Comparison of the efficacy of rabeprazole 10 mg and omeprazole 20 mg for the healing rapidity of peptic ulcer diseases.

Abstract:

AIM:Rabeprazole has been known to inhibit H(+)/K(+)-ATPase more rapidly than omeprazole, the prototype proton pump inhibitor (PPI). The aim of this study was to demonstrate equivalence between low-dose rabeprazole 10 mg and omeprazole 20 mg for the healing rapidity of active peptic ulcer and for improvement of symptoms. Also, the effect of CYP2C19 genotypes on ulcer healing rapidity was investigated. METHODS:A total of 112 patients with active peptic ulcer were randomized to receive either rabeprazole 10 mg q.d. or omeprazole 20 mg q.d. for 6 weeks. The remaining ratios (%) and complete healing of the ulcer were determined by endoscopy at 1 week and 6 weeks of treatment. The severity of ulcer pain was also investigated during treatment. CYP2C19 genotype was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS:The remaining ratio of peptic ulcers after 1 week and the complete healing rate after 6 weeks in the rabeprazole versus omeprazole group were 45.5% versus 50.3% (P = 0.475) and 80.6% versus 87.0% (P = 0.423), respectively. CYP2C19 genotypes had no effect on the remaining ratio of peptic ulcers after 1 week and the healing rate of peptic ulcers after 6 weeks in both groups. The proportions of patients with symptom improvement or resolution were comparable between the two groups. CONCLUSION:Low-dose rabeprazole 10 mg has a similar efficacy for the healing rapidity of active peptic ulcer disease and symptom improvement compared with standard-dose omeprazole 20 mg.

authors

Ji S,Kim HS,Kim JW,Jee MK,Park KW,Uh Y,Lee DK,Song JS,Baik SK,Kwon SO

doi

10.1111/j.1440-1746.2006.04314.x

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1381-7

issue

9

eissn

0815-9319

issn

1440-1746

pii

JGH4314

journal_volume

21

pub_type

杂志文章,随机对照试验
  • Evaluation of two stool antigen tests for the detection of Helicobacter pylori infection in the Chinese population.

    abstract:BACKGROUND AND AIM:The stool antigen test, the HpSA test, has been validated mainly in Western countries, but not properly in the Chinese population. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. The aim of this study is to compare the accuracy of thes...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.02926.x

    authors: Wong BC,Xia HH,Cheung HK,Ng FH,Wong SY,Chow KC,Lin SK,Yin Y,Wong WM,Yuen MF,Lam SK

    更新日期:2003-01-01 00:00:00

  • Increased melibiose/rhamnose ratio in bile of rats with acute cholestasis.

    abstract:BACKGROUND AND AIM:Melibiose/rhamnose permeability test is used for noninvasive intestinal mucosa barrier testing. However, the possible escape route of the absorbed saccharides through either intact or impaired blood-biliary barriers has not so far been explored. The objective of the present study was therefore two-fo...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05505.x

    authors: Tomsik P,Sispera L,Rezacova M,Niang M,Stoklasova A,Cerman J,Knizek J,Brcakova E,Cermanova J,Micuda S

    更新日期:2008-12-01 00:00:00

  • Extending the reading time increases the accuracy of rapid whole blood test for diagnosis of Helicobacter pylori infection.

    abstract:BACKGROUND:To evaluate the accuracy of two rapid whole blood tests (the BM-Test Helicobacter pylori and the QuikPac IV One Step H. pylori Whole Blood Test), and compare this to a conventional quantitative ELISA test (HEL-p TEST II). METHODS:Helicobacter pylori status in dyspeptic patients was assessed by culture, hist...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2001.02630.x

    authors: Chen TS,Chang FY,Lee SD

    更新日期:2001-12-01 00:00:00

  • Homology model of the DNA gyrase enzyme of Helicobacter pylori, a target of quinolone-based eradication therapy.

    abstract:BACKGROUND AND AIMS:Resistance of Helicobacter pylori to the standard therapeutic antimicrobial agents has been demonstrated. Although quinolones are an alternative candidate for third-line eradication therapy, quinolone resistance of H. pylori is also increasing. Quinolone resistance of H. pylori is caused by a point ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06245.x

    authors: Matsuzaki J,Suzuki H,Tsugawa H,Nishizawa T,Hibi T

    更新日期:2010-05-01 00:00:00

  • Dengue fever related acalculous cholecystitis in a North Indian tertiary care hospital.

    abstract:BACKGROUND AND AIMS:To document the clinical outcome and prognosis of acalculous cholecystitis in dengue fever. METHODS:Prospective analysis of 27 cases of dengue fever presenting to the medical emergency of a tertiary care referral hospital in Chandigarh, India. RESULTS:All patients with dengue fever presenting with...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04295.x

    authors: Sharma N,Mahi S,Bhalla A,Singh V,Varma S,Ratho RK

    更新日期:2006-04-01 00:00:00

  • Increased esophageal mucosal/submucosal blood flow in patients with gastroesophageal reflux disease: normalization by treatment with a proton pump inhibitor.

    abstract:BACKGROUND AND AIM:Mucosal injury caused by gastroesophageal reflux may result in changes in esophageal mucosal blood flow. Little is known about esophageal mucosal blood flow in patients with gastroesophageal reflux disease (GERD). Here we examined esophageal mucosal blood flow and the effects of treatment in patients...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.05113.x

    authors: Mine S,Iida T,Tabata T,Okada Y,Tanaka Y

    更新日期:2008-02-01 00:00:00

  • Favorable outcomes of prepackaged low-residue diet on bowel preparation for colonoscopy: Endoscopist-blinded randomized controlled trial.

    abstract:BACKGROUND AND AIM:2 L polyethylene glycol plus an ascorbic acid (PEGA) is known to be as effective. However, 2 L polyethylene glycol-based regimens are often still difficult for patients to tolerate. Therefore, we conducted this study to evaluate the potential of 1 L PEGA with prepackaged low-residue diet (PLD) as an ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/jgh.14499

    authors: Lee JW,Choi JY,Yoon H,Shin CM,Park YS,Kim N,Lee DH

    更新日期:2019-05-01 00:00:00

  • Spectrum of histopathologic findings in patients with achalasia reflects different etiologies.

    abstract:BACKGROUND:The etiology of achalasia is still unknown. The aim of the present study was to elucidate its underlying pathologies and their chronology by investigation of esophageal specimens in patients undergoing surgery (esophageal resection or myotomy) for achalasia. METHODS:In 17 patients with achalasia, histopatho...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04250.x

    authors: Gockel I,Bohl JR,Doostkam S,Eckardt VF,Junginger T

    更新日期:2006-04-01 00:00:00

  • Impact of the branched-chain amino acid to tyrosine ratio and branched-chain amino acid granule therapy in patients with hepatocellular carcinoma: A propensity score analysis.

    abstract:BACKGROUND AND AIM:It has been reported that the branched-chain amino acid (BCAA) to tyrosine ratio (BTR) is a useful indicator of liver function and BCAA therapy is associated with a decreased incidence of hepatocellular carcinoma (HCC). However, there has not been sufficient research on the relationship between BTR a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12954

    authors: Tada T,Kumada T,Toyoda H,Kiriyama S,Tanikawa M,Hisanaga Y,Kanamori A,Kitabatake S,Yama T

    更新日期:2015-09-01 00:00:00

  • Roles of putative neurotransmitters in the regulation of gastric and intestinal slow waves in conscious dogs.

    abstract:BACKGROUND AND AIMS:Slow waves play an important role in controlling the frequency and propagation of gastrointestinal contractions. However, mechanisms involved in the modulation of slow wave activity in vivo are still unclear. In this study, the roles of different neurotransmitters in the regulation of gastrointestin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04916.x

    authors: Liu S,Xu J,Chen JDz

    更新日期:2007-07-01 00:00:00

  • Marked retention of indocyanine green and sulfobromophthalein with chronic persistent hepatitis.

    abstract::A hepatitis B virus (HBV) carrier with marked retention of indocyanine green (ICG) and sulfobromophthalein (BSP) was admitted to our hospital for assessment of liver function. On admission, he was asymptomatic and blood chemistry tests showed normal values for transaminases and bilirubin. Serum hepatitis B surface ant...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1993.tb01554.x

    authors: Ikejima K,Ichikawa S,Kitamura T,Watanabe S,Hirose M,Yokoi Y,Uchida S,Oide H,Suzuki H,Kitami N

    更新日期:1993-09-01 00:00:00

  • Vasoactive intestinal polypeptide appears to be one of the mediators in misoprostol-enhanced small intestinal transit in rats.

    abstract:BACKGROUND AND AIMS:Prostaglandin analogs have the pharmacologic effect of speeding up small intestinal transit (SIT). It remains unknown whether some gut peptides also mediate this enhancement. We studied the effect of misoprostol on rat SIT and looked at the role of vasoactive intestinal polypeptide (VIP) release dur...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2000.02306.x

    authors: Chang FY,Doong ML,Chen TS,Lee SD,Wang PS

    更新日期:2000-10-01 00:00:00

  • Effects of Helicobacter pylori eradication therapy on gastric emptying measured using the 13C-octanoic acid breath test and the acetaminophen method.

    abstract:BACKGROUND:The relationship between Helicobacter pylori eradication and gastric emptying has been reported; however, the effect of eradication therapy on gastric emptying is still unclear. This study evaluated the relationship between three gastric emptying techniques, the scintigraphic technique, the 13C-octanoic acid...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04075.x

    authors: Kachi M,Shirasaka D,Aoyama N,Ebara S,Miki I,Morita Y,Tamura T,Kasuga M

    更新日期:2006-05-01 00:00:00

  • Australian clinical practice guidelines for the diagnosis and management of Barrett's esophagus and early esophageal adenocarcinoma.

    abstract::Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances i...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.12913

    authors: Whiteman DC,Appleyard M,Bahin FF,Bobryshev YV,Bourke MJ,Brown I,Chung A,Clouston A,Dickins E,Emery J,Eslick GD,Gordon LG,Grimpen F,Hebbard G,Holliday L,Hourigan LF,Kendall BJ,Lee EY,Levert-Mignon A,Lord RV,Lord SJ

    更新日期:2015-05-01 00:00:00

  • Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease.

    abstract:BACKGROUND AND AIMS:Dysbiosis is thought to be relevant to the etiology and pathogenesis of Crohn's disease (CD). In this study, we investigated the abundance of Faecalibacterium prausnitzii, as well as Bilophila wadsworthia, in the gut microbiota of Japanese CD patients. METHODS:Forty-seven CD patients and 20 healthy...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12073

    authors: Fujimoto T,Imaeda H,Takahashi K,Kasumi E,Bamba S,Fujiyama Y,Andoh A

    更新日期:2013-04-01 00:00:00

  • Inflammatory pseudotumors of the liver: experience of a specialist surgical unit.

    abstract:BACKGROUND AND AIM:To present the experience in management of inflammatory liver pseudotumors from a specialist surgical unit and to review the medical literature on this rare manifestation. METHODS:Between 1995 and 2008, four patients were identified with this type of tumor from a total of 108 resected benign liver l...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2009.05951.x

    authors: Milias K,Madhavan KK,Bellamy C,Garden OJ,Parks RW

    更新日期:2009-09-01 00:00:00

  • Hepatitis B immunoglobulins and/or lamivudine for preventing hepatitis B recurrence after liver transplantation: a systematic review.

    abstract:BACKGROUND:Currently, hepatitis B immunoglobulins (HBIg) and/or lamivudine have become the main options for prevention of hepatitis B recurrence after liver transplantation. AIM:To assess the benefits of HBIg and/or lamivudine for prevention of hepatitis B recurrence after liver transplantation. METHODS:We conducted ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1440-1746.2009.06151.x

    authors: Chen J,Yi L,Jia JD,Ma H,You H

    更新日期:2010-05-01 00:00:00

  • Genetic polymorphisms of CD14 and Toll-like receptor-2 (TLR2) in patients with ulcerative colitis.

    abstract:BACKGROUND AND AIM:Ulcerative colitis (UC) is a multifactorial disease resulting from a complex interaction of genetic and environmental factors. Identifying genetic variants that alter the innate immune response is highly relevant to understanding the pathogenesis of UC. The aim of this study was to investigate the as...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04909.x

    authors: Wang F,Tahara T,Arisawa T,Shibata T,Nakamura M,Fujita H,Iwata M,Kamiya Y,Nagasaka M,Takahama K,Watanabe M,Hirata I,Nakano H

    更新日期:2007-06-01 00:00:00

  • Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon.

    abstract:BACKGROUND:The pathophysiology of constipation is not clearly identified as yet, and the interstital cells of Cajal (ICC), known to generate the slow wave activity and to be involved in intestinal neurotransmission and the enteric nervous system (ENS), are suspected to play an important role. The aims of the present st...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.03809.x

    authors: Lee JI,Park H,Kamm MA,Talbot IC

    更新日期:2005-08-01 00:00:00

  • Liver transplantation: Issues for the next 20 years.

    abstract::The growing numbers of potential transplant recipients on waiting lists is increasingly disproportionate to the supply of cadaveric donor organs. The hope for the next 20 years is that supply will satisfy demand. This requires both a reduction in indications for the procedure and an increase in the transplants perform...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1440-1746.2009.06081.x

    authors: Perera MT,Mirza DF,Elias E

    更新日期:2009-10-01 00:00:00

  • Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. Previous studies have investigated the association between dietary patterns and NAFLD, but their results are contradictory. Therefore, we carried out this meta-analysis to examine the association betw...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15363

    authors: Hassani Zadeh S,Mansoori A,Hosseinzadeh M

    更新日期:2020-12-02 00:00:00

  • Prognostic value of hepatocyte nuclear factors 4α and 1α identified by tissue microarray in resectable hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:This study aimed to investigate the prognostic value of expression of hepatocyte nuclear factors (HNFs) involved in hepatic gene transcription in patients undergoing curative resection for hepatocellular carcinoma (HCC). METHODS:We performed immunohistochemical analyses on microarrays of the tumors ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12371

    authors: Shim JH,Kang HJ,Han S,Lee YJ,Lee SG,Yu E,Lee HC

    更新日期:2014-03-01 00:00:00

  • Clinicopathological staging for colorectal cancer: an International Documentation System (IDS) and an International Comprehensive Anatomical Terminology (ICAT).

    abstract::The purpose of tumour staging for colorectal cancer (CRC) is to help define clinical management, facilitate communication between physicians, provide a basis for stratification and analysis of treatment results in prospective studies, and provide some prognostic information for patients and their families. The World C...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1991.tb00867.x

    authors: Fielding LP,Arsenault PA,Chapuis PH,Dent O,Gathright B,Hardcastle JD,Hermanek P,Jass JR,Newland RC

    更新日期:1991-07-01 00:00:00

  • Meta-analysis: is sequential therapy superior to standard triple therapy for Helicobacter pylori infection in Asian adults?

    abstract:BACKGROUND AND AIM:Although several meta-analyses suggested that sequential therapy (SQT) is superior to standard triple therapy (STT) for the eradication of Helicobacter pylori, these results were mainly based on the studies from Italy. The aim of this study was to assess the efficacy of 10-day SQT for H. pylori infec...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析

    doi:10.1111/jgh.12397

    authors: Yoon H,Lee DH,Kim N,Park YS,Shin CM,Kang KK,Oh DH,Jang DK,Chung JW

    更新日期:2013-12-01 00:00:00

  • Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2).

    abstract:BACKGROUND AND AIM:The major transporter responsible for bile acid uptake from the intestinal lumen is the apical sodium-dependent bile acid transporter (ASBT, SLC10A2). Analysis of the SLC10A2 gene has identified a variety of sequence variants including coding region single nucleotide polymorphisms (SNPs) that may inf...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2011.06805.x

    authors: Ho RH,Leake BF,Urquhart BL,Gregor JC,Dawson PA,Kim RB

    更新日期:2011-12-01 00:00:00

  • Sustained virologic response achieved after curative treatment of hepatitis C virus-related hepatocellular carcinoma as an independent prognostic factor.

    abstract:BACKGROUND AND AIM:Whether an antiviral interferon (IFN)-based therapy (IBT) after curative treatment of hepatocellular carcinoma (HCC) improves the prognosis in patients with hepatitis C virus (HCV)-related HCC remains to be elucidated. METHODS:A total of 178 patients within the Milan criteria underwent curative trea...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12925

    authors: Kanogawa N,Ogasawara S,Chiba T,Saito T,Motoyama T,Suzuki E,Ooka Y,Tawada A,Kanda T,Mikami S,Azemoto R,Kaiho T,Shinozaki M,Ohtsuka M,Miyazaki M,Yokosuka O

    更新日期:2015-07-01 00:00:00

  • Use of transient elastography in patients with HIV-HCV coinfection: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:Patients with HIV-hepatitis C virus (HCV) coinfection progress towards liver fibrosis and cirrhosis more rapidly compared with HCV mono-infected individuals. This necessitates an accurate assessment of liver stiffness with transient elastography to guide treatment. METHODS:Searches of PubMed, EMBASE...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/jgh.13337

    authors: Njei B,McCarty TR,Luk J,Ewelukwa O,Ditah I,Lim JK

    更新日期:2016-10-01 00:00:00

  • A pilot study of three-dimensional conformal radiotherapy in unresectable hepatocellular carcinoma.

    abstract:BACKGROUND:The purpose of this study was to determine the potential role of three-dimensional (3-D) conformal radiotherapy (RT) in treatment of unresectable hepatocellular carcinoma (HCC). METHODS:Thirteen patients were included in this study, which was conducted between 1993 and 1996. Nine patients (group A) were tre...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1440-1746.1999.01994.x

    authors: Cheng SH,Lin YM,Chuang VP,Yang PS,Cheng JC,Huang AT,Sung JL

    更新日期:1999-10-01 00:00:00

  • Hepatitis B virus infection in dialysis patients.

    abstract::Hepatitis B virus (HBV) infection remains a major issue among dialysis patients. It is associated with a high risk of hepatic complication. The liver disease runs a unique clinical course in dialysis patients, as it can progress with modest hepatic inflammation and prominent fibrosis. The conventional cut-off level of...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2005.03837.x

    authors: Wong PN,Fung TT,Mak SK,Lo KY,Tong GM,Wong Y,Loo CK,Lam EK,Wong AK

    更新日期:2005-11-01 00:00:00

  • Epidemiology, characteristics, and survival of post-colonoscopy colorectal cancer in Asia: A population-based study.

    abstract:BACKGROUND AND AIM:Population-based studies on post-colonoscopy colorectal cancer (CRC) from Asia are sparse. We aimed to determine the characteristics and predictive factors and survival of post-colonoscopy CRC in Hong Kong. METHODS:This is a territory-wide retrospective cohort study. Patients aged ≥ 40 years with co...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14674

    authors: Cheung KS,Chen L,Seto WK,Leung WK

    更新日期:2019-09-01 00:00:00