Abstract：
:The Swift Increase in Alcohol Metabolism occurs within 2.5 h after an acute gavage of ethanol causing an increase in hepatic respiration, an increase in alcohol metabolism, and pericentral hypoxia in the perfused liver. Alcohol treatment causes a release of endotoxin, activation of Kupffer cells to produce PGE(2), therefore, stimulating mitochondrial function resulting in an increase in cofactor supply for nicotinamide adenine dinucleotide (NAD)-dependent alcohol metabolism and depletion of glycogen reserves. Additionally, liberation of peripheral fatty acids via activation of an adrenergic response to alcohol provides added substrate for peroxisomes. In this study, rats were treated in vivo with ethanol, methanol or oleate and basal rates of oxygen uptake in perfused liver were significantly increased as compared to untreated controls. Methanol (25 mmol/L), a selective substrate for catalase in rodents, was infused into the liver and rates of methanol metabolism were increased 3-4-fold as compared to controls. Gadolinium chloride blocked the increase in oxygen and alcohol metabolism and inhibited the increase in ketogenesis normally observed after ethanol treatment. Excess fatty acids from oleate treatment in vivo provided additional substrate for peroxisomal alcohol metabolism and an increase in alcohol metabolism occurred even when Kupffer cells were eliminated. These data demonstrate that fatty acid supply either via peripheral reserves or after fatty acid treatment to peroxisomes generate sufficient H(2)O(2) for activation of catalase-dependent alcohol metabolism.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Bradford BUdoi
10.1111/j.1440-1746.2006.04641.xsubject
Has Abstractpub_date
2007-06-01 00:00:00pages
S28-30eissn
0815-9319issn
1440-1746pii
JGH4641journal_volume
22 Suppl 1pub_type
杂志文章abstract：:Wilson's disease is an autosomal recessive, inborn error of copper metabolism. The basic defect is unknown but decreased biliary excretion of copper is associated with copper accumulation and damage to the liver, brain and other organs with variable clinical expression. The gene for the disease has been mapped to band...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1746.1990.tb01427.x
更新日期：1990-07-01 00:00:00
abstract：AIM:To investigate the factors affecting the outcome of fulminant hepatic failure (FHF) in children in relation to hepatitis B virus (HBV) infection. METHODS:Retrospective review of a total of 94 cases (61 males and 33 females, aged from 1 month to 15 years) recruited from nine tertiary referral centers in Taiwan from...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2005.03923.x
更新日期：2005-08-01 00:00:00
abstract：:Maintaining high levels of intracellular cyclic AMP (cAMP) is known to inhibit the growth of various proliferating cells including hepatocytes. We show here that transient (30 min) elevations of cAMP induced by addition of 8-bromo-cAMP (1 mmol/L) to rat hepatocytes in primary culture at three time points (12 h, 16 h a...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1998.tb00704.x
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND AND AIMS:The objective of this study was to describe the prevalence of pathogenic microorganisms in asymptomatic individuals in a community study in Melbourne, Australia. METHODS:The study population was a subset of 2803 individuals participating in the Water Quality Study; a community based randomized tria...
journal_title：Journal of gastroenterology and hepatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1440-1746.2000.02089.x
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:CYP2C19 polymorphism plays an important role in the metabolism of proton pump inhibitors. The multidrug resistance (MDR)1 genotype is associated with the successful eradication of Helicobacter pylori. The aim of the present study was to investigate the effects of CYP2C19 and MDR1 genotypes on the eradication...
journal_title：Journal of gastroenterology and hepatology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1440-1746.2008.05605.x
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND AND AIM:Estimates suggest that in Asia, more than 31 million individuals have hepatitis C virus infection. The present analysis was conducted to assess the efficacy and safety of elbasvir/grazoprevir in Asian participants enrolled in the elbasvir/grazoprevir phase 2/3 clinical trials. METHODS:This is an int...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.14636
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND AND AIM:Early endoscopic intervention reduces morbidity and mortality for patients with high-risk gastrointestinal hemorrhage and gallstones causing pancreatitis or ascending cholangitis. For low-risk bleeds 'after-hours' endoscopy services allow risk stratification and early, safe discharge leading to reduc...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2006.04141.x
更新日期：2006-03-01 00:00:00
abstract：:Sensitive and specific enzyme-linked immunosorbent assays (ELISA) were developed to detect separately the binding of polymerized human serum albumin (PHSA) to its antibody (A-PHSA) and to the hepatitis B surface antigen (HBsAg). A-PHSA was not detected in normal serum, whereas more than one-third to about half of sera...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1990.tb01763.x
更新日期：1990-01-01 00:00:00
abstract：:The anti-pre-S antibody in the samples of sera from normal healthy persons and patients with different clinical types of liver diseases due to hepatitis B virus (HBV) infection was detected by a newly established enzyme-linked immunosorbent assay technique. This test is a blocking assay where anti-pre-S antibody in th...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1989.tb00803.x
更新日期：1989-01-01 00:00:00
abstract：:In order to study the process of hepatocellular carcinoma (HCC) development, and to search for a clue to histologic diagnosis of well-differentiated HCC (wd-HCC), interstitial invasion in small HCC was evaluated. The study material consisted of 35 cases of HCC that were smaller than 3 cm that comprised 17 cases of wd-...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1994.tb01569.x
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:Colorectal cancer (CRC) ranks third of all cancer mortalities in Hong Kong. CRC screening can reduce mortality. However, participation in the CRC screening program depends on the knowledge and attitude of the population. The aim of this study is to investigate the knowledge and attitude towards CRC screening...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2005.04000.x
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND AND AIMS:It has been proposed that the expression of Fas ligand (Fas L) in tumors may play an important role in immune escape. This study was undertaken to test a 'counterattack' theory as a mechanism of immune escape in gastric carcinoma. METHODS:Expression of Fas and Fas L was examined in the human gastri...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2002.02657.x
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:The pathophysiology of constipation is not clearly identified as yet, and the interstital cells of Cajal (ICC), known to generate the slow wave activity and to be involved in intestinal neurotransmission and the enteric nervous system (ENS), are suspected to play an important role. The aims of the present st...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2005.03809.x
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND AND AIM:The risk of hepatocellular carcinoma (HCC) is known to be age dependent; the influence of age on prognosis is, however, controversial. The aim of this study was to compare the tumor characteristics and survival rates of young and old HCC patients, with respect to tumor stage. METHODS:We reviewed the...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2007.04914.x
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND AND AIM:The improvements in surgical technique and perioperative management in the recent decades may warrant revisit for survival outcomes and prognostic factors after liver resection for hepatocellular carcinoma (HCC). This study aimed to analyze the survival outcomes after liver resection for HCC for a co...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.13632
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND AND AIM:Extracorporeal shockwave lithotripsy (ESWL) has an established role in the management of pancreatic ductal stones. Its efficacy in management of multiple stones in tropical pancreatitis is unknown. The aim of this study was to prospectively evaluate: (i) the efficacy of main pancreatic duct stone cle...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1746.2006.04224.x
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND AND AIM:To validate an early discharge policy in patients admitted with upper gastrointestinal bleeding (UGIB) due to ulcers. METHODS:Patients with gastroduodenal ulcer or erosive gastritis/duodenitis were included in a previous study aiming to develop a practice guideline for early discharge of patients wi...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2010.06374.x
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND AND AIM:Owing to persistent controversy regarding the use of routine antibiotic prophylaxis in patients undergoing elective laparoscopic cholecystectomy and the availability of several new randomized controlled trials (RCTs), we conducted an up-to-date meta-analysis to provide the best current evidence. The ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/jgh.13246
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND AND AIM:Non-alcoholic fatty liver disease is the result of an imbalance in hepatic lipid partitioning that favors fatty acid synthesis and storage over fatty acid oxidation and triglyceride secretion. The progressive, inflammatory disorder of steatohepatitis can be prevented or reversed by correcting this li...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2007.05157.x
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND AND AIM:The incidence of colorectal cancer (CC) is increasing in many Asian countries, but decreasing in western countries. The present study examined the local incidence of CC in the past few decades. METHODS:A population based study, using data from Hong Kong (HK) Cancer Registry, was carried out to exami...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2009.06130.x
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND AND AIM:Hepatic fibrosis is a worldwide healthy burden associated with significant morbidity and mortality. It is caused by a variety of chronic liver injuries. There is currently no effective treatment for liver fibrosis. In this report, we tested an imidazolium salt, 1,3-diisopropylimidazolium tetrafluorob...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2012.07265.x
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND AND AIM:This study examined the effects of adrenergic blockade on muscle wasting and expression of the ubiquitin-proteasome system, tumor necrosis factor-α (TNF-α) and its signaling pathways in skeletal muscles of cirrhotic rats. METHODS:Cirrhosis was induced by bile duct ligation in adult male Sprague-Dawl...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.13159
更新日期：2016-04-01 00:00:00
abstract：:Ki-67 expression in tumours has been shown to be associated with prognosis in patients with hepatocellular carcinoma (HCC). In this study, primary HCC samples were obtained from 67 patients undergoing surgical resection. None of these patients had been subjected previously to any other form of therapy, such as arteria...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1998.01555.x
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND AND AIM:To investigate the relationship between human leptin receptor (LEPR) gene G3057A polymorphism and type 2 diabetes mellitus (T2DM) patients complicated with or without non-alcoholic fatty liver disease (NAFLD). METHODS:Two hundred and sixteen cases of newly diagnosed T2DM patients (104 cases complica...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2008.05544.x
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND AND AIMS:The relationship between gastroesophageal reflux disease and sliding hernia is controversial, especially following distal partial gastrectomy in patients with gastric cancer. The aim of this study was to examine the relationship between gastroesophageal reflux disease and sliding hernia of the esoph...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2006.04135.x
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND AND AIM:Although the esophagus is a common site of opportunistic infection in AIDS patients, little is known about the impact of HIV as well as opportunistic infection in the esophageal mucosa. Our aim is to analyze the esophageal immune profile in HIV+ patients with different immunological status with and w...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.13800
更新日期：2017-11-01 00:00:00
abstract：:A hepatitis B virus (HBV) carrier with marked retention of indocyanine green (ICG) and sulfobromophthalein (BSP) was admitted to our hospital for assessment of liver function. On admission, he was asymptomatic and blood chemistry tests showed normal values for transaminases and bilirubin. Serum hepatitis B surface ant...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1993.tb01554.x
更新日期：1993-09-01 00:00:00
abstract：:The transjugular intrahepatic portosystemic stent-shunt (TIPS) technique consists of a transhepatic puncture of the portal vein and stenting of the parenchymal tract between the hepatic and portal veins. Complications of both puncture and stenting are observed in approximately 5% of procedures. Most of the complicatio...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1746.1996.tb00079.x
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND AND AIM:Monotherapy has been proven insufficient in achieving sustained control of chronic hepatitis B. We aimed to assess the efficacy of combined sequential administration of lamivudine and pegylated interferon alfa-2b in patients with hepatitis Be antigen (HBeAg)-negative chronic hepatitis B. METHODS:Eig...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2007.05103.x
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND AND AIM:The PyloriTek Test Kit (a 1-h rapid urease test) was developed for the rapid diagnosis of Helicobacter pylori (H. pylori) during endoscopy. Most studies were performed in Western populations. The aim of this study was to evaluate the PyloriTek test for the diagnosis of H. pylori infection in Chinese ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2001.02565.x
更新日期：2001-09-01 00:00:00
