The impact of sodium glucose co-transporter 2 inhibitors on non-alcoholic fatty liver disease.

abstract：BACKGROUND AND AIM:Transforming growth factor-β (TGF-β) has been shown to play a central role in the promotion of cell motility, but its functional mechanism has remained unclear. With the aim of investigating the diagnostic and treatment modalities for patients with hepatocellular carcinoma (HCC), the signaling pathwa...

journal_title：Journal of gastroenterology and hepatology

authors： Sato M,Matsuda Y,Wakai T,Kubota M,Osawa M,Fujimaki S,Sanpei A,Takamura M,Yamagiwa S,Aoyagi Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Probucol is a lipid-lowering agent with anti-oxidant effects. Oxidative stress and inflammation are important in the pathophysiology of insulin resistance. We aimed to evaluate the effects of probucol on liver histological changes, serum and hepatic levels of adipokines in rats with high fat-induced...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang X,Li Z,Liu D,Xu X,Shen W,Mei Z

更新日期：2009-06-01 00:00:00

abstract：:Apoptosis, a programmed cell death, was ignored, just like Helicobacter pylori, only to reappear recently. However, the number of current publications dealing with apoptosis or H. pylori has increased exponentially. Although gastric epithelial apoptosis is a programmed physiological event in the superficial aspect of ...

journal_title：Journal of gastroenterology and hepatology

authors： Suzuki H,Ishii H

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Enriched blood vessels occur in the stroma of Barrett's esophagus and are related to the ease of tumor invasion in the early stage of the cancer. Hypoxia-inducible factor (HIF) is closely related with angiogenesis through expression of vascular endothelial growth factor. The aim of the present study was to d...

journal_title：Journal of gastroenterology and hepatology

authors： Moriyama N,Amano Y,Mishima Y,Okita K,Takahashi Y,Yuki T,Ishimura N,Ishihara S,Kinoshita Y

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND AIM:  The clinical utility of capsule endoscopy (CE) is often limited by incomplete small-bowel transit. The aim was to determine whether the use of an external real-time viewer could reduce delays caused by delayed gastric emptying of the capsule or delayed intestinal transit and also improve the rate o...

journal_title：Journal of gastroenterology and hepatology

authors： Shiotani A,Honda K,Kawakami M,Nishi R,Murao T,Ishii M,Matsumoto H,Kusunoki H,Hata J,Haruma K

更新日期：2011-08-01 00:00:00

abstract：:The main purpose of the present study was to demonstrate the incidence of Paneth cells in colorectal tubular adenomas of Japanese descendants in Hawaii. Paneth cells were found in 73 of 322 adenomas (22.7%) of Japanese descendants in Hawaii. The incidence of Paneth cells in adenomas located from the caecum to the tran...

journal_title：Journal of gastroenterology and hepatology

authors： Wada R,Kuwabara N,Suda K

更新日期：1994-05-01 00:00:00

abstract：:Two intertwined compartments coexisting in nonpolypoid conventional (i.e. tubular or villous) adenomas are highlighted in this review: one built of dysplastic tissue on top and the other portraying crypts with irregular, corrupted shapes, albeit lined with normal epithelium, below. The latter compartment has remained ...

journal_title：Journal of gastroenterology and hepatology

authors： Rubio CA

更新日期：2020-08-05 00:00:00

abstract：BACKGROUND AND AIM:Whether an early use of azathioprine (AZA) can alter the natural history of Crohn's disease (CD) remains debated. The aim of this study is to evaluate the impact of AZA on disease progression in a cohort of patients with early CD. METHODS:This longitudinal cohort study examined patients with early C...

journal_title：Journal of gastroenterology and hepatology

authors： Qiu Y,Chen BL,Feng R,Zhang SH,He Y,Zeng ZR,Ben-Horin S,Peyrin-Biroulet L,Mao R,Chen MH

更新日期：2018-03-01 00:00:00

abstract：:The expression of thrombomodulin on sinusoidal endothelial cells was studied using the immuno-peroxidase method and both light and electron microscopy in patients with chronic viral hepatitis (type B: four cases; type C: 28 cases). Thrombomodulin was found on sinusoidal endothelial cells, especially on the surface in ...

journal_title：Journal of gastroenterology and hepatology

authors： Zeniya M,Fukata H,Toda G

更新日期：1995-01-01 00:00:00

abstract：:Patients with end-stage liver disease have significant mortality often associated with intercurrent episodes of bleeding or sepsis. Intact adrenal function is essential in such situations. In order to test the hypothesis that adrenal insufficiency might be present in severe liver disease, hypothalamic-pituitary adrena...

journal_title：Journal of gastroenterology and hepatology

authors： McDonald JA,Handelsman DJ,Dilworth P,Conway AJ,McCaughan GW

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND AND AIM:Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology, which usually progresses to cirrhosis if not diagnosed and treated promptly. Data on long-term follow up in children with AIH are scant. The aim of this study is to assess the long-term outcome of autoimmune hepatitis in children wi...

journal_title：Journal of gastroenterology and hepatology

authors： Saadah OI,Smith AL,Hardikar W

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Positron emission tomography with computed tomography (PET/CT) has been used to detect metastasis in the diagnosis of esophageal adenocarcinoma (EAC). However, the utility of PET/CT to assess primary tumor for endoscopic resectability and prognosis in early EAC remains unclear. We conducted a retros...

journal_title：Journal of gastroenterology and hepatology

authors： Sun G,Tian J,Gorospe EC,Johnson GB,Hunt CH,Lutzke LS,Leggett CL,Iyer PG,Wang KK

更新日期：2013-06-01 00:00:00

abstract：:A 57 year old Japanese male was incidentally found to have a 7.5 cm diameter hepatic haemangioma. Eleven years later he was operated on because the haemangioma had grown into a 17 cm mass causing upper abdominal fullness. Volumetry on computerized tomograms disclosed that the haemangioma had grown from 123 cm3 to 1343...

journal_title：Journal of gastroenterology and hepatology

authors： Yoshida J,Yamasaki S,Yamamoto J,Kosuge T,Takayama T,Hasegawa H,Takayasu K,Muramatsu Y,Moriyama N,Hirohashi S

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND AND AIM:Colorectal cancer (CRC) screening improves survival and requires appropriate recommendation by general practitioners (GPs). Screening practises may be influenced by barriers related to ethnicity and training. METHODS:A mail survey assessed GPs' practises and the barriers towards CRC screening. The a...

journal_title：Journal of gastroenterology and hepatology

authors： Koo JH,You MY,Liu K,Athureliya MD,Tang CW,Redmond DM,Connor SJ,Leong RW

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIM:Helicobacter pylori cagA can be classified into mainly two types (East-Asian-type and Western-type cagA) according to the repeat regions located in the 3' region. Recent studies showed that the Western-type cagA in strains from Okinawa, Japan formed a different cluster (J-Western-type cagA subtype). ...

journal_title：Journal of gastroenterology and hepatology

authors： Matsuo Y,Shiota S,Matsunari O,Suzuki R,Watada M,Binh TT,Kinjo N,Kinjo F,Yamaoka Y

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Bile duct damage and hepatic steatosis are two characteristic histological findings in hepatitis C virus infection; and high prevalence of hepatitis C antibody is noted in patients with cholangiocarcinoma. The purpose of the present study was to examine the relationship between biliary diseases and hepatitis...

journal_title：Journal of gastroenterology and hepatology

authors： Chang TS,Lo SK,Shyr HY,Fang JT,Lee WC,Tai DI,Sheen IS,Lin DY,Chu CM,Liaw YF

更新日期：2005-09-01 00:00:00

abstract：:The relationship between the intragastric pH measured by 24 h pH monitoring system and the serum pepsinogen I/II ratio was studied in 68 cases. When pepsinogen I/II ratio was compared with pH 3.0 holding time (the percentage time during which the gastric pH is above 3.0), there was a negative correlation between these...

journal_title：Journal of gastroenterology and hepatology

authors： Kinoshita Y,Yamashita Y,Kitajima N,Tojo M,Itoh T,Fukuzaki H,Chiba T

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND AIM:Safety and efficacy data on endoscopic treatment of duodenal neoplasm are limited. We suggest the technical feasibility of endoscopic procedures by evaluating the results of endoscopic treatment for nonampullary duodenal adenoma and adenocarcinoma. METHODS:Forty-five patients who underwent endoscopi...

journal_title：Journal of gastroenterology and hepatology

authors： Seo JY,Hong SJ,Han JP,Jang HY,Myung YS,Kim C,Lee YN,Ko BM

更新日期：2014-09-01 00:00:00

abstract：:We have previously established a cell damage model, with damage induced by either acid or pepsin treatment for 30 min, involving a rat gastric epithelial cell line (RGM1). In the present study, pretreatment of cells with epidermal growth factor (EGF; 0.1-10 ng/mL) or sucralfate (0.1-3 mg/mL) for 4 h prevented such cel...

journal_title：Journal of gastroenterology and hepatology

authors： Furukawa O,Okabe S

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND AND AIM:We aimed to investigate the ability of fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) to detect synchronous neoplasms, specifically obstructive colorectal cancer (CRC) and CRC in the proximal colon and to suggest a management strategy based on FDG PET/CT fi...

journal_title：Journal of gastroenterology and hepatology

authors： Kim WS,Lee HS,Lee JM,Kwak MS,Hwang SW,Park SH,Yang DH,Kim KJ,Myung SJ,Yang SK,Byeon JS

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:CYP2C19 polymorphism plays an important role in the metabolism of proton pump inhibitors. The multidrug resistance (MDR)1 genotype is associated with the successful eradication of Helicobacter pylori. The aim of the present study was to investigate the effects of CYP2C19 and MDR1 genotypes on the eradication...

journal_title：Journal of gastroenterology and hepatology

authors： Oh JH,Dong MS,Choi MG,Yoo HW,Lee SB,Park YI,Chung IS

更新日期：2009-02-01 00:00:00

abstract：:To evaluate the long-term efficacy and the timing of booster injection of a lyophilized, inactivated hepatitis A vaccine (HAV), we studied the acquired anti-hepatitis A virus titres in 45 subjects who received either two or three doses of the vaccine. With three doses > or = 0.5 microgram administered at 0, 1 and 6 mo...

journal_title：Journal of gastroenterology and hepatology

authors： Fujiyama S,Odoh K,Tanaka M,Kuramoto I,Tomita K

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Direct-acting antivirals (DAAs) rapidly clear hepatitis C virus (HCV), but the lipid dynamics after DAA treatment remain unknown. Low-density lipoprotein (LDL) cholesterolemia is the predicting factor for the onset and death of atherosclerotic cardiovascular diseases. Thus, in this study, we examined the fre...

journal_title：Journal of gastroenterology and hepatology

authors： Morihara D,Ko YL,Shibata K,Yamauchi R,Fukuda H,Tsuchiya N,Fukunaga A,Kunimoto H,Iwashita H,Takata K,Tanaka T,Sakurai K,Inomata S,Yokoyama K,Nishizawa S,Takeyama Y,Irie M,Shakado S,Sohda T,Sakisaka S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND AIM:Non-invasive diagnosis of colorectal disease remains problematic, fecal biomarkers presenting the only current option. Colorectal mucus is the diagnostically informative element of stool samples, but its separation from stool is difficult. We aimed to: (i) test a novel method of non-invasive colorect...

journal_title：Journal of gastroenterology and hepatology

authors： Loktionov A,Chhaya V,Bandaletova T,Poullis A

更新日期：2016-02-01 00:00:00

abstract：:Coffee is one of the most popular beverages in the world. Several studies consistently show that coffee drinkers with chronic liver disease have a reduced risk of cirrhosis and a lower incidence of hepatocellular carcinoma regardless of primary etiology. With the increasing prevalence of non-alcoholic fatty liver dise...

journal_title：Journal of gastroenterology and hepatology

authors： Chen S,Teoh NC,Chitturi S,Farrell GC

更新日期：2014-03-01 00:00:00

abstract：:Platelets contain not only proteins needed for hemostasis but also many growth factors that are required for organ development, tissue regeneration, and repair. Thrombocytopenia, which is frequently observed in patients with chronic liver disease (CLD) and cirrhosis, is due to various causes, such as decreased thrombo...

journal_title：Journal of gastroenterology and hepatology

authors： Kurokawa T,Zheng YW,Ohkohchi N

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND AIM:Although several techniques for improved outcomes in endoscopic ultrasound (EUS)-guided tissue acquisition have been reported, the reported diagnostic yield for pancreatic masses is not satisfactory. The effects of novel technique (torque method) on twisting the scope in the clockwise or counterclock...

journal_title：Journal of gastroenterology and hepatology

authors： Park SW,Lee SS,Song TJ,Koh DH,Hyun B,Chung D,Lee J,Shin E,Hong SM,Park CH

更新日期：2020-03-01 00:00:00

abstract：:In 18 patients with cancers of the gastrointestinal tract, lymphokine-activated killer (LAK) cell activity was studied and compared with that of healthy subjects. After cultivation with 10(3) iu/mL of recombinant interleukin-2, the cytotoxicity of patients' lymphoid cells was increased from 13.6 +/- 6.8% to 76.2 +/- 1...

journal_title：Journal of gastroenterology and hepatology

authors： Tsugita M,Yamauchi K,Komatsu T,Suzuki H,Hanyu F

更新日期：1990-03-01 00:00:00

abstract：:Continuing advances in molecular biology have provided tools for a promising approach to the treatment of cancer. Among the various strategies of gene therapy for cancer, many are aimed at killing tumour cells indirectly by the induction or reinforcement of a host immune response by gene transduction of various cytoki...

journal_title：Journal of gastroenterology and hepatology

authors： Cao G,Kuriyama S,Du P,Sakamoto T,Yang W,Masui K,Qi Z

更新日期：1996-11-01 00:00:00

abstract：:The structural analysis, replicative efficiency and immunogenicity of hepatitis B virus (HBV) full-length genomes isolated from different patients or asymptomatic carriers are presented in the present review. Data indicate the importance of viral genome-based studies in elucidating the pathogenesis of HBV infections. ...

journal_title：Journal of gastroenterology and hepatology

authors： Wen YM

更新日期：2004-05-01 00:00:00