Abstract：
BACKGROUND AND AIM:The presence of spur-cell anemia (SCA) is due to lipid disturbances of the erythrocyte membrane and may develop in patients with advanced liver cirrhosis. The accurate predicting value of SC for survival has not been clarified. The aim of this study was to evaluate SCA as a prognostic indicator in patients with cirrhosis. METHODS:We prospectively evaluated clinical, laboratory parameters, and survival in patients with cirrhosis, with or without SCA, during the period 2008-2011. Patients who had at admission renal failure, other causes of hemolytic anemia, hepatocellular carcinoma, sepsis, and/or active bleeding, were excluded. One hundred sixteen patients with cirrhosis were included. The presence of SCA (SC rate higher or equal to 5% [≥ 5%]) was diagnosed in 36 (31%) patients. RESULTS:Patients with SCA compared to those without had more advanced liver disease (higher Model for End-Stage Liver Disease [MELD], P < 0.001), higher total bilirubin (P < 0.001), and International Normalized Ratio (P < 0.001). Patients with SCA had worse survival (log rank P < 0.001). Survival of patients with SCA at the first, second, and third month of follow-up was 77%, 45%, and 33%, respectively. In multivariate Cox's regression analysis, the presence of SCA was an independent predictor of mortality (hazard ratio = 3.17 [95% CI 1.55-6.48]). CONCLUSIONS:The presence of spur-cell anemia is not uncommon in cirrhosis and seems to be strongly associated with mortality. SCA can be used in combination with MELD as an additional predictor of early mortality.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Alexopoulou A,Vasilieva L,Kanellopoulou T,Pouriki S,Soultati A,Dourakis SPdoi
10.1111/jgh.12473subject
Has Abstractpub_date
2014-04-01 00:00:00pages
830-4issue
4eissn
0815-9319issn
1440-1746journal_volume
29pub_type
杂志文章abstract：BACKGROUND AND AIM:We elucidated the clinical significance of distal contractile integral-to-esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients. METHODS:We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.14981
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:The efficacy and safety of peginterferon alpha-2a (40 KD) (peg-IFNalpha-2a) plus ribavirin has not been reported for Japanese patients with chronic hepatitis C. The aim of this study was to evaluate this combination in treatment-naïve patients and in non-responders or relapsers to interferon monotherapy. ME...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1440-1746.2007.04834.x
更新日期：2007-05-01 00:00:00
abstract：:The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. The increasing number of studies on the incidence and course of IBD in East has enabled us to explore East versus West differences in the epidemiology of IBD which could enhance our understanding of th...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/jgh.14872
更新日期：2020-03-01 00:00:00
abstract：:Hepatic ischemia reperfusion (IR) injury is an important clinical problem complicating liver surgery and transplantation. The pathogenesis underlying reperfusion injury after warm ischemia is complex, encompassing a multitude of different cell types and signalling mechanisms innate and/or mobilized to the liver. Since...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2010.06584.x
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND AND AIM:There is scanty data on the occurrence of celiac disease in patients with type 1 diabetes mellitus in South Asia. Our aim was to study the prevalence and clinical profile of celiac disease in patients with type 1 diabetes mellitus in a tertiary care referral centre in north India. METHODS:Consecutiv...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2010.06508.x
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND AND AIM:The prevalence of ulcerative colitis (UC) is increasing steadily in Japan. In Western countries, a bimodal distribution, with UC onset peaks in youth and middle age, is observed, and smoking cessation is reported as a risk factor for UC. However, there are few reports on a bimodal distribution of ons...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.12616
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND AND AIM:Disease activity and severity of ulcerative colitis (UC) is assessed using colonoscopy, which is invasive, costly and has poor patient acceptability. The role of non-invasive biomarkers of intestinal inflammation in the evaluation of patients with UC is not known. The aim of the study was to examine ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2009.06048.x
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND AND AIMS:We have recently reported quantitative and qualitative differences of the bone marrow (BM) hematopoietic progenitor cells in autoimmune hepatitis type-1 (AIH-1) and primary biliary cirrhosis (PBC). In order to better investigate the possible involvement of BM in these diseases, we studied the morpho...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2008.05309.x
更新日期：2008-08-01 00:00:00
abstract：:Epidemiological evidence consistently indicates that aspirin or non-aspirin non-steroidal anti-inflammatory drug use is associated with the occurrence of gastric ulceration, gastric and ulcer bleeding, and ulcer death. Evidence on duodenal ulcer occurrence conflicts, possibly because of differences in study population...
journal_title：Journal of gastroenterology and hepatology
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1111/j.1440-1746.1991.tb00885.x
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND AND AIM:Thyroid dysfunction is the most common endocrinopathy associated with hepatitis C and its interferon-based treatment. When undergoing treatment, interferon and ribavirin synergize to potently stimulate the immune system in order to eradicate the virus. One of the innocent bystanders in this accentuat...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1440-1746.2009.05874.x
更新日期：2009-07-01 00:00:00
abstract：:Gastric varices (GVs) are a major complication of portal hypertension in patients with liver cirrhosis. The mortality rate associated with the bleeding from GVs is not low. Balloon-occluded retrograde transvenous obliteration (BRTO) was first introduced by Kanagawa et al. as a treatment for isolated GVs in 1994. It ha...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/jgh.14463
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND AND AIMS:The (13)C-urea breath test ((13)C-UBT) is a reliable non-invasive method of diagnosing Helicobacter pylori infection in adults and children. However, only a few validation studies have been performed on the (13)C-UBT in very young children. The purpose of the present study was to evaluate the diagno...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2004.03541.x
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:In order to evaluate the prophylactic impact of sclerotherapy of small varices in patients with cirrhosis and no endoscopic signs suggesting risk of haemorrhage, a randomized clinical trial was performed. METHODS:Seventy-one hospitalized patients met the inclusion criteria of diagnosis of cirrhosis with no ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1440-1746.1999.01799.x
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND AND AIM:Locoregional therapies for hepatocellular carcinoma (HCC) are considered to confer a survival advantage, however, the patient group that should be targeted is not clearly defined. This study aimed to determine the impact on survival of locoregional therapies compared with supportive care, within prog...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2010.06267.x
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND AND AIM:The risk of hepatocellular carcinoma (HCC) is known to be age dependent; the influence of age on prognosis is, however, controversial. The aim of this study was to compare the tumor characteristics and survival rates of young and old HCC patients, with respect to tumor stage. METHODS:We reviewed the...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2007.04914.x
更新日期：2007-08-01 00:00:00
abstract：:The growing numbers of potential transplant recipients on waiting lists is increasingly disproportionate to the supply of cadaveric donor organs. The hope for the next 20 years is that supply will satisfy demand. This requires both a reduction in indications for the procedure and an increase in the transplants perform...
journal_title：Journal of gastroenterology and hepatology
pub_type： 历史文章,杂志文章,评审
doi：10.1111/j.1440-1746.2009.06081.x
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND AND AIM:Estimates suggest that in Asia, more than 31 million individuals have hepatitis C virus infection. The present analysis was conducted to assess the efficacy and safety of elbasvir/grazoprevir in Asian participants enrolled in the elbasvir/grazoprevir phase 2/3 clinical trials. METHODS:This is an int...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.14636
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND AND AIM:A high yield of biopsy is mandatory to perform molecular genetic research with endoscopically obtained gastric cancer tissues. We evaluated whether probe-based confocal laser endomicroscopy (pCLE) can increase the yield of endoscopic biopsy for gastric cancer compared with white light endoscopy (WLE)...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jgh.14471
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND AIM:The Baveno VI Consensus recommends repeating examination in patients with high liver stiffness measurement (LSM) by transient elastography to reduce false-positive diagnosis of advanced liver disease. We tested whether repeating transient elastography can increase the overall diagnostic accuracy. ME...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.14311
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND AIMS:This study was aimed to find clinical predictors for developing delirium tremens (DT) in alcohol dependence. METHODS:This cohort study was retrospectively carried out among patients who were diagnosed as having alcohol dependence between January 2001 and July 2004. Fifteen parameters were compared ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2005.03932.x
更新日期：2005-12-01 00:00:00
abstract：:Alcohol induces Ca(2+)-dependent intracellular trypsinogen activation in the apical granular area via non-oxidative metabolites, such as fatty acid ethyl esters and fatty acids. Intracellular trypsinogen activation is a crucial initiating event in the development of acute pancreatitis, but the specific organelle in wh...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1746.2007.05281.x
更新日期：2008-03-01 00:00:00
abstract：:Due to the ever increasing popularity of laparoscopic cholecystectomy (LC), many radiologists and gastroenterologists have noticed an epidemic of bile duct injuries due to subsequent complications. We report on five cases of post-LC minor bile duct injuries and document our preliminary experience in their management. ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1997.tb00342.x
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND AND AIM:Multiple diagnostic and therapeutic endoscopic ultrasound (EUS) procedures have been widely performed using a standard oblique-viewing (OV) curvilinear array (CLA) echoendoscope. Recently, a new, forward-viewing (FV) CLA was developed, with the advantages of improved endoscopic viewing and manipulati...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2011.06923.x
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND AND AIM:To validate an early discharge policy in patients admitted with upper gastrointestinal bleeding (UGIB) due to ulcers. METHODS:Patients with gastroduodenal ulcer or erosive gastritis/duodenitis were included in a previous study aiming to develop a practice guideline for early discharge of patients wi...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2010.06374.x
更新日期：2010-09-01 00:00:00
abstract：:Gilbert's syndrome, an hereditary, chronic, mild, unconjugated hyperbilirubinaemia resulting from impaired hepatic bilirubin clearance and otherwise normal liver function, is arguably the most common syndrome known in humans. Recent molecular genetic studies have determined that the clinical phenotype can be described...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1746.1999.01984.x
更新日期：1999-10-01 00:00:00
abstract：:Although the advancement of molecular oncology in gastric cancer lags behind that of colorectal cancer, the rapid developments witnessed in recent years have improved our understanding of the carcinogenesis, aetiology, progression and metastasis of gastric cancer. The different molecular genetic alterations in intesti...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1746.1999.02000.x
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Minimal hepatic encephalopathy (MHE) is the mildest form of hepatic encephalopathy (HE) and is characterized by deficits in neurocognitive performance without any clinical symptoms of HE. In the current study, we aim to evaluate and compare the neurocognitive, biochemical, and brain magnetic resonan...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.13427
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND AND AIMS:It is well known that endotoxemia, which is caused by a bacterial infection, can exacerbate acute pancreatitis, whereas pancreatitis-associated protein (PAP) has the ability to induce bacterial aggregation. Pancreatitis-associated protein is supposed to protect the tissue from infection during infla...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2001.02389.x
更新日期：2001-01-01 00:00:00
abstract：:Hepatocellular adenoma (HCA) is a benign liver neoplasm with a risk of spontaneous bleeding and malignant transformation. The aim of this review article is to review all the case reports and case series of patients with HCA from 1998 to 2008 in China and other parts of the world in order to compare clinical presentati...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1746.2010.06502.x
更新日期：2011-01-01 00:00:00
abstract：:A prospective double blind and randomized study was conducted to compare 4-aminosalicylic acid (4-ASA) and prednisolone-21-phosphate enemas in inducing remission in patients with acute distal ulcerative colitis. Patients with ulcerative colitis distal to the splenic flexure as assessed by flexible colonoscopy, barium ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1440-1746.1992.tb00957.x
更新日期：1992-03-01 00:00:00
