Recurrence pattern and surveillance strategy for rectal neuroendocrine tumors after endoscopic resection.


BACKGROUND AND AIM:Endoscopic resection is highly effective treatment option for rectal neuroendocrine tumors (NETs) as they usually present as small localized tumors. However, there are no well-established surveillance strategies following endoscopic resection. We established our own protocol for the surveillance of rectal NETs after endoscopic resection since 2013. This study aimed to assess the outcome and to optimize the surveillance strategies after endoscopic resection. METHODS:We retrospectively analyzed the data of patients with endoscopically treated rectal NETs between January 2013 and April 2018 at Samsung Medical Center. We analyzed 337 patients with a median follow-up duration of 35.0 months (min-max: 12.0-88.3). RESULTS:A total of 329 (97.6%) patients had tumors ≤ 1 cm in size, and eight (2.4%) patients had tumors > 1 cm in diameter. Synchronous rectal NETs were diagnosed in nine (2.7%) patients. Thirteen (3.9%) patients were identified as having positive resection margins. Regardless of the salvage treatment, none of these patients developed recurrence. Metachronous rectal NETs were diagnosed in nine (2.7%) patients. Metachronous lesions were associated with the number of synchronous lesions at initial diagnosis (P < 0.001, hazard ratio = 1.75, 95% confidence interval = 1.38-2.23). Extracolonic metastasis was not detected in this study. CONCLUSION:Although initial screening for detecting metastatic lesions using computed tomography is recommended, repeated imaging for detecting extracolonic recurrence was not necessary for small non-metastatic rectal NETs. However, regular endoscopic follow-up seems reasonable, especially in case of synchronous rectal NETs, for detecting metachronous rectal NETs.


Chung HG,Goh MJ,Kim ER,Hong SN,Kim TJ,Chang DK,Kim YH




Has Abstract


2020-08-31 00:00:00






  • Multiple main pancreatic duct stones in tropical pancreatitis: safe clearance with extracorporeal shockwave lithotripsy.

    abstract:BACKGROUND AND AIM:Extracorporeal shockwave lithotripsy (ESWL) has an established role in the management of pancreatic ductal stones. Its efficacy in management of multiple stones in tropical pancreatitis is unknown. The aim of this study was to prospectively evaluate: (i) the efficacy of main pancreatic duct stone cle...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Ong WC,Tandan M,Reddy V,Rao GV,Reddy N

    更新日期:2006-10-01 00:00:00

  • Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon.

    abstract:BACKGROUND:The pathophysiology of constipation is not clearly identified as yet, and the interstital cells of Cajal (ICC), known to generate the slow wave activity and to be involved in intestinal neurotransmission and the enteric nervous system (ENS), are suspected to play an important role. The aims of the present st...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lee JI,Park H,Kamm MA,Talbot IC

    更新日期:2005-08-01 00:00:00

  • Clinical outcomes of endoscopic submucosal dissection and endoscopic mucosal resection for laterally spreading tumors larger than 20 mm.

    abstract:BACKGROUND AND AIMS:Colorectal laterally spreading tumors (LST) > 20 mm are usually treated by endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR). Endoscopic piecemeal mucosal resection (EPMR) is sometimes required. The aim of our study was to compare the outcomes of ESD and EMR, including EPM...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Terasaki M,Tanaka S,Oka S,Nakadoi K,Takata S,Kanao H,Yoshida S,Chayama K

    更新日期:2012-04-01 00:00:00

  • Use of transient elastography in patients with HIV-HCV coinfection: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:Patients with HIV-hepatitis C virus (HCV) coinfection progress towards liver fibrosis and cirrhosis more rapidly compared with HCV mono-infected individuals. This necessitates an accurate assessment of liver stiffness with transient elastography to guide treatment. METHODS:Searches of PubMed, EMBASE...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审


    authors: Njei B,McCarty TR,Luk J,Ewelukwa O,Ditah I,Lim JK

    更新日期:2016-10-01 00:00:00

  • The efficacy of oral Zhizhu Kuanzhong, a traditional Chinese medicine, in patients with postprandial distress syndrome.

    abstract:BACKGROUND AND AIM:The treatment of patients with functional dyspepsia (FD) remains unsatisfactory. We assessed the efficacy of Zhizhu Kuanzhong (ZZKZ) capsule, a traditional Chinese medicine formula, in patients with postprandial distress syndrome (PDS) of FD. METHODS:The study was designed as a multicenter, randomiz...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Xiao Y,Li Y,Shu J,Li Y,Xu J,Ren J,Liu D,Wang J,Zhou L,Li Y,Tang G,Tian D,Zhang S,Hou X,Wang H,Li Z,Lv N,Chen M

    更新日期:2019-03-01 00:00:00

  • Prevalence of pancreatic cystic lesions detected by magnetic resonance imaging in the Chinese population.

    abstract:BACKGROUND AND AIM:Incidental pancreatic cystic lesions (PCLs) are being diagnosed more frequently. However, little is known about the prevalence of PCLs in the Chinese population. The aim of the study was to assess the crude prevalence of PCLs in individuals who underwent magnetic resonance imaging (MRI). METHODS:Dat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Sun L,Wang Y,Jiang F,Qian W,Shao C,Jin Z

    更新日期:2019-09-01 00:00:00

  • Fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography for the detection of proximal synchronous lesions in patients with obstructive colorectal cancer.

    abstract:BACKGROUND AND AIM:We aimed to investigate the ability of fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) to detect synchronous neoplasms, specifically obstructive colorectal cancer (CRC) and CRC in the proximal colon and to suggest a management strategy based on FDG PET/CT fi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kim WS,Lee HS,Lee JM,Kwak MS,Hwang SW,Park SH,Yang DH,Kim KJ,Myung SJ,Yang SK,Byeon JS

    更新日期:2017-02-01 00:00:00

  • Hepatic stellate cell contraction is inhibited by lipo-prostaglandin E1 in vitro.

    abstract::Prostaglandin E1 (PGE1) has been reported to have, experimentally and clinically, a protective effect against liver damage. This effect may result from the relaxation of hepatic stellate cells, whose contraction induces vasoconstriction of hepatic sinusoids. However, prostaglandins are unstable and a new drug delivery...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Wang XE,Watanabe S,Oide H,Hirose M,Itatsu T,Osada T,Takazakura Y,Yokoi Y,Sato N

    更新日期:1998-09-01 00:00:00

  • High-mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.

    abstract:BACKGROUND AND AIM:The high-mobility group box 1 (HMGB1) protein plays an important role in a lot of biological behaviors, including DNA damage repair, gene transcription, cell replication, and cell death, and its expression is higher in many solid tumors tissues than in their adjacent normal tissues, and it is always ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Di X,He G,Chen H,Zhu C,Qin Q,Yan J,Zhang X,Sun X

    更新日期:2019-04-01 00:00:00

  • Hepatic steatosis in chronic hepatitis C virus infection: prevalence and clinical correlation.

    abstract:BACKGROUND AND AIMS:Hepatic steatosis is a histological characteristic in patients with chronic hepatitis C virus (HCV) infection. The aim of this study was to evaluate the prevalence of hepatic steatosis in Chinese patients with chronic hepatitis C, and to look for possible correlation with various histopathological c...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Hwang SJ,Luo JC,Chu CW,Lai CR,Lu CL,Tsay SH,Wu JC,Chang FY,Lee SD

    更新日期:2001-02-01 00:00:00

  • Increased oxidative stress may lead to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rat.

    abstract:BACKGROUND AND AIMS:In the gastric mucosa of portal hypertensive rats, adaptive cytoprotection against ethanol-induced damage is impaired. The aim of this study was to determine relation between impaired adaptive cytoprotection and oxidative stress. METHODS:Portal hypertension was produced in male Sprague-Dawley rats ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kawano Y,Ohta M,Eguchi H,Iwashita Y,Inomata M,Kitano S

    更新日期:2013-04-01 00:00:00

  • Homing of the bone marrow-derived interstitial cells of Cajal is decreased in diabetic mouse intestine.

    abstract:BACKGROUND:Interstitial cells of Cajal (ICCs), which express c-Kit receptor tyrosine kinase (KIT), play an important role in gastrointestinal motility. Loss of ICCs likely contributes to diabetic gastrointestinal motility disorder, however, the mechanism of attrition remains unknown. Here, we test the hypothesis that t...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Li Y,Kojima H,Fujino K,Matsumura K,Katagi M,Urabe H,Chan L,Eguchi Y,Zhao L,Kimura H

    更新日期:2011-06-01 00:00:00

  • Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: its relation to vascular endothelial growth factor and cyclooxygenase-2.

    abstract:BACKGROUND:There are clinical reports that Helicobacter heilmannii, as well as Helicobacter pylori, has been clinically reported to cause gastric low-grade mucosa-associated lymphoid tissue-type (MALT) lymphoma, although its precise mechanism remains to be clarified. Thus, the present study was undertaken to elucidate ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nakamura M,Takahashi S,Matsui H,Murayama SY,Aikawa C,Sekiya Y,Nishikawa K,Matsumoto T,Yamada H,Tsuchimoto K

    更新日期:2008-12-01 00:00:00

  • Amount of Helicobacter pylori in gastric mucus during anti-H. pylori treatment.

    abstract::Helicobacter pylori is present in infected patients not only on the gastric epithelial cell surface but also in gastric mucus. We developed a competitive polymerase chain reaction (cPCR) method for quantitative measurement of H. pylori in gastric mucus. The aim of this study was to determine the number of H. pylori in...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Furuta T,Takashima M,Futami H,Arai H,Hanai H,Kaneko E

    更新日期:1998-05-01 00:00:00

  • Diabetes mellitus and operated peptic ulcer disease.

    abstract::There is some evidence of an antagonism between peptic ulcer and diabetes mellitus. This antagonism is possibly related to anomalous insulin metabolism in duodenal ulcer patients. To evaluate this issue, 471 Rochester, Minnesota residents who had surgery for peptic ulcer were examined and then followed for up to 34 ye...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Duggan JM,O'Keefe EA,Weaver AL,Zinsmeister AR,Melton LJ 3rd

    更新日期:1992-05-01 00:00:00

  • Short Message Service reminders reduce outpatient colonoscopy nonattendance rate: A randomized controlled study.

    abstract:BACKGROUND AND AIM:Nonattendance of outpatient colonoscopy leads to inefficient use of health-care resources. We aimed to study the effectiveness of using Short Message Service (SMS) reminder prior in patients scheduled for outpatient colonoscopy on their nonattendance rate. METHODS:Patients who scheduled for an outpa...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lam TYT,Hui AJ,Sia F,Wong MY,Lee CCP,Chung KW,Lau JYW,Wu PI,Sung JJY

    更新日期:2020-08-16 00:00:00

  • Endoscopic management of acute calculous cholangitis.

    abstract::Acute cholangitis is associated with significant morbidity and mortality. Endoscopic drainage procedures have been shown to be a safe and effective mode of treatment in acute cholangitis. As there is paucity of large series on endoscopic management of acute cholangitis, a study was performed to evaluate safety and eff...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章


    authors: Sharma BC,Agarwal DK,Baijal SS,Saraswat VA,Choudhuri G,Naik SR

    更新日期:1997-12-01 00:00:00

  • Management of patients with chronic hepatitis B.

    abstract::Better understanding of hepatitis B virus (HBV) replication and the natural history and immunopathogenesis of chronic hepatitis B, together with the introduction of effective agents with different mechanisms of action, is the basis for better therapeutic strategies against chronic hepatitis B. Substantial experience h...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Liaw YF

    更新日期:2002-04-01 00:00:00

  • Natural history of chronic hepatitis B virus infection: an immunopathological study.

    abstract::Three clinicopathological phases of chronic hepatitis B virus (HBV) infection are identified. First, is immune tolerance of HBV. High levels of viraemia are associated with normal alanine aminotransferase (ALT) levels and minimal histological lesions. More than 30-40% of hepatocytes have the hepatitis B core antigen (...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Chu CM,Liaw YF

    更新日期:1997-10-01 00:00:00

  • Acute hepatitis C transmitted by needlestick accident despite short duration interferon treatment.

    abstract::Hepatitis C virus (HCV) transmission by needlestick accidents involving hospital employees has become an important problem. The present report is of a case of acute hepatitis C that developed after a needlestick injury, despite short duration interferon treatment performed just after the accident in a trial effort to ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nakano Y,Kiyosawa K,Sodeyama T,Tanaka E,Matsumoto A,Ichijo T,Mizokami M,Furuta S

    更新日期:1995-09-01 00:00:00

  • Heterogeneous distribution of Fusobacterium nucleatum in the progression of colorectal cancer.

    abstract:BACKGROUND AND AIM:Fusobacterium nucleatum (Fn) is involved in colorectal cancer (CRC) growth and is a biomarker for patient prognosis and management. However, the ecology of Fn in CRC and the distribution of intratumoral Fn are unknown. METHODS:We evaluated Fn and the status of KRAS and BRAF in 200 colorectal neoplas...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Yamamoto S,Kinugasa H,Hirai M,Terasawa H,Yasutomi E,Oka S,Ohmori M,Yamasaki Y,Inokuchi T,Harada K,Hiraoka S,Nouso K,Tanaka T,Teraishi F,Fujiwara T,Okada H

    更新日期:2020-11-26 00:00:00

  • Decreased anti-Saccharomyces cerevisiae antibody titer by mesalazine in patients with Crohn's disease.

    abstract:BACKGROUND:Saccharomyces cerevisiae may contribute to the pathophysiology of Crohn's disease. We determined serum anti-Saccharomyces cerevisiae antibody (ASCA) levels in patients with inflammatory bowel disease. METHODS AND RESULTS:Immunoglobulin G (IgG) ASCA was measured by using an ELISA in serum samples from 19 pat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Oshitani N,Hato F,Matsumoto T,Jinno Y,Sawa Y,Hara J,Nakamura S,Seki S,Arakawa T,Kitano A,Kitagawa S,Kuroki T

    更新日期:2000-12-01 00:00:00

  • Computed tomography findings of sorafenib-treated hepatic tumors in patients with advanced hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:The purpose of this study was to describe the computed tomography (CT) findings of sorafenib-treated hepatic tumors in patients with advanced hepatocellular carcinoma and to correlate the findings to the overall survival (OS). METHODS:Twenty-eight sorafenib-treated patients who had advanced hepatoce...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kim MJ,Choi JI,Lee JS,Park JW

    更新日期:2011-07-01 00:00:00

  • miR-873-5p inhibits the progression of colon cancer via repression of tumor suppressor candidate 3/AKT signaling.

    abstract:BACKGROUND AND AIM:We previously discovered that tumor suppressor candidate 3 (TUSC3) was overexpressed and predicted worse prognosis in colon cancer patients. However, the mechanisms of upregulation of TUSC3 in colon cancer remained unclear. METHODS:MiR-873-5p was predicted and identified as the regulator of TUSC3 vi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Zhu Y,Zhang X,Qi M,Zhang Y,Ding F

    更新日期:2019-12-01 00:00:00

  • Enhancement of poly-adenosine diphosphate-ribosylation in human hepatocellular carcinoma.

    abstract:BACKGROUND:Poly-adenosine diphosphate (ADP)-ribosylation, catalysed by poly(ADP-ribose) polymerase (PARP), is a post-translational modification of nuclear proteins and is involved in a wide range of biological processes including DNA repair, cell proliferation and malignant transformation. Alteration of this reaction i...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nomura F,Yaguchi M,Togawa A,Miyazaki M,Isobe K,Miyake M,Noda M,Nakai T

    更新日期:2000-05-01 00:00:00

  • Extraesophageal and atypical manifestations of GERD.

    abstract::Extraesophageal manifestations of gastroesophageal reflux disease (GERD) are essentially complications of GERD that primarily involve organs that are in proximity to the esophagus. Non-cardiac chest pain (NCCP) is an atypical manifestation of GERD, because symptoms originate in essence from the esophagus. In both atyp...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Wong WM,Fass R

    更新日期:2004-09-01 00:00:00

  • Treatment with a novel lipid A analogue, FS-112, and partial hepatectomy causes submassive liver necrosis and impaired liver regeneration in mice.

    abstract::A novel experimental model of submassive liver necrosis with impaired regeneration has been established. A novel lipid A analogue, FS-112, was injected intravenously into male BALB/c mice, followed 2 days later by a 70% partial hepatectomy. Over the next 9 days, mice became severely jaundiced, with a peak total biliru...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Maeda T,Ohnishi H,Hayashi T,Ishiki Y,Moriwaki H,Muto Y

    更新日期:1996-05-01 00:00:00

  • Medical treatment of duodenal ulcer: acid inhibition or Helicobacter pylori eradication?

    abstract::To ascertain whether acid inhibition or Helicobacter pylori (HP) colonization is the decisive factor in the healing of duodenal ulcer, we treated 54 patients with famotidine and carried out long-term follow-up. Helicobacter pylori colonization was found in 70.4% of patients before treatment. There were no differences ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lai KH,Chang FY,Tsay SH,Lu LC,Cheng JT,Jeng SS,Wu TC,Ng WW,Jeng JS,Lee SD

    更新日期:1991-03-01 00:00:00

  • Use of hepatitis B virus core-related antigen to evaluate natural history of chronic hepatitis B.

    abstract:BACKGROUND AND AIM:Hepatitis B core-related antigen (HBcrAg) has been shown to correlate with various viral markers in chronic hepatitis B, but its role in defining natural history is not well studied. We aimed to investigate the use of HBcrAg to define different phases of chronic hepatitis B. METHODS:Stored residual ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chan HLY,Yasuda S,Wong GLH,Tada T,Chan CKM,Kumada T,Tse YK,Wong VWS,Toyoda H

    更新日期:2020-04-15 00:00:00

  • Prediction of improved liver function after balloon-occluded retrograde transvenous obliteration: relation to hepatic vein pressure gradient.

    abstract:BACKGROUND AND AIMS:Balloon-occluded retrograde transvenous obliteration (B-RTO) is an effective treatment for gastric varices (GVx), as well as hepatic encephalopathy. The aim of this study was to examine the changes of the hepatic vein pressure gradient (HVPG) after B-RTO and determine the relation between the change...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Uehara H,Akahoshi T,Tomikawa M,Kinjo N,Hashimoto N,Nagao Y,Kamori M,Maehara Y

    更新日期:2012-01-01 00:00:00