Medical treatment of duodenal ulcer: acid inhibition or Helicobacter pylori eradication?

Abstract:

:To ascertain whether acid inhibition or Helicobacter pylori (HP) colonization is the decisive factor in the healing of duodenal ulcer, we treated 54 patients with famotidine and carried out long-term follow-up. Helicobacter pylori colonization was found in 70.4% of patients before treatment. There were no differences in the pre-treatment characteristics between patients with HP positive or HP negative ulcers. The 4-week and 8-week healing rates after famotidine treatment were 72.5% and 82.4% respectively. No difference in HP colonization was found between patients with ulcer healed and those with ulcer not healed (78.4% vs 64.3% at 4th week and 77.3% vs 71.4% at 8th week, P greater than 0.05). In patients with ulcer healed at 4th week, the intragastric pH was raised significantly and the antral acute inflammation was less severe than those with ulcer not healed. Ulcer recurrence was found in 76.9% of patients within 1 year, but there was no difference in ulcer recurrence between the patients with positive or negative HP colonization at the time of ulcer healing. Our results suggest that duodenal ulcer healing and recurrence are closely related to acid inhibition rather than to HP colonization.

authors

Lai KH,Chang FY,Tsay SH,Lu LC,Cheng JT,Jeng SS,Wu TC,Ng WW,Jeng JS,Lee SD

doi

10.1111/j.1440-1746.1991.tb01454.x

subject

Has Abstract,Author List Incomplete

pub_date

1991-03-01 00:00:00

pages

141-4

issue

2

eissn

0815-9319

issn

1440-1746

journal_volume

6

pub_type

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