听力与言语-语言病理学

行为科学

医学伦理学

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  • Increased CD11b and Decreased CD62L in Blood and Airway Neutrophils from Long-Term Smokers with and without COPD.

    abstract::There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as ne...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000509715

    authors: Stockfelt M,Christenson K,Andersson A,Björkman L,Padra M,Brundin B,Ganguly K,Asgeirsdottir H,Lindén S,Qvarfordt I,Bylund J,Lindén A

    更新日期:2020-01-01 00:00:00

  • Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis.

    abstract::The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice wit...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000509111

    authors: Issara-Amphorn J,Chancharoenthana W,Visitchanakun P,Leelahavanichkul A

    更新日期:2020-01-01 00:00:00

  • Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus.

    abstract::Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. We were able to show that MGHs also differ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000502646

    authors: Cinege G,Lerner Z,Magyar LB,Soós B,Tóth R,Kristó I,Vilmos P,Juhász G,Kovács AL,Hegedűs Z,Sensen CW,Kurucz É,Andó I

    更新日期:2020-01-01 00:00:00

  • Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study.

    abstract:BACKGROUND:We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of "hub genes" and upstream regulators during...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000492301

    authors: Francis A,Bosio E,Stone SF,Fatovich DM,Arendts G,MacDonald SPJ,Burrows S,Brown SGA

    更新日期:2019-01-01 00:00:00

  • Anopheles stephensi Dual Oxidase Silencing Activates the Thioester-Containing Protein 1 Pathway to Suppress Plasmodium Development.

    abstract::We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000497417

    authors: Kakani P,Kajla M,Choudhury TP,Gupta L,Kumar S

    更新日期:2019-01-01 00:00:00

  • Augmentation of Urinary Lactoferrin Enhances Host Innate Immune Clearance of Uropathogenic Escherichia coli.

    abstract::Urinary tract infection (UTI) is a prominent global health care burden. Although UTI is readily treated with antibiotics in healthy adults, complicated cases in immune-compromised individuals and the emerging antibiotic resistance of several uropathogens have accelerated the need for new treatment strategies. Here, we...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000499342

    authors: Patras KA,Ha AD,Rooholfada E,Olson J,Ramachandra Rao SP,Lin AE,Nizet V

    更新日期:2019-01-01 00:00:00

  • DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70.

    abstract::Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000480740

    authors: Takashima K,Oshiumi H,Matsumoto M,Seya T

    更新日期:2018-01-01 00:00:00

  • PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.

    abstract::As a key molecule in the antiviral innate immune response, the activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation. Knockdown of PLA1A expression suppressed the innate imm...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000489832

    authors: Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

    更新日期:2018-01-01 00:00:00

  • Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice.

    abstract:BACKGROUND:Pseudomonas aeruginosa (PS) infection results in severe morbidity and mortality, especially in immune-deficient populations. Aerobic exercise (AE) modulates the immune system, but its effects on the outcomes of pulmonary PS infection in elderly mice are unknown. METHODS:BALB/c mice (24 weeks old) were rando...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000488953

    authors: Stravinskas Durigon T,MacKenzie B,Carneiro Oliveira-Junior M,Santos-Dias A,De Angelis K,Malfitano C,Kelly da Palma R,Moreno Guerra J,Damaceno-Rodrigues NR,Garcia Caldini E,de Almeida FM,Aquino-Santos HC,Rigonato-Oliveira NC,Lea

    更新日期:2018-01-01 00:00:00

  • Immune Consequences of in vitro Infection of Human Peripheral Blood Leukocytes with Vesicular Stomatitis Virus.

    abstract:BACKGROUND:Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. Our study aimed to assess the overall immunological consequences of ex vivo infection of ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000485143

    authors: Tomczyk T,Wróbel G,Chaber R,Siemieniec I,Piasecki E,Krzystek-Korpacka M,Orzechowska BU

    更新日期:2018-01-01 00:00:00

  • Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines.

    abstract::Different liver cell types are endowed with immunological properties, including cell-intrinsic innate immune functions that are important to initially control pathogen infections. However, a full landscape of expression and functionality of the innate immune signaling pathways in the major human liver cells is still m...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000489966

    authors: Faure-Dupuy S,Vegna S,Aillot L,Dimier L,Esser K,Broxtermann M,Bonnin M,Bendriss-Vermare N,Rivoire M,Passot G,Lesurtel M,Mabrut JY,Ducerf C,Salvetti A,Protzer U,Zoulim F,Durantel D,Lucifora J

    更新日期:2018-01-01 00:00:00

  • Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).

    abstract::The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has been implicated that the translocation of myeloperoxidase (MPO) from neutrophilic granules to the nucleus is crucial to this process. Under di...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000480386

    authors: Neumann A,Papareddy P,Westman J,Hyldegaard O,Snäll J,Norrby-Teglund A,Herwald H

    更新日期:2018-01-01 00:00:00

  • Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer.

    abstract::Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted by goblet cells. In addition, mucosal epithelial cells express cell-bound...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章,评审

    doi:10.1159/000453594

    authors: van Putten JPM,Strijbis K

    更新日期:2017-01-01 00:00:00

  • Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease.

    abstract:BACKGROUND:Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000451055

    authors: Chowdhury IH,Koo SJ,Gupta S,Liang LY,Bahar B,Silla L,Nuñez-Burgos J,Barrientos N,Zago MP,Garg NJ

    更新日期:2017-01-01 00:00:00

  • A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.

    abstract:BACKGROUND:Alpha-synuclein (αS) is a nerve cell protein associated with Parkinson disease (PD). Accumulation of αS within the enteric nervous system (ENS) and its traffic from the gut to the brain are implicated in the pathogenesis and progression of PD. αS has no known function in humans and the reason for its accumul...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000477990

    authors: Stolzenberg E,Berry D,Yang,Lee EY,Kroemer A,Kaufman S,Wong GCL,Oppenheim JJ,Sen S,Fishbein T,Bax A,Harris B,Barbut D,Zasloff MA

    更新日期:2017-01-01 00:00:00

  • The TLR2 Antagonist Staphylococcal Superantigen-Like Protein 3 Acts as a Virulence Factor to Promote Bacterial Pathogenicity in vivo.

    abstract::Toll-like receptor (TLR) signaling is important in the initiation of immune responses and subsequent instigation of adaptive immunity. TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus. Many studies have dem...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000479100

    authors: Koymans KJ,Goldmann O,Karlsson CAQ,Sital W,Thänert R,Bisschop A,Vrieling M,Malmström J,van Kessel KPM,de Haas CJC,van Strijp JAG,Medina E

    更新日期:2017-01-01 00:00:00

  • Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia.

    abstract::Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapid...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000447713

    authors: Armitage AE,Lim PJ,Frost JN,Pasricha SR,Soilleux EJ,Evans E,Morovat A,Santos A,Diaz R,Biggs D,Davies B,Gileadi U,Robbins PA,Lakhal-Littleton S,Drakesmith H

    更新日期:2016-01-01 00:00:00

  • Streptococcus pyogenes Escapes Killing from Extracellular Histones through Plasminogen Binding and Activation by Streptokinase.

    abstract::Histones are small basic proteins and highly conserved among eukaryotes. Their main function is binding, packaging and organizing of DNA in the nucleus, but extracellular histones are also potent antimicrobial proteins. Here we found that Streptococcus pyogenes - an important human pathogen - protects itself from hist...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000448039

    authors: Nitzsche R,Köhler J,Kreikemeyer B,Oehmcke-Hecht S

    更新日期:2016-01-01 00:00:00

  • Functional Interaction between Apolipophorins and Complement Regulate the Mosquito Immune Response to Systemic Infections.

    abstract::The complement-like protein thioester-containing protein 1 (TEP1) is the hallmark effector molecule against Plasmodium ookinetes in the malaria vector Anopheles gambiae. We have previously shown that the knockdown of the noncatalytic clip domain serine protease CLIPA2 increased TEP1-mediated killing rendering mosquito...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000443883

    authors: Kamareddine L,Nakhleh J,Osta MA

    更新日期:2016-01-01 00:00:00

  • Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.

    abstract::Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000443401

    authors: García-Laorden MI,Stroo I,Blok DC,Florquin S,Medema JP,de Vos AF,van der Poll T

    更新日期:2016-01-01 00:00:00

  • Glucocorticoid-Induced Leucine Zipper Is Expressed in Human Neutrophils and Promotes Apoptosis through Mcl-1 Down-Regulation.

    abstract::Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000439052

    authors: Espinasse MA,Pépin A,Virault-Rocroy P,Szely N,Chollet-Martin S,Pallardy M,Biola-Vidamment A

    更新日期:2016-01-01 00:00:00

  • Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells.

    abstract::γδ T cells function at the interface between innate and adaptive immunity and have well-demonstrated roles in response to infection, autoimmunity and tumors. A common characteristic of these seemingly disparate conditions may be cellular stress or death. However, the conditions under which ligands for γδ T cells are i...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000446498

    authors: Collins CC,Bashant K,Erikson C,Thwe PM,Fortner KA,Wang H,Morita CT,Budd RC

    更新日期:2016-01-01 00:00:00

  • TNFα Augments Cytokine-Induced NK Cell IFNγ Production through TNFR2.

    abstract::NK cells play a central role in innate immunity, acting directly through cell-mediated cytotoxicity and by secreting cytokines. TNFα activation of TNFR2 enhances NK cell cytotoxicity, but its effects on the other essential function of NK cells - cytokine production, for which IFNγ is paramount - are poorly defined. We...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000448077

    authors: Almishri W,Santodomingo-Garzon T,Le T,Stack D,Mody CH,Swain MG

    更新日期:2016-01-01 00:00:00

  • Induction of Neutrophil Extracellular Traps in Shiga Toxin-Associated Hemolytic Uremic Syndrome.

    abstract::Hemolytic uremic syndrome (HUS), a vascular disease characterized by hemolytic anemia, thrombocytopenia, and acute renal failure, is caused by enterohemorrhagic Shiga toxin (Stx)-producing bacteria, which mainly affect children. Besides Stx, the inflammatory response mediated by neutrophils (PMN) is essential to HUS e...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000445770

    authors: Ramos MV,Mejias MP,Sabbione F,Fernandez-Brando RJ,Santiago AP,Amaral MM,Exeni R,Trevani AS,Palermo MS

    更新日期:2016-01-01 00:00:00

  • C4a: An Anaphylatoxin in Name Only.

    abstract::Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing and regenerative properties among othe...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章,评审

    doi:10.1159/000371423

    authors: Barnum SR

    更新日期:2015-01-01 00:00:00

  • Interleukin 1β-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands.

    abstract::Unwarranted overproduction of cytokines, such as interleukin (IL)-1β, can cause moderate to severe pathological complications, and thus elaborate mechanisms are needed to regulate its onset and termination. One such, well-known, mechanism is endotoxin tolerance, generally described as controlling lipopolysaccharide To...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000371517

    authors: Nahid MA,Satoh M,Chan EK

    更新日期:2015-01-01 00:00:00

  • The Janus face of α-toxin: a potent mediator of cytoprotection in staphylococci-infected macrophages.

    abstract::After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-t...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000368048

    authors: Koziel J,Chmiest D,Bryzek D,Kmiecik K,Mizgalska D,Maciag-Gudowska A,Shaw LN,Potempa J

    更新日期:2015-01-01 00:00:00

  • Thrombospondin 1 Modulates Monocyte Properties to Suppress Intestinal Mucosal Inflammation.

    abstract::Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of T...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000398799

    authors: Fang LL,Yu HQ,Wu RJ,He C,Li M,Yan H,Li JJ,Wang S,Liu ZG,Liu ZJ,Yang PC

    更新日期:2015-01-01 00:00:00

  • The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections.

    abstract::Listeria monocytogenes is a facultative intracellular pathogen which can infect Drosophila melanogaster. Upon infection, Drosophila mounts an immune response including antimicrobial peptide production and autophagy activation. A set of previously published results prompted us to study the role of the deubiquitinating ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000360293

    authors: Taillebourg E,Schneider DS,Fauvarque MO

    更新日期:2014-01-01 00:00:00

  • The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis.

    abstract::The role of the transcription factor nuclear factor of activated T cells (NFAT) was initially identified in T and B cell gene expression, but its role in regulating gene expression in macrophages during sepsis is not known. Our data show that NFATc3 regulates expression of inducible nitric oxide synthase (iNOS) in mac...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000362647

    authors: Ranjan R,Deng J,Chung S,Lee YG,Park GY,Xiao L,Joo M,Christman JW,Karpurapu M

    更新日期:2014-01-01 00:00:00

  • Highly pathogenic influenza viruses inhibit inflammatory response in monocytes via activation of rar-related orphan receptor RORα.

    abstract::Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000346706

    authors: Friesenhagen J,Viemann D,Börgeling Y,Schmolke M,Spiekermann C,Kirschnek S,Ludwig S,Roth J

    更新日期:2013-01-01 00:00:00

  • Evidence for specific genotype-dependent immune priming in the lophotrochozoan Biomphalaria glabrata snail.

    abstract::Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more c...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000345909

    authors: Portela J,Duval D,Rognon A,Galinier R,Boissier J,Coustau C,Mitta G,Théron A,Gourbal B

    更新日期:2013-01-01 00:00:00

  • Differential regulation by Toll-like receptor agonists reveals that MCPIP1 is the potent regulator of innate immunity in bacterial and viral infections.

    abstract::Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an im...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000339826

    authors: Blazusiak E,Florczyk D,Jura J,Potempa J,Koziel J

    更新日期:2013-01-01 00:00:00

  • Systems biology of circadian-immune interactions.

    abstract::There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental d...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章,评审

    doi:10.1159/000342427

    authors: Mavroudis PD,Scheff JD,Calvano SE,Androulakis IP

    更新日期:2013-01-01 00:00:00

  • Impairment in natural killer cells editing of immature dendritic cells by infection with a virulent Trypanosoma cruzi population.

    abstract::Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000350242

    authors: Batalla EI,Pino Martínez AM,Poncini CV,Duffy T,Schijman AG,González Cappa SM,Alba Soto CD

    更新日期:2013-01-01 00:00:00

  • Effects of ex vivo γ-tocopherol on airway macrophage function in healthy and mild allergic asthmatics.

    abstract::Elevated inflammation and altered immune responses are features found in atopic asthmatic airways. Recent studies indicate γ-tocopherol (GT) supplementation can suppress airway inflammation in allergic asthma. We studied the effects of in vitro GT supplementation on receptor-mediated phagocytosis and expression of cel...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000350234

    authors: Geiser M,Lay JC,Bennett WD,Zhou H,Wang X,Peden DB,Alexis NE

    更新日期:2013-01-01 00:00:00

  • Antiviral innate immunity disturbs podocyte cell function.

    abstract::Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis throughout the world. A majority (approx. 60%) of patients with IgAN experience disease exacerbations associated with an acute respiratory or gastrointestinal illness that appears to represent a viral infection. However, the exact mechan...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000345255

    authors: Yamashita M,Millward CA,Inoshita H,Saikia P,Chattopadhyay S,Sen GC,Emancipator SN

    更新日期:2013-01-01 00:00:00

  • Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis.

    abstract::We demonstrated recently that Francisella tularensis profoundly impairs human neutrophil apoptosis, but how this is achieved is largely unknown. Herein we used human oligonucleotide microarrays to test the hypothesis that changes in neutrophil gene expression contribute to this phenotype, and now demonstrate that F. t...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000342430

    authors: Schwartz JT,Bandyopadhyay S,Kobayashi SD,McCracken J,Whitney AR,Deleo FR,Allen LA

    更新日期:2013-01-01 00:00:00

  • Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1.

    abstract::Fibroblasts are known to eliminate intracellular bacteria, but the lethal hit of the bactericidal mechanism has not been defined. We show that primary embryonic and established fibroblasts can be induced by interferons or by intracellular bacterial infection to express a perforin-like mRNA previously described as macr...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000345249

    authors: McCormack R,de Armas LR,Shiratsuchi M,Ramos JE,Podack ER

    更新日期:2013-01-01 00:00:00

  • HIV-1 Gag-virus-like particles induce natural killer cell immune responses via activation and maturation of dendritic cells.

    abstract::Despite the extensive efforts that have been made to combat acquired immune deficiency syndrome (AIDS), the number of people infected each year with human immunodeficiency virus type 1 (HIV-1) is still increasing worldwide, and a safe and effective vaccine to control HIV infection is urgently needed. Recently, the nat...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000329226

    authors: Chang MO,Suzuki T,Suzuki H,Takaku H

    更新日期:2012-01-01 00:00:00

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