Abstract:
BACKGROUND AND AIM:As an important cytokine that modulate the cell cycle, the involvement of transforming growth factor beta-1 (TGF-beta1) in carcinogenesis has been extensively studied for many years. Literatures have demonstrated that TGF-beta1 gene polymorphisms may alter the risk of various cancers, such as lung, prostate and breast. To investigate whether polymorphisms of the TGF-beta1 gene can modify the risk of gastric cancer, we conduct this hospital-based, case-control study. METHODS:One hundred and sixty-seven cases and 193 gender, age-matched healthy controls were enrolled in this case-control study. TGF-beta1 polymorphisms C-509T and T + 869C were identified by PCR-RFLP and ARMS-PCR protocols, respectively. RESULTS:Significantly different distributions of both genes were demonstrated between the case and control. Variant genotypes -509CT, -509TT, +869TC and +869CC were associated with increased risk of gastric cancer (P = 0.001, OR = 2.54; P = 0.016, OR = 2.09; P < 0.001, OR = 3.46; P < 0.001, OR = 4.04, respectively). With haplotype analysis, wild type CT (-509C and +869T) led to a lower frequency in case than that in control (P < 0.001), while haplotype TC was more frequent in case than in control (P < 0.001). Multiple logistic regression analysis revealed that individuals with haplotype TC had an increased likelihood of developing gastric cancer (OR = 3.19, 95%CI = 1.72-5.90). CONCLUSIONS:Our findings imply that -509C > T and +869T > C gene polymorphisms in TGF-beta1 may be a critical risk factor of genetic susceptibility to gastric cancer in the Chinese population.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Li T,Cao BW,Dai Y,Cui H,Yang HL,Xu CQdoi
10.1111/j.1440-1746.2008.05324.xsubject
Has Abstractpub_date
2008-04-01 00:00:00pages
638-42issue
4eissn
0815-9319issn
1440-1746pii
JGH5324journal_volume
23pub_type
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