Abstract:
BACKGROUND:Saccharomyces cerevisiae may contribute to the pathophysiology of Crohn's disease. We determined serum anti-Saccharomyces cerevisiae antibody (ASCA) levels in patients with inflammatory bowel disease. METHODS AND RESULTS:Immunoglobulin G (IgG) ASCA was measured by using an ELISA in serum samples from 19 patients with ulcerative colitis, 18 patients with Crohn's disease and 7 healthy controls. The ASCA level was significantly higher in patients with ulcerative colitis and patients with Crohn's disease than in controls, and was significantly higher in patients with Crohn's disease compared with patients with ulcerative colitis. Age, gender, disease activity, extent of disease and small bowel involvement each did not affect ASCA levels. The use of elemental or polymeric diet therapy for Crohn's disease and administration of corticosteroids to patients with inflammatory bowel disease also did not affect ASCA levels. The ASCA titer was significantly lower in patients with Crohn's disease taking mesalazine than in those not taking it, although, serum IgG levels did not differ between these two groups, which might imply a suppression of IgG production by mesalazine at the intestinal level. CONCLUSIONS:The finding of increased serum ASCA titers in patients with inflammatory bowel disease suggests that Saccharomyces cerevisiae may play a role in the pathophysiology of this condition.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Oshitani N,Hato F,Matsumoto T,Jinno Y,Sawa Y,Hara J,Nakamura S,Seki S,Arakawa T,Kitano A,Kitagawa S,Kuroki Tdoi
10.1046/j.1440-1746.2000.02357.xsubject
Has Abstractpub_date
2000-12-01 00:00:00pages
1400-3issue
12eissn
0815-9319issn
1440-1746journal_volume
15pub_type
杂志文章abstract:INTRODUCTION:The aim of the present study was to determine whether rats with moderately fatty liver could withstand a 90% hepatectomy, which rats with normal livers can survive. MATERIAL AND METHODS:Nine-week-old male Wistar rats were used. Normal rat chow was fed to the normal liver group, and fat-enriched rat chow w...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章,评审
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journal_title:Journal of gastroenterology and hepatology
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journal_title:Journal of gastroenterology and hepatology
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更新日期:2011-09-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.2008.05729.x
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pub_type: 杂志文章,评审
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更新日期:2012-02-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
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pub_type: 杂志文章
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journal_title:Journal of gastroenterology and hepatology
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doi:10.1046/j.1440-1746.2001.02380.x
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journal_title:Journal of gastroenterology and hepatology
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doi:10.1111/j.1440-1746.1994.tb01290.x
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
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journal_title:Journal of gastroenterology and hepatology
pub_type: 临床试验,杂志文章
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更新日期:2006-01-01 00:00:00