Immune response after hepatitis A vaccination in haemodialysis patients: comparison with hepatitis B vaccination.

Abstract:

:This study evaluates the immune response of 20 haemodialysis (HD) patients vaccinated with hepatitis A (HA) vaccine and eight patients vaccinated with hepatitis B (HB) vaccine. Twenty patients and 22 healthy adults were immunized three times (months 0, 1 and 6) intramuscularly with a 0.5 microgram dose. All members of both groups were positive for the antibody to hepatitis A virus (anti-HAV) after three vaccinations. The geometric mean titres at 7 months were similar in both groups. No serious side effects were observed. Eight of the HD patients with HA vaccination were injected with yeast-derived hepatitis B vaccine. The three doses of 10 micrograms were administered intramuscularly at 0, 1 and 6 months. The occurrence of antibody to hepatitis B surface antigen (anti-HBs) was late in HD patients and the anti-HBs level in HD patients was lower than that in healthy subjects. These results indicate that this HA vaccine has good immunogenicity compared with the HB vaccine and that the standard three doses of HA vaccine given at 0, 1 and 6 months are safe and effective even in HD patients.

authors

Kuramoto I,Fujiyama S,Matsushita K,Sato T

doi

10.1111/j.1440-1746.1994.tb01714.x

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

228-31

issue

3

eissn

0815-9319

issn

1440-1746

journal_volume

9

pub_type

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