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Prevalence of erosive esophagitis among Japanese patients taking low-dose aspirin.

Abstract：

BACKGROUND AND AIM:The risk for erosive esophagitis (EE) with low-dose aspirin (ASA) remains unknown, especially among Japanese patients. We conducted the present study to compare the risk of EE with that of gastroduodenal mucosal injury among Japanese patients taking ASA. METHODS:From 5555 patients undergoing upper gastrointestinal endoscopy from January 2005 to December 2006 at Teikyo University Hospital, Tokyo, Japan, 159 patients (76 males and 83 females, mean age: 69.3 +/- 11 years) fulfilling the following conditions were selected: (i) taking ASA (less than 100 mg/day) continuously; (ii) not taking acid suppressants; and (iii) no history of gastrointestinal tract surgery, malignancies, severe cardiac failure, or liver cirrhosis. Age- and sex-matched patients not taking aspirin were randomly chosen as controls (n = 159). Two well-experienced endoscopic examiners evaluated endoscopic records to determine the presence or absence of esophageal hiatal hernia, EE, and gastroduodenal ulcers. RESULTS:The prevalence of EE in patients taking aspirin (9.4%) was not different from that of the controls (6.3%, odds ratio [OR]: 1.5, 95% confidence interval [CI]: 0.7-3.2), whereas peptic ulcers were found more frequently in the aspirin group (14%) than in the control group (4%, OR: 3.6, 95% CI: 1.5-8.8). CONCLUSION:In Japanese patients taking ASA, EE was not as common as peptic ulcers.

journal_name

J Gastroenterol Hepatol

journal_title

Journal of gastroenterology and hepatology

authors

Yamamoto T,Mishina Y,Ebato T,Isono A,Abe K,Hattori K,Ishii T,Kuyama Y

doi

10.1111/j.1440-1746.2009.06105.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

792-4

issue

4

eissn

0815-9319

issn

1440-1746

pii

JGH6105

journal_volume

25

pub_type

杂志文章

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