Case report: interferon induced coma in Sheehan's syndrome.

Abstract:

:A 54-year-old woman who was being treated with 10 million units (mu) of natural interferon (IFN)-alpha per day for chronic active hepatitis C at a local clinic, developed coma on the fourth day of treatment. On admission to Yamagata University Hospital, she was still in a state of semicoma with severe hyponatraemia (122 mEq/L) and hypochloraemia (89 mEq/L). After the administration of electrolytes, her condition improved remarkably. Endocrinological loading tests showed a hypofunction of the anterior pituitary gland. In consideration of these results, and her past experiences of haemorrhage during childbirth and subsequent amenorrhoea, we diagnosed her illness as a coma as a result of Sheehan's syndrome which had become overt during IFN therapy. She recovered completely after treatment with hydrocortisone and l-thyroxine.

authors

Mabe K,Shinzawa H,Yamatani K,Takeda T,Ishibashi M,Yamada N,Misawa H,Wakabayashi H,Togashi H,Takahashi T

doi

10.1111/j.1440-1746.1997.tb00483.x

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

551-3

issue

7

eissn

0815-9319

issn

1440-1746

journal_volume

12

pub_type

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