A commentary on: career paths for basic scientists in medical research.

abstract：BACKGROUND AND AIMS:Cancer invasion and metastasis are critical events for patient prognosis; however, the most important step in the whole process of lymph node (LN) metastasis in gastric cancer remains obscure. In this study, the significance of cancer cell behaviors, such as cell detachment, stromal invasion and lym...

journal_title：Journal of gastroenterology and hepatology

authors： Kamata I,Ishikawa Y,Akishima-Fukasawa Y,Ito K,Akasaka Y,Uzuki M,Fujimoto A,Morita H,Tamai S,Maehara T,Ogata K,Shimokawa R,Igarashi Y,Miki K,Ishii T

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND AIM:Chronic hepatitis C virus (HCV) infection is the leading cause of liver diseases including cirrhosis and hepatocellular carcinoma. In China, it is a major national health problem that demands nationwide coordinated emphasis on prevention and treatment. To inform these initiatives, a nationwide survey...

journal_title：Journal of gastroenterology and hepatology

authors： Wei L,Li J,Yang X,Wang G,Feng B,Hou J,Duan Z,Jia J,Ren H,Niu J,Chen X,Wang FS,Shang J,Bo Q,Li R,Liu Y,Zhuang H

更新日期：2016-12-01 00:00:00

abstract：:One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an abundant desmoplastic/stromal reaction. Until recently, this stroma had received little attention from researchers studying the pathogenesis of pancreatic cancer, with most of the research focus resting on the biology of tumo...

journal_title：Journal of gastroenterology and hepatology

authors： Apte MV,Wilson JS

更新日期：2012-03-01 00:00:00

abstract：:Complete duplication of the entire large bowel with partial ileal involvement is very rare and diagnosis can often be difficult as illustrated by this case report. We also review the other clinical associations of this rare condition and briefly discuss the embryology of duplications of the gastrointestinal tract. ...

journal_title：Journal of gastroenterology and hepatology

authors： Jimenez SG,Oliver MR,Stokes KB,Morreau PN,Chow CW

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND AIMS:To evaluate and compare laparoscopic splenectomy and partial splenic embolization as supportive intervention for cirrhotic patients with hypersplenism to overcome peripheral cytopenia before the initiation of and during interferon therapy or anticancer therapy for hepatocellular carcinoma. METHODS:...

journal_title：Journal of gastroenterology and hepatology

authors： Tomikawa M,Akahoshi T,Sugimachi K,Ikeda Y,Yoshida K,Tanabe Y,Kawanaka H,Takenaka K,Hashizume M,Maehara Y

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIM:Patients with non-alcoholic fatty liver disease (NAFLD) have an increased risk of atherosclerosis and alanine aminotransferase (ALT) is associated with insulin resistance independently of metabolic factors. The aim of the present study was to investigate whether NAFLD patients with ALT elevation had ...

journal_title：Journal of gastroenterology and hepatology

authors： Wang CC,Lin SK,Tseng YF,Hsu CS,Tseng TC,Lin HH,Wang LY,Kao JH

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND AIM:A substantial number of patients with gastroesophageal reflux disease show symptomatic resistance to high-dose proton pump inhibitors. In those cases, prokinetics are possible candidates for treatment. The aim of the present study was to determine whether mosapride, a prokinetic agent, stimulates eso...

journal_title：Journal of gastroenterology and hepatology

authors： Koshino K,Adachi K,Furuta K,Ohara S,Morita T,Nakata S,Tanimura T,Miki M,Kinoshita Y

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND AIM:Fully covered self-expandable metal stents (FCSEMS) may be better than plastic stents (PS) for preoperative biliary drainage (PBD) to relieve cholangitis or jaundice for resectable malignant biliary obstruction (MBO). However, modification of current FCSEMS designed originally for nonresectable MBO i...

journal_title：Journal of gastroenterology and hepatology

authors： Lee HW,Moon JH,Lee YN,Chung JC,Lee TH,Choi MH,Cha SW,Cho YD,Park SH

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND AND AIM:Data about the efficacy of de novo combination therapies, or optimization strategy by adding the other drug based on the virological response at week 24 of low genetic barrier antiviral agents is still limited. This study aimed to compare the efficacy at week 104 of lamivudine monotherapy (MONO), lam...

journal_title：Journal of gastroenterology and hepatology

authors： Liang X,Cheng J,Sun Y,Chen X,Li T,Wang H,Jiang J,Chen X,Long H,Tang H,Yu Y,Sheng J,Chen S,Niu J,Ren H,Shi J,Dou X,Wan M,Jiang J,Xie Q,Shi G,Ning Q,Chen C,Tan D,Ma H,Sun J,Jia J,Zhuang H,Hou J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Overexpression of signaling proteins including epidermal growth factor receptor (EGFR), Akt, mitogen activated protein kinase (MAPK) and cyclooxygenase-2 (COX-2) occurs in cholangiocarcinoma cell lines. However, the prognostic value of these markers is unknown. No prior study correlated the expression of the...

journal_title：Journal of gastroenterology and hepatology

authors： Javle MM,Yu J,Khoury T,Chadha KS,Iyer RV,Foster J,Kuvshinoff BW,Gibbs JF,Geradts J,Black JD,Brattain MG

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND AND AIM:Contrast harmonic endoscopic ultrasound (CH-EUS) was recently introduced to clinical practice; its reproducibility among endosonographers is unknown. Our aim was to assess the interobserver agreement (IA) in CH-EUS. METHODS:Fifteen endosonographers (eight experienced and seven non-experienced) from ...

journal_title：Journal of gastroenterology and hepatology

authors： Fusaroli P,Kypraios D,Mancino MG,Spada A,Benini MC,Bianchi M,Bocus P,De Angelis C,De Luca L,Fabbri C,Grillo A,Marzioni M,Reggio D,Togliani T,Zanarini S,Caletti G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Saccharomyces cerevisiae may contribute to the pathophysiology of Crohn's disease. We determined serum anti-Saccharomyces cerevisiae antibody (ASCA) levels in patients with inflammatory bowel disease. METHODS AND RESULTS:Immunoglobulin G (IgG) ASCA was measured by using an ELISA in serum samples from 19 pat...

journal_title：Journal of gastroenterology and hepatology

authors： Oshitani N,Hato F,Matsumoto T,Jinno Y,Sawa Y,Hara J,Nakamura S,Seki S,Arakawa T,Kitano A,Kitagawa S,Kuroki T

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND AND AIM:T-cell activation, mediated by the interaction with major histocompatibility complex (MHC)-peptide complexes and B7 costimulatory molecules on antigen-presenting cells, is an essential event in the pathogenesis of inflammatory bowel disease (IBD). We investigated the expression of B7 costimulatory mo...

journal_title：Journal of gastroenterology and hepatology

authors： Grose RH,Howarth GS,Xian CJ,Hohmann AW

更新日期：2001-11-01 00:00:00

abstract：:To study the short- and long-term outcomes of acute hepatitis C, three groups of patients were enrolled. Of 26 patients with acute hepatitis C, 18 (69%) maintained HCV viraemia and 8 had cleared virus naturally at 12 months after the onset. Normalization of ALT was seen in all 8 patients with acute resolving hepatitis...

journal_title：Journal of gastroenterology and hepatology

authors： Tanaka E,Kiyosawa K

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND AIM:Repeated water avoidance stress (WAS) induces visceral hypersensitivity. Additionally, it is also known to activate corticotropin-releasing factor (CRF), mast cells, and pro-inflammatory cytokines systems, but their precise roles on visceral sensation have not been determined definitely. The aim of t...

journal_title：Journal of gastroenterology and hepatology

authors： Nozu T,Miyagishi S,Nozu R,Takakusaki K,Okumura T

更新日期：2017-12-01 00:00:00

abstract：:The focus on colorectal neoplasia has led to an exponential increase in the use of colonoscopy in many countries. Although colonoscopy facilitates the diagnosis and treatment of colonic disease, there are public health issues that include access, training, diagnostic accuracy, complications and additions to health-car...

journal_title：Journal of gastroenterology and hepatology

authors： Roberts-Thomson IC,Teo E

更新日期：2009-02-01 00:00:00

abstract：:The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. The increasing number of studies on the incidence and course of IBD in East has enabled us to explore East versus West differences in the epidemiology of IBD which could enhance our understanding of th...

journal_title：Journal of gastroenterology and hepatology

authors： Mak WY,Zhao M,Ng SC,Burisch J

更新日期：2020-03-01 00:00:00

abstract：:Infection by verocytotoxin-producing Escherichia coli (VTEC) is prevalent in many parts of the world but relatively uncommon in Asia, except Japan. A territory wide screening for VTEC (April to August 1996) in diarrhoeal stool samples sent to six hospital microbiology laboratories in Hong Kong revealed only four isola...

journal_title：Journal of gastroenterology and hepatology

authors： Wong S,Yam WC,Leung P,Woo P,Yuen KY

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Annexin A10 (ANXA10) and its liver-specific short isoform (ANXA10S) had tissue-restricted expression. The downregulation of ANXA10S is correlated with tumor progression and poor prognosis in hepatocellular carcinoma. The aim of the present study was to validate the tissue distribution and explore th...

journal_title：Journal of gastroenterology and hepatology

authors： Lu SH,Chen YL,Shun CT,Lai JN,Peng SY,Lai PL,Hsu HC

更新日期：2011-01-01 00:00:00

abstract：:The Swift Increase in Alcohol Metabolism occurs within 2.5 h after an acute gavage of ethanol causing an increase in hepatic respiration, an increase in alcohol metabolism, and pericentral hypoxia in the perfused liver. Alcohol treatment causes a release of endotoxin, activation of Kupffer cells to produce PGE(2), the...

journal_title：Journal of gastroenterology and hepatology

authors： Bradford BU

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND AIM:The risk for erosive esophagitis (EE) with low-dose aspirin (ASA) remains unknown, especially among Japanese patients. We conducted the present study to compare the risk of EE with that of gastroduodenal mucosal injury among Japanese patients taking ASA. METHODS:From 5555 patients undergoing upper g...

journal_title：Journal of gastroenterology and hepatology

authors： Yamamoto T,Mishina Y,Ebato T,Isono A,Abe K,Hattori K,Ishii T,Kuyama Y

更新日期：2010-04-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC), a chronic inflammatory process affecting the extrahepatic and/or medium to large bile ducts, is not rare in children. It has features suggesting an autoimmune pathogenesis, although the mechanism of tissue damage remains unknown. The clinical presentation of childhood primary scle...

journal_title：Journal of gastroenterology and hepatology

authors： Roberts EA

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND AND AIM:Although larger biopsies sample had been recommended for the study of non-invasive liver fibrosis assessment, few studies with larger biopsies for transient elastography (TE) detecting liver fibrosis had been reported. The present study tries to re-evaluate the performance of TE for detecting advance...

journal_title：Journal of gastroenterology and hepatology

authors： Chen YP,Liang XE,Zhang Q,Peng J,Zhu YF,Wen WQ,Hou JL

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND AIM:Histological criteria for intracapsular venous invasion (IVI) that would allow its discrimination between portal and hepatic venous invasion in hepatocellular carcinoma (HCC) have not been established. METHODS:We evaluated IVI immunohistochemically to discriminate between portal and hepatic venous i...

journal_title：Journal of gastroenterology and hepatology

authors： Ohashi M,Wakai T,Korita PV,Ajioka Y,Shirai Y,Hatakeyama K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND AIM:On endoscopic ultrasound (EUS)-guided biliary drainage, fistula dilation may be accompanied by leakage of bile juice, potentially along with bacteria or air, so this procedure should be kept as simple and short as possible. To date, various techniques to dilate the fistula have been reported. This pr...

journal_title：Journal of gastroenterology and hepatology

authors： Amano M,Ogura T,Onda S,Takagi W,Sano T,Okuda A,Miyano A,Masuda D,Higuchi K

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND AIM:Little is known about the role of hepatitis B virus (HBV) factors in the long-term prognosis of hepatocellular carcinoma (HCC) after resection. The objective of the present study was to identify the changing patterns of HBV levels and its effect on outcome after resection. METHODS:This study recruit...

journal_title：Journal of gastroenterology and hepatology

authors： An HJ,Jang JW,Bae SH,Choi JY,Cho SH,Yoon SK,Han JY,Lee KH,Kim DG,Jung ES

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:A daily injection of glycyrrhizin (Stronger Neo-Minophagen C (SNMC) containing 40 mg glycyrrhizin in a 20 mL ampoule) lowers alanine aminotransferase (ALT) levels in patients with chronic viral hepatitis. METHODS:The therapeutic effects of intermittent administration of SNMC three times a week for 12 weeks ...

journal_title：Journal of gastroenterology and hepatology

authors： Miyake K,Tango T,Ota Y,Mitamura K,Yoshiba M,Kako M,Hayashi S,Ikeda Y,Hayashida N,Iwabuchi S,Sato Y,Tomi T,Funaki N,Hashimoto N,Umeda T,Miyazaki J,Tanaka K,Endo Y,Suzuki H

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Advanced glycation end products (AGEs) are nonenzymatic modifications of proteins by reducing sugars. These compounds accumulate in a number of chronic disease states, contributing to tissue injury via several mechanisms, including activation of the receptor for advanced glycation end products (RAGE...

journal_title：Journal of gastroenterology and hepatology

authors： Goodwin M,Herath C,Jia Z,Leung C,Coughlan MT,Forbes J,Angus P

更新日期：2013-02-01 00:00:00

abstract：:Proliferating tumour cells in 92 patients with hepatocellular carcinoma (HCC) were identified by an immunohistochemical method using a monoclonal antibody against proliferating cell nuclear antigen (PCNA). The rate of PCNA-positive cells in HCC tissues was positively correlated with histological grade and the tumour s...

journal_title：Journal of gastroenterology and hepatology

authors： Nishimori H,Tsukishiro T,Nambu S,Okada K,Shimizu Y,Miyabayashi C,Higuchi K,Watanabe A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Few data were available on the optimal diagnostic strategy for Chinese patients with hematochezia. We aimed to evaluate the impact of age and distal colonic findings on the yield of diagnostic strategies in young Chinese patients with hematochezia. METHODS:Consecutive outpatients aged less than 50 ...

journal_title：Journal of gastroenterology and hepatology

authors： Liou JM,Lin JT,Wang HP,Huang SP,Lin JW,Wu MS

更新日期：2007-11-01 00:00:00