Structural and functional analysis of full-length hepatitis B virus genomes in patients: implications in pathogenesis.

Abstract:

:The structural analysis, replicative efficiency and immunogenicity of hepatitis B virus (HBV) full-length genomes isolated from different patients or asymptomatic carriers are presented in the present review. Data indicate the importance of viral genome-based studies in elucidating the pathogenesis of HBV infections. Comparison of structural and functional characteristics of viral genomes isolated from various geographical regions might contribute to explaining the differences in HBV clinical manifestation and prognosis in different geographical regions.

authors

Wen YM

doi

10.1111/j.1440-1746.2003.03158.x

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

485-9

issue

5

eissn

0815-9319

issn

1440-1746

pii

JGH3158

journal_volume

19

pub_type

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