Mucosal pharmacokinetics and pilot study of short course of parenteral imipenem in the eradication of Helicobacter pylori.


:Eradication of Helicobacter pylori infection is known to reduce the incidence of duodenal ulcer recurrence. The most commonly used regimen for H. pylori infection is triple antimicrobial therapy for 1-2 weeks. This treatment is associated with frequent side effects and hence unsatisfactory compliance. As in vitro data showed that H. pylori is sensitive to imipenem, the pharmacokinetics of this drug in the gastric milieu, and the clinical efficacy of imipenem with omeprazole in eradicating H. pylori infection were studied. Imipenem/cilastatin levels in serum, gastric secretion and gastric mucosa were assayed in four patients after intravenous injection of a bolus dose of 500 mg. The serum and gastric secretion levels of imipenem achieved were more than 10 times the minimum inhibitory concentration of the drug for H. pylori. Gastric mucosal levels of imipenem vary considerably with time, which probably indicates rapid elimination of the drug into the gastric lumen. In the second part of this study, imipenem/cilastatin was given intravenously for the first 2 days after diagnosis of H. pylori infection in patients with endoscopically confirmed duodenal ulcers. The patients were also treated with 4 weeks of omeprazole. Clearance of H. pylori was initially achieved at the end of 2 days in 20 out of 22 (91%) patients. However, when the biopsies were repeated at 8 weeks, recurrence of H. pylori infection was evident in 19 cases (86.3%) indicating a failure of eradication. It was concluded that imipenem/cilastatin in combination with omeprazole failed to eradicate H. pylori infection.


Sung JJ,Chung SC,Hosking SW,Chan RC,Ling TK,Yung MY,Cheng AF,Li AK




Has Abstract


1995-01-01 00:00:00












  • Five-lipoxygenase-activating protein inhibitor MK-886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax.

    abstract:BACKGROUND AND AIM:Products of the arachidonic acid metabolizing enzyme, 5-lipoxygenase (5-LOX), stimulate the growth of several cancer types. Inhibitors of 5-LOX and 5-LOX-activating protein (FLAP) induce apoptosis in some cancer cells. Here, the authors investigated the effect of a FLAP inhibitor, MK-886, on the inhi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Fan XM,Tu SP,Lam SK,Wang WP,Wu J,Wong WM,Yuen MF,Lin MC,Kung HF,Wong BC

    更新日期:2004-01-01 00:00:00

  • Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation.

    abstract:BACKGROUND AND AIM:Non-alcoholic fatty liver disease is the result of an imbalance in hepatic lipid partitioning that favors fatty acid synthesis and storage over fatty acid oxidation and triglyceride secretion. The progressive, inflammatory disorder of steatohepatitis can be prevented or reversed by correcting this li...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Larter CZ,Yeh MM,Cheng J,Williams J,Brown S,dela Pena A,Bell-Anderson KS,Farrell GC

    更新日期:2008-02-01 00:00:00

  • Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats.

    abstract:BACKGROUND AND AIMS:Probucol is a lipid-lowering agent with anti-oxidant effects. Oxidative stress and inflammation are important in the pathophysiology of insulin resistance. We aimed to evaluate the effects of probucol on liver histological changes, serum and hepatic levels of adipokines in rats with high fat-induced...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Zhang X,Li Z,Liu D,Xu X,Shen W,Mei Z

    更新日期:2009-06-01 00:00:00

  • Validation of European evidence-based guidelines and American College of Gastroenterology guidelines as predictors of advanced neoplasia in patients with suspected mucinous pancreatic cystic neoplasms.

    abstract:BACKGROUND AND AIM:The European evidence-based guidelines (EEG) and American College of Gastroenterology Guidelines (ACGG) have been published to guide the management of pancreatic cystic lesions. We aim to evaluate the value of both guidelines in predicting advanced pancreatic cystic lesions (A-PCLs) with preoperative...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Sun L,Wang W,Wang Y,Jiang F,Peng L,Jin G,Jin Z

    更新日期:2020-09-01 00:00:00

  • Hepatic and systemic hemodynamic derangements predict early mortality and recovery in patients with acute-on-chronic liver failure.

    abstract:BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is a clinical entity where there is a potential for reversibility of hepatic dysfunction once the acute hepatic insult resolves. The portal and systemic hemodynamics in ACLF patients to study its relevance in determining the clinical outcomes was studied. METHO...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Garg H,Kumar A,Garg V,Kumar M,Kumar R,Sharma BC,Sarin SK

    更新日期:2013-08-01 00:00:00

  • The antiangiogenic effect of thalidomide on occult liver metastases: an in vivo study in mice.

    abstract:AIM:To investigate the morphological changes of intratumoral microvessels after administration of thalidomide in occult hepatic metastases. METHODS:Twenty mice with hepatic metastases created by injection of colon-26 tumor cells into the spleen were enrolled. Ten mice were treated with thalidomide (200 mg/kg) by intra...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Liu Y,Li H,Matsui O

    更新日期:2009-06-01 00:00:00

  • Prevalence of enteric pathogens among community based asymptomatic individuals.

    abstract:BACKGROUND AND AIMS:The objective of this study was to describe the prevalence of pathogenic microorganisms in asymptomatic individuals in a community study in Melbourne, Australia. METHODS:The study population was a subset of 2803 individuals participating in the Water Quality Study; a community based randomized tria...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hellard ME,Sinclair MI,Hogg GG,Fairley CK

    更新日期:2000-03-01 00:00:00

  • Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expression of Abcg5 and Abcg8 in the rat.

    abstract:BACKGROUND AND AIM:Multidrug resistance associated gene product 2 (Mdr2) is believed to have a significant role in biliary cholesterol and phospholipid secretions. Both pravastatin and bezafibrate resulted in Mdr2 induction, but increased cholesterol secretion was observed only in pravastatin treatment. To explore the ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kamisako T,Ogawa H

    更新日期:2004-08-01 00:00:00

  • Risk factors for covered metallic stent migration in patients with distal malignant biliary obstruction due to pancreatic cancer.

    abstract:BACKGROUND AND AIM:Covered metallic stents (CMSs) were developed to overcome tumor ingrowth in uncovered metallic stents (UMSs) for malignant biliary obstruction, but superiority of CMSs over UMSs is still controversial due to the high migration rate in CMS. Therefore, we conducted this retrospective analysis to clarif...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nakai Y,Isayama H,Kogure H,Hamada T,Togawa O,Ito Y,Matsubara S,Arizumi T,Yagioka H,Mizuno S,Sasaki T,Yamamoto N,Hirano K,Tada M,Koike K

    更新日期:2014-09-01 00:00:00

  • Significance of lymphatic invasion and cancer invasion-related proteins on lymph node metastasis in gastric cancer.

    abstract:BACKGROUND AND AIMS:Cancer invasion and metastasis are critical events for patient prognosis; however, the most important step in the whole process of lymph node (LN) metastasis in gastric cancer remains obscure. In this study, the significance of cancer cell behaviors, such as cell detachment, stromal invasion and lym...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kamata I,Ishikawa Y,Akishima-Fukasawa Y,Ito K,Akasaka Y,Uzuki M,Fujimoto A,Morita H,Tamai S,Maehara T,Ogata K,Shimokawa R,Igarashi Y,Miki K,Ishii T

    更新日期:2009-09-01 00:00:00

  • A multicenter prospective study on the prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drugs-negative idiopathic peptic ulcers in Japan.

    abstract:BACKGROUND AND AIM:The prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drug-negative peptic ulcers, commonly known as idiopathic peptic ulcers (IPUs), has been reported to be very low (0.9-2.6%) in Japan based on data from the 1990s. However, recent trends have yet to be been reported. Her...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究


    authors: Kanno T,Iijima K,Abe Y,Yagi M,Asonuma S,Ohyauchi M,Ito H,Koike T,Shimosegawa T

    更新日期:2015-05-01 00:00:00

  • Repeated water avoidance stress induces visceral hypersensitivity: Role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor.

    abstract:BACKGROUND AND AIM:Repeated water avoidance stress (WAS) induces visceral hypersensitivity. Additionally, it is also known to activate corticotropin-releasing factor (CRF), mast cells, and pro-inflammatory cytokines systems, but their precise roles on visceral sensation have not been determined definitely. The aim of t...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nozu T,Miyagishi S,Nozu R,Takakusaki K,Okumura T

    更新日期:2017-12-01 00:00:00

  • Recent development of balloon-occluded retrograde transvenous obliteration.

    abstract::Gastric varices (GVs) are a major complication of portal hypertension in patients with liver cirrhosis. The mortality rate associated with the bleeding from GVs is not low. Balloon-occluded retrograde transvenous obliteration (BRTO) was first introduced by Kanagawa et al. as a treatment for isolated GVs in 1994. It ha...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Kobayakawa M,Ohnishi S,Suzuki H

    更新日期:2019-03-01 00:00:00

  • Validation of structured scoring using the LA classification for esophagitis and endoscopically suspected Barrett's esophagus in a tertiary Asian endoscopy center.

    abstract:AIM:To determine the inter-observer agreement and validity of the LA Classification in scoring the severity of esophagitis in Asian patients. METHODS:Video endoscopy clips were selected from 45 consecutive patients participating in reflux studies. The videos were viewed by endoscopists who then independently scored th...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Wong RK,Yeoh KG,Gwee KA,Tay HW,Ho KY

    更新日期:2009-01-01 00:00:00

  • Post-infectious irritable bowel syndrome in patients with Shigella infection.

    abstract:BACKGROUND AND AIMS:Bacterial gastroenteritis has been known as a risk factor of irritable bowel syndrome (IBS). Several risk factors of post-infectious IBS (PI-IBS) have been documented. The aims of this study were to verify the role of bacterial gastroenteritis in the development of IBS and the risk factors for the d...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Ji S,Park H,Lee D,Song YK,Choi JP,Lee SI

    更新日期:2005-03-01 00:00:00

  • Usefulness of serum IgG4 in the diagnosis and follow up of autoimmune pancreatitis: A systematic literature review and meta-analysis.

    abstract::High circulating serum immunoglobulin G4 (IgG4) levels have been proposed as a marker of autoimmune pancreatitis (AIP). The aim of the present study was to review the data existing in the English literature on the usefulness of the IgG4 serum levels in the diagnosis and follow up of patients with AIP. A total of 159 p...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审


    authors: Morselli-Labate AM,Pezzilli R

    更新日期:2009-01-01 00:00:00

  • Influence of cytochrome P450 2C19 genetic polymorphism and dosage of rabeprazole on accuracy of proton-pump inhibitor testing in Chinese patients with gastroesophageal reflux disease.

    abstract:BACKGROUND AND AIM:To evaluate the optimal dosage of rabeprazole for proton-pump inhibitor (PPI) testing of gastroesophageal reflux disease (GERD) and to test the influence of cytochrome P450 (CYP) 2C19 polymorphism in a population with a high prevalence of people who metabolize PPI poorly. METHODS:In this randomized,...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Lee YC,Lin JT,Wang HP,Chiu HM,Wu MS

    更新日期:2007-08-01 00:00:00

  • Lamivudine/pegylated interferon alfa-2b sequential combination therapy compared with lamivudine monotherapy in HBeAg-negative chronic hepatitis B.

    abstract:BACKGROUND AND AIM:Monotherapy has been proven insufficient in achieving sustained control of chronic hepatitis B. We aimed to assess the efficacy of combined sequential administration of lamivudine and pegylated interferon alfa-2b in patients with hepatitis Be antigen (HBeAg)-negative chronic hepatitis B. METHODS:Eig...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Vassiliadis T,Tziomalos K,Patsiaoura K,Zagris T,Giouleme O,Soufleris K,Grammatikos N,Theodoropoulos K,Mpoumponaris A,Dona K,Zezos P,Nikolaidis N,Orfanou-Koumerkeridou E,Balaska A,Eugenidis N

    更新日期:2007-10-01 00:00:00

  • Long-term follow up of a randomized, controlled trial on prophylactic sclerotherapy of small oesophageal varices in liver cirrhosis.

    abstract:BACKGROUND:In order to evaluate the prophylactic impact of sclerotherapy of small varices in patients with cirrhosis and no endoscopic signs suggesting risk of haemorrhage, a randomized clinical trial was performed. METHODS:Seventy-one hospitalized patients met the inclusion criteria of diagnosis of cirrhosis with no ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Strauss E,Ribeiro MF,Albano A,Honain NZ,Maffei RA Jr,Caly WR

    更新日期:1999-03-01 00:00:00

  • Liver disease in Viet Nam: screening, surveillance, management and education: a 5-year plan and call to action.

    abstract::Despite a high prevalence of liver disease in Viet Nam, there has been no nationwide approach to the disease and no systematic screening of at-risk individuals. Risk factors include chronic hepatitis B (estimated prevalence of 12%), chronic hepatitis C (at least 2% prevalence), and heavy consumption of alcohol among m...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Gish RG,Bui TD,Nguyen CT,Nguyen DT,Tran HV,Tran DM,Trinh HN,International Group for Liver Health in Viet Nam.

    更新日期:2012-02-01 00:00:00

  • Comparison of four current staging systems for Chinese patients with hepatocellular carcinoma undergoing curative resection: Okuda, CLIP, TNM and CUPI.

    abstract:BACKGROUND AND AIM:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. However, there is no general consensus as to which staging system is the most reliable for predicting the survival of patients with HCC. The aims of this study were to compare commonly-used staging systems in a cohort of Chin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lu W,Dong J,Huang Z,Guo D,Liu Y,Shi S

    更新日期:2008-12-01 00:00:00

  • Clinicopathological features of patients with acute graft-versus-host disease of the upper digestive tract.

    abstract:BACKGROUND AND AIMS:Acute graft-versus-host disease (GVHD) occurring within 100 days post-transplant is one of critical factors influencing prognosis in transplant recipients. Among cases of GVHD of the gastrointestinal (GI) tract, GVHD rarely affects the upper GI. In this study, we retrospectively examined the frequen...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nomura K,Iizuka T,Kaji D,Yamamoto H,Kuribayashi Y,Kimura R,Yamada A,Furuhata T,Yamashita S,Kikuchi D,Matsui A,Mitani T,Ogawa O,Hoteya S,Ota Y,Taniguchi S,Kaise M

    更新日期:2014-11-01 00:00:00

  • Antiviral efficacy of lamivudine versus entecavir in patients with hepatitis B virus-related advanced hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:Little information is available about the antiviral efficacy of lamivudine (LAM) and entecavir (ETV) in patients with hepatitis B virus (HBV)-related advanced hepatocellular carcinoma (HCC). Thus, we compared the antiviral efficacy of LAM and ETV in these patients. METHODS:The medical records of 134...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Shin HS,Kim SU,Park JY,Kim DY,Han KH,Chon CY,Baatarkhuu O,Ahn SH

    更新日期:2012-09-01 00:00:00

  • Extending the reading time increases the accuracy of rapid whole blood test for diagnosis of Helicobacter pylori infection.

    abstract:BACKGROUND:To evaluate the accuracy of two rapid whole blood tests (the BM-Test Helicobacter pylori and the QuikPac IV One Step H. pylori Whole Blood Test), and compare this to a conventional quantitative ELISA test (HEL-p TEST II). METHODS:Helicobacter pylori status in dyspeptic patients was assessed by culture, hist...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chen TS,Chang FY,Lee SD

    更新日期:2001-12-01 00:00:00

  • Effects of terlipressin on systemic, hepatic and renal hemodynamics in patients with cirrhosis.

    abstract:BACKGROUND AND AIM:Terlipressin has been shown to be effective in the management of hepatorenal syndrome. However, how terlipressin exerts its effect on the renal artery is unknown. The aim of the present study was to assess the effects of terlipressin on systemic, hepatic and renal hemodynamics in cirrhosis. METHODS:...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Narahara Y,Kanazawa H,Taki Y,Kimura Y,Atsukawa M,Katakura T,Kidokoro H,Harimoto H,Fukuda T,Matsushita Y,Nakatsuka K,Sakamoto C

    更新日期:2009-11-01 00:00:00

  • Terminal ileum intubation is not associated with colonoscopy quality measures.

    abstract:BACKGROUND AND AIM:Intubation of the terminal ileum (TI) demonstrates a complete colonoscopy, but its clinical value during screening exams is unknown. We aimed to determine whether TI intubation during screening colonoscopy is associated with colonoscopy quality measures or identifies subclinical pathology. METHODS:W...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Leiman DA,Jawitz NG,Lin L,Wood RK,Gellad ZF

    更新日期:2020-09-01 00:00:00

  • Natural history of hepatic fibrosis progression in chronic hepatitis C virus infection in India.

    abstract:BACKGROUND AND AIM:The rate of fibrosis progression per year can predict the time for the development of cirrhosis in chronic hepatitis C (CHC). We assessed the rate of fibrosis progression and the predictors of disease severity in Indian CHC patients. METHODS:Of the 355 treatment-naïve, histologically-proven CHC pati...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Hissar SS,Kumar M,Tyagi P,Goyal A,Suneetha PV,Agarwal S,Rastogi A,Sakhuja P,Sarin SK

    更新日期:2009-04-01 00:00:00

  • Achalasia of the oesophagus: treatments with pneumatic dilatation.

    abstract::A series of 51 patients with achalasia of the oesophagus treated by pneumatic dilatation between 1980 and 1988 is reported. Treatment was assessed as effective (no or minimal dysphagia) in 78% of patients, followed for a mean of 30 months. Thirty-four patients required only one dilatation and only two patients had mor...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Prewett EJ,Desmond PV,Breen KJ

    更新日期:1990-11-01 00:00:00

  • Analysis of HLA alleles in Japanese patients with cirrhosis due to chronic hepatitis C.

    abstract::Hepatitis C virus (HCV) leads to chronic liver disease in at least 50-60% of infected people and approximately 40-50% of these patients will go on to develop cirrhosis due to chronic hepatitis C (HCV-C). The pathogenic mechanisms that result in HCV-C are unknown. Sixty Japanese patients with HCV-C were examined for HL...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Higashi Y,Kamikawaji N,Suko H,Ando M

    更新日期:1996-03-01 00:00:00

  • Hyposplenism in alcoholic cirrhosis, facts or artifacts? A comparative analysis with non-alcoholic cirrhosis and extrahepatic portal venous obstruction.

    abstract:BACKGROUND AND AIMS:Hyposplenism has been described in patients with alcoholic cirrhosis (AC). However, no data are available regarding hyposplenism in patients with non-alcoholic cirrhosis (NAC) and other forms of portal hypertension such as extrahepatic portal venous obstruction (EHPVO). The aim is to study the splen...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Satapathy SK,Narayan S,Varma N,Dhiman RK,Varma S,Chawla Y

    更新日期:2001-09-01 00:00:00