Clinical outcomes of cryptogenic compared with non-cryptogenic cirrhosis: A retrospective cohort study.

Abstract:

BACKGROUND AND AIM:The consequences of the association between the metabolic syndrome and cryptogenic cirrhosis are uncertain. We aimed to compare the differences in clinical outcomes between cryptogenic and non-cryptogenic cirrhosis. METHODS:A retrospective cohort study was conducted in a large, single academic center, over a 5-year duration. RESULTS:Complete data were available in 301 patients with cirrhosis (cryptogenic n = 94, non-cryptogenic n = 207). Compared with non-cryptogenic cirrhosis, patients with cryptogenic cirrhosis were older (mean age 66.4 ± 12.5 vs 60.7 ± 11.3 years, P < 0.0001), had more females (43.6% vs 26.6%, P = 0.003), had less disease severity (Child-Pugh C 8.5% vs 15.9%, P = 0.042), and had a higher prevalence of the metabolic syndrome (83% vs 51.2%, P < 0.0001). During the 5-year period, adults with cryptogenic Child-Pugh A cirrhosis had a longer total hospital admission duration compared with non-cryptogenic cirrhosis (median 7.0 vs 3.0 days, P = 0.035), but this was less evident in patients with more advanced disease. This difference was due to a longer duration of hospitalization for non-liver-related morbidity (median 14.0 days vs 8.0 days, P = 0.04), rather than liver-related morbidity (median 10.5 days vs 8.0 days, P = 0.34), in patients with cryptogenic compared with non-cryptogenic cirrhosis. Kaplan-Meier survival analysis showed no significant differences in survival between both types of cirrhosis for all grades of severity. CONCLUSIONS:Cryptogenic cirrhosis is associated with a longer duration of hospitalization compared with non-cryptogenic cirrhosis at an early stage of the disease. This difference is due to a greater burden of non-liver-related complications in the former.

authors

Mohammed OK,Mahadeva S

doi

10.1111/jgh.12978

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

1423-8

issue

9

eissn

0815-9319

issn

1440-1746

journal_volume

30

pub_type

杂志文章
  • Safety and efficacy of elbasvir/grazoprevir in Asian participants with hepatitis C virus genotypes 1 and 4 infection.

    abstract:BACKGROUND AND AIM:Estimates suggest that in Asia, more than 31 million individuals have hepatitis C virus infection. The present analysis was conducted to assess the efficacy and safety of elbasvir/grazoprevir in Asian participants enrolled in the elbasvir/grazoprevir phase 2/3 clinical trials. METHODS:This is an int...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14636

    authors: Wei L,Kumada H,Perumalswami PV,Tanwandee T,Cheng W,Heo J,Cheng PN,Hwang P,Mu SM,Zhao XM,Asante-Appiah E,Caro L,Hanna GJ,Robertson MN,Haber BA,Talwani R

    更新日期:2019-09-01 00:00:00

  • The impact of sodium glucose co-transporter 2 inhibitors on non-alcoholic fatty liver disease.

    abstract::Affecting one fourth of the global population, non-alcoholic fatty liver disease (NAFLD) is the commonest chronic liver disorder. It encompasses the simple liver fat accumulation to more progressive steatosis, inflammation, and fibrosis characterized as non-alcoholic steatohepatitis (NASH) and in some cases cirrhosis ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.15202

    authors: Chrysavgis L,Papatheodoridi AM,Chatzigeorgiou A,Cholongitas E

    更新日期:2020-07-27 00:00:00

  • High incidence of zinc deficiency among Filipino children with compensated and decompensated liver disease.

    abstract:BACKGROUND AND AIM:The role of zinc in the nutrition and growth of children with chronic liver disease is poorly defined. The present study determined the serum zinc levels of children with compensated liver disease (CLD) and decompensated liver disease (DLD) and compared this with healthy children. Zinc levels were al...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.06003.x

    authors: Umusig-Quitain P,Gregorio GV

    更新日期:2010-02-01 00:00:00

  • Enhancement of poly-adenosine diphosphate-ribosylation in human hepatocellular carcinoma.

    abstract:BACKGROUND:Poly-adenosine diphosphate (ADP)-ribosylation, catalysed by poly(ADP-ribose) polymerase (PARP), is a post-translational modification of nuclear proteins and is involved in a wide range of biological processes including DNA repair, cell proliferation and malignant transformation. Alteration of this reaction i...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2000.02193.x

    authors: Nomura F,Yaguchi M,Togawa A,Miyazaki M,Isobe K,Miyake M,Noda M,Nakai T

    更新日期:2000-05-01 00:00:00

  • Barrett's esophagus: A historical perspective, an update on core practicalities and predictions on future evolutions of management.

    abstract::Interpretation of exploding knowledge about Barrett's esophagus is impaired by use of several conflicting definitions. Because any histological type of esophageal columnar metaplasia carries risk for esophageal adenocarcinoma, the diagnosis of Barrett's esophagus should no longer require demonstration of intestinal-ty...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1440-1746.2010.06535.x

    authors: Dent J

    更新日期:2011-01-01 00:00:00

  • Effects of Helicobacter pylori eradication therapy on gastric emptying measured using the 13C-octanoic acid breath test and the acetaminophen method.

    abstract:BACKGROUND:The relationship between Helicobacter pylori eradication and gastric emptying has been reported; however, the effect of eradication therapy on gastric emptying is still unclear. This study evaluated the relationship between three gastric emptying techniques, the scintigraphic technique, the 13C-octanoic acid...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04075.x

    authors: Kachi M,Shirasaka D,Aoyama N,Ebara S,Miki I,Morita Y,Tamura T,Kasuga M

    更新日期:2006-05-01 00:00:00

  • Clinical validation of the "7 × 7" questionnaire for patients with functional gastrointestinal disorders.

    abstract:BACKGROUND AND AIM:Physicians use different scales and questionnaires to assess the severity of clinical symptoms in patients with functional gastrointestinal disorders. The current study aimed to validate the "7 × 7" questionnaire for assessment of severity of the symptoms as a tool for the efficacy of treatment of fu...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14546

    authors: Ivashkin V,Sheptulin A,Shifrin O,Poluektova E,Pavlov C,Ivashkin K,Drozdova A,Lyashenko O,Korolev A

    更新日期:2019-06-01 00:00:00

  • Persistent ileitis after ileal salvage from a failed Kock pouch.

    abstract::A case of persistent ileitis following the refashioning of a Kock ileal pouch into a Brooke ileostomy for severe pouchitis is reported. Preserving the terminal ileum by a salvage procedure may not be a safe alternative to pouch excision with the formation of a new end ileostomy in the surgical management of pouchitis ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1992.tb00999.x

    authors: de Silva HJ,Mortensen NJ

    更新日期:1992-07-01 00:00:00

  • What is the clinical significance of stromal angiogenesis in Barrett's esophagus?

    abstract:BACKGROUND:Enriched blood vessels occur in the stroma of Barrett's esophagus and are related to the ease of tumor invasion in the early stage of the cancer. Hypoxia-inducible factor (HIF) is closely related with angiogenesis through expression of vascular endothelial growth factor. The aim of the present study was to d...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05440.x

    authors: Moriyama N,Amano Y,Mishima Y,Okita K,Takahashi Y,Yuki T,Ishimura N,Ishihara S,Kinoshita Y

    更新日期:2008-12-01 00:00:00

  • Lamivudine/pegylated interferon alfa-2b sequential combination therapy compared with lamivudine monotherapy in HBeAg-negative chronic hepatitis B.

    abstract:BACKGROUND AND AIM:Monotherapy has been proven insufficient in achieving sustained control of chronic hepatitis B. We aimed to assess the efficacy of combined sequential administration of lamivudine and pegylated interferon alfa-2b in patients with hepatitis Be antigen (HBeAg)-negative chronic hepatitis B. METHODS:Eig...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.05103.x

    authors: Vassiliadis T,Tziomalos K,Patsiaoura K,Zagris T,Giouleme O,Soufleris K,Grammatikos N,Theodoropoulos K,Mpoumponaris A,Dona K,Zezos P,Nikolaidis N,Orfanou-Koumerkeridou E,Balaska A,Eugenidis N

    更新日期:2007-10-01 00:00:00

  • Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:Exportin 4 (XPO4) is a recently-discovered candidate tumor-suppressor gene identified in a liver cancer mouse model. To investigate the role of XPO4 in hepatocellular carcinoma (HCC) pathogenesis, we determined XPO4 expression and its correlation to prognosis in human primary HCC. METHODS:The XPO4 m...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06434.x

    authors: Liang XT,Pan K,Chen MS,Li JJ,Wang H,Zhao JJ,Sun JC,Chen YB,Ma HQ,Wang QJ,Xia JC

    更新日期:2011-03-01 00:00:00

  • Validation of an extension of the international non-invasive criteria for the diagnosis of hepatocellular carcinoma to the characterization of macroscopic portal vein thrombosis.

    abstract:BACKGROUND AND AIM:We aimed to validate the non-invasive criteria for the characterization of portal vein thrombosis (PVT) in patients with cirrhosis and hepatocellular carcinoma (HCC). In a prospective study, we examined the impact of arterial hypervascularity, as established by the European Association for the Study ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06564.x

    authors: Sorrentino P,Tarantino L,D'Angelo S,Terracciano L,Ferbo U,Bracigliano A,Panico L,De Chiara G,Lepore M,De Stefano N,Fiorentino F,Vecchione R

    更新日期:2011-04-01 00:00:00

  • Hepatocellular carcinoma in the Asia pacific region.

    abstract::Primary liver cancer, particularly hepatocellular carcinoma (HCC) remains a significant disease worldwide. It is among the top three causes of cancer death in the Asia Pacific region because of the high prevalence of its main etiological agents, chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. I...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2009.05784.x

    authors: Yuen MF,Hou JL,Chutaputti A,Asia Pacific Working Party on Prevention of Hepatocellular Carcinoma.

    更新日期:2009-03-01 00:00:00

  • Role of apoptosis in Helicobacter pylori-associated gastric mucosal injury.

    abstract::Apoptosis, a programmed cell death, was ignored, just like Helicobacter pylori, only to reappear recently. However, the number of current publications dealing with apoptosis or H. pylori has increased exponentially. Although gastric epithelial apoptosis is a programmed physiological event in the superficial aspect of ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1746.2000.02147.x

    authors: Suzuki H,Ishii H

    更新日期:2000-03-01 00:00:00

  • Increased melibiose/rhamnose ratio in bile of rats with acute cholestasis.

    abstract:BACKGROUND AND AIM:Melibiose/rhamnose permeability test is used for noninvasive intestinal mucosa barrier testing. However, the possible escape route of the absorbed saccharides through either intact or impaired blood-biliary barriers has not so far been explored. The objective of the present study was therefore two-fo...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05505.x

    authors: Tomsik P,Sispera L,Rezacova M,Niang M,Stoklasova A,Cerman J,Knizek J,Brcakova E,Cermanova J,Micuda S

    更新日期:2008-12-01 00:00:00

  • Magnetic resonance enterocolonography in detecting erosion and redness in intestinal mucosa of patients with Crohn's disease.

    abstract:BACKGROUND AND AIM:In Crohn's disease (CD), assessment of disease activity and extension is important for clinical management. Endoscopy is the most reliable tool for evaluating disease activity in these patients and it distinguishes between lesions based on ulcer, erosion, and redness. Magnetic resonance imaging (MRI)...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12851

    authors: Sato H,Tamura C,Narimatsu K,Shimizu M,Takajyo T,Yamashita M,Inoue Y,Ozaki H,Furuhashi H,Maruta K,Yasutake Y,Yoshikawa K,Watanabe C,Komoto S,Tomita K,Nagao S,Miura S,Shinmoto H,Hokari R

    更新日期:2015-04-01 00:00:00

  • Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients.

    abstract:BACKGROUND AND AIMS:Th17 cells have been shown to mediate host defensive mechanisms in various infections, but their role in HBV infection in humans has not been well characterized. In this study, we analyzed the frequency and cytokines secretion of circulating Th17 cells in HBV infected patients with different statuse...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.06154.x

    authors: Wu W,Li J,Chen F,Zhu H,Peng G,Chen Z

    更新日期:2010-04-01 00:00:00

  • Absolute lymphocyte count recovery at 1 month after transplantation predicts favorable outcomes of patients with hepatocellular carcinoma.

    abstract:BACKGROUND AND AIMS:Absolute lymphocyte count (ALC) and the recovery of ALC after treatment have been identified as a prognostic biomarker for several malignancies. In this study, we aimed to investigate the prognostic role of peritransplant ALC and ALC recovery after liver transplantation (LT) in hepatocellular carcin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12782

    authors: Zheng Z,Lin B,Zhang J,Yang Z,Xie H,Zhou L,Zhang M,Zheng S

    更新日期:2015-04-01 00:00:00

  • Changes in the first line Helicobacter pylori eradication rates using the triple therapy-a multicenter study in the Tokyo metropolitan area (Tokyo Helicobacter pylori study group).

    abstract:BACKGROUND AND AIM:Helicobacter pylori (H. pylori) infection is a strong risk factor for the development of gastric cancer. In 2013, the Japanese government approved H. pylori eradication therapy in patients with chronic gastritis as well as peptic ulcer. However, the continuing decline in eradication rates for first-l...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12796

    authors: Kawai T,Takahashi S,Suzuki H,Sasaki H,Nagahara A,Asaoka D,Matsuhisa T,Masaoaka T,Nishizawa T,Suzuki M,Ito M,Kurihara N,Omata F,Mizuno S,Torii A,Kawakami K,Ohkusa T,Tokunaga K,Mine T,Sakaki N

    更新日期:2014-12-01 00:00:00

  • Regulatory effects of corticosterone on ornithine decarboxylase activity during liver regeneration in rats.

    abstract:AIMS:The regulation of ornithine decarboxylase (ODC) gene expression and enzyme activity by corticosterone during rat liver regeneration induced by partial hepatectomy (PH) was evaluated. METHODS:Bilateral adrenalectomies were performed on ether-anesthetized rats 3 days before PH. Corticosterone in sesame oil was inje...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04795.x

    authors: Ning Q,Li C,Wei K,He J,Xu C,Shao Q

    更新日期:2007-11-01 00:00:00

  • Precore stop codon mutation of hepatitis B virus is associated with low breakthrough rate following long-term lamivudine therapy.

    abstract:BACKGROUND:Frequent viral breakthroughs limit the usefulness of lamivudine in the treatment of chronic hepatitis B (CHB). The purpose of the present study was to evaluate the effects of precore stop codon mutation (G to A mutation at nucleotide 1896; A(1896)) of hepatitis B virus (HBV) on the occurrence of viral breakt...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.03824.x

    authors: Shin JW,Chung YH,Choi MH,Kim JA,Ryu SH,Jang MK,Kim IS,Park NH,Lee HC,Lee YS,Suh DJ

    更新日期:2005-06-01 00:00:00

  • Biology of hepatic cancer stem cells.

    abstract::Hepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver and is the third most frequent cause of cancer death worldwide. Although advances in HCC detection and treatment have increased the likelihood of a cure at early stages of the disease, HCC remains largely incurable because of late pr...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2011.06762.x

    authors: Tong CM,Ma S,Guan XY

    更新日期:2011-08-01 00:00:00

  • Meta-analysis used to identify factors associated with the effectiveness of proton pump inhibitors against non-erosive reflux disease.

    abstract:BACKGROUND:A lack of published data remains on factors associated with the treatment response to proton pump inhibitors (PPI) in patients with non-erosive reflux disease (NERD). METHODS:Studies on effectiveness of PPI in patients with NERD were identified using the MEDLINE database and manual searches of the available...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1440-1746.2009.05879.x

    authors: Hiyama T,Matsuo K,Urabe Y,Fukuhara T,Tanaka S,Yoshihara M,Haruma K,Chayama K

    更新日期:2009-08-01 00:00:00

  • Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver.

    abstract:BACKGROUND AND AIM:Reactive oxygen species produced by cytochrome P4502E1 (CYP2E1) are believed to play a role in pathophysiology of non-alcoholic fatty liver disease (NAFLD). However, little is known about the expression, protein content and activity of anti-oxidant enzymes and the role of inducible nitric oxide synth...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.06196.x

    authors: Kathirvel E,Chen P,Morgan K,French SW,Morgan TR

    更新日期:2010-06-01 00:00:00

  • Laurence-Moon-Biedl syndrome accompanied by congenital hepatic fibrosis.

    abstract::A 33 year old woman with mental deficiency, retinitis pigmentosa, obesity, and parental consanguinity (heredity) was diagnosed as having Laurence-Moon-Biedl syndrome. She also had diabetes mellitus, slight hepatic dysfunction, and hepatomegaly. Liver biopsy showed perilobular fibrosis and bile duct proliferation with ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1990.tb01826.x

    authors: Nakamura F,Sasaki H,Kajihara H,Yamanoue M

    更新日期:1990-03-01 00:00:00

  • Morphological comparison and functional reconstitution of rat hepatic parenchymal cells on various matrices.

    abstract::Four types of materials, type I collagen coat (Coat), acid-soluble type I collagen gel (Hardgel), pepsin-treated acid-soluble type I collagen gel (Softgel), and an extract of extracellular matrix of the murine Engelbreth-Holm-Swarm sarcoma (Matrigel), were used as matrices to culture rat hepatic parenchymal cells, and...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.1998.13.s1.55

    authors: Awata R,Sawai H,Imai K,Terada K,Senoo H,Sugiyama T

    更新日期:1998-09-01 00:00:00

  • A multicenter prospective study on the prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drugs-negative idiopathic peptic ulcers in Japan.

    abstract:BACKGROUND AND AIM:The prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drug-negative peptic ulcers, commonly known as idiopathic peptic ulcers (IPUs), has been reported to be very low (0.9-2.6%) in Japan based on data from the 1990s. However, recent trends have yet to be been reported. Her...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgh.12876

    authors: Kanno T,Iijima K,Abe Y,Yagi M,Asonuma S,Ohyauchi M,Ito H,Koike T,Shimosegawa T

    更新日期:2015-05-01 00:00:00

  • Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.

    abstract:BACKGROUND AND AIM:Alpha-lipoic acid (ALA) has been shown to combat oxidative stress by quenching a variety of reactive oxygen species. It is involved in the regeneration of exogenous and endogenous antioxidants, chelation of metal ions, and repair of oxidized proteins. This study aimed to evaluate the potential benefi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04504.x

    authors: Kolgazi M,Jahovic N,Yüksel M,Ercan F,Alican I

    更新日期:2007-11-01 00:00:00

  • The diagnostic performance of novel torque technique for endoscopic ultrasound-guided tissue acquisition in solid pancreatic lesions: A prospective randomized controlled trial.

    abstract:BACKGROUND AND AIM:Although several techniques for improved outcomes in endoscopic ultrasound (EUS)-guided tissue acquisition have been reported, the reported diagnostic yield for pancreatic masses is not satisfactory. The effects of novel technique (torque method) on twisting the scope in the clockwise or counterclock...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14840

    authors: Park SW,Lee SS,Song TJ,Koh DH,Hyun B,Chung D,Lee J,Shin E,Hong SM,Park CH

    更新日期:2020-03-01 00:00:00

  • Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection?

    abstract::Coffee is one of the most popular beverages in the world. Several studies consistently show that coffee drinkers with chronic liver disease have a reduced risk of cirrhosis and a lower incidence of hepatocellular carcinoma regardless of primary etiology. With the increasing prevalence of non-alcoholic fatty liver dise...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.12422

    authors: Chen S,Teoh NC,Chitturi S,Farrell GC

    更新日期:2014-03-01 00:00:00