Induction and clinical utilization of lymphokine-activated killer cells in patients with gastrointestinal tract cancers.

abstract：BACKGROUND AND AIMS:Dysbiosis is thought to be relevant to the etiology and pathogenesis of Crohn's disease (CD). In this study, we investigated the abundance of Faecalibacterium prausnitzii, as well as Bilophila wadsworthia, in the gut microbiota of Japanese CD patients. METHODS:Forty-seven CD patients and 20 healthy...

journal_title：Journal of gastroenterology and hepatology

authors： Fujimoto T,Imaeda H,Takahashi K,Kasumi E,Bamba S,Fujiyama Y,Andoh A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:A lack of published data remains on factors associated with the treatment response to proton pump inhibitors (PPI) in patients with non-erosive reflux disease (NERD). METHODS:Studies on effectiveness of PPI in patients with NERD were identified using the MEDLINE database and manual searches of the available...

journal_title：Journal of gastroenterology and hepatology

authors： Hiyama T,Matsuo K,Urabe Y,Fukuhara T,Tanaka S,Yoshihara M,Haruma K,Chayama K

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND AIM:Since the advent of direct-acting antiviral (DAA) therapy, the total eradication of hepatitis C virus has been achievable with the recovery of hepatic reserve after achievement of sustained virologic response (SVR). Hence, here, we examined the factors affecting the recovery of hepatic reserve. METH...

journal_title：Journal of gastroenterology and hepatology

authors： Nakajima T,Karino Y,Hige S,Suii H,Tatsumi R,Yamaguchi M,Arakawa T,Kuwata Y,Hasegawa T,Toyota J

更新日期：2020-09-29 00:00:00

abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) comprise the idiopathic inflammatory bowel diseases (IBD) of the gut. The etiology of IBD is poorly understood, but an autoimmune disturbance has been suggested to play an important role in this incurable disease. Extracorporeal leukocytapheresis (CAP) is an additional ...

journal_title：Journal of gastroenterology and hepatology

authors： Fukunaga K,Matsumoto T

更新日期：2012-06-01 00:00:00

abstract：AIM:Rabeprazole has been known to inhibit H(+)/K(+)-ATPase more rapidly than omeprazole, the prototype proton pump inhibitor (PPI). The aim of this study was to demonstrate equivalence between low-dose rabeprazole 10 mg and omeprazole 20 mg for the healing rapidity of active peptic ulcer and for improvement of symptoms...

journal_title：Journal of gastroenterology and hepatology

authors： Ji S,Kim HS,Kim JW,Jee MK,Park KW,Uh Y,Lee DK,Song JS,Baik SK,Kwon SO

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND AIM:Colorectal cancer (CRC) screening is based on colonoscopy or fecal occult blood tests, but is imperfect and costly. The Asia Pacific Colorectal Screening Score (APCS) is derived from age, sex, family history of CRC, and smoking history and has been validated in Asian populations. Validation in a West...

journal_title：Journal of gastroenterology and hepatology

authors： Corte C,Zhang L,Chen J,Westbury S,Shaw J,Yeoh KG,Leong R

更新日期：2016-02-01 00:00:00

abstract：:Hepatic ischemia reperfusion (IR) injury is an important clinical problem complicating liver surgery and transplantation. The pathogenesis underlying reperfusion injury after warm ischemia is complex, encompassing a multitude of different cell types and signalling mechanisms innate and/or mobilized to the liver. Since...

journal_title：Journal of gastroenterology and hepatology

authors： Teoh NC

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIM:The effect of solid debris on walled-off necrosis (WON) drainage remains unknown. Our study evaluated the role of solid debris in endoscopic ultrasound (EUS)-guided drainage of WON compared lumen-apposing metal stent (LAMS) with double-pigtail plastic stent (DPPS). METHODS:We retrospectively evaluat...

journal_title：Journal of gastroenterology and hepatology

authors： Zhu H,Xie P,Wang Y,Jin Z,Li Z,Du Y

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND AND AIM:Epithelial-mesenchymal transition (EMT) of biliary epithelial cells (BECs) plays an important role in biliary fibrosis. This study investigated the effects of simvastatin on the lipopolysaccharide (LPS)-induced EMT and related signal pathways in BECs. METHODS:Biliary epithelial cells were exposed to...

journal_title：Journal of gastroenterology and hepatology

authors： Kim Y,Lee EJ,Jang HK,Kim CH,Kim DG,Han JH,Park SM

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:CYP2C19 polymorphism plays an important role in the metabolism of proton pump inhibitors. The multidrug resistance (MDR)1 genotype is associated with the successful eradication of Helicobacter pylori. The aim of the present study was to investigate the effects of CYP2C19 and MDR1 genotypes on the eradication...

journal_title：Journal of gastroenterology and hepatology

authors： Oh JH,Dong MS,Choi MG,Yoo HW,Lee SB,Park YI,Chung IS

更新日期：2009-02-01 00:00:00

abstract：:Mucus and bicarbonate secretions have been widely implicated as an important pre-epithelial protective barrier against autodigestion of the gastric mucosa by acid and pepsin. Evidence from several independent studies shows there is a continuous layer of resilient viscoelastic mucus gel adherent to the surface of the g...

journal_title：Journal of gastroenterology and hepatology

authors： Copeman M,Matuz J,Leonard AJ,Pearson JP,Dettmar PW,Allen A

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND AIM:Although several molecular biomarkers for esophageal adenocarcinoma (EAC) have been shown to be useful disease indicators, none has been established as a reliable indicator for risk of EAC or have progressed to routine use. The aim was to identify biomarkers of high risk for EAC in patients with Barr...

journal_title：Journal of gastroenterology and hepatology

authors： Murao T,Shiotani A,Fujita Y,Yamanaka Y,Kamada T,Manabe N,Hata J,Nishio K,Haruma K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIM:Barrett's esophagus (BE) is a premalignant condition to esophageal adenocarcinoma. It is currently not clear whether cigarette smoking increases the risk of developing BE, and no meta-analysis has been performed on the topic. We conducted a systematic review and meta-analysis, providing a quantitativ...

journal_title：Journal of gastroenterology and hepatology

authors： Andrici J,Cox MR,Eslick GD

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIM:As an important cytokine that modulate the cell cycle, the involvement of transforming growth factor beta-1 (TGF-beta1) in carcinogenesis has been extensively studied for many years. Literatures have demonstrated that TGF-beta1 gene polymorphisms may alter the risk of various cancers, such as lung, p...

journal_title：Journal of gastroenterology and hepatology

authors： Li T,Cao BW,Dai Y,Cui H,Yang HL,Xu CQ

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND AIM:It has been reported that the branched-chain amino acid (BCAA) to tyrosine ratio (BTR) is a useful indicator of liver function and BCAA therapy is associated with a decreased incidence of hepatocellular carcinoma (HCC). However, there has not been sufficient research on the relationship between BTR a...

journal_title：Journal of gastroenterology and hepatology

authors： Tada T,Kumada T,Toyoda H,Kiriyama S,Tanikawa M,Hisanaga Y,Kanamori A,Kitabatake S,Yama T

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND AIM:Host genetic factors have been reported as influencing the progress to fulminant hepatitis (FH). Our previous data showed the serum level of tumor necrosis factor (TNF)-alpha influenced by gene polymorphisms to be markedly increased. It was investigated whether polymorphisms in the IL-10 gene, in add...

journal_title：Journal of gastroenterology and hepatology

authors： Takakura M,Tokushige K,Matsushita N,Hashimoto E,Shiratori K

更新日期：2007-08-01 00:00:00

abstract：:Gilbert's syndrome, an hereditary, chronic, mild, unconjugated hyperbilirubinaemia resulting from impaired hepatic bilirubin clearance and otherwise normal liver function, is arguably the most common syndrome known in humans. Recent molecular genetic studies have determined that the clinical phenotype can be described...

journal_title：Journal of gastroenterology and hepatology

authors： Burchell B,Hume R

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:The efficiency of Helicobacter pylori eradication varies geographically, as do many parameters that might affect therapeutic efficiency. The aims of this study were to investigate the relationship between different genotypes of H. pylori and bacterium-related histopathological lesions in patients with duoden...

journal_title：Journal of gastroenterology and hepatology

authors： Zhao JJ,Wang JB,Yang L,Li Y

更新日期：2007-12-01 00:00:00

abstract：:Herein, we report on an adult with intussusception of an invaginated Meckel's diverticulum presenting mainly with acute intermittent lower gastrointestinal bleeding, whereas the common symptom of abdominal pain, indicating intussusception, was absent. Colonoscopy revealed a reducible polypoid lesion in the ileocecal a...

journal_title：Journal of gastroenterology and hepatology

authors： Lu CL,Chen CY,Chiu ST,Chang FY,Lee SD

更新日期：2001-04-01 00:00:00

abstract：:A hepatitis B virus (HBV) carrier with marked retention of indocyanine green (ICG) and sulfobromophthalein (BSP) was admitted to our hospital for assessment of liver function. On admission, he was asymptomatic and blood chemistry tests showed normal values for transaminases and bilirubin. Serum hepatitis B surface ant...

journal_title：Journal of gastroenterology and hepatology

authors： Ikejima K,Ichikawa S,Kitamura T,Watanabe S,Hirose M,Yokoi Y,Uchida S,Oide H,Suzuki H,Kitami N

更新日期：1993-09-01 00:00:00

abstract：:Hepatitis C virus infection is a global health problem; however, the interaction between pregnancy and chronic hepatitis C remains controversial. A Taiwanese woman with chronic hepatitis C had an uncomplicated pregnancy and gave birth to a female baby through spontaneous vaginal delivery. The serum levels of alanine a...

journal_title：Journal of gastroenterology and hepatology

authors： Chen JD,Chung JL,Kao JH,Chen DS

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The expressions of CD95 (Fas/APO-1) and Bcl-2 are determinants of apoptosis in normal lymphocytes, and abnormalities in their expressions might contribute to the induction of autoimmunity. In this study, we examined the expressions of CD95 and Bcl-2 on freshly isolated T and B cells from patients with autoim...

journal_title：Journal of gastroenterology and hepatology

authors： Ogawa S,Sakaguchi K,Takaki A,Shiraga K,Sawayama T,Mouri H,Miyashita M,Koide N,Tsuji T

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND AIM:Liver stiffness (LS), measured by transient elastography, has been validated as a non-invasive surrogate for liver fibrosis. METHODS:We investigated the long-term predictive ability of LS for hepatocellular carcinoma (HCC) development and overall survival in 1146 patients with chronic hepatitis C by...

journal_title：Journal of gastroenterology and hepatology

authors： Nakagomi R,Tateishi R,Masuzaki R,Soroida Y,Iwai T,Kondo M,Fujiwara N,Sato M,Minami T,Uchino K,Enooku K,Nakagawa H,Asaoka Y,Kondo Y,Tanaka Y,Otsuka M,Kato N,Moriya K,Ikeda H,Koike K

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND AIM:T-cell activation, mediated by the interaction with major histocompatibility complex (MHC)-peptide complexes and B7 costimulatory molecules on antigen-presenting cells, is an essential event in the pathogenesis of inflammatory bowel disease (IBD). We investigated the expression of B7 costimulatory mo...

journal_title：Journal of gastroenterology and hepatology

authors： Grose RH,Howarth GS,Xian CJ,Hohmann AW

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND AIM:Pepsinogen (PG) method is widely used to identify high risk groups of gastric cancer. It is very useful before Helicobacter pylori eradication, but after eradication the method becomes useless because the PGI, PGII, PGI/II ratios change. Therefore, we aimed to identify a high risk group for gastric c...

journal_title：Journal of gastroenterology and hepatology

authors： Haneda M,Kato M,Ishigaki S,Suzuki M,Takahashi M,Nakagawa M,Ono S,Mori Y,Mabe K,Nakagawa S,Kudo T,Shimizu Y,Asaka M

更新日期：2013-01-01 00:00:00

abstract：:Functional gastrointestinal disorders (FGIDs) are common in clinical practice and in communities around the world, including Korea. In a recent point prevalence study on functional dyspepsia (FD) in Korea using the Rome III criteria, 13.4% of community respondents reported dyspepsia. Forty-seven percent of these FD ca...

journal_title：Journal of gastroenterology and hepatology

authors： Park H

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND AIM:Little information is available about the antiviral efficacy of lamivudine (LAM) and entecavir (ETV) in patients with hepatitis B virus (HBV)-related advanced hepatocellular carcinoma (HCC). Thus, we compared the antiviral efficacy of LAM and ETV in these patients. METHODS:The medical records of 134...

journal_title：Journal of gastroenterology and hepatology

authors： Shin HS,Kim SU,Park JY,Kim DY,Han KH,Chon CY,Baatarkhuu O,Ahn SH

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND AIM:Studies focused on the naturally occurring resistance mutation rate in treatment-naïve chronic hepatitis B (CHB) patients have set off a furious dispute. We conduct this meta-analysis to appraise the pooled incidence of spontaneous hepatitis B virus resistance mutations worldwide and its distribution...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang Q,Liao Y,Cai B,Li Y,Li L,Zhang J,An Y,Wang L

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND AIM:Tobacco smoking is a risk factor for gastrointestinal disorders, causing mucosal damage and impairing immune responses. However, smoking has been found to be protective against ulcerative colitis (UC). Human leukocyte antigen (HLA) is a major susceptibility locus for UC, and HLA-DRB1*15:02 has the st...

journal_title：Journal of gastroenterology and hepatology

authors： Lee HS,Kim K,Jung S,Hong M,Kim BM,Yoo DS,Moon JW,Baek J,Hwang SW,Park SH,Yang SK,Han B,Song K,Ye BD

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND AIM:Glypican-3 (GPC3) expression is correlated with poor prognosis and progression in hepatocellular carcinoma (HCC). HCC progression can be associated with the differentiation status of tumor cell before malignant transformation. Our aim was to investigate the dynamic expression of GPC3 during tumor cel...

journal_title：Journal of gastroenterology and hepatology

authors： Xue R,Feng J,Meng Q,Lv F,Zhu Y,Yu H,Zhang S,Song C,Sun L,Yue Z,Feng S,Che R,Xiang Q,Jing X

更新日期：2017-08-01 00:00:00