Effects of mosapride on esophageal functions and gastroesophageal reflux.

Abstract:

BACKGROUND AND AIM:A substantial number of patients with gastroesophageal reflux disease show symptomatic resistance to high-dose proton pump inhibitors. In those cases, prokinetics are possible candidates for treatment. The aim of the present study was to determine whether mosapride, a prokinetic agent, stimulates esophageal functions, and prevents acidic and non-acidic gastroesophageal reflux. METHODS:Normal volunteers (nine and 13 for two experiments, respectively) were enrolled. Salivary secretion, esophageal peristaltic contractions, and resting lower esophageal sphincter pressure with and without mosapride administration were recorded using a cross-over protocol. Post-prandial acidic and non-acidic reflux levels were also recorded. RESULTS:Mosapride at a standard dose of 15 mg/day did not stimulate salivary secretion or any esophageal motor functions. It also failed to prevent acidic and non-acidic post-prandial gastroesophageal reflux. CONCLUSIONS:Mosapride at 15 mg/day, a standard dose in Japan, did not change the esophageal motility and salivary secretion in healthy volunteers. Future study on a larger number of individuals with higher dose of mosapride is worthwhile.

authors

Koshino K,Adachi K,Furuta K,Ohara S,Morita T,Nakata S,Tanimura T,Miki M,Kinoshita Y

doi

10.1111/j.1440-1746.2010.06280.x

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

1066-71

issue

6

eissn

0815-9319

issn

1440-1746

pii

JGH6280

journal_volume

25

pub_type

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