Angiopoietin-2 levels in the hepatic vein as a useful predictor of tumor invasiveness and prognosis in human hepatocellular carcinoma.

Abstract:

BACKGROUND AND AIM:Hepatocellular carcinoma (HCC) is characteristically a hypervascular tumor and its progression is known to be closely related to angiogenesis. In this study, we investigated angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) levels in the hepatic vein draining from HCC, as well as in the peripheral vein, to evaluate their relation to clinicopathological features and prognosis. METHODS:To obtain hepatic venous blood samples, a catheter was placed into the main branch of the hepatic vein draining from HCC in 21 patients. The Ang-2 and VEGF levels in both the hepatic and peripheral veins were investigated. Furthermore, Ang-2 mRNA expression in surgically resected HCC was evaluated by quantitative reverse-transcription polymerase chain reaction (RT-PCR), as well as microvessel density (MVD) by CD34 immunostaining. RESULTS:Ang-2 levels in the hepatic vein significantly correlated with Ang-2 mRNA expression in HCC, but Ang-2 levels in the peripheral vein did not correlate. Furthermore, a significant correlation was found between hepatic venous Ang-2 and MVD levels, whereas there was no significant correlation with hepatic venous VEGF levels. When hepatic venous Ang-2 levels were compared with clinicopathological features, a significant relationship was found between high Ang-2 levels and portal vein invasion. The survival for patients in the high hepatic venous Ang-2 group was significantly poorer when compared with the low group. CONCLUSION:Preoperative hepatic venous Ang-2 levels may be a good predictor for portal vein invasion and also prognosis in patients with HCC.

authors

Kuboki S,Shimizu H,Mitsuhashi N,Kusashio K,Kimura F,Yoshidome H,Ohtsuka M,Kato A,Yoshitomi H,Miyazaki M

doi

10.1111/j.1440-1746.2007.05175.x

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

e157-64

issue

7 Pt 2

eissn

0815-9319

issn

1440-1746

pii

JGH5175

journal_volume

23

pub_type

杂志文章
  • Case report: hypoechoic submucosal nodules: a sign of Epstein-Barr virus-associated early gastric cancer.

    abstract::The Epstein-Barr virus (EBV) has been reported to be detectable in about 10% of gastric carcinomas. We performed a comparative study of endosonographic findings of EBV-positive and -negative early gastric carcinomas. Epstein-Barr virus was detected in 11.8% (four of 34) of endosonographically observed early gastric ca...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1998.tb00694.x

    authors: Nishikawa J,Yanai H,Mizugaki Y,Takada K,Tada M,Okita K

    更新日期:1998-06-01 00:00:00

  • The diagnostic performance of novel torque technique for endoscopic ultrasound-guided tissue acquisition in solid pancreatic lesions: A prospective randomized controlled trial.

    abstract:BACKGROUND AND AIM:Although several techniques for improved outcomes in endoscopic ultrasound (EUS)-guided tissue acquisition have been reported, the reported diagnostic yield for pancreatic masses is not satisfactory. The effects of novel technique (torque method) on twisting the scope in the clockwise or counterclock...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14840

    authors: Park SW,Lee SS,Song TJ,Koh DH,Hyun B,Chung D,Lee J,Shin E,Hong SM,Park CH

    更新日期:2020-03-01 00:00:00

  • Efficacy and safety of sofosbuvir/velpatasvir in a real-world chronic hepatitis C genotype 3 cohort.

    abstract:BACKGROUND AND AIM:Real-world data on sofosbuvir/velpatasvir with and without ribavirin (SOF/VEL ± RBV), particularly among patients with genotype 3 (GT3) decompensated cirrhosis, prior treatment, coinfection, and hepatocellular carcinoma (HCC), are scarce. We aimed to assess the efficacy and safety of SOF/VEL ± RBV in...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15324

    authors: Wong YJ,Thurairajah PH,Kumar R,Tan J,Fock KM,Law NM,Li W,Kwek A,Tan YB,Koh J,Lee ZC,Kumar LS,Teo EK,Ang TL

    更新日期:2020-11-20 00:00:00

  • Elevated level of interleukin-6 predicts organ failure and severe disease in patients with acute pancreatitis.

    abstract:BACKGROUND AND AIM:Cytokines play an important role in the pathogenesis of acute pancreatitis (AP). The aim of the present paper was to study the profile of anti- and proinflammatory cytokines in AP and to determine their predictive value for severity of AP, organ failure and mortality. METHODS:Consecutive patients wi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04752.x

    authors: Sathyanarayan G,Garg PK,Prasad H,Tandon RK

    更新日期:2007-04-01 00:00:00

  • Prevalence of enteric pathogens among community based asymptomatic individuals.

    abstract:BACKGROUND AND AIMS:The objective of this study was to describe the prevalence of pathogenic microorganisms in asymptomatic individuals in a community study in Melbourne, Australia. METHODS:The study population was a subset of 2803 individuals participating in the Water Quality Study; a community based randomized tria...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1440-1746.2000.02089.x

    authors: Hellard ME,Sinclair MI,Hogg GG,Fairley CK

    更新日期:2000-03-01 00:00:00

  • Gastrointestinal bleeding from hepatocellular carcinoma invading the stomach.

    abstract::Bleeding from hepatocellular carcinoma (HCC) invading the gastrointestinal tract is very uncommon. We report the case of a 61 year old man who had a large bleed from HCC invading the fundus of the stomach. Diagnosis was eventually made at laparotomy and he is still alive 7 months after local resection. ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1994.tb01290.x

    authors: Nicoll AJ,Ireton HJ,Crotty B

    更新日期:1994-09-01 00:00:00

  • Radiology of pancreatic adenocarcinoma: current status of imaging.

    abstract::Pancreatic adenocarcinoma is one of the leading causes of cancer death in the West, with a poor overall 5-year survival rate of only 4%. Late clinical presentation with an advanced disease results in a low rate of surgical intervention. Tumor serum marker CA 19-9 is sensitive, although not specific for the diagnosis o...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2007.05117.x

    authors: Sahani DV,Shah ZK,Catalano OA,Boland GW,Brugge WR

    更新日期:2008-01-01 00:00:00

  • Acute Budd-Chiari syndrome with liver failure: the experience of a policy of initial interventional radiological treatment using transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND AND AIMS:The optimal management of acute Budd-Chiari syndrome (BCS) with liver failure is controversial. Options include anticoagulation, portal systemic shunting or liver transplantation. In recent years, transjugular intrahepatic portosystemic shunts (TIPS) have been tried in place of shunt surgery. We rep...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2004.03427.x

    authors: Kavanagh PM,Roberts J,Gibney R,Malone D,Hegarty J,McCormick PA

    更新日期:2004-10-01 00:00:00

  • Randomized, three-arm study to optimize lamivudine efficacy in hepatitis B e antigen-positive chronic hepatitis B patients.

    abstract:BACKGROUND AND AIM:Data about the efficacy of de novo combination therapies, or optimization strategy by adding the other drug based on the virological response at week 24 of low genetic barrier antiviral agents is still limited. This study aimed to compare the efficacy at week 104 of lamivudine monotherapy (MONO), lam...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/jgh.12835

    authors: Liang X,Cheng J,Sun Y,Chen X,Li T,Wang H,Jiang J,Chen X,Long H,Tang H,Yu Y,Sheng J,Chen S,Niu J,Ren H,Shi J,Dou X,Wan M,Jiang J,Xie Q,Shi G,Ning Q,Chen C,Tan D,Ma H,Sun J,Jia J,Zhuang H,Hou J

    更新日期:2015-04-01 00:00:00

  • Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects.

    abstract:BACKGROUND AND AIM:Numerous mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with familial unconjugated hyperbilirubinemia. The UGT1A1 mutation appears to be considerably different among ethnic groups. To clarify the incidence of this gene mutation in the J...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2004.03370.x

    authors: Takeuchi K,Kobayashi Y,Tamaki S,Ishihara T,Maruo Y,Araki J,Mifuji R,Itani T,Kuroda M,Sato H,Kaito M,Adachi Y

    更新日期:2004-09-01 00:00:00

  • Serum hepatitis B surface antigen quantification as a useful assessment for significant fibrosis in hepatitis B e antigen-positive hepatitis B virus carriers.

    abstract:BACKGROUND AND AIMS:The role of serum quantitative hepatitis B surface antigen (qHBsAg) in identifying hepatitis B virus (HBV) carriers with significant fibrosis is unknown. This study aims to evaluate the diagnostic value of qHBsAg for hepatic fibrosis in hepatitis B e antigen (HBeAg)-positive HBV carriers. METHODS:C...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12304

    authors: Xun YH,Zang GQ,Guo JC,Yu XL,Liu H,Xiang J,Liu J,Shi JP

    更新日期:2013-11-01 00:00:00

  • Androgen profiles among Egyptian adults considering liver status.

    abstract:BACKGROUND AND AIM:Hepatitis C virus (HCV) and environmental hepatotoxins may have an indirect influence on health by altering the synthesis and function of hormones, particularly reproductive hormones. We aimed to evaluate liver diseases and sex steroid hormones in Egypt, which has the highest prevalence of HCV worldw...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04949.x

    authors: Aguilar CE,Soliman AS,McConnell DS,Zekri AR,Banerjee M,Omar A,Sharawy M,Omar S,Raouf A,Sowers MR

    更新日期:2008-07-01 00:00:00

  • Childhood pancreatitis.

    abstract::Inflammation of the pancreas has many presentations in children and adolescents. The etiology is often elusive, with a great number of cases being idiopathic. However, there have been a number of recent advances in the areas of cell biology, genetics and imaging technology, which should be highlighted. Herein is provi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2006.04246.x

    authors: Nydegger A,Couper RT,Oliver MR

    更新日期:2006-03-01 00:00:00

  • Inhibition of TXA synthesis with OKY-046 improves liver preservation by prolonged hypothermic machine perfusion in rats.

    abstract:BACKGROUND AND AIM:We previously reported that hypothermic machine perfusion (HMP) for liver preservation is feasible, but hepatic microcirculatory dysfunction and significant liver damage remain major obstacles in its application when the preservation is extended to 24 h. The underlying injury mechanism is not well un...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.05061.x

    authors: Xu H,Lee CY,Clemens MG,Zhang JX

    更新日期:2008-07-01 00:00:00

  • Restoration in vitro of impaired T-cell responses in patients with chronic hepatitis B by autologous dendritic cells loaded with hepatitis B virus proteins (R2).

    abstract:BACKGROUND:The purpose of the present paper was to investigate dendritic cell (DC) and T-cell functions in patients with chronic hepatitis B (CHB) and determine whether therapeutic DC vaccines could restore T-cell function in those patients in vitro. METHODS:Twelve patients with CHB and 10 normal control subjects with...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04262.x

    authors: Duan XZ,He HX,Zhuang H

    更新日期:2006-06-01 00:00:00

  • Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats.

    abstract:BACKGROUND:Arterial vasodilatation, which is a major factor in the pathogenesis of the hyperkinetic circulatory state and portal hypertension in cirrhosis, is due to arterial nitric oxide (NO) overproduction secondary to endothelial NO synthase (eNOS) and inducible NOS (iNOS) upregulation. However, in cirrhosis, the re...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04608.x

    authors: Malyshev E,Tazi KA,Moreau R,Lebrec D

    更新日期:2007-12-01 00:00:00

  • Hepatic steatosis in chronic hepatitis C virus infection: prevalence and clinical correlation.

    abstract:BACKGROUND AND AIMS:Hepatic steatosis is a histological characteristic in patients with chronic hepatitis C virus (HCV) infection. The aim of this study was to evaluate the prevalence of hepatic steatosis in Chinese patients with chronic hepatitis C, and to look for possible correlation with various histopathological c...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2001.02407.x

    authors: Hwang SJ,Luo JC,Chu CW,Lai CR,Lu CL,Tsay SH,Wu JC,Chang FY,Lee SD

    更新日期:2001-02-01 00:00:00

  • Barrett's esophagus: A historical perspective, an update on core practicalities and predictions on future evolutions of management.

    abstract::Interpretation of exploding knowledge about Barrett's esophagus is impaired by use of several conflicting definitions. Because any histological type of esophageal columnar metaplasia carries risk for esophageal adenocarcinoma, the diagnosis of Barrett's esophagus should no longer require demonstration of intestinal-ty...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1440-1746.2010.06535.x

    authors: Dent J

    更新日期:2011-01-01 00:00:00

  • Newly-developed, forward-viewing echoendoscope: a comparative pilot study to the standard echoendoscope in the imaging of abdominal organs and feasibility of endoscopic ultrasound-guided interventions.

    abstract:BACKGROUND AND AIM:Multiple diagnostic and therapeutic endoscopic ultrasound (EUS) procedures have been widely performed using a standard oblique-viewing (OV) curvilinear array (CLA) echoendoscope. Recently, a new, forward-viewing (FV) CLA was developed, with the advantages of improved endoscopic viewing and manipulati...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2011.06923.x

    authors: Iwashita T,Nakai Y,Lee JG,Park DH,Muthusamy VR,Chang KJ

    更新日期:2012-02-01 00:00:00

  • Magnetic resonance enterocolonography in detecting erosion and redness in intestinal mucosa of patients with Crohn's disease.

    abstract:BACKGROUND AND AIM:In Crohn's disease (CD), assessment of disease activity and extension is important for clinical management. Endoscopy is the most reliable tool for evaluating disease activity in these patients and it distinguishes between lesions based on ulcer, erosion, and redness. Magnetic resonance imaging (MRI)...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12851

    authors: Sato H,Tamura C,Narimatsu K,Shimizu M,Takajyo T,Yamashita M,Inoue Y,Ozaki H,Furuhashi H,Maruta K,Yasutake Y,Yoshikawa K,Watanabe C,Komoto S,Tomita K,Nagao S,Miura S,Shinmoto H,Hokari R

    更新日期:2015-04-01 00:00:00

  • Non-steroid anti-inflammatory drug associated ulcer: epidemiology, causation and treatment.

    abstract::Epidemiological evidence consistently indicates that aspirin or non-aspirin non-steroidal anti-inflammatory drug use is associated with the occurrence of gastric ulceration, gastric and ulcer bleeding, and ulcer death. Evidence on duodenal ulcer occurrence conflicts, possibly because of differences in study population...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验,评审

    doi:10.1111/j.1440-1746.1991.tb00885.x

    authors: Langman MJ,Brooks P,Hawkey CJ,Silverstein F,Yeomans N

    更新日期:1991-09-01 00:00:00

  • Epidemiology of alcoholic and nonalcoholic fatty liver disease in China.

    abstract::The prevalence of patients presenting with fatty liver disease (FLD) in China has approximately doubled over the past two decades. At present, FLD, which is typically diagnosed by imaging, is highly prevalent (≈ 27% urban population) in China and is mainly related to obesity and metabolic syndrome (MetS). However, the...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.12036

    authors: Fan JG

    更新日期:2013-08-01 00:00:00

  • Overview of hepatitis B prevalence, prevention, and management in the Pacific Islands and Territories.

    abstract::There are over 500-750 000 deaths per year because of hepatitis B virus (HBV)-related cirrhosis and liver cancer worldwide and the World Health Organization Western Pacific Region has some of the highest endemic levels of HBV in the world, particularly within China, South East Asia and Pacific Island Countries and Ter...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12684

    authors: Howell J,Van Gemert C,Lemoine M,Thursz M,Hellard M

    更新日期:2014-11-01 00:00:00

  • Anti-pre-S antibodies in different groups of patients with hepatitis B virus infection.

    abstract::The anti-pre-S antibody in the samples of sera from normal healthy persons and patients with different clinical types of liver diseases due to hepatitis B virus (HBV) infection was detected by a newly established enzyme-linked immunosorbent assay technique. This test is a blocking assay where anti-pre-S antibody in th...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1989.tb00803.x

    authors: Irshad M,Gandhi BM,Acharya SK,Joshi YK,Tandon BN

    更新日期:1989-01-01 00:00:00

  • Risk of colorectal cancer in patients with hematologic disease.

    abstract:BACKGROUND AND AIMS:A relatively large number of patients with multiple myeloma have been reported to develop a secondary malignancy such as cancer of the breast, biliary system or bowel. METHODS:A retrospective study was perfomed in 734 patients with hematologic disease diagnosed at Nippon Medical School Hospital bet...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:

    authors: Kishida T,Yonezawa M,Shibata Y,Tanaka S,Shinozawa I,Hoshino T,Tatsuguchi A,Feng L,Sato J,Fujimori S,Yoshida Y,Sakamoto C,Kobayashi M

    更新日期:2000-11-01 00:00:00

  • Hepatitis C in childhood.

    abstract::The approach of a pediatric hepatologist in managing children with hepatitis C virus (HCV) differs from adult practice, because the pediatric hepatologist is dealing with the beginning of a chronic illness in which long-term outcomes will not occur for 20 or 40 years, and it is not possible to predict in the early sta...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1746.2002.02731.x

    authors: Hardikar W

    更新日期:2002-04-01 00:00:00

  • Induction and clinical utilization of lymphokine-activated killer cells in patients with gastrointestinal tract cancers.

    abstract::In 18 patients with cancers of the gastrointestinal tract, lymphokine-activated killer (LAK) cell activity was studied and compared with that of healthy subjects. After cultivation with 10(3) iu/mL of recombinant interleukin-2, the cytotoxicity of patients' lymphoid cells was increased from 13.6 +/- 6.8% to 76.2 +/- 1...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1990.tb01813.x

    authors: Tsugita M,Yamauchi K,Komatsu T,Suzuki H,Hanyu F

    更新日期:1990-03-01 00:00:00

  • High dose probiotic and prebiotic cotherapy for remission induction of active Crohn's disease.

    abstract:BACKGROUND:Clinical trials of probiotic treatment for Crohn's disease (CD) have yielded conflicting results. This study assessed the clinical usefulness of combined probiotic and prebiotic therapy in the treatment of active CD. METHOD:Ten active CD outpatients without history of operation for CD were enrolled. Their m...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1746.2006.04535.x

    authors: Fujimori S,Tatsuguchi A,Gudis K,Kishida T,Mitsui K,Ehara A,Kobayashi T,Sekita Y,Seo T,Sakamoto C

    更新日期:2007-08-01 00:00:00

  • Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease.

    abstract:BACKGROUND AND AIM:6-Mercaptopurine (6-MP) and azathioprine (AZA) are widely used as maintenance therapy in children with inflammatory bowel disease (IBD). However, proper 6-thioguanine nucleotide (6-TGN) concentrations in Japanese children with IBD have not been reported. METHODS:This retrospective review examines 32...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06364.x

    authors: Ohtsuka Y,Arai K,Aoyagi Y,Fujii T,Yamakawa Y,Ohtani K,Ikuse T,Baba Y,Inage E,Kudo T,Suzuki R,Nagata S,Shimizu T

    更新日期:2010-10-01 00:00:00

  • Locoregional therapies for hepatocellular carcinoma: which patients are most likely to gain a survival advantage?

    abstract:BACKGROUND AND AIM:Locoregional therapies for hepatocellular carcinoma (HCC) are considered to confer a survival advantage, however, the patient group that should be targeted is not clearly defined. This study aimed to determine the impact on survival of locoregional therapies compared with supportive care, within prog...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06267.x

    authors: Mahady SE,Charlton B,Fitzgerald P,Koorey DJ,Perry JF,Waugh RC,McCaughan GW,Strasser SI

    更新日期:2010-07-01 00:00:00