abstract：PURPOSE:The spaceflight-associated neuro-ocular syndrome (SANS) affects astronauts on missions to the International Space Station (ISS). The SANS has blurred vision and ocular changes as typical features. The objective of this study was to investigate if microgravity can create deformations or movements of the eye or o...

journal_title：Ophthalmology

authors： Wåhlin A,Holmlund P,Fellows AM,Malm J,Buckey JC,Eklund A

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:To evaluate the short-term and long-term variability of intraocular pressure (IOP) in eyes with primary open-angle glaucoma. DESIGN:Prospective study. PARTICIPANTS:Twenty-two patients previously implanted with a sulcus-based IOP sensor (EyeMate, Implandata GmbH, Germany). METHODS:Twenty-two patients previous...

journal_title：Ophthalmology

authors： Mansouri K,Rao HL,Weinreb RN,ARGOS-02 Study Group.

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:To evaluate outcomes of bilateral cataract surgery in children aged 7 to 24 months and compare rates of adverse events (AEs) with other Toddler Aphakia and Pseudophakia Study (TAPS) registry outcomes. DESIGN:Retrospective clinical study at 10 Infant Aphakia Treatment Study (IATS) sites. Statistical analyses co...

journal_title：Ophthalmology

authors： Bothun ED,Wilson ME,Yen KG,Anderson JS,Weil NC,Loh AR,Morrison D,Freedman SF,Plager DA,Vanderveen DK,Traboulsi EI,Hodge DO,Lambert SR,Toddler Aphakia and Pseudophakia Study.

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:To assess anatomical changes after laser peripheral iridotomy (LPI) and predictors of angle widening based on anterior segment OCT (AS-OCT) and angle opening based on gonioscopy in mainland Chinese primary angle closure suspects (PACS). DESIGN:Prospective observational study. PARTICIPANTS:454 subjects aged 50...

journal_title：Ophthalmology

authors： Xu BY,Friedman DS,Foster PJ,Jiang Y,Pardeshi AA,Jiang Y,Munoz B,Aung T,He M

更新日期：2021-01-23 00:00:00

abstract：:Taping the superior aspect of patient masks qualitatively decreases air flow and bacterial dispersion towards the ocular surface while inappropriately worn masks both qualitatively and quantitatively increase bacterial dispersion towards the ocular surface. ...

journal_title：Ophthalmology

authors： Raevis JJ,Gjyzeli G,Mititelu M,Rogers J,Lasarev M,Chang JS

更新日期：2021-01-11 00:00:00

abstract：PURPOSE:To evaluate the performance of retinal specialists in detecting retinal fluid presence in spectral domain OCT (SD-OCT) scans from eyes with age-related macular degeneration (AMD) and compare performance with an artificial intelligence algorithm. DESIGN:Prospective comparison of retinal fluid grades from human ...

journal_title：Ophthalmology

authors： Keenan TDL,Clemons TE,Domalpally A,Elman MJ,Havilio M,Agrón E,Benyamini G,Chew EY

更新日期：2021-01-01 00:00:00

abstract：:In 2019, the American Academy of Ophthalmology (AAO) created the Task Force on Myopia in recognition of the substantial global increases in myopia prevalence and its associated complications. The Task Force, led by Richard L. Abbott, MD, and Donald Tan, MD, comprised recognized experts in myopia prevention and treatme...

journal_title：Ophthalmology

authors： Modjtahedi BS,Abbott RL,Fong DS,Lum F,Tan D,Task Force on Myopia.

更新日期：2020-12-30 00:00:00

abstract：PURPOSE:To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. DESIGN:Randomized, 20-month, multicenter, subject- and efficacy evaluator-masked, par...

journal_title：Ophthalmology

authors： Medeiros FA,Walters TR,Kolko M,Coote M,Bejanian M,Goodkin ML,Guo Q,Zhang J,Robinson MR,Weinreb RN,ARTEMIS 1 Study Group.

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of intravitreal sirolimus in the management of noninfectious uveitis of the posterior segment (NIU-PS). DESIGN:Combined analysis of 2 phase 3, randomized, double-masked, multinational, 6-month studies. PARTICIPANTS:Adults with active NIU-PS (intermediate uveitis, posterior ...

journal_title：Ophthalmology

authors： Merrill PT,Clark WL,Banker AS,Fardeau C,Franco P,LeHoang P,Ohno S,Rathinam SR,Ali Y,Mudumba S,Shams N,Nguyen QD,Sirolimus Study Assessing Double-Masked Uveitis Treatment (SAKURA) Study Group.

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Although the impact of vision-related quality of life (VRQoL) is assessed optimally using binocular visual acuity (VA), uniocular VA remains the preferred measurement method in clinic-based and epidemiologic studies. We compared the impact of distance presenting binocular VA and uniocular VA in the better-seein...

journal_title：Ophthalmology

authors： Kidd Man RE,Liang Gan AT,Fenwick EK,Thakur S,Gupta P,Teo ZL,Cheng CY,Wong TY,Lamoureux EL

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To review the published literature on the visual acuity results and complications of different surgical techniques for intraocular lens (IOL) implantation in the absence of zonular support. METHODS:Peer-reviewed literature searches were conducted last in PubMed and the Cochrane Library in July 2019. The search...

journal_title：Ophthalmology

authors： Shen JF,Deng S,Hammersmith KM,Kuo AN,Li JY,Weikert MP,Shtein RM

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The complement pathway may play a key role in the pathogenesis of age-related macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura, IVERIC bio Inc, New York, NY), a C5 inhibitor, were assessed in participants with geographic atrophy (GA) secondary to AMD (GATHER1 Study). DESIGN:Int...

journal_title：Ophthalmology

authors： Jaffe GJ,Westby K,Csaky KG,Monés J,Pearlman JA,Patel SS,Joondeph BC,Randolph J,Masonson H,Rezaei KA

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Intravitreal anti-vascular endothelial growth factor (VEGF) pharmacotherapy plays a central role in the management of neovascular age-related macular degeneration (nAMD), diabetic retinal disease (DRD), and retinal venous occlusive disease (RVO). Within clinical trials, rates of systemic serious adverse events ...

journal_title：Ophthalmology

authors： Maloney MH,Payne SR,Herrin J,Sangaralingham LR,Shah ND,Barkmeier AJ

更新日期：2020-08-08 00:00:00

abstract：PURPOSE:To examine the normative profile and determinants of macular ganglion cell-inner plexiform layer (GCIPL) thickness based on spectral-domain OCT (SD-OCT) in a nonglaucoma, multi-ethnic Asian population. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:Ethnic Chinese, Malay, and Indian adults aged ≥...

journal_title：Ophthalmology

authors： Tham YC,Chee ML,Dai W,Lim ZW,Majithia S,Siantar R,Thakur S,Rim T,Cheung CY,Sabanayagam C,Aung T,Wong TY,Cheng CY

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To report the 3-month results of a randomized trial (Femtosecond Laser-Assisted Cataract Trial [FACT]) comparing femtosecond laser-assisted cataract surgery (FLACS) with standard phacoemulsification cataract surgery (PCS). DESIGN:Multicenter, randomized controlled trial funded by the UK National Institute of H...

journal_title：Ophthalmology

authors： Day AC,Burr JM,Bennett K,Bunce C,Doré CJ,Rubin GS,Nanavaty MA,Balaggan KS,Wilkins MR,FACT group.

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The identification of healthy persons more susceptible to dry eye (DED) symptoms developing after surgery remains an unmet need. We performed this study to build a new Ocular Surface Frailty Index (OSFI) and assess its predictive value for DED symptom onset after cataract surgery. DESIGN:Single-center, observa...

journal_title：Ophthalmology

authors： Villani E,Marelli L,Bonsignore F,Lucentini S,Luccarelli S,Sacchi M,Serafino M,Nucci P

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of 0.05%, 0.025%, and 0.01% atropine eye drops over 2 years to determine which is the optimal concentration for longer-term myopia control. DESIGN:Randomized, double-masked trial extended from the Low-Concentration Atropine for Myopia Progression (LAMP) Study. PARTICIPANTS:...

journal_title：Ophthalmology

authors： Yam JC,Li FF,Zhang X,Tang SM,Yip BHK,Kam KW,Ko ST,Young AL,Tham CC,Chen LJ,Pang CP

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To identify susceptibility genes associated with hereditary predisposition to uveal melanoma (UM) in patients with no detectable germline BAP1 alterations. DESIGN:Retrospective case series from academic referral centers. PARTICIPANTS:Cohort of 154 UM patients with high risk of hereditary cancer defined as pat...

journal_title：Ophthalmology

authors： Abdel-Rahman MH,Sample KM,Pilarski R,Walsh T,Grosel T,Kinnamon D,Boru G,Massengill JB,Schoenfield L,Kelly B,Gordon D,Johansson P,DeBenedictis MJ,Singh A,Casadei S,Davidorf FH,White P,Stacey AW,Scarth J,Fewings E,T

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy, effect profile, and safety of dexamethasone implant on diabetic macular edema (DME) in a real-life setting, further comparing results by DME duration, previous treatment status, and diabetic control. DESIGN:A multicenter, retrospective cohort of 340 DME eyes of 287 patients from 25 cl...

journal_title：Ophthalmology

authors： Rosenblatt A,Udaondo P,Cunha-Vaz J,Sivaprasad S,Bandello F,Lanzetta P,Kodjikian L,Goldstein M,Habot-Wilner Z,Loewenstein A,ARTES Study Group.

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Ophthalmologic telemedicine has the ability to provide eye care for patients remotely, and many countries have used screening tele-ophthalmology programs for several years. One such initiative at the Veterans Affairs (VA) Healthcare System is Technology-based Eye Care Services (TECS). The TECS services are loca...

journal_title：Ophthalmology

authors： Maa AY,Medert CM,Lu X,Janjua R,Howell AV,Hunt KJ,McCord S,Giangiacomo A,Lynch MG

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. METHODS:Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citat...

journal_title：Ophthalmology

authors： Shtein RM,Shen JF,Kuo AN,Hammersmith KM,Li JY,Weikert MP

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To analyze the potential association between aspirin use and progression of age-related macular degeneration (AMD). DESIGN:Two prospective cohort studies within 2 controlled clinical trials of oral supplementation for age-related eye disease. PARTICIPANTS:Age-Related Eye Disease Study (AREDS) participants 55 ...

journal_title：Ophthalmology

authors： Keenan TD,Wiley HE,Agrón E,Aronow ME,Christen WG,Clemons TE,Chew EY,Age-Related Eye Disease Study and Age-Related Eye Disease Study 2 Research Groups.

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To determine the trends in prevalence of myopia in Israeli young adults over approximately a generation, as well as associated factors and variation in the impact of these factors on myopia prevalence in this region over time. DESIGN:Retrospective, cross-sectional study. PARTICIPANTS:One hundred four thousand...

journal_title：Ophthalmology

authors： Shapira Y,Mimouni M,Machluf Y,Chaiter Y,Saab H,Mezer E

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To investigate characteristics associated with visual and anatomic outcomes in branch and central retinal vein occlusion (BRVO and CRVO) patients treated with ranibizumab. DESIGN:Post hoc analysis of patients with BRVO and CRVO from 2 multicenter clinical trials who completed month 12 of the HORIZON extension ...

journal_title：Ophthalmology

authors： Sophie R,Wang PW,Channa R,Quezada-Ruiz C,Clark A,Campochiaro PA

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To determine if there is a benefit to adjuvant intrastromal voriconazole (ISV) injections for primary treatment of filamentous fungal keratitis. DESIGN:Outcome-masked, randomized controlled clinical trial. PARTICIPANTS:Patients with moderate vision loss resulting from a smear-positive fungal ulcer. METHODS:S...

journal_title：Ophthalmology

authors： Narayana S,Krishnan T,Ramakrishnan S,Samantaray PP,Austin A,Pickel J,Porco T,Lietman T,Rose-Nussbaumer J

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:To determine the association between physical activity levels and the rate of visual field (VF) loss in glaucoma. DESIGN:Longitudinal, observational study. PARTICIPANTS:Older adults with suspect or manifest glaucoma. METHODS:Participants wore accelerometers for 1 week to define average steps per day, minutes...

journal_title：Ophthalmology

authors： Lee MJ,Wang J,Friedman DS,Boland MV,De Moraes CG,Ramulu PY

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To describe variations in retinal nerve fiber layer (RNFL) thickness based on spectral-domain (SD) OCT in a multiethnic Asian population. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:Ethnic Chinese, Malay, and Indian adults older than 48 years without glaucoma who were recruited from the Singa...

journal_title：Ophthalmology

authors： Ho H,Tham YC,Chee ML,Shi Y,Tan NYQ,Wong KH,Majithia S,Cheung CY,Aung T,Wong TY,Cheng CY

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To understand the impact of deep learning diabetic retinopathy (DR) algorithms on physician readers in computer-assisted settings. DESIGN:Evaluation of diagnostic technology. PARTICIPANTS:One thousand seven hundred ninety-six retinal fundus images from 1612 diabetic patients. METHODS:Ten ophthalmologists (5 ...

journal_title：Ophthalmology

authors： Sayres R,Taly A,Rahimy E,Blumer K,Coz D,Hammel N,Krause J,Narayanaswamy A,Rastegar Z,Wu D,Xu S,Barb S,Joseph A,Shumski M,Smith J,Sood AB,Corrado GS,Peng L,Webster DR

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Previous approaches using deep learning (DL) algorithms to classify glaucomatous damage on fundus photographs have been limited by the requirement for human labeling of a reference training set. We propose a new approach using quantitative spectral-domain (SD) OCT data to train a DL algorithm to quantify glauco...

journal_title：Ophthalmology

authors： Medeiros FA,Jammal AA,Thompson AC

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Low-concentration atropine is an emerging therapy for myopia progression, but its efficacy and optimal concentration remain uncertain. Our study aimed to evaluate the efficacy and safety of low-concentration atropine eye drops at 0.05%, 0.025%, and 0.01% compared with placebo over a 1-year period. DESIGN:Rando...

journal_title：Ophthalmology

authors： Yam JC,Jiang Y,Tang SM,Law AKP,Chan JJ,Wong E,Ko ST,Young AL,Tham CC,Chen LJ,Pang CP

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To investigate the relationship between the degree of posterior bowing of the lamina cribrosa (LC) at baseline and the rate of subsequent visual field (VF) progression in eyes with primary open-angle glaucoma (POAG). DESIGN:Prospective, observational study. PARTICIPANTS:One hundred one early-stage (VF mean de...

journal_title：Ophthalmology

authors： Ha A,Kim TJ,Girard MJA,Mari JM,Kim YK,Park KH,Jeoung JW

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement. DESIGN:Prospective cohort study within a controlled clinical trial. PARTICIPANTS:Age-Related Eye Dise...

journal_title：Ophthalmology

authors： Keenan TD,Agrón E,Domalpally A,Clemons TE,van Asten F,Wong WT,Danis RG,Sadda S,Rosenfeld PJ,Klein ML,Ratnapriya R,Swaroop A,Ferris FL 3rd,Chew EY,AREDS2 Research Group.

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To investigate optic disc margin anatomic features in myopic eyes with open-angle glaucoma (OAG) using spectral-domain (SD) OCT. DESIGN:Cross-sectional study. PARTICIPANTS:Two hundred four eyes of 102 participants with OAG and 106 eyes of 53 participants without glaucoma with axial length of 24 mm or more. M...

journal_title：Ophthalmology

authors： Sawada Y,Araie M,Shibata H,Ishikawa M,Iwata T,Yoshitomi T

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To review the current published literature on the use of spectral domain (SD) OCT to help detect changes associated with the diagnosis of glaucoma. METHODS:Searches of the peer-reviewed literature were conducted on June 11, 2014, November 7, 2016, August 8, 2017, and April 19, 2018, in the PubMed and Cochrane ...

journal_title：Ophthalmology

authors： Chen TC,Hoguet A,Junk AK,Nouri-Mahdavi K,Radhakrishnan S,Takusagawa HL,Chen PP

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To analyze the incidence of adrenal suppression and the glucocorticoid (GC) dose per kilogram body weight given in infants treated with standard protocol for topical ophthalmic GCs after congenital cataract surgery. DESIGN:Retrospective, consecutive case series. PARTICIPANTS:All children younger than 2 years ...

journal_title：Ophthalmology

authors： Bangsgaard R,Main KM,Boberg-Ans G,la Cour M,Forman JL,Haargaard B,Kiilgaard JF

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:To compare the rotational stability of the 2 most commonly used toric intraocular lenses (TIOLs). DESIGN:Retrospective cohort study in a single private practice. SUBJECTS:The study included all patients receiving an Acrysof (n = 626) or Tecnis TIOL (n = 647) over an 18-month period from April 2015 to Septembe...

journal_title：Ophthalmology

authors： Lee BS,Chang DF

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To investigate the independent impact of the incidence and progression of diabetic retinopathy (DR) on visual functioning (VF). DESIGN:Population-based cohort study. PARTICIPANTS:A total of 518 participants aged 40 to 80 years (baseline visit 2007-2009 and second visit 6 years later, 2013-2015), with diabetes...

journal_title：Ophthalmology

authors： Gupta P,Liang Gan AT,Kidd Man RE,Fenwick EK,Kumari N,Tan G,Mitchell P,Sabanayagam C,Wong TY,Cheng CY,Lamoureux EL

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN:Open-label multicenter study of ADA-treated patients with BD uveitis refractory t...

journal_title：Ophthalmology

authors： Martín-Varillas JL,Calvo-Río V,Beltrán E,Sánchez-Bursón J,Mesquida M,Adán A,Hernandez MV,Garfella MH,Pascual EV,Martínez-Costa L,Sellas-Fernández A,Cordero-Coma M,Díaz-Llopis M,Gallego R,Salom D,Ortego N,García-Serrano JL

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Posterior vitreous detachment (PVD) plays an important role in vitreoretinal interface disorders. Historically, observations of PVD using OCT have been limited to the macular region. The purpose of this study is to image the wide-angle vitreoretinal interface after PVD in normal subjects using montaged OCT imag...

journal_title：Ophthalmology

authors： Tsukahara M,Mori K,Gehlbach PL,Mori K

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD) is a common threat to vision. While classification of disease stages is critical to understanding disease risk and progression, several systems based on color fundus photographs are known. Most of these require in-depth and time-consuming analysis of fundus images. Herein,...

journal_title：Ophthalmology

authors： Grassmann F,Mengelkamp J,Brandl C,Harsch S,Zimmermann ME,Linkohr B,Peters A,Heid IM,Palm C,Weber BHF

更新日期：2018-09-01 00:00:00