Non-steroid anti-inflammatory drug associated ulcer: epidemiology, causation and treatment.

Abstract:

:Epidemiological evidence consistently indicates that aspirin or non-aspirin non-steroidal anti-inflammatory drug use is associated with the occurrence of gastric ulceration, gastric and ulcer bleeding, and ulcer death. Evidence on duodenal ulcer occurrence conflicts, possibly because of differences in study populations. A wide range of mechanisms could explain the occurrence of non steroidal-induced damage. These include inhibition of bicarbonate secretion, effects on mucus formation, and vascular actions. Not all effects are dependent on cyclo-oxygenase inhibition. Short-term studies in humans provide indications of likely therapeutic effects, but cannot demonstrate clinical efficiency. Although anti-secretory drugs and prostaglandins can protect patients against the development of duodenal or gastric ulcers, but not both, there is no clinical evidence which bears upon the critical issue of protection against complications.

authors

Langman MJ,Brooks P,Hawkey CJ,Silverstein F,Yeomans N

doi

10.1111/j.1440-1746.1991.tb00885.x

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

442-9

issue

5

eissn

0815-9319

issn

1440-1746

journal_volume

6

pub_type

临床试验,杂志文章,随机对照试验,评审
  • Overview of hepatitis B prevalence, prevention, and management in the Pacific Islands and Territories.

    abstract::There are over 500-750 000 deaths per year because of hepatitis B virus (HBV)-related cirrhosis and liver cancer worldwide and the World Health Organization Western Pacific Region has some of the highest endemic levels of HBV in the world, particularly within China, South East Asia and Pacific Island Countries and Ter...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12684

    authors: Howell J,Van Gemert C,Lemoine M,Thursz M,Hellard M

    更新日期:2014-11-01 00:00:00

  • The clinical significances of irritable bowel syndrome in Taiwan.

    abstract:BACKGROUND AND AIM:According to the Rome III definition, irritable bowel syndrome (IBS) has been a biopsychosocial dysfunction. We tried to know whether the IBS clinical manifestations were comparable to other countries. METHOD:We have reviewed the IBS publications in Taiwan, thus its clinical significances are summar...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2011.06646.x

    authors: Chang FY,Lu CL

    更新日期:2011-04-01 00:00:00

  • Comparison between modified wet suction and dry suction technique for endoscopic ultrasound-guided fine-needle biopsy in pancreatic solid lesions.

    abstract:BACKGROUND AND AIM:Although endoscopic ultrasound-guided fine-needle biopsy is widely applied, there is no clear consensus on the optimal biopsy technique. We described a modified wet suction technique (MWEST) with the aim to compare the efficacy and safety between MWEST and the dry suction technique (DST). METHODS:In...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15371

    authors: Tong T,Tian L,Deng M,Liu Y,Yang Y,Yin H,Long X,Pan S,Yang Z,Luo W,Nie K,Meng X,Xiao M,Wu X,Zhang C,Wang X

    更新日期:2020-12-08 00:00:00

  • Absolute lymphocyte count recovery at 1 month after transplantation predicts favorable outcomes of patients with hepatocellular carcinoma.

    abstract:BACKGROUND AND AIMS:Absolute lymphocyte count (ALC) and the recovery of ALC after treatment have been identified as a prognostic biomarker for several malignancies. In this study, we aimed to investigate the prognostic role of peritransplant ALC and ALC recovery after liver transplantation (LT) in hepatocellular carcin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12782

    authors: Zheng Z,Lin B,Zhang J,Yang Z,Xie H,Zhou L,Zhang M,Zheng S

    更新日期:2015-04-01 00:00:00

  • Hypothalamic-pituitary adrenal function in end-stage non-alcoholic liver disease.

    abstract::Patients with end-stage liver disease have significant mortality often associated with intercurrent episodes of bleeding or sepsis. Intact adrenal function is essential in such situations. In order to test the hypothesis that adrenal insufficiency might be present in severe liver disease, hypothalamic-pituitary adrena...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1993.tb01195.x

    authors: McDonald JA,Handelsman DJ,Dilworth P,Conway AJ,McCaughan GW

    更新日期:1993-05-01 00:00:00

  • Risk of liver cirrhosis and hepatocellular carcinoma in subjects with hepatitis B and delta virus infection: a study from Kure, Japan.

    abstract::To investigate the effect of hepatitis delta virus (HDV) superinfection on the long-term outcome of Japanese subjects with chronic hepatitis B virus (HBV) infection, we examined the presence of antibodies to hepatitis delta antigen (anti-HD) in serial serum samples collected from 1127 subjects with chronic HBV infecti...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1993.tb01543.x

    authors: Tamura I,Kurimura O,Koda T,Ichimura H,Katayama S,Kurimura T,Inaba Y

    更新日期:1993-09-01 00:00:00

  • Effect of ecabet sodium treatment on urea breath test and stool antigen tests in volunteers with Helicobacter pylori infection.

    abstract:BACKGROUND AND AIM:Ecabet sodium is reported to have a bactericidal effect on Helicobacter pylori and inhibit urease activity in vitro. METHODS:Seven male volunteers (mean age, 51.3 years; range, 45-55 years) with H. pylori infection were medicated with 1 g ecabet sodium t.i.d. for 4 weeks. The urea breath test (UBT) ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2012.07080.x

    authors: Okuda M,Yamamoto N,Fukuda N,Maekawa K,Kusaka T,Hashimoto M,Kotake J,Koizuka H,Fukuda Y

    更新日期:2012-04-01 00:00:00

  • Antipyrine clearance in chronic and neoplastic liver diseases: a study of 518 patients.

    abstract::Antipyrine metabolism is widely used as an index of the drug-metabolizing reserve of the liver. It is well known that metabolism of this drug is impaired in subjects with acute hepatitis or cirrhosis, but conflicting data have been reported regarding patients with chronic postinfectious hepatitis or liver cancer. We s...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1746.1998.tb00668.x

    authors: Grieco A,Castellano R,Matera A,Marcoccia S,Di Rocco P,Ragazzoni E,Vecchio FM,Gasbarrini G

    更新日期:1998-05-01 00:00:00

  • Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.

    abstract:BACKGROUND AND AIM:A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variati...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2011.07045.x

    authors: Hyysalo J,Stojkovic I,Kotronen A,Hakkarainen A,Sevastianova K,Makkonen J,Lundbom N,Rissanen A,Krauss RM,Melander O,Orho-Melander M,Yki-Järvinen H

    更新日期:2012-05-01 00:00:00

  • Contrast media-enhanced power Doppler sonography for evaluation of hemangiomas and malignant tumors in the liver.

    abstract:AIM:To evaluate the characterization of liver hemangiomas and malignant tumors using power Doppler sonography before and after intravenous injection of a sonocontrast agent. METHODS:Forty-five patients with 57 liver tumors (22 hemangiomas, 24 metastases, 10 hepatocellular carcinomas (HCC) and one cholangiocellular car...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.02900.x

    authors: Karabacakoglu A,Karakose S,Cil AS,Kaya A

    更新日期:2003-01-01 00:00:00

  • Case report: acanthosis nigricans in association with primary biliary cirrhosis: resolution after liver transplantation.

    abstract::A case is described of a 58 year old Caucasian male with primary biliary cirrhosis (PBC) who first presented with acanthosis nigricans of both axillae, skin pigmentation, which was pronounced over the posterior surface of the neck, and generalized pruritus. Following orthotopic liver transplantation for progressive li...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1996.tb00025.x

    authors: Pham TH,Kaushik S,Lin BP,Jones DB

    更新日期:1996-11-01 00:00:00

  • Hepatitis B virus infection in dialysis patients.

    abstract::Hepatitis B virus (HBV) infection remains a major issue among dialysis patients. It is associated with a high risk of hepatic complication. The liver disease runs a unique clinical course in dialysis patients, as it can progress with modest hepatic inflammation and prominent fibrosis. The conventional cut-off level of...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2005.03837.x

    authors: Wong PN,Fung TT,Mak SK,Lo KY,Tong GM,Wong Y,Loo CK,Lam EK,Wong AK

    更新日期:2005-11-01 00:00:00

  • Detection of Chlamydia pneumoniae by polymerase chain reaction-enzyme immunoassay in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls.

    abstract:BACKGROUND AND AIM:It has been suggested that Chlamydia is an organism that may have the potential to cause inflammatory bowel disease (IBD) in susceptible individuals. Chlamydia pneumoniae has emerged as an important human pathogen in the last decade. The objective of the present study was to investigate the frequency...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2002.02793.x

    authors: Chen W,Li D,Wilson I,Chadwick VS

    更新日期:2002-09-01 00:00:00

  • Effects of washout following indomethacin administration on electrical field stimulation-induced isolated rat gastric fundus strip contractions.

    abstract:BACKGROUND AND AIM:Although gastric hypermotility is one of the mechanisms proposed to explain the ulcerogenic action of indomethacin, the drug has shown relaxatory effects on isolated longitudinal and transverse rat gastric fundus. To explain the above discrepancy, the aim of this study was to investigate the effects ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04860.x

    authors: Keshavarz M,Afshin S,Djahanguiri B

    更新日期:2007-09-01 00:00:00

  • Helicobacter pylori vacuolating cytotoxin induces apoptosis via activation of endoplasmic reticulum stress in dendritic cells.

    abstract:BACKGROUND AND AIM:Dendritic cells (DCs) are observed on the Helicobacter pylori-infected gastric mucosa. DCs generally play an important role in the regulation of inflammation. Although stimulation of gastric epithelial cells with H. pylori vacuolating cytotoxin (VacA) has been reported to induce apoptosis and endopla...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12663

    authors: Kim JM,Kim JS,Kim N,Ko SH,Jeon JI,Kim YJ

    更新日期:2015-01-01 00:00:00

  • Association between the methylation of the STAT1 and SOCS3 in peripheral blood and gastric cancer.

    abstract:BACKGROUND AND AIM:DNA methylation is an important epigenetic modification that can promote the development of various cancers. The STAT1 and SOCS3 have been observed to be hypermethylated in tumor tissues and peripheral blood. This study aimed to explore the relationship between the methylation status of the STAT1 and...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15021

    authors: Han Q,Zhou H,Xie W,Sun T,Wei R,Nie C,Hong J,Zhu L,Tian W

    更新日期:2020-08-01 00:00:00

  • Hepatitis B vaccine boosters: is there a clinical need in high endemicity populations?

    abstract::The Steering Committee for the Prevention and Control of Infectious Diseases in Asia recently conducted a survey of primary-care physicians in Asia, which revealed that many physicians administer boosters in their clinical practice and that there is considerable variation and uncertainty among physicians regarding thi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2004.03398.x

    authors: John TJ,Cooksley G,Steering Committee for the Prevention and Control of Infectious Diseases in Asia.

    更新日期:2005-01-01 00:00:00

  • Long-term follow up of gastric low-grade mucosa-associated lymphoid tissue lymphoma by endosonography emphasizing the application of a miniature ultrasound probe.

    abstract:BACKGROUND AND AIMS:Endoscopic ultrasonography (EUS) is a useful tool for the evaluation of gastric wall infiltration including gastric lymphoma. The aims of this study were to characterize gastric low-grade mucosa-associated lymphoid tissue (MALT) lymphoma according to EUS findings and to evaluate the role of a miniat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.02938.x

    authors: Yeh HZ,Chen GH,Chang WD,Poon SK,Yang SS,Lien HC,Chang CS,Chou G

    更新日期:2003-02-01 00:00:00

  • Effect of transient cyclic AMP elevation on DNA synthesis in rat hepatocytes at G1 phase.

    abstract::Maintaining high levels of intracellular cyclic AMP (cAMP) is known to inhibit the growth of various proliferating cells including hepatocytes. We show here that transient (30 min) elevations of cAMP induced by addition of 8-bromo-cAMP (1 mmol/L) to rat hepatocytes in primary culture at three time points (12 h, 16 h a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1998.tb00704.x

    authors: Kikukawa M,Okamoto Y,Nakano H

    更新日期:1998-06-01 00:00:00

  • Classical Kaposi's: a rare cause of gastrointestinal haemorrhage.

    abstract::Classical Kaposi's sarcoma (KS) is an indolent neoplasm involving mucocutaneous sites predominantly in elderly Mediterranean or Jewish persons. Whilst gastrointestinal involvement is common, it is usually asymptomatic. This case report presents a case of massive gastrointestinal haemorrhage in a patient with stable cu...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1996.tb01391.x

    authors: Chapman SM,Bell SJ,Chen S,Cosolo W

    更新日期:1996-04-01 00:00:00

  • Prevalence and risk of colorectal adenoma in asymptomatic Koreans aged 40-49 years undergoing screening colonoscopy.

    abstract:BACKGROUND AND AIM:Colorectal cancer screening is recommended for average-risk persons beginning at age 50. However, information about the incidence and risk factors of precursor adenoma in preceding decades is limited. The aim of this study was to determine the prevalence and risk factors of colorectal adenoma in pers...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.06147.x

    authors: Chung SJ,Kim YS,Yang SY,Song JH,Park MJ,Kim JS,Jung HC,Song IS

    更新日期:2010-03-01 00:00:00

  • Molecular epidemiology of hepatitis C in Australia.

    abstract::The aim of this study was to determine the distribution of hepatitis C virus (HCV) genotypes in Australian patients with hepatitis C and to identify factors associated with particular genotypes. Serum isolates of HCV-RNA were genotyped using a commercial oligonucleotide hybridization (line probe) assay. Relationships ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1998.tb00761.x

    authors: Kaba S,Dutta U,Byth K,Crewe EB,Khan MH,Coverdale SA,Lin R,Liddle C,Farrell GC

    更新日期:1998-09-01 00:00:00

  • Ultrasound-guided fine needle aspiration biopsy of portal vein thrombosis in liver cirrhosis: results in 15 patients.

    abstract::Between 1988 and 1992 ultrasound-guided fine needle aspiration biopsies of thromboses in the main branches of the portal vein were carried out in 15 patients with liver cirrhosis. The aims of the study were to evaluate the usefulness, feasibility and diagnostic accuracy of this procedure in cirrhotics with known or su...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1995.tb01367.x

    authors: De Sio I,Castellano L,Calandra M,Romano M,Persico M,Del Vecchio-Blanco C

    更新日期:1995-11-01 00:00:00

  • Interobserver agreement in contrast harmonic endoscopic ultrasound.

    abstract:BACKGROUND AND AIM:Contrast harmonic endoscopic ultrasound (CH-EUS) was recently introduced to clinical practice; its reproducibility among endosonographers is unknown. Our aim was to assess the interobserver agreement (IA) in CH-EUS. METHODS:Fifteen endosonographers (eight experienced and seven non-experienced) from ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1440-1746.2012.07115.x

    authors: Fusaroli P,Kypraios D,Mancino MG,Spada A,Benini MC,Bianchi M,Bocus P,De Angelis C,De Luca L,Fabbri C,Grillo A,Marzioni M,Reggio D,Togliani T,Zanarini S,Caletti G

    更新日期:2012-06-01 00:00:00

  • Diabetes mellitus correlates with increased risk of pancreatic cancer: a population-based cohort study in Taiwan.

    abstract:BACKGROUND AND AIM:This study investigated whether diabetes mellitus (DM) increased the risk of pancreatic cancer and whether anti-diabetic drugs reduced the risk in Taiwan. METHODS:We designed a population-based cohort study using the Taiwan National Health Insurance Database, which consisted of 49,803 patients aged ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2011.06938.x

    authors: Liao KF,Lai SW,Li CI,Chen WC

    更新日期:2012-04-01 00:00:00

  • Long-term outcomes of early gastric cancer diagnosed as mixed adenocarcinoma after endoscopic submucosal dissection.

    abstract:BACKGROUND AND AIMS:The clinical significance and prognosis of mixed adenocarcinoma in early gastric cancer (EGC) are incompletely understood. The aim of this study was to evaluate the clinicopathological characteristics and long-term outcomes of mixed adenocarcinoma diagnosed as EGC after endoscopic submucosal dissect...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12838

    authors: Han JP,Hong SJ,Kim HK

    更新日期:2015-02-01 00:00:00

  • Impact of COVID-19 outbreak on the care of patients with inflammatory bowel disease: A comparison before and after the outbreak in South China.

    abstract:BACKGROUND AND AIMS:Epidemics pose a great challenge to health care of patients. However, the impact of unprecedented situation of COVID-19 outbreak on health care of inflammatory bowel disease (IBD) patients in real-world setting has seldom been investigated. METHODS:We performed an observational study in a tertiary ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15205

    authors: Zhang YF,Qiu Y,He JS,Tan JY,Li XZ,Zhu LR,Chen Y,Liu ZJ,Iacucci M,Chen BL,He Y,Ben-Horin S,Shen B,Zeng ZR,Ghosh S,Chen MH,Mao R

    更新日期:2020-08-01 00:00:00

  • Human leukocyte antigen allele associations in type-1 autoimmune hepatitis patients from western India.

    abstract:BACKGROUND AND AIMS:The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type-1 autoimmune hepatitis (AIH) among patients from western India. METHODS:In 20 patients and 120 healthy controls, polymerase chain reaction ampli...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2004.03608.x

    authors: Shankarkumar U,Amarapurkar DN,Kankonkar S

    更新日期:2005-02-01 00:00:00

  • Two histologic compartments in nonpolypoid conventional colon adenomas.

    abstract::Two intertwined compartments coexisting in nonpolypoid conventional (i.e. tubular or villous) adenomas are highlighted in this review: one built of dysplastic tissue on top and the other portraying crypts with irregular, corrupted shapes, albeit lined with normal epithelium, below. The latter compartment has remained ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.15210

    authors: Rubio CA

    更新日期:2020-08-05 00:00:00

  • Generation and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen.

    abstract:BACKGROUND:Antibody against hepatitis B surface antigen (HBsAg) is used for passive immunotherapy in certain cases of hepatitis B infection. The authors have earlier reported a high-affinity mouse monoclonal (5S) against HBsAg. However, this mouse antibody cannot be used for therapeutic purposes because it may elicit a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04329.x

    authors: Bose B,Khanna N,Acharya SK,Sinha S

    更新日期:2006-09-01 00:00:00