 infection.

abstract：BACKGROUND AND AIM:There are few studies investigating the treatment of hepatitis C virus (HCV) infection in current and former drug users. With this in mind, we sought to evaluate the antiviral efficacy of interferon alpha-2b (IFN alpha-2b) or pegylated-interferon alpha-2b (PEG-IFN alpha-2b) and ribavirin (RBV) in inj...

journal_title：Journal of gastroenterology and hepatology

authors： Grebely J,Raffa JD,Meagher C,Duncan F,Genoway KA,Khara M,McLean M,Mead A,Viljoen M,DeVlaming S,Fraser C,Conway B

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND AIMS:A prospective, non-randomized cohort study on long-term lamivudine treatment, comparing efficacy, drug resistance, and prognosis for various stages of chronic hepatitis B virus (HBV)-related liver disease was performed to elucidate the significance and indication of lamivudine for individual patient...

journal_title：Journal of gastroenterology and hepatology

authors： Nishida T,Kobashi H,Fujioka S,Fujio K,Takaguchi K,Ikeda H,Kawaguchi M,Ando M,Araki Y,Higashi T,Shoji B,Takaki A,Iwasaki Y,Sakaguchi K,Shiratori Y,Yamamoto K

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Annexin A10 (ANXA10) and its liver-specific short isoform (ANXA10S) had tissue-restricted expression. The downregulation of ANXA10S is correlated with tumor progression and poor prognosis in hepatocellular carcinoma. The aim of the present study was to validate the tissue distribution and explore th...

journal_title：Journal of gastroenterology and hepatology

authors： Lu SH,Chen YL,Shun CT,Lai JN,Peng SY,Lai PL,Hsu HC

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIM:Same-day bidirectional endoscopy, including esophagogastroduodenoscopy (EGD) and colonoscopy, is frequently performed to screen for cancer and gastrointestinal bleeding. However, the optimal sequence for the procedures is unclear thus far. The aim of this study was to evaluate the optimal sequence fo...

journal_title：Journal of gastroenterology and hepatology

authors： Hsieh YH,Lin HJ,Tseng KC

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIM:Reactive oxygen species produced by cytochrome P4502E1 (CYP2E1) are believed to play a role in pathophysiology of non-alcoholic fatty liver disease (NAFLD). However, little is known about the expression, protein content and activity of anti-oxidant enzymes and the role of inducible nitric oxide synth...

journal_title：Journal of gastroenterology and hepatology

authors： Kathirvel E,Chen P,Morgan K,French SW,Morgan TR

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND AIM:Glypican-3 (GPC3) expression is correlated with poor prognosis and progression in hepatocellular carcinoma (HCC). HCC progression can be associated with the differentiation status of tumor cell before malignant transformation. Our aim was to investigate the dynamic expression of GPC3 during tumor cel...

journal_title：Journal of gastroenterology and hepatology

authors： Xue R,Feng J,Meng Q,Lv F,Zhu Y,Yu H,Zhang S,Song C,Sun L,Yue Z,Feng S,Che R,Xiang Q,Jing X

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:There are few detailed clinical reports about extrahepatic metastases of hepatocellular carcinoma (HCC). The purpose of the present study was to elucidate the clinical features of extrahepatic metastases of HCC. METHODS:The clinical records of 482 patients who had been diagnosed as having HCC during the per...

journal_title：Journal of gastroenterology and hepatology

authors： Natsuizaka M,Omura T,Akaike T,Kuwata Y,Yamazaki K,Sato T,Karino Y,Toyota J,Suga T,Asaka M

更新日期：2005-11-01 00:00:00

abstract：:We have previously established a cell damage model, with damage induced by either acid or pepsin treatment for 30 min, involving a rat gastric epithelial cell line (RGM1). In the present study, pretreatment of cells with epidermal growth factor (EGF; 0.1-10 ng/mL) or sucralfate (0.1-3 mg/mL) for 4 h prevented such cel...

journal_title：Journal of gastroenterology and hepatology

authors： Furukawa O,Okabe S

更新日期：1997-05-01 00:00:00

abstract：:The Asia-Pacific Consensus Conference was convened to review and synthesize the most current information on Helicobacter pylori management so as to update the previously published regional guidelines. The group recognized that in addition to long-established indications, such as peptic ulcer disease, early mucosa-asso...

journal_title：Journal of gastroenterology and hepatology

authors： Fock KM,Katelaris P,Sugano K,Ang TL,Hunt R,Talley NJ,Lam SK,Xiao SD,Tan HJ,Wu CY,Jung HC,Hoang BH,Kachintorn U,Goh KL,Chiba T,Rani AA,Second Asia-Pacific Conference.

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND AIM:Extracorporeal shockwave lithotripsy (ESWL) has an established role in the management of pancreatic ductal stones. Its efficacy in management of multiple stones in tropical pancreatitis is unknown. The aim of this study was to prospectively evaluate: (i) the efficacy of main pancreatic duct stone cle...

journal_title：Journal of gastroenterology and hepatology

authors： Ong WC,Tandan M,Reddy V,Rao GV,Reddy N

更新日期：2006-10-01 00:00:00

abstract：:The production of interleukin-8 (CINC: cytokine-induced neutrophil chemo-attractant) from different cell populations in the rat liver was studied and cells related to the initiation of CINC production in lipopolysaccharide (LPS)-injected endotoxaemic rats were characterized. Sinusoidal endothelial cells (16.4 +/- 10.6...

journal_title：Journal of gastroenterology and hepatology

authors： Ohkubo K,Masumoto T,Horiike N,Onji M

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatitis E virus (HEV) infection is endemic in several developing countries. Clinical manifestations of this infection vary widely from asymptomatic infection to uncomplicated acute viral hepatitis and fulminant hepatic failure. The pathogenesis of this disease and the reason of varying disease seve...

journal_title：Journal of gastroenterology and hepatology

authors： Srivastava R,Aggarwal R,Sachdeva S,Alam MI,Jameel S,Naik S

更新日期：2011-02-01 00:00:00

abstract：:A novel experimental model of submassive liver necrosis with impaired regeneration has been established. A novel lipid A analogue, FS-112, was injected intravenously into male BALB/c mice, followed 2 days later by a 70% partial hepatectomy. Over the next 9 days, mice became severely jaundiced, with a peak total biliru...

journal_title：Journal of gastroenterology and hepatology

authors： Maeda T,Ohnishi H,Hayashi T,Ishiki Y,Moriwaki H,Muto Y

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND AIM:Rejection of liver grafts is a difficult issue that has not been resolved. Preoperative replacement of liver cells in the graft with cells from the intended recipient may attenuate rejection. We investigated whether preoperative transplant of recipient bone marrow cells (BMCs) to the donor replaced l...

journal_title：Journal of gastroenterology and hepatology

authors： Endo K,Hori T,Jobara K,Hata T,Tsuruyama T,Uemoto S

更新日期：2015-05-01 00:00:00

abstract：:A randomized controlled trial was designed to investigate whether a high dose of terlipressin could control acute variceal haemorrhage more effectively than a low dose of terlipressin. Forty cirrhotic patients with bleeding oesophageal varices were included, with low-dose terlipressin in 21 patients and high-dose terl...

journal_title：Journal of gastroenterology and hepatology

authors： Chang TT,Lee FY,Tsai YT,Lai KH,Chao Y,Hsia HC,Lin HC,Wang SS,Lee SD,Lo KJ

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND AIM:Epidemiology of Helicobacter pylori infection has regional variation. Effect of eradication of H. pylori on symptoms of functional dyspepsia is uncertain, and the data in Asian scenario are scanty. The study aimed to see H. pylori positivity rate in patients of functional dyspepsia and the effect of ...

journal_title：Journal of gastroenterology and hepatology

authors： Sodhi JS,Javid G,Zargar SA,Tufail S,Shah A,Khan BA,Yattoo GN,Gulzar GM,Khan MA,Lone MI,Saif Ru,Parveen S,Shoukat A

更新日期：2013-05-01 00:00:00

abstract：:Forty-six patients with primary biliary cirrhosis from a single centre were studied in a randomized placebo-controlled trial to determine the effectiveness of ursodeoxycholic acid (UDCA) over a 2 year period. The two groups were well-matched at baseline. For each parameter, by calculating the difference between the me...

journal_title：Journal of gastroenterology and hepatology

authors： Turner IB,Myszor M,Mitchison HC,Bennett MK,Burt AD,James OF

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Mongolian gerbils are frequently used to study Helicobacter pylori-induced gastritis and its consequences. The presence of some gastric flora with a suppressive effect on H. pylori suggests inhibitory microflora against H. pylori infection. The aim of the present study was to analyze the microflora ...

journal_title：Journal of gastroenterology and hepatology

authors： Zaman C,Osaki T,Hanawa T,Yonezawa H,Kurata S,Kamiya S

更新日期：2010-05-01 00:00:00

abstract：:The structural analysis, replicative efficiency and immunogenicity of hepatitis B virus (HBV) full-length genomes isolated from different patients or asymptomatic carriers are presented in the present review. Data indicate the importance of viral genome-based studies in elucidating the pathogenesis of HBV infections. ...

journal_title：Journal of gastroenterology and hepatology

authors： Wen YM

更新日期：2004-05-01 00:00:00

abstract：:The hepatitis C virus was first identified in 1989. It causes chronic hepatitis, cirrhosis and hepatocellular carcinoma. Global anti-HCV prevalence is 1-3%. Contaminated blood product, dirty needles and instruments, and injection drug use are the main parenteral routes of transmission. Cultural practices, such as acup...

journal_title：Journal of gastroenterology and hepatology

authors： Leung NW

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Upper gastrointestinal endoscopy remains the gold standard for diagnosis of esophageal varices. Trans-abdominal ultrasound, as a noninvasive routine examination for the follow-up of cirrhosis patient, is safe, cheap, easy to perform, and plays an important role. In this study, we attempt to design a...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang CX,Xu JM,Li JB,Kong DR,Wang L,Xu XY,Zhao DM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIM:The significance of serum levels of transforming growth factor (TGF)-beta1 in the development of gastric cancer is unclear. The purpose of this study is to determine whether serum TGF-beta1 correlated with the clinicopathological findings of patients with gastric cancer. METHODS:Transforming growth ...

journal_title：Journal of gastroenterology and hepatology

authors： Lin Y,Kikuchi S,Obata Y,Yagyu K,Tokyo Research Group on Prevention of Gastric Cancer.

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND AIM:Although regulatory T cells (Treg) and interleukin-17-producing CD4 T cells (Th17) have been demonstrated to play opposing roles in inflammation-associated diseases, their frequency and balance in different stages of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) remain unknown...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang GL,Xie DY,Lin BL,Xie C,Ye YN,Peng L,Zhang SQ,Zhang YF,Lai Q,Zhu JY,Zhang Y,Huang YS,Hu ZX,Gao ZL

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND AIM:Non-invasive markers are essential to assess the progression of chronic liver diseases to fibrosis/ cirrhosis and the effectiveness of therapeutic strategies. The aim of this study was to evaluate the ability of non-invasive markers to identify significant fibrosis, severe fibrosis, and cirrhosis in ...

journal_title：Journal of gastroenterology and hepatology

authors： Sheptulina A,Shirokova E,Nekrasova T,Blum H,Ivashkin V

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND AIM:Contrast harmonic endoscopic ultrasound (CH-EUS) was recently introduced to clinical practice; its reproducibility among endosonographers is unknown. Our aim was to assess the interobserver agreement (IA) in CH-EUS. METHODS:Fifteen endosonographers (eight experienced and seven non-experienced) from ...

journal_title：Journal of gastroenterology and hepatology

authors： Fusaroli P,Kypraios D,Mancino MG,Spada A,Benini MC,Bianchi M,Bocus P,De Angelis C,De Luca L,Fabbri C,Grillo A,Marzioni M,Reggio D,Togliani T,Zanarini S,Caletti G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:There is a wide variation in the prevalence of peptic ulcer in India both before and since the use of endoscopy. We studied the prevalence of peptic ulcer disease in a community in northern India and its relationship with Helicobacter pylori infection. METHODS:A house-to-house survey of residents aged 15 ye...

journal_title：Journal of gastroenterology and hepatology

authors： Singh V,Trikha B,Nain CK,Singh K,Vaiphei K

更新日期：2002-06-01 00:00:00

abstract：:The immunogenicity and adverse reaction of an inactivated hepatitis A (HA) vaccine were investigated. Sixty healthy adult volunteers who lacked antibody to HA virus (anti-HAV) received three doses of vaccine containing 720 enzyme-linked immunosorbent assay (ELISA) units (EL.U) according to a 0, 1 and 6 month schedule....

journal_title：Journal of gastroenterology and hepatology

authors： Horng YC,Chang MH,Lee CY,Safary A,Andre FE,Chen DS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Regional variations in inflammatory bowel disease (IBD) rates have been observed. Limited epidemiological data are available from Australasia. IBD prevalence rates have never been assessed in an Australian population-based setting. In addition, there are few historical IBD incidence data to allow as...

journal_title：Journal of gastroenterology and hepatology

authors： Studd C,Cameron G,Beswick L,Knight R,Hair C,McNeil J,Desmond P,Wilson J,Connell W,Bell S

更新日期：2016-01-01 00:00:00

abstract：:In order to evaluate the relationship between local immune response to Helicobacter pylori and the diversity of disease, 77 asymptomatic subjects who underwent a health examination were studied. Helicobacter pylori-specific IgG in serum and H. pylori-specific IgA in gastric juice were measured by ELISA, and the measur...

journal_title：Journal of gastroenterology and hepatology

authors： Watanabe T,Goto H,Arisawa T,Hase S,Niwa Y,Hayakawa T,Asai J

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND AND AIM:The European evidence-based guidelines (EEG) and American College of Gastroenterology Guidelines (ACGG) have been published to guide the management of pancreatic cystic lesions. We aim to evaluate the value of both guidelines in predicting advanced pancreatic cystic lesions (A-PCLs) with preoperative...

journal_title：Journal of gastroenterology and hepatology

authors： Sun L,Wang W,Wang Y,Jiang F,Peng L,Jin G,Jin Z

更新日期：2020-09-01 00:00:00