Ca2+-induced pancreatic cell death: roles of the endoplasmic reticulum, zymogen granules, lysosomes and endosomes.

abstract：BACKGROUND AND AIM:Little is known about the role of hepatitis B virus (HBV) factors in the long-term prognosis of hepatocellular carcinoma (HCC) after resection. The objective of the present study was to identify the changing patterns of HBV levels and its effect on outcome after resection. METHODS:This study recruit...

journal_title：Journal of gastroenterology and hepatology

authors： An HJ,Jang JW,Bae SH,Choi JY,Cho SH,Yoon SK,Han JY,Lee KH,Kim DG,Jung ES

更新日期：2010-12-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC), a chronic inflammatory process affecting the extrahepatic and/or medium to large bile ducts, is not rare in children. It has features suggesting an autoimmune pathogenesis, although the mechanism of tissue damage remains unknown. The clinical presentation of childhood primary scle...

journal_title：Journal of gastroenterology and hepatology

authors： Roberts EA

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND AND AIM:It has been reported that the branched-chain amino acid (BCAA) to tyrosine ratio (BTR) is a useful indicator of liver function and BCAA therapy is associated with a decreased incidence of hepatocellular carcinoma (HCC). However, there has not been sufficient research on the relationship between BTR a...

journal_title：Journal of gastroenterology and hepatology

authors： Tada T,Kumada T,Toyoda H,Kiriyama S,Tanikawa M,Hisanaga Y,Kanamori A,Kitabatake S,Yama T

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Antiviral therapy has not been adequately evaluated in patients with hepatitis C virus (HCV)-related advanced liver disease due to apprehensions of adverse events and intolerance. The titrable dose of interferon (IFN)-alpha and ribavirin was evaluated in a flexible regimen in a pilot study. METHODS:Twenty-f...

journal_title：Journal of gastroenterology and hepatology

authors： Kumar R,Kumar S,Sharma BC,Singh J,Sarin SK

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND AIMS:It has been proposed that the expression of Fas ligand (Fas L) in tumors may play an important role in immune escape. This study was undertaken to test a 'counterattack' theory as a mechanism of immune escape in gastric carcinoma. METHODS:Expression of Fas and Fas L was examined in the human gastri...

journal_title：Journal of gastroenterology and hepatology

authors： Lee TB,Min YD,Lim SC,Kim KJ,Jeon HJ,Choi SM,Choi CH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND AIM:Ulcerative colitis (UC) is a multifactorial disease resulting from a complex interaction of genetic and environmental factors. Identifying genetic variants that alter the innate immune response is highly relevant to understanding the pathogenesis of UC. The aim of this study was to investigate the as...

journal_title：Journal of gastroenterology and hepatology

authors： Wang F,Tahara T,Arisawa T,Shibata T,Nakamura M,Fujita H,Iwata M,Kamiya Y,Nagasaka M,Takahama K,Watanabe M,Hirata I,Nakano H

更新日期：2007-06-01 00:00:00

abstract：:Interpretation of exploding knowledge about Barrett's esophagus is impaired by use of several conflicting definitions. Because any histological type of esophageal columnar metaplasia carries risk for esophageal adenocarcinoma, the diagnosis of Barrett's esophagus should no longer require demonstration of intestinal-ty...

journal_title：Journal of gastroenterology and hepatology

authors： Dent J

更新日期：2011-01-01 00:00:00

abstract：:Alcoholic liver diseases (ALD) are frequently associated with iron overload. Until recently, the effects of ethanol in hepatic iron uptake and intestinal iron absorption have not been clarified in detail. Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the...

journal_title：Journal of gastroenterology and hepatology

authors： Kohgo Y,Ohtake T,Ikuta K,Suzuki Y,Torimoto Y,Kato J

更新日期：2008-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) transmission by needlestick accidents involving hospital employees has become an important problem. The present report is of a case of acute hepatitis C that developed after a needlestick injury, despite short duration interferon treatment performed just after the accident in a trial effort to ...

journal_title：Journal of gastroenterology and hepatology

authors： Nakano Y,Kiyosawa K,Sodeyama T,Tanaka E,Matsumoto A,Ichijo T,Mizokami M,Furuta S

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND AIM:6-Mercaptopurine (6-MP) and azathioprine (AZA) are widely used as maintenance therapy in children with inflammatory bowel disease (IBD). However, proper 6-thioguanine nucleotide (6-TGN) concentrations in Japanese children with IBD have not been reported. METHODS:This retrospective review examines 32...

journal_title：Journal of gastroenterology and hepatology

authors： Ohtsuka Y,Arai K,Aoyagi Y,Fujii T,Yamakawa Y,Ohtani K,Ikuse T,Baba Y,Inage E,Kudo T,Suzuki R,Nagata S,Shimizu T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Epidemics pose a great challenge to health care of patients. However, the impact of unprecedented situation of COVID-19 outbreak on health care of inflammatory bowel disease (IBD) patients in real-world setting has seldom been investigated. METHODS:We performed an observational study in a tertiary ...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang YF,Qiu Y,He JS,Tan JY,Li XZ,Zhu LR,Chen Y,Liu ZJ,Iacucci M,Chen BL,He Y,Ben-Horin S,Shen B,Zeng ZR,Ghosh S,Chen MH,Mao R

更新日期：2020-08-01 00:00:00

abstract：:Eradication of Helicobacter pylori infection is known to reduce the incidence of duodenal ulcer recurrence. The most commonly used regimen for H. pylori infection is triple antimicrobial therapy for 1-2 weeks. This treatment is associated with frequent side effects and hence unsatisfactory compliance. As in vitro data...

journal_title：Journal of gastroenterology and hepatology

authors： Sung JJ,Chung SC,Hosking SW,Chan RC,Ling TK,Yung MY,Cheng AF,Li AK

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Currently, hepatitis B immunoglobulins (HBIg) and/or lamivudine have become the main options for prevention of hepatitis B recurrence after liver transplantation. AIM:To assess the benefits of HBIg and/or lamivudine for prevention of hepatitis B recurrence after liver transplantation. METHODS:We conducted ...

journal_title：Journal of gastroenterology and hepatology

authors： Chen J,Yi L,Jia JD,Ma H,You H

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Interstitial cells of Cajal (ICCs), which express c-Kit receptor tyrosine kinase (KIT), play an important role in gastrointestinal motility. Loss of ICCs likely contributes to diabetic gastrointestinal motility disorder, however, the mechanism of attrition remains unknown. Here, we test the hypothesis that t...

journal_title：Journal of gastroenterology and hepatology

authors： Li Y,Kojima H,Fujino K,Matsumura K,Katagi M,Urabe H,Chan L,Eguchi Y,Zhao L,Kimura H

更新日期：2011-06-01 00:00:00

abstract：:Forty-six patients with primary biliary cirrhosis from a single centre were studied in a randomized placebo-controlled trial to determine the effectiveness of ursodeoxycholic acid (UDCA) over a 2 year period. The two groups were well-matched at baseline. For each parameter, by calculating the difference between the me...

journal_title：Journal of gastroenterology and hepatology

authors： Turner IB,Myszor M,Mitchison HC,Bennett MK,Burt AD,James OF

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND AND AIM:To guide selection of optimal screening strategies for advanced colorectal neoplasia (ACRN), we evaluated the screening performances of sigmoidoscopy, fecal immunochemical test (FIT), and the Asia-Pacific Colorectal Screening (APCS) system, as well as combinations of these techniques. METHODS:We rev...

journal_title：Journal of gastroenterology and hepatology

authors： Jung YS,Park CH,Kim NH,Park JH,Park DI,Sohn CI

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND AIM:Whether an antiviral interferon (IFN)-based therapy (IBT) after curative treatment of hepatocellular carcinoma (HCC) improves the prognosis in patients with hepatitis C virus (HCV)-related HCC remains to be elucidated. METHODS:A total of 178 patients within the Milan criteria underwent curative trea...

journal_title：Journal of gastroenterology and hepatology

authors： Kanogawa N,Ogasawara S,Chiba T,Saito T,Motoyama T,Suzuki E,Ooka Y,Tawada A,Kanda T,Mikami S,Azemoto R,Kaiho T,Shinozaki M,Ohtsuka M,Miyazaki M,Yokosuka O

更新日期：2015-07-01 00:00:00

abstract：:Artificial liver systems are used to bridge between transplantation or to allow a patient's liver to recover. They are used in patients with acute liver failure (ALF) and acute-on-chronic liver failure. There are five artificial systems currently in use: molecular adsorbent recirculating system (MARS), single-pass alb...

journal_title：Journal of gastroenterology and hepatology

authors： Tandon R,Froghi S

更新日期：2020-09-12 00:00:00

abstract：BACKGROUND AND AIMS:Regional variations in inflammatory bowel disease (IBD) rates have been observed. Limited epidemiological data are available from Australasia. IBD prevalence rates have never been assessed in an Australian population-based setting. In addition, there are few historical IBD incidence data to allow as...

journal_title：Journal of gastroenterology and hepatology

authors： Studd C,Cameron G,Beswick L,Knight R,Hair C,McNeil J,Desmond P,Wilson J,Connell W,Bell S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of the present study was to compare the therapeutic efficacy of three different regimens in childhood chronic hepatitis B (CHB) infection. METHODS:A total of 182 children with CHB infection were prospectively allocated to three random groups. Sixty-two patients in the first group received hi...

journal_title：Journal of gastroenterology and hepatology

authors： Dikici B,Ozgenc F,Kalayci AG,Targan S,Ozkan T,Selimoglu A,Doganci T,Kansu A,Tosun S,Arslan N,Kasirga E,Bosnak M,Haspolat K,Buyukgebiz B,Aydogdu S,Girgin N,Yagci RV

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND AIM:Colonic mucosal defects might be a route for bacterial invasion into the portal system, with subsequent hematogenous spread to the liver. We retrospectively investigated the results of colonoscopy and the clinical characteristics of patients with pyogenic liver abscess of colonic origin. METHODS:A t...

journal_title：Journal of gastroenterology and hepatology

authors： Jeong SW,Jang JY,Lee TH,Kim HG,Hong SW,Park SH,Kim SG,Cheon YK,Kim YS,Cho YD,Kim JO,Kim BS,Lee EJ,Kim TH

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The binucleation of hepatocytes, which was known as an important feature of liver growth and physiology, has been reported to be increased during the chronic oxidative injury stage and has been regarded as an age-related change of hepatic structures. Therefore, we investigated the binuclearity patte...

journal_title：Journal of gastroenterology and hepatology

authors： Park JK,Hong IH,Ki MR,Chung HY,Ishigami A,Ji AR,Goo MJ,Kim DH,Kwak JH,Min CW,Lee SS,Jeong KS

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND AIM:To appraise the current reporting methodological quality of meta-analyses in five leading gastroenterology and hepatology journals, and to identify the variables associated with the reporting quality. METHODS:We systematically searched the literature of meta-analyses in Gastroenterology, Gut, Hepato...

journal_title：Journal of gastroenterology and hepatology

authors： Liu P,Qiu Y,Qian Y,Chen X,Wang Y,Cui J,Zhai X

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The purpose of the present paper was to investigate dendritic cell (DC) and T-cell functions in patients with chronic hepatitis B (CHB) and determine whether therapeutic DC vaccines could restore T-cell function in those patients in vitro. METHODS:Twelve patients with CHB and 10 normal control subjects with...

journal_title：Journal of gastroenterology and hepatology

authors： Duan XZ,He HX,Zhuang H

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND AIM:Current treatments of functional dyspepsia (FD) are unsatisfied. Tricyclic antidepressants alter visceral hypersensitivity and brain-gut interaction. We assessed the efficacy and safety of nortriptyline in patients with FD. METHODS:Patients diagnosed with FD according to Rome III criteria who failed...

journal_title：Journal of gastroenterology and hepatology

authors： Kaosombatwattana U,Pongprasobchai S,Limsrivilai J,Maneerattanaporn M,Leelakusolvong S,Tanwandee T

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND AIM:Exogenous 8-hydroxydeoxyguanosine (8-OHdG) was suggested as an inhibitor of Rac1 and NADPH oxidase (NOX). The aim of this study was to evaluate the effects of the exogenous 8-OHdG on hepatic fibrogenesis in vitro and in vivo model of liver fibrosis. METHODS:Adult Sprague-Dawley rats were allocated t...

journal_title：Journal of gastroenterology and hepatology

authors： Shin SK,Kim KO,Kim SH,Kwon OS,Choi CS,Jeong SH,Kim YS,Kim JH,Chung MH

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:To elucidate the cause of possible occurrence of reflux esophagitis after Helicobacter pylori eradication, gastric and esophageal function among H. pylori infected Japanese patients were evaluated both before and after eradication therapy. METHODS:Nine H. pylori-positive patients were studied before and 6 m...

journal_title：Journal of gastroenterology and hepatology

authors： Tanaka I,Tatsumi Y,Kodama T,Kato K,Fujita S,Mitsufuji S,Kashima K

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND AIM:In Japan, peptic ulcer disease (PUD) is treated clinically with a combination of a mucosal protectant and acid suppressants, but there is scant information regarding the effects of these drugs on normal gastric mucus cells. In the present study, the effects of co-administration of methylmethionine su...

journal_title：Journal of gastroenterology and hepatology

authors： Ichikawa T,Ito Y,Saegusa Y,Iwai T,Goso Y,Ikezawa T,Ishihara K

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND AIM:A significant number of autoantibodies have been reported in patients with non-alcoholic fatty liver disease (NAFLD) patients. In the present study, our aim was to assess the role of disease and cell-specific antibodies, namely anti-adipocyte antibodies (anti-AdAb) in patients with NAFLD and non-alco...

journal_title：Journal of gastroenterology and hepatology

authors： Karrar A,Stepanova M,Alaparthi L,Lingam S,Younoszai Z,Zheng L,Malik KS,Younossi E,Monge F,Hunt SL,Goodman Z,Younossi ZM

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND AIM:Esophageal cancer is the second most common cancer among Indian males and is mostly associated with tobacco smoking and alcohol consumption. Epidermal growth factor receptor (EGFR) is a member of Type I tyrosine kinases. Its activation causes the docking of various proteins in its cytosolic tail. In ...

journal_title：Journal of gastroenterology and hepatology

authors： Parthasarathy S,Dhayaparan D,Jayanthi V,Devaraj SN,Devaraj H

更新日期：2011-02-01 00:00:00