Amount of Helicobacter pylori in gastric mucus during anti-H. pylori treatment.


:Helicobacter pylori is present in infected patients not only on the gastric epithelial cell surface but also in gastric mucus. We developed a competitive polymerase chain reaction (cPCR) method for quantitative measurement of H. pylori in gastric mucus. The aim of this study was to determine the number of H. pylori in gastric mucus before and after anti-H. pylori treatment. Patients with duodenal ulcer were treated with lansoprazole alone (n = 11) or lansoprazole and amoxycillin (n = 12). The amount of H. pylori in gastric mucus was measured over time by a cPCR assay. Helicobacter pylori infection was also tested for using histology, culture, and the rapid urease test (RUT). Although most patients treated with lansoprazole alone had become H. pylori-negative by the end of treatment when tested by histology, RUT, and culture, a large number of H. pylori organisms were found in the gastric mucus at that time by cPCR. These patients returned to being H. pylori positive 1 to 12 months later on the basis of histology, RUT, and culture. However, cPCR results indicated eradication of H. pylori by the end of treatment in eight of the 12 patients treated with lansoprazole and amoxicillin, and these patients remained H. pylori negative on histology, RUT, culture, and cPCR 1 to 12 months later. Testing for H. pylori in gastric mucus is thus useful for precise determination of the success or failure of H. pylori eradication therapy.


Furuta T,Takashima M,Futami H,Arai H,Hanai H,Kaneko E




Has Abstract


1998-05-01 00:00:00












  • Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury.

    abstract:BACKGROUND AND AIM:It has recently been reported that Toll-like receptor 4 (TLR4) is involved in cellular responses to lipopolysaccharides (LPS) and early liver injury induced by LPS. The aim of the present study was to investigate the alterations of TLR4 gene expression in liver tissues and Kupffer cells during the co...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Hua J,Qiu DK,Li JQ,Li EL,Chen XY,Peng YS

    更新日期:2007-06-01 00:00:00

  • Long-term follow up of a randomized, controlled trial on prophylactic sclerotherapy of small oesophageal varices in liver cirrhosis.

    abstract:BACKGROUND:In order to evaluate the prophylactic impact of sclerotherapy of small varices in patients with cirrhosis and no endoscopic signs suggesting risk of haemorrhage, a randomized clinical trial was performed. METHODS:Seventy-one hospitalized patients met the inclusion criteria of diagnosis of cirrhosis with no ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Strauss E,Ribeiro MF,Albano A,Honain NZ,Maffei RA Jr,Caly WR

    更新日期:1999-03-01 00:00:00

  • Anxiety, depression and quality of life differences between functional and organic dyspepsia.

    abstract:OBJECTIVE AND BACKGROUND:The role of psychological disturbance in the pathogenesis of functional dyspepsia is uncertain. We aimed to examine for differences in anxiety, depression and health-related quality of life (HRQOL) between adults with organic (OD) and functional dyspepsia (FD). METHODOLOGY:A prospective, cross...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Mahadeva S,Goh KL

    更新日期:2011-04-01 00:00:00

  • Hepatitis C virus infection facilitates gallstone formation.

    abstract:BACKGROUND:Bile duct damage and hepatic steatosis are two characteristic histological findings in hepatitis C virus infection; and high prevalence of hepatitis C antibody is noted in patients with cholangiocarcinoma. The purpose of the present study was to examine the relationship between biliary diseases and hepatitis...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chang TS,Lo SK,Shyr HY,Fang JT,Lee WC,Tai DI,Sheen IS,Lin DY,Chu CM,Liaw YF

    更新日期:2005-09-01 00:00:00

  • Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function.

    abstract:BACKGROUND AND AIM:Inflammatory bowel disease results from a dysregulated immune response to intestinal microbial flora in individuals with genetic predisposition(s). This study aimed to determine the effects of compound polysaccharides (CP) containing yam polysaccharide and inulin on the rat model of colitis induced b...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Cai Y,Liu W,Lin Y,Zhang S,Zou B,Xiao D,Lin L,Zhong Y,Zheng H,Liao Q,Xie Z

    更新日期:2019-09-01 00:00:00

  • Relationship between Helicobacter pylori hopQ genotype and clinical outcome in Asian and Western populations.

    abstract:BACKGROUND AND AIMS:Outer membrane proteins of Helicobacter pylori mediate important pathogen-host interactions such as colonization, adhesion and the inflammatory response. hopQ genotypes have been suggested to be associated with increased risk of peptic ulcer. The aim of this study was to test the relation of hopQ ge...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Ohno T,Sugimoto M,Nagashima A,Ogiwara H,Vilaichone RK,Mahachai V,Graham DY,Yamaoka Y

    更新日期:2009-03-01 00:00:00

  • Repeating measurements by transient elastography in non-alcoholic fatty liver disease patients with high liver stiffness.

    abstract:BACKGROUND AND AIM:The Baveno VI Consensus recommends repeating examination in patients with high liver stiffness measurement (LSM) by transient elastography to reduce false-positive diagnosis of advanced liver disease. We tested whether repeating transient elastography can increase the overall diagnostic accuracy. ME...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chow JC,Wong GL,Chan AW,Shu SS,Chan CK,Leung JK,Choi PC,Chim AM,Chan HL,Wong VW

    更新日期:2019-01-01 00:00:00

  • Prevention and management of biliary anastomotic stricture in right-lobe living-donor liver transplantation.

    abstract::Biliary strictures can be categorized according to technical factor as anastomotic or nonanastomotic strictures. Biliary anastomotic stricture is a common complication after living-donor liver transplantation, occasionally causing deaths. The two most commonly used methods for biliary anastomosis are duct-to-duct anas...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Chok KS,Lo CM

    更新日期:2014-10-01 00:00:00

  • Analysis of tolvaptan non-responders and outcomes of tolvaptan treatment of ascites.

    abstract:BACKGROUND AND AIM:The goals of the study were to identify an effective treatment for ascites and to examine the influence of tolvaptan on outcomes by investigating non-responders to tolvaptan and comparing outcomes of hepatic cirrhosis in patients treated with and without tolvaptan. METHODS:In Study 1, of 145 patient...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Iwamoto T,Maeda M,Saeki I,Hidaka I,Tajima K,Ishikawa T,Takami T,Sakaida I

    更新日期:2019-07-01 00:00:00

  • Marked pneumoperitoneum 3 weeks after percutaneous endoscopic gastrostomy.

    abstract::In November 2001, a 29-year-old woman was admitted to the hospital because of dysphagia due to an apallic state caused by cerebral anoxia. Nutritional support was maintained by nasogastric tube feeding for approximately 3 months. For improvement of the body state maintenance and quality of life, a percutaneous endosco...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chen W,Kawahara H,Takahasi M,Matsushima A,Takase S

    更新日期:2006-05-01 00:00:00

  • Secreted protein acidic and rich in cysteine promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells and acquisition of cancerstem cell phenotypes.

    abstract:BACKGROUND AND AIM:Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that plays a significant role in tumor development. SPARC has been indicated that promotes tumorigenesis, metastasis, and poor prognosis in prostate cancer and lung cancer. Therefore, we sought to investigate the mol...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Jiang X,Liu F,Wang Y,Gao J

    更新日期:2019-10-01 00:00:00

  • Overlap in disease concept of functional esophageal disorders and minor esophageal motility disorders.

    abstract:BACKGROUND AND AIM:Functional gastrointestinal disorders are the most common disorders in gastroenterology and are currently considered as gut-brain interaction disorders with multiple related factors including motility disturbance. However, high-resolution manometry (HRM) had revealed a new disease concept known as mi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Sato H,Takahashi K,Mizuno KI,Hashimoto S,Kawata Y,Mizusawa T,Tominaga K,Yokoyama J,Terai S

    更新日期:2019-11-01 00:00:00

  • Th17 cells are increased with severity of liver inflammation in patients with chronic hepatitis C.

    abstract:BACKGROUND AND AIM:As a newly identified subset of T helper cells, T-helper 17 cells (Th17) are major mediators of inflammation-associated disease. Some reports have revealed significantly increased Th17 cells in hepatitis B virus-infected patients, and a recent study has demonstrated that hepatitis C virus (HCV)-speci...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chang Q,Wang YK,Zhao Q,Wang CZ,Hu YZ,Wu BY

    更新日期:2012-02-01 00:00:00

  • Natural history of hepatic fibrosis progression in chronic hepatitis C virus infection in India.

    abstract:BACKGROUND AND AIM:The rate of fibrosis progression per year can predict the time for the development of cirrhosis in chronic hepatitis C (CHC). We assessed the rate of fibrosis progression and the predictors of disease severity in Indian CHC patients. METHODS:Of the 355 treatment-naïve, histologically-proven CHC pati...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Hissar SS,Kumar M,Tyagi P,Goyal A,Suneetha PV,Agarwal S,Rastogi A,Sakhuja P,Sarin SK

    更新日期:2009-04-01 00:00:00

  • Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: its relation to vascular endothelial growth factor and cyclooxygenase-2.

    abstract:BACKGROUND:There are clinical reports that Helicobacter heilmannii, as well as Helicobacter pylori, has been clinically reported to cause gastric low-grade mucosa-associated lymphoid tissue-type (MALT) lymphoma, although its precise mechanism remains to be clarified. Thus, the present study was undertaken to elucidate ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nakamura M,Takahashi S,Matsui H,Murayama SY,Aikawa C,Sekiya Y,Nishikawa K,Matsumoto T,Yamada H,Tsuchimoto K

    更新日期:2008-12-01 00:00:00

  • Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm.

    abstract:BACKGROUND AND AIM:Pathological grading is important in defining the therapeutic strategy in pancreatic neuroendocrine neoplasm (PNEN) but is difficult for unresectable cases. Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) is useful in the diagnosis of PNEN, but its usefulness for pathological grading ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Horiguchi S,Kato H,Shiraha H,Tsutsumi K,Yamamoto N,Matsumoto K,Tomoda T,Uchida D,Akimoto Y,Mizukawa S,Tanaka T,Ichimura K,Takaki A,Yagi T,Okada H

    更新日期:2017-04-01 00:00:00

  • P21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migration.

    abstract:BACKGROUND AND AIM:Transforming growth factor-β (TGF-β) has been shown to play a central role in the promotion of cell motility, but its functional mechanism has remained unclear. With the aim of investigating the diagnostic and treatment modalities for patients with hepatocellular carcinoma (HCC), the signaling pathwa...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Sato M,Matsuda Y,Wakai T,Kubota M,Osawa M,Fujimaki S,Sanpei A,Takamura M,Yamagiwa S,Aoyagi Y

    更新日期:2013-06-01 00:00:00

  • Risk of alanine aminotransferase flare-up among asymptomatic hepatitis C virus RNA carriers: a 10-year follow-up study.

    abstract:AIMS:The aim of this study was to determine the cumulative rate of flare-up of serum alanine aminotransferase (ALT) level during a 10-year follow-up period, and characterize the clinical, virologic features in 120 hepatitis C virus (HCV) RNA-positive asymptomatic carriers with persistently normal ALT levels for 6 month...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Tsuji K,Yamasaki K,Yamanishi M,Kawakami M,Shirahama S

    更新日期:2001-05-01 00:00:00

  • Hepatic resection for benign tumours of the liver.

    abstract::The most frequent benign tumours of the liver include haemangioma, liver cell adenoma and focal nodular hyperplasia. Patients may undergo hepatic resection because of a preoperative diagnosis of malignancy or uncertainty in diagnosis despite an extensive work-up. ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Chen MF

    更新日期:2000-06-01 00:00:00

  • Incidence and risk factors of Pneumocystis jirovecii pneumonia in Korean patients with inflammatory bowel disease.

    abstract:BACKGROUND AND AIM:Little is known whether routine prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is needed in patients with inflammatory bowel disease (IBD) on immunosuppression, especially in Asian populations. We, therefore, sought to investigate the incidence and risk factors of PJP in patients with IBD...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nam K,Park SH,Lee J,Jo S,Kim SO,Noh S,Park JC,Kim JY,Kim J,Ham NS,Oh EH,Song EM,Hwang SW,Yang DH,Ye BD,Byeon JS,Myung SJ,Yang SK

    更新日期:2020-02-01 00:00:00

  • Clinical predictors for delirium tremens in alcohol dependence.

    abstract:BACKGROUND AND AIMS:This study was aimed to find clinical predictors for developing delirium tremens (DT) in alcohol dependence. METHODS:This cohort study was retrospectively carried out among patients who were diagnosed as having alcohol dependence between January 2001 and July 2004. Fifteen parameters were compared ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lee JH,Jang MK,Lee JY,Kim SM,Kim KH,Park JY,Lee JH,Kim HY,Yoo JY

    更新日期:2005-12-01 00:00:00

  • Factors contributing to ribavirin-induced anemia.

    abstract:BACKGROUND AND AIM:Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia. This study was conducted to identify the factors contributing to ribavirin-induced anemia. METHODS:Eighty-eight patients with chronic hepatitis C who received interferon-alpha-2b at a dose of 6 MU adminis...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nomura H,Tanimoto H,Kajiwara E,Shimono J,Maruyama T,Yamashita N,Nagano M,Higashi M,Mukai T,Matsui Y,Hayashi J,Kashiwagi S,Ishibashi H

    更新日期:2004-11-01 00:00:00

  • Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome.

    abstract:BACKGROUND AND AIMS:Emerging evidence suggests aldosterone (aldo) and NLRP3 inflammasome are important factors for HSC activation and liver fibrosis. However, the interaction between aldo and NLRP3 inflammasome in HSC activation and liver fibrosis remains largely unknown. The aim of this study is to investigate the rel...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Li Y,Zhang Y,Chen T,Huang Y,Zhang Y,Geng S,Li X

    更新日期:2020-06-01 00:00:00

  • Acute Budd-Chiari syndrome with liver failure: the experience of a policy of initial interventional radiological treatment using transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND AND AIMS:The optimal management of acute Budd-Chiari syndrome (BCS) with liver failure is controversial. Options include anticoagulation, portal systemic shunting or liver transplantation. In recent years, transjugular intrahepatic portosystemic shunts (TIPS) have been tried in place of shunt surgery. We rep...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kavanagh PM,Roberts J,Gibney R,Malone D,Hegarty J,McCormick PA

    更新日期:2004-10-01 00:00:00

  • Colorectal cancer screening practise is influenced by ethnicity of medical practitioner and patient.

    abstract:BACKGROUND AND AIM:Colorectal cancer (CRC) screening improves survival and requires appropriate recommendation by general practitioners (GPs). Screening practises may be influenced by barriers related to ethnicity and training. METHODS:A mail survey assessed GPs' practises and the barriers towards CRC screening. The a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Koo JH,You MY,Liu K,Athureliya MD,Tang CW,Redmond DM,Connor SJ,Leong RW

    更新日期:2012-02-01 00:00:00

  • Development of thyroid diseases in the treatment of chronic hepatitis C with alpha-interferon may be a good prognosticator in achieving a sustained virological response: a meta-analysis.

    abstract:BACKGROUND AND AIM:Thyroid dysfunction is the most common endocrinopathy associated with hepatitis C and its interferon-based treatment. When undergoing treatment, interferon and ribavirin synergize to potently stimulate the immune system in order to eradicate the virus. One of the innocent bystanders in this accentuat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审


    authors: Tran HA,Malcolm Reeves GE,Gibson R,Attia JR

    更新日期:2009-07-01 00:00:00

  • Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: a randomized controlled comparative trial with cimetidine, an H2-receptor antagonist.

    abstract:BACKGROUND AND AIMS:According to reports in Japanese patients, 1 week of Helicobacter pylori eradication therapy alone is not adequate for healing of gastric ulcers; 7-8 weeks of anti-ulcer therapy are subsequently required. We compared a gastroprotective drug, sofalcone, and an H(2)-receptor antagonist, cimetidine, in...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Higuchi K,Watanabe T,Tanigawa T,Tominaga K,Fujiwara Y,Arakawa T

    更新日期:2010-05-01 00:00:00

  • Hypothalamic-pituitary adrenal function in end-stage non-alcoholic liver disease.

    abstract::Patients with end-stage liver disease have significant mortality often associated with intercurrent episodes of bleeding or sepsis. Intact adrenal function is essential in such situations. In order to test the hypothesis that adrenal insufficiency might be present in severe liver disease, hypothalamic-pituitary adrena...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: McDonald JA,Handelsman DJ,Dilworth P,Conway AJ,McCaughan GW

    更新日期:1993-05-01 00:00:00

  • Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review.

    abstract:BACKGROUND AND AIM:Barrett's esophagus and colorectal polyps have several overlapping risk factors. Whereas several reports in Western countries have indicated a close relationship between Barrett's esophagus and colorectal polyps, the relationship between these two diseases remains unclear in Japan. This study was per...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Takedomi H,Tsuruoka N,Takamori A,Miyahara K,Yamanouchi K,Shimamura T,Fujimoto Y,Noda T,Matsunaga T,Takara Y,Shimada F,Hidaka H,Endo H,Anzai K,Fujimoto K

    更新日期:2019-07-01 00:00:00

  • Granulocytapheresis versus methylprednisolone in patients with acute ulcerative colitis: 12-month follow up.

    abstract:AIM:To evaluate granulocytapheresis (GCAP) in active ulcerative colitis (UC), with particular attention to the long-term effects of such treatment. METHODS:We included 80 patients with UC. Activity of the disease was evaluated by clinical activity index and endoscopic index. Patients were randomly divided in two group...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Bresci G,Parisi G,Mazzoni A,Scatena F,Capria A

    更新日期:2008-11-01 00:00:00