Abstract:
:A novel experimental model of submassive liver necrosis with impaired regeneration has been established. A novel lipid A analogue, FS-112, was injected intravenously into male BALB/c mice, followed 2 days later by a 70% partial hepatectomy. Over the next 9 days, mice became severely jaundiced, with a peak total bilirubin (TBil) concentration of (mean +/- s.d.) 12.9 +/- 2.1 mg/dL 7 days postoperatively. In contrast, the TBil concentration in vehicle-treated mice remained less than 2 mg/dL. Significant elevations of L-alanine:2-oxoglutarate aminotransferase (ALT) were also observed 3-7 days after the operation in mice pretreated with FS-112, compared with mice pretreated with the vehicle. Submassive liver necrosis was observed with extensive mononuclear cell infiltration in mice treated with FS-112 and subjected to partial hepatectomy. Furthermore, both the BrdU and the proliferating cell nuclear antigen (PCNA) labelling index (LI) 1 day following partial hepatectomy in mice pretreated with FS-112 (8.6 +/- 4.3 and 7.9 +/- 4.2%, respectively) were significantly lower than levels in vehicle-treated mice (25.8 +/- 3.8 and 26.5 +/- 10.5%, respectively). The time course of changes in the BrdU LI in liver specimens from mice treated with both FS-112 and partial hepatectomy did not increase, even 3, 5, and 7 days postoperatively. Excellent liver regeneration with a PCNA LI 10-fold higher than the resting level was observed in mice treated with D-galactosamine hydrochloride. These results strongly suggest that this animal model of submassive liver necrosis may be suitable for clarifying the mechanisms of impaired liver cell regeneration often seen in fulminant hepatitis.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Maeda T,Ohnishi H,Hayashi T,Ishiki Y,Moriwaki H,Muto Ydoi
10.1111/j.1440-1746.1996.tb00293.xsubject
Has Abstractpub_date
1996-05-01 00:00:00pages
471-7issue
5eissn
0815-9319issn
1440-1746journal_volume
11pub_type
杂志文章abstract::Brief periods of tissue ischemia produced tissue resistance to prolonged ischemia and reperfusion, a phenomenon called ischemic preconditioning. The mechanisms of ischemic preconditioning were examined in a rat warm ischemia-reperfusion model as well as the effect of ischemic preconditioning on liver regeneration. Isc...
journal_title:Journal of gastroenterology and hepatology
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doi:10.1111/j.1440-1746.1998.tb00761.x
更新日期:1998-09-01 00:00:00
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doi:10.1046/j.1440-1746.2000.02044.x
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pub_type: 杂志文章
doi:10.1111/j.1440-1746.1995.tb01805.x
更新日期:1995-01-01 00:00:00
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doi:10.1111/j.1440-1746.2006.04250.x
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abstract:BACKGROUND AND AIM:As bacterial resistance to clarithromycin limits the efficacy of clarithromycin-based regimens for Helicobacter pylori infection, attention has turned to quinolone-based rescue therapies. Resistance of H. pylori to both clarithromycin and quinolone can be predicted by genetic testing. Here, we used t...
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doi:10.1111/j.1440-1746.2011.06815.x
更新日期:2011-09-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.1993.tb01526.x
更新日期:1993-07-01 00:00:00
abstract::The immunogenicity and adverse reaction of an inactivated hepatitis A (HA) vaccine were investigated. Sixty healthy adult volunteers who lacked antibody to HA virus (anti-HAV) received three doses of vaccine containing 720 enzyme-linked immunosorbent assay (ELISA) units (EL.U) according to a 0, 1 and 6 month schedule....
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pub_type: 杂志文章
doi:10.1111/j.1440-1746.1993.tb01524.x
更新日期:1993-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1440-1746.2003.03038.x
更新日期:2003-07-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1440-1746.1999.01799.x
更新日期:1999-03-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1746.1998.tb00726.x
更新日期:1998-07-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1046/j.1440-1746.2003.02900.x
更新日期:2003-01-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.1996.tb00025.x
更新日期:1996-11-01 00:00:00
abstract::Here we identify a previously unreported cause of rectal bleeding (juvenile polyposis) in a patient with cystic fibrosis (CF). We believe this patient most likely has two coexisting genetic diseases. It also raises many issues about organ transplantation in a patient with medical conditions that individually increase ...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1046/j.1440-1746.1999.01849.x
更新日期:1999-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1440-1746.2000.02357.x
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/j.1440-1746.2009.05831.x
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.1995.tb01795.x
更新日期:1995-01-01 00:00:00
abstract::A 22-year-old man visited our hospital (National Cancer Center Hospital East) complaining of fatigue and anorexia. A laboratory investigation demonstrated a biochemical 'picture' of obstructive jaundice. An abdominal CT showed a low density mass in the retropancreatic area with multiple enlarged periportal lymph nodes...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1046/j.1440-1746.2001.02332.x
更新日期:2001-02-01 00:00:00