当前位置： SCI文献检索 > JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY期刊下所有文献 > Repeating measurements by transient elastography in non-alcoholic fatty liver disease patients with high liver stiffness.

Repeating measurements by transient elastography in non-alcoholic fatty liver disease patients with high liver stiffness.

Abstract：

BACKGROUND AND AIM:The Baveno VI Consensus recommends repeating examination in patients with high liver stiffness measurement (LSM) by transient elastography to reduce false-positive diagnosis of advanced liver disease. We tested whether repeating transient elastography can increase the overall diagnostic accuracy. METHODS:Ninety-seven patients with non-alcoholic fatty liver disease who underwent two FibroScan examinations within 6 months prior to liver biopsy were evaluated. An LSM cut-off of 7.9 kPa was used to exclude F3-4 fibrosis. RESULTS:Seventy-eight patients had high LSM at baseline, among whom 27 had low LSM on repeated testing; only four had F3 and none had cirrhosis. In contrast, 31 of 51 patients with high LSM at both examinations had F3-4. Nineteen patients had low LSM at baseline; none of them had F3-4 regardless of the second LSM results. If we took LSM <7.9 kPa at either examination as sufficient to exclude F3-4, the negative predictive value remained high at 91%. The positive predictive value for F3-4 increased from 45% in patients with high LSM at baseline to 61% in those with high LSM at both examinations. Sensitivity analysis using different cut-offs yielded similar results, with 76% of patients with LSM >12 kPa at both examinations having F3-4. CONCLUSIONS:Transient elastography is a highly sensitive screening test to exclude F3-4 fibrosis in non-alcoholic fatty liver disease patients. One-third of patients with high LSM may have normal results on repeated examination. By repeating examination in cases with high LSM, one may spare patients from unnecessary liver biopsy.

journal_name

J Gastroenterol Hepatol

journal_title

Journal of gastroenterology and hepatology

authors

Chow JC,Wong GL,Chan AW,Shu SS,Chan CK,Leung JK,Choi PC,Chim AM,Chan HL,Wong VW

doi

10.1111/jgh.14311

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

241-248

issue

1

eissn

0815-9319

issn

1440-1746

journal_volume

34

pub_type

杂志文章

相关文献

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY文献大全
  • Predictors for developing intestinal failure in patients with Crohn's disease.

    abstract：BACKGROUND AND AIM:Intestinal failure (IF) is a rare but devastating complication of Crohn's disease (CD). The clinical and surgical factors that predispose to IF are poorly understood. The aim of this study was to define clinical factors that predispose to IF. METHODS:A retrospective case-control study was performed ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.12115

    authors： Gearry RB,Kamm MA,Hart AL,Bassett P,Gabe SM,Nightingale JM

    更新日期：2013-05-01 00:00:00

  • Post-infectious irritable bowel syndrome in patients with Shigella infection.

    abstract：BACKGROUND AND AIMS:Bacterial gastroenteritis has been known as a risk factor of irritable bowel syndrome (IBS). Several risk factors of post-infectious IBS (PI-IBS) have been documented. The aims of this study were to verify the role of bacterial gastroenteritis in the development of IBS and the risk factors for the d...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2005.03574.x

    authors： Ji S,Park H,Lee D,Song YK,Choi JP,Lee SI

    更新日期：2005-03-01 00:00:00

  • Effects of ammonia solution on the gastric mucosa in cirrhotic rats and therapeutic effects of geranylgeranylacetone.

    abstract：BACKGROUND:We designed an animal model in order to clarify whether Helicobacter pylori infection causes the gastric mucosal lesion frequently seen in cirrhotic patients. METHODS:Ammonia (NH3) solution was given to rats with carbon tetrachloride-induced cirrhosis. The gastric mucosal hexosamine (Hx) content and histopa...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1746.1999.01910.x

    authors： Sugimoto M,Machida Y,Ito K

    更新日期：1999-06-01 00:00:00

  • Thiopurines prevented surgical recurrence in patients with Crohn's disease after intestinal resection: Strategy based on risk stratification.

    abstract：BACKGROUND AND AIM:Thiopurines (TPs) are effective in reducing clinical and endoscopic recurrence in postoperative patients with Crohn's disease (CD). However, whether TPs could prevent surgical recurrence (SR) remains unknown. We aimed to explore whether TPs could prevent SR and identify risk factors associated with S...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.13922

    authors： Guo J,Chen BL,Chen ZH,Luo XP,Qiu Y,Zhang SH,Feng R,He Y,Zeng ZR,Song XM,Ben-Horin S,Mao R,Chen MH

    更新日期：2018-03-01 00:00:00

  • Repeated stereotactic ablative radiotherapy using CyberKnife for patients with hepatocellular carcinoma.

    abstract：BACKGROUND AND AIM:This study aimed to evaluate the outcomes and toxicities of repeated stereotactic ablative radiotherapy (SABR) in hepatocellular carcinoma (HCC). METHODS:Fourteen HCC patients with local recurrence (18 lesions) after liver SABR received repeated radiotherapy with SABR using CyberKnife. No patients e...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.12659

    authors： Lo CH,Huang WY,Lin KT,Lin MJ,Lin TP,Jen YM

    更新日期：2014-11-01 00:00:00

  • Pegylated alpha-interferon-2a plus ribavirin compared with pegylated alpha-interferon-2b plus ribavirin for initial treatment of chronic hepatitis C virus: prospective, non-randomized study.

    abstract：BACKGROUND AND AIM:We assessed whether the two regimens of pegylated alpha-interferon-2b (PEG-IFN-alpha2b) plus ribavirin and pegylated alpha-interferon-2a (PEG-IFN-alpha2a) plus ribavirin showed differences in terms of sustained virological response, withdrawal due to side-effects and dose adjustment requirements in t...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2008.05397.x

    authors： Escudero A,Rodríguez F,Serra MA,Del Olmo JA,Montes F,Rodrigo JM

    更新日期：2008-06-01 00:00:00

  • Adverse effects and other safety aspects of the hepatitis C antivirals.

    abstract：:The preferred treatment for patients with chronic hepatitis C, either treatment-naive, relapsers or nonresponders to IFN monotherapy, is now IFN-ribavirin combination treatment. The adverse effects of IFN are well established and familiar to hepatologists all over the world. More than 25,000 patients worldwide have be...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1746.2000.02114.x

    authors： Chutaputti A

    更新日期：2000-05-01 00:00:00

  • Viral hepatitis and liver transplantation.

    abstract：:This article highlights the importance of hepatotropic viruses as pathogens in patients undergoing transplantation, their contribution to morbidity and mortality after transplantation and the approach to treatment of these pathogens when they cause disease. Although many advances have been made in the management of vi...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1746.1999.01878.x

    authors： Bzowej NH,Wright TL

    更新日期：1999-05-01 00:00:00

  • Quantitative analysis of endosonographic parenchymal echogenicity in patients with chronic pancreatitis.

    abstract：BACKGROUND AND AIM:The aim of the study was to develop a method of quantitation of endoscopic ultrasonography (EUS) changes of chronic pancreatitis (CP). METHODS:Twenty-three patients with chronic pancreatitis by EUS were compared with nine normal subjects. Hyperechogenicity was evaluated as the size of the hyperechoi...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2004.03468.x

    authors： Irisawa A,Mishra G,Hernandez LV,Bhutani MS

    更新日期：2004-10-01 00:00:00

  • Influence of Helicobacter pylori genotype on triple eradication therapy.

    abstract：BACKGROUND:The efficiency of Helicobacter pylori eradication varies geographically, as do many parameters that might affect therapeutic efficiency. The aims of this study were to investigate the relationship between different genotypes of H. pylori and bacterium-related histopathological lesions in patients with duoden...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2007.04836.x

    authors： Zhao JJ,Wang JB,Yang L,Li Y

    更新日期：2007-12-01 00:00:00

  • Safety limit of the extent of hepatectomy for rats with moderately fatty liver: experimental study concerning living liver donor safety.

    abstract：INTRODUCTION:The aim of the present study was to determine whether rats with moderately fatty liver could withstand a 90% hepatectomy, which rats with normal livers can survive. MATERIAL AND METHODS:Nine-week-old male Wistar rats were used. Normal rat chow was fed to the normal liver group, and fat-enriched rat chow w...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2005.03972.x

    authors： Morioka D,Watanabe K,Makino H,Saito S,Ueda M,Kubota T,Sekido H,Matsuo K,Ichikawa Y,Endo I,Togo S,Shimada H

    更新日期：2006-02-01 00:00:00

  • Risk factors for covered metallic stent migration in patients with distal malignant biliary obstruction due to pancreatic cancer.

    abstract：BACKGROUND AND AIM:Covered metallic stents (CMSs) were developed to overcome tumor ingrowth in uncovered metallic stents (UMSs) for malignant biliary obstruction, but superiority of CMSs over UMSs is still controversial due to the high migration rate in CMS. Therefore, we conducted this retrospective analysis to clarif...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.12602

    authors： Nakai Y,Isayama H,Kogure H,Hamada T,Togawa O,Ito Y,Matsubara S,Arizumi T,Yagioka H,Mizuno S,Sasaki T,Yamamoto N,Hirano K,Tada M,Koike K

    更新日期：2014-09-01 00:00:00

  • Role of peroxisomes in the swift increase in alcohol metabolism.

    abstract：:The Swift Increase in Alcohol Metabolism occurs within 2.5 h after an acute gavage of ethanol causing an increase in hepatic respiration, an increase in alcohol metabolism, and pericentral hypoxia in the perfused liver. Alcohol treatment causes a release of endotoxin, activation of Kupffer cells to produce PGE(2), the...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2006.04641.x

    authors： Bradford BU

    更新日期：2007-06-01 00:00:00

  • Detection of Chlamydia pneumoniae by polymerase chain reaction-enzyme immunoassay in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls.

    abstract：BACKGROUND AND AIM:It has been suggested that Chlamydia is an organism that may have the potential to cause inflammatory bowel disease (IBD) in susceptible individuals. Chlamydia pneumoniae has emerged as an important human pathogen in the last decade. The objective of the present study was to investigate the frequency...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1746.2002.02793.x

    authors： Chen W,Li D,Wilson I,Chadwick VS

    更新日期：2002-09-01 00:00:00

  • Five-lipoxygenase-activating protein inhibitor MK-886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax.

    abstract：BACKGROUND AND AIM:Products of the arachidonic acid metabolizing enzyme, 5-lipoxygenase (5-LOX), stimulate the growth of several cancer types. Inhibitors of 5-LOX and 5-LOX-activating protein (FLAP) induce apoptosis in some cancer cells. Here, the authors investigated the effect of a FLAP inhibitor, MK-886, on the inhi...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2004.03194.x

    authors： Fan XM,Tu SP,Lam SK,Wang WP,Wu J,Wong WM,Yuen MF,Lin MC,Kung HF,Wong BC

    更新日期：2004-01-01 00:00:00

  • KRAS mutation analysis by next-generation sequencing in endoscopic ultrasound-guided sampling for solid liver masses.

    abstract：BACKGROUND AND AIM:KRAS mutation analysis may provide ancillary diagnostic yield in an endoscopic ultrasound (EUS)-guided histopathological evaluation. We evaluated the clinical impact of KRAS mutation analysis with cytological and histological evaluations in EUS-guided tissue sampling, using a core biopsy needle for s...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.13423

    authors： Choi HJ,Moon JH,Kim HK,Lee YN,Lee TH,Cha SW,Cho YD,Park SH

    更新日期：2017-01-01 00:00:00

  • Genetic basis of chronic pancreatitis in Asia Pacific region.

    abstract：:Chronic pancreatitis (CP) is a disease characterized by irreversible destruction and fibrosis of the parenchyma, leading to pancreatic exocrine insufficiency. In developed countries, the etiology for 60% to 70% of CP amongst male patients is alcohol and 25% are classified as idiopathic chronic pancreatitis (ICP). The ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1746.2010.06598.x

    authors： Reddy DN,Prasad SS

    更新日期：2011-03-01 00:00:00

  • Natural history of chronic hepatitis B and C.

    abstract：:Hepatitis B virus (HBV) affects more than 300 million individuals worldwide and in the United States approximately 1.25 million individuals are chronic carriers of HBV. The risk of becoming a chronic hepatitis B virus surface antigen carrier is dependent upon the mode of acquisition of infection as well as the age of ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1746.1999.01903.x

    authors： Imperial JC

    更新日期：1999-05-01 00:00:00

  • Fibroscan can avoid liver biopsy in Indian patients with chronic hepatitis B.

    abstract：BACKGROUND AND AIM:Liver fibrosis is an established determinant of prognosis and therapy in chronic hepatitis B (CHB). The role of fibroscan in assessing fibrosis in CHB remains unclear. Present study was designed to correlate fibroscan with liver biopsy and determine whether fibroscan can avoid liver biopsy in patient...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.12318

    authors： Goyal R,Mallick SR,Mahanta M,Kedia S,Shalimar,Dhingra R,Sharma H,Das P,Datta Gupta S,Panda S,Acharya SK

    更新日期：2013-11-01 00:00:00

  • Case report: interferon induced coma in Sheehan's syndrome.

    abstract：:A 54-year-old woman who was being treated with 10 million units (mu) of natural interferon (IFN)-alpha per day for chronic active hepatitis C at a local clinic, developed coma on the fourth day of treatment. On admission to Yamagata University Hospital, she was still in a state of semicoma with severe hyponatraemia (1...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.1997.tb00483.x

    authors： Mabe K,Shinzawa H,Yamatani K,Takeda T,Ishibashi M,Yamada N,Misawa H,Wakabayashi H,Togashi H,Takahashi T

    更新日期：1997-07-01 00:00:00

  • High-mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.

    abstract：BACKGROUND AND AIM:The high-mobility group box 1 (HMGB1) protein plays an important role in a lot of biological behaviors, including DNA damage repair, gene transcription, cell replication, and cell death, and its expression is higher in many solid tumors tissues than in their adjacent normal tissues, and it is always ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.14371

    authors： Di X,He G,Chen H,Zhu C,Qin Q,Yan J,Zhang X,Sun X

    更新日期：2019-04-01 00:00:00

  • Homology model of the DNA gyrase enzyme of Helicobacter pylori, a target of quinolone-based eradication therapy.

    abstract：BACKGROUND AND AIMS:Resistance of Helicobacter pylori to the standard therapeutic antimicrobial agents has been demonstrated. Although quinolones are an alternative candidate for third-line eradication therapy, quinolone resistance of H. pylori is also increasing. Quinolone resistance of H. pylori is caused by a point ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2010.06245.x

    authors： Matsuzaki J,Suzuki H,Tsugawa H,Nishizawa T,Hibi T

    更新日期：2010-05-01 00:00:00

  • Assessment of cytology and mucin 2 in colorectal mucus collected from patients with inflammatory bowel disease: Results of a pilot trial.

    abstract：BACKGROUND AND AIM:Non-invasive diagnosis of colorectal disease remains problematic, fecal biomarkers presenting the only current option. Colorectal mucus is the diagnostically informative element of stool samples, but its separation from stool is difficult. We aimed to: (i) test a novel method of non-invasive colorect...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.13083

    authors： Loktionov A,Chhaya V,Bandaletova T,Poullis A

    更新日期：2016-02-01 00:00:00

  • Attenuation of hepatic fibrosis by an imidazolium salt in thioacetamide-induced mouse model.

    abstract：BACKGROUND AND AIM:Hepatic fibrosis is a worldwide healthy burden associated with significant morbidity and mortality. It is caused by a variety of chronic liver injuries. There is currently no effective treatment for liver fibrosis. In this report, we tested an imidazolium salt, 1,3-diisopropylimidazolium tetrafluorob...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2012.07265.x

    authors： Ding Z,Zhuo L

    更新日期：2013-01-01 00:00:00

  • Utility and limitations of noninvasive fibrosis markers for predicting prognosis in biopsy-proven Japanese non-alcoholic fatty liver disease patients.

    abstract：BACKGROUND AND AIM:The fibrosis stage of non-alcoholic fatty liver disease (NAFLD) is closely associated with long-term prognosis, including liver-related mortality. However, it is not yet clear whether noninvasive fibrosis markers can predict the incidence of non-liver-related complications in Japanese NAFLD. In this ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.14448

    authors： Ito T,Ishigami M,Ishizu Y,Kuzuya T,Honda T,Hayashi K,Nishimura D,Toyoda H,Kumada T,Goto H,Hirooka Y

    更新日期：2019-01-01 00:00:00

  • Acute Budd-Chiari syndrome with liver failure: the experience of a policy of initial interventional radiological treatment using transjugular intrahepatic portosystemic shunt.

    abstract：BACKGROUND AND AIMS:The optimal management of acute Budd-Chiari syndrome (BCS) with liver failure is controversial. Options include anticoagulation, portal systemic shunting or liver transplantation. In recent years, transjugular intrahepatic portosystemic shunts (TIPS) have been tried in place of shunt surgery. We rep...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2004.03427.x

    authors： Kavanagh PM,Roberts J,Gibney R,Malone D,Hegarty J,McCormick PA

    更新日期：2004-10-01 00:00:00

  • Factors associated with diagnostic accuracy, technical success and adverse events of endoscopic ultrasound-guided fine-needle biopsy: A systematic review and meta-analysis.

    abstract：BACKGROUND AND AIM:Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is used to diagnose lesions within or adjacent to the digestive tract. However, there is no report on the overall diagnostic accuracy, technical success, and adverse events of FNB. The aims of this study were to conduct a systematic review and...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,meta分析

    doi：10.1111/jgh.14999

    authors： Li DF,Wang JY,Yang MF,Xiong F,Zhang DG,Xu ZL,Luo MH,Jing ZD,Wang KX,Wang LS,Yao J

    更新日期：2020-08-01 00:00:00

  • Attitudes and knowledge of colorectal cancer and screening in Hong Kong: a population-based study.

    abstract：BACKGROUND:Colorectal cancer (CRC) ranks third of all cancer mortalities in Hong Kong. CRC screening can reduce mortality. However, participation in the CRC screening program depends on the knowledge and attitude of the population. The aim of this study is to investigate the knowledge and attitude towards CRC screening...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2005.04000.x

    authors： Wong BC,Chan AO,Wong WM,Hui WM,Kung HF,Lam SK

    更新日期：2006-01-01 00:00:00

  • Dysregulation of systemic iron metabolism in alcoholic liver diseases.

    abstract：:Alcoholic liver diseases (ALD) are frequently associated with iron overload. Until recently, the effects of ethanol in hepatic iron uptake and intestinal iron absorption have not been clarified in detail. Two possible mechanisms for iron overload are the uptake of iron into hepatocytes in a specific manner through the...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1746.2007.05290.x

    authors： Kohgo Y,Ohtake T,Ikuta K,Suzuki Y,Torimoto Y,Kato J

    更新日期：2008-03-01 00:00:00

  • Liver disease and the renin-angiotensin system: recent discoveries and clinical implications.

    abstract：:The renin-angiotensin system (RAS) is a key regulator of vascular resistance, sodium and water homeostasis and the response to tissue injury. Historically, angiotensin II (Ang II) was thought to be the primary effector peptide of this system. Ang II is produced predominantly by the effect of angiotensin converting enz...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1746.2008.05461.x

    authors： Lubel JS,Herath CB,Burrell LM,Angus PW

    更新日期：2008-09-01 00:00:00