Role of apoptosis in Helicobacter pylori-associated gastric mucosal injury.

Abstract:

:Apoptosis, a programmed cell death, was ignored, just like Helicobacter pylori, only to reappear recently. However, the number of current publications dealing with apoptosis or H. pylori has increased exponentially. Although gastric epithelial apoptosis is a programmed physiological event in the superficial aspect of the mucosa and is important for healthy cell turnover, H. pylori infection reportedly promotes such a cell death sequence. Because apoptosis regulates the cycle of cell turnover in balance with proliferation, dysregulation of apoptosis or proliferation evoked by H. pylori colonization would be linked to the gastric carcinogenesis. In other words, a reduced level of apoptosis could contribute to the generation of gastric cancer. Herein, we review apoptosis as well as its associated pathological events, such as hyperproliferation, in H. pylori-colonized gastric mucosa.

authors

Suzuki H,Ishii H

doi

10.1046/j.1440-1746.2000.02147.x

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

D46-54

eissn

0815-9319

issn

1440-1746

journal_volume

15 Suppl

pub_type

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