Homology model of the DNA gyrase enzyme of Helicobacter pylori, a target of quinolone-based eradication therapy.

abstract：BACKGROUND:Australia receives many migrants from countries with a high prevalence of hepatitis C infection. General practitioners, who are often the first health professionals consulted, need to be aware of risk factors and complications associated with hepatitis C in this group. METHODS:Four hundred and forty-seven g...

journal_title：Journal of gastroenterology and hepatology

authors： Dev A,Sievert W

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Poly-adenosine diphosphate (ADP)-ribosylation, catalysed by poly(ADP-ribose) polymerase (PARP), is a post-translational modification of nuclear proteins and is involved in a wide range of biological processes including DNA repair, cell proliferation and malignant transformation. Alteration of this reaction i...

journal_title：Journal of gastroenterology and hepatology

authors： Nomura F,Yaguchi M,Togawa A,Miyazaki M,Isobe K,Miyake M,Noda M,Nakai T

更新日期：2000-05-01 00:00:00

abstract：:AL amyloidosis complicating multiple myeloma is rare but well recognized. Endoscopic appearances of amyloid in the gastrointestinal tract can, however, be highly variable. Macroscopic appearances of the duodenum can range from scalloping (often seen in celiac disease) to that of duodenitis; erosive disease, frank ulce...

journal_title：Journal of gastroenterology and hepatology

authors： Hurlstone DP

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Treatment of post-transplantation recurrence of hepatitis B virus (HBV) infection despite prophylaxis with hepatitis B immunoglobulin (HBIG) and lamivudine combination therapy is not easy. Because HBV reinfection has a severe course and could result in graft failure in liver transplant recipients, prompt med...

journal_title：Journal of gastroenterology and hepatology

authors： Akyildiz M,Karasu Z,Zeytunlu M,Aydin U,Ozacar T,Kilic M

更新日期：2007-12-01 00:00:00

abstract：:Alcoholic hepatitis is a potentially life-threatening complication of alcoholic abuse, typically presenting with symptoms and signs of hepatitis in the presence of an alcohol use disorder. The definitive diagnosis requires liver biopsy, but this is not generally required. The pathogenesis is uncertain, but relevant fa...

journal_title：Journal of gastroenterology and hepatology

authors： Haber PS,Warner R,Seth D,Gorrell MD,McCaughan GW

更新日期：2003-12-01 00:00:00

abstract：UNLABELLED:A case-control study was conducted in southern Thailand to test the hypothesis that alcohol consumption, smoking, rubber processing and nutritional deficiency were risk factors for oesophageal cancer. Cases (n = 40) were recruited from patients admitted to the University Hospital, where the first interview t...

journal_title：Journal of gastroenterology and hepatology

authors： Chongsuvivatwong V

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatitis E virus (HEV) infection is endemic in several developing countries. Clinical manifestations of this infection vary widely from asymptomatic infection to uncomplicated acute viral hepatitis and fulminant hepatic failure. The pathogenesis of this disease and the reason of varying disease seve...

journal_title：Journal of gastroenterology and hepatology

authors： Srivastava R,Aggarwal R,Sachdeva S,Alam MI,Jameel S,Naik S

更新日期：2011-02-01 00:00:00

abstract：:Brief periods of tissue ischemia produced tissue resistance to prolonged ischemia and reperfusion, a phenomenon called ischemic preconditioning. The mechanisms of ischemic preconditioning were examined in a rat warm ischemia-reperfusion model as well as the effect of ischemic preconditioning on liver regeneration. Isc...

journal_title：Journal of gastroenterology and hepatology

authors： Arai M,Tejima K,Ikeda H,Tomiya T,Yanase M,Inoue Y,Nagashima K,Nishikawa T,Watanabe N,Omata M,Fujiwara K

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Haemosuccus pancreaticus is a rare complication of pancreatitis. It is a diagnostic problem for even the most astute clinician and a challenge for the expert endoscopist. We report a 25-year-old male patient who had all the features usually seen in haemosuccus pancreaticus patients: recurrent obscure upper g...

journal_title：Journal of gastroenterology and hepatology

authors： Yattoo GN,Khuroo MS,Wani NA,Wani KA,Bhat FA

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND AND AIM:Little is known about the role of platelet-derived growth factor (PDGF) in biliary fibrosis in the setting of bacterial colonization of the biliary tree. We therefore sought to investigate whether exposure to bacterial lipopolysaccharide (LPS) alters PDGF isoform and receptor expression in cultured r...

journal_title：Journal of gastroenterology and hepatology

authors： Kim TH,Moon JH,Savard CE,Kuver R,Lee SP

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND AIMS:We identified patients with nonalcoholic fatty liver disease (NAFLD) to determine the predictive value of serum markers to diagnose histological steatohepatitis (NASH). METHODS:Demographic, serological, radiological and histological variables on 95 consecutive patients with NAFLD were recorded. The...

journal_title：Journal of gastroenterology and hepatology

authors： Malik R,Chang M,Bhaskar K,Nasser I,Curry M,Schuppan D,Byrnes V,Afdhal N

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND AIM:We have previously found high incidence of inflammatory bowel disease (IBD) in Australia. A population-based registry was established to assess disease severity, frequency of complications, and prognostic factors. METHODS:Incident cases were prospectively identified over 4 years. Early disease sever...

journal_title：Journal of gastroenterology and hepatology

authors： Niewiadomski O,Studd C,Hair C,Wilson J,Ding NS,Heerasing N,Ting A,McNeill J,Knight R,Santamaria J,Prewett E,Dabkowski P,Dowling D,Alexander S,Allen B,Popp B,Connell W,Desmond P,Bell S

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND AIM:Mitochondrial damage is commonly involved in liver injury. We have previously shown that normal mitochondria can be coated with a carrier protein to form complexes that are specifically taken up by liver cells in culture. The aim of the current study was to determine whether mitochondrial complexes c...

journal_title：Journal of gastroenterology and hepatology

authors： Liu X,Khouri-Farah N,Wu CH,Wu GY

更新日期：2020-05-09 00:00:00

abstract：BACKGROUND AND AIM:The treatment of patients with functional dyspepsia (FD) remains unsatisfactory. We assessed the efficacy of Zhizhu Kuanzhong (ZZKZ) capsule, a traditional Chinese medicine formula, in patients with postprandial distress syndrome (PDS) of FD. METHODS:The study was designed as a multicenter, randomiz...

journal_title：Journal of gastroenterology and hepatology

authors： Xiao Y,Li Y,Shu J,Li Y,Xu J,Ren J,Liu D,Wang J,Zhou L,Li Y,Tang G,Tian D,Zhang S,Hou X,Wang H,Li Z,Lv N,Chen M

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND AIM:Although gastric hypermotility is one of the mechanisms proposed to explain the ulcerogenic action of indomethacin, the drug has shown relaxatory effects on isolated longitudinal and transverse rat gastric fundus. To explain the above discrepancy, the aim of this study was to investigate the effects ...

journal_title：Journal of gastroenterology and hepatology

authors： Keshavarz M,Afshin S,Djahanguiri B

更新日期：2007-09-01 00:00:00

abstract：:A series of 51 patients with achalasia of the oesophagus treated by pneumatic dilatation between 1980 and 1988 is reported. Treatment was assessed as effective (no or minimal dysphagia) in 78% of patients, followed for a mean of 30 months. Thirty-four patients required only one dilatation and only two patients had mor...

journal_title：Journal of gastroenterology and hepatology

authors： Prewett EJ,Desmond PV,Breen KJ

更新日期：1990-11-01 00:00:00

abstract：:A 57 year old Japanese male was incidentally found to have a 7.5 cm diameter hepatic haemangioma. Eleven years later he was operated on because the haemangioma had grown into a 17 cm mass causing upper abdominal fullness. Volumetry on computerized tomograms disclosed that the haemangioma had grown from 123 cm3 to 1343...

journal_title：Journal of gastroenterology and hepatology

authors： Yoshida J,Yamasaki S,Yamamoto J,Kosuge T,Takayama T,Hasegawa H,Takayasu K,Muramatsu Y,Moriyama N,Hirohashi S

更新日期：1991-07-01 00:00:00

abstract：:Fatty acids in our daily diet are broadly classified into cis and trans fatty acids (TFAs). TFAs are formed during the manufacturing process of hydrogenated vegetable oils such as margarine. Modern diets such as deep-fried products, frozen foods, and packaged snacks commonly include large quantities of margarine conta...

journal_title：Journal of gastroenterology and hepatology

authors： Okada Y,Tsuzuki Y,Ueda T,Hozumi H,Sato S,Hokari R,Kurihara C,Watanabe C,Tomita K,Komoto S,Kawaguchi A,Nagao S,Miura S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND AIM:Monotherapy has been proven insufficient in achieving sustained control of chronic hepatitis B. We aimed to assess the efficacy of combined sequential administration of lamivudine and pegylated interferon alfa-2b in patients with hepatitis Be antigen (HBeAg)-negative chronic hepatitis B. METHODS:Eig...

journal_title：Journal of gastroenterology and hepatology

authors： Vassiliadis T,Tziomalos K,Patsiaoura K,Zagris T,Giouleme O,Soufleris K,Grammatikos N,Theodoropoulos K,Mpoumponaris A,Dona K,Zezos P,Nikolaidis N,Orfanou-Koumerkeridou E,Balaska A,Eugenidis N

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND AIM:The technical performance of colonoscopy performed in deeply sedated patients differs from that performed without sedation or under minimal to moderate sedation. The aim of this study is to evaluate the factors affecting cecal intubation during colonoscopy performed under deep sedation. METHODS:A to...

journal_title：Journal of gastroenterology and hepatology

authors： Hsu CM,Lin WP,Su MY,Chiu CT,Ho YP,Chen PC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIM:To investigate a possible association between HLA genes with serum alanine aminotransferase (ALT) levels and evaluate whether the HLA-DQA1, DQB1, and DRB1 genes could influence the development of liver damage in chronic hepatitis C. METHODS:A total of 145 patients with chronic hepatitis C virus (HCV...

journal_title：Journal of gastroenterology and hepatology

authors： Yu RB,Hong X,Ding WL,Tan YF,Zhang YX,Sun NX,Wu GL,Zhan SW,Ge DF

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND AIM:Current treatments of functional dyspepsia (FD) are unsatisfied. Tricyclic antidepressants alter visceral hypersensitivity and brain-gut interaction. We assessed the efficacy and safety of nortriptyline in patients with FD. METHODS:Patients diagnosed with FD according to Rome III criteria who failed...

journal_title：Journal of gastroenterology and hepatology

authors： Kaosombatwattana U,Pongprasobchai S,Limsrivilai J,Maneerattanaporn M,Leelakusolvong S,Tanwandee T

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND AIM:Oral mucosal pathologies are frequent in inflammatory bowel disease (IBD). Since host-microbiome interactions are implicated in the pathogenesis of IBD, in this study the potential for changes affecting the oral microbiome was evaluated using two complementary mouse models of colitis: either chemical...

journal_title：Journal of gastroenterology and hepatology

authors： Rautava J,Pinnell LJ,Vong L,Akseer N,Assa A,Sherman PM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The purpose of the present paper was to investigate dendritic cell (DC) and T-cell functions in patients with chronic hepatitis B (CHB) and determine whether therapeutic DC vaccines could restore T-cell function in those patients in vitro. METHODS:Twelve patients with CHB and 10 normal control subjects with...

journal_title：Journal of gastroenterology and hepatology

authors： Duan XZ,He HX,Zhuang H

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVES:The epidemiology of lower gastrointestinal bleeding (LGIB) in Western populations has been reported; however, there are scant Asian reports. The aim of the present study was to determine the etiology of LGIB in a Chinese population by reporting a retrospective case series and a systematic analysis of Chinese...

journal_title：Journal of gastroenterology and hepatology

authors： Bai Y,Peng J,Gao J,Zou DW,Li ZS

更新日期：2011-04-01 00:00:00

abstract：:Sinusoidal endothelial cell damage is produced by activation of hepatic macrophages after endotoxin administration in rats pretreated with Cornyebacterium parvum or undergoing 70% hepatectomy. Such damage causes fibrin deposition in the hepatic sinusoids leading to massive hepatic necrosis. In the C. parvum model, cyt...

journal_title：Journal of gastroenterology and hepatology

authors： Mochida S,Ohno A,Arai M,Fujiwara K

更新日期：1995-01-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) has been reported to be detectable in about 10% of gastric carcinomas. We performed a comparative study of endosonographic findings of EBV-positive and -negative early gastric carcinomas. Epstein-Barr virus was detected in 11.8% (four of 34) of endosonographically observed early gastric ca...

journal_title：Journal of gastroenterology and hepatology

authors： Nishikawa J,Yanai H,Mizugaki Y,Takada K,Tada M,Okita K

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Bile duct damage and hepatic steatosis are two characteristic histological findings in hepatitis C virus infection; and high prevalence of hepatitis C antibody is noted in patients with cholangiocarcinoma. The purpose of the present study was to examine the relationship between biliary diseases and hepatitis...

journal_title：Journal of gastroenterology and hepatology

authors： Chang TS,Lo SK,Shyr HY,Fang JT,Lee WC,Tai DI,Sheen IS,Lin DY,Chu CM,Liaw YF

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The parasympathetic nervous system (PNS), via neurotransmitter acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear. AIMS:We aimed to determine the fibrogenic responses of human hepatic stellate cells (hHSC) to ACh and the relevance ...

journal_title：Journal of gastroenterology and hepatology

authors： Morgan ML,Sigala B,Soeda J,Cordero P,Nguyen V,McKee C,Mouraliderane A,Vinciguerra M,Oben JA

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND AIM:To study the histological changes caused by transfection of the hepatocyte growth factor (HGF) gene using electroporation (EP) in a non-alcoholic steatohepatitis (NASH) cirrhotic liver model. METHODS:NASH cirrhotic livers were prepared by administering a choline-deficient diet to 5-week-old male Wis...

journal_title：Journal of gastroenterology and hepatology

authors： Kiyama S,Yamada T,Iwata H,Sekino T,Matsuo H,Yoshida N,Miyahara T,Umeda Y,Matsuno Y,Kimura M,Matsumoto K,Nakamura T,Takemura H

更新日期：2008-08-01 00:00:00