C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial.

abstract：PURPOSE:The human orbit is an environment that is vulnerable to inflammation and edema in the setting of autoimmune thyroid disease. Our study investigated the tenet that orbital adipose tissue lacks lymphatic vessels and analyzed the clinicopathologic differences between patients with acute and chronic thyroid eye dis...

journal_title：Ophthalmology

authors： Wong LL,Lee NG,Amarnani D,Choi CJ,Bielenberg DR,Freitag SK,D'Amore PA,Kim LA

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:To study the clinical and electroretinographic findings of affected males and female carriers in a family with X-linked cone-rod dystrophy (COD-1). DESIGN:Observational case series. PARTICIPANTS:Twenty-five members of a five-generation pedigree were examined. METHODS:A history of visual impairment includin...

journal_title：Ophthalmology

authors： Brown J Jr,Kimura AE,Gorin MB

更新日期：2000-06-01 00:00:00

abstract：:Aphakic cystoid macular edema (ACME) is a common condition seen after intracapsular cataract extractions. In an overwhelming majority of these cases, the condition improves spontaneously. Those cases that persist for months or years, however, are often associated with vitreous strands adherent to the surgical wound an...

journal_title：Ophthalmology

authors： Fung WE

更新日期：1982-08-01 00:00:00

abstract：:A 9-year-old boy was diagnosed with fundus flavimaculatus in his left eye. The boy's fellow eye was enucleated at 16 months of age for retinoblastoma. The authors reviewed the material submitted for histopathologic examination and found that the retinal pigment epithelial cells demonstrated increased autofluorescence ...

journal_title：Ophthalmology

authors： Steinmetz RL,Garner A,Maguire JI,Bird AC

更新日期：1991-06-01 00:00:00

abstract：PURPOSE:A previous study of Old Order Amish families showed an association of ocular refraction with markers proximal to matrix metalloproteinase (MMP) genes MMP1 and MMP10 and intragenic to MMP2. A candidate gene replication study of association between refraction and single nucleotide polymorphisms (SNPs) within thes...

journal_title：Ophthalmology

authors： Wojciechowski R,Yee SS,Simpson CL,Bailey-Wilson JE,Stambolian D

更新日期：2013-02-01 00:00:00

abstract：:Enucleation is the beginning of a long-term relationship between the ophthalmologist and the patient to provide a comfortable, cosmetically acceptable, anophthalmic socket. The ideal socket should have a low risk of implant extrusion, normal volume, and normal motility of the prosthesis. Aspheric motility implants pro...

journal_title：Ophthalmology

authors： Nunery WR,Hetzler KJ

更新日期：1983-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether artificial tears and cold compress alone or in combination provide a treatment benefit and whether they were as effective as or could enhance topical antiallergic medication. DESIGN:Randomized, masked clinical trial. PARTICIPANTS:Eighteen subjects (mean age, 29.5±11.0 years) allergic ...

journal_title：Ophthalmology

authors： Bilkhu PS,Wolffsohn JS,Naroo SA,Robertson L,Kennedy R

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To determine whether adjusting the intraocular pressure (IOP) change of the trial eye for the IOP change of the fellow eye (i.e., monocular trial) is a better assessment of medication response than testing each eye independently. DESIGN:Analysis of data from a prospective, randomized, clinical trial. PARTIC...

journal_title：Ophthalmology

authors： Bhorade AM,Wilson BS,Gordon MO,Palmberg P,Weinreb RN,Miller E,Chang RT,Kass MA,Ocular Hypertension Treatment Study Group.

更新日期：2010-11-01 00:00:00

abstract：:Thirteen cases of rhegmatogenous retinal detachment repaired by pneumatic retinopexy were reviewed retrospectively. All patients were followed for a minimum of 6 months after surgery. At the end of follow-up, retinal detachment repair by pneumatic retinopexy succeeded in nine cases (70%) and failed in four (30%). With...

journal_title：Ophthalmology

authors： Poliner LS,Grand MG,Schoch LH,Olk RJ,Johnston GP,Okun E,Boniuk I,Escoffery RF

更新日期：1987-04-01 00:00:00

abstract：:Nylon line lawn trimmers represent a source of potentially devastating ocular trauma. Five cases of ocular trauma associated with the use of line trimmers are reported. These case reports document new mechanisms and circumstances of injury, including trauma from debris other than nylon line fragments and injury to bys...

journal_title：Ophthalmology

authors： Lubniewski A,Olk RJ,Grand MG

更新日期：1988-07-01 00:00:00

abstract：:After the appropriate workup, the size, location, and consistency of an orbital mass will dictate the surgical approach chosen. Masses in the muscle cone area or in the temporal portion of the orbit are most easily approached by the lateral orbitotomy. For lacrimal gland tumors a superior extension of the lateral orbi...

journal_title：Ophthalmology

authors： Leone CR Jr

更新日期：1979-05-01 00:00:00

abstract：PURPOSE:To report the immediate postoperative complications and the 6- and 12-month clinical results in a large series of cases undergoing the new triple-procedure Descemet's stripping automated endothelial keratoplasty (DSAEK) and concurrent cataract surgery. DESIGN:Prospective, noncomparative, interventional case se...

journal_title：Ophthalmology

authors： Terry MA,Shamie N,Chen ES,Phillips PM,Shah AK,Hoar KL,Friend DJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Low-concentration atropine is an emerging therapy for myopia progression, but its efficacy and optimal concentration remain uncertain. Our study aimed to evaluate the efficacy and safety of low-concentration atropine eye drops at 0.05%, 0.025%, and 0.01% compared with placebo over a 1-year period. DESIGN:Rando...

journal_title：Ophthalmology

authors： Yam JC,Jiang Y,Tang SM,Law AKP,Chan JJ,Wong E,Ko ST,Young AL,Tham CC,Chen LJ,Pang CP

更新日期：2019-01-01 00:00:00

abstract：:Argon laser trabeculoplasty was performed in one eye of 57 phakic patients with primary open-angle glaucoma. The eyes received a mean of 78 +/- 7 treatments over 360 degrees to the anterior trabecular meshwork. The power was titrated to produce blanching without bubble formation. Increased intraocular pressure (range ...

journal_title：Ophthalmology

authors： Krupin T,Kolker AE,Kass MA,Becker B

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:To study the effects of trabeculectomy and needling revision of poorly functioning blebs on the optic nerve head (ONH) circulation in patients with primary open-angle glaucoma (POAG). DESIGN:Prospective, nonrandomized, self-controlled trial. PARTICIPANTS:Nineteen POAG patients (age range, 52 +/- 12 years; m...

journal_title：Ophthalmology

authors： Tamaki Y,Araie M,Hasegawa T,Nagahara M

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To analyze the association of the polymorphisms in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and AP endonuclease-1 (APE1) genes in the base excision repair pathway and xeroderma pigmentosum complementation group D (XPD) in the nucleotide excision repair pathway with the risk...

journal_title：Ophthalmology

authors： Zhang Y,Zhang L,Song Z,Sun DL,Liu HR,Fu SB,Liu DR,Liu P

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of resident participation in cataract surgery on operative time and cost. DESIGN:Retrospective chart review. PARTICIPANTS:All patients who underwent phacoemulsification cataract surgery by an attending or resident surgeon of the Penn State Hershey Eye Center between July 1, 2004, a...

journal_title：Ophthalmology

authors： Hosler MR,Scott IU,Kunselman AR,Wolford KR,Oltra EZ,Murray WB

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To compare adverse medical events by different anesthesia strategies for cataract surgery. DESIGN:Prospective cohort study. PARTICIPANTS:Patients 50 years of age and older undergoing 19,250 cataract surgeries at nine centers in the United States and Canada between June 1995 and June 1997. INTERVENTION:Loca...

journal_title：Ophthalmology

authors： Katz J,Feldman MA,Bass EB,Lubomski LH,Tielsch JM,Petty BG,Fleisher LA,Schein OD,Study of Medical Testing for Cataract Surgery Study Team.

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:As of December 31, 2000, the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser posterior capsulotomy rate for the Alcon AcrySof intraocular lens (IOL) as measured in our database was 3.3%. This was the lowest of any IOL model used in the United States. Only 12 of 361 cases required treatment. We analyzed possibl...

journal_title：Ophthalmology

authors： Schmidbauer JM,Vargas LG,Apple DJ,Escobar-Gomez M,Izak A,Arthur SN,Golescu A,Peng Q

更新日期：2002-08-01 00:00:00

abstract：:The authors studied 80 eyes of patients with choroidal neovascular membranes (CNVMs) associated with age-related macular degeneration between 1982 and 1988. In each case, fluorescein angiography was done on two occasions separated by an interval of 2 days to 11 weeks (average, 13 days) without intervening photocoagula...

journal_title：Ophthalmology

authors： Klein ML,Jorizzo PA,Watzke RC

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVE:To report a patient with agenesis of the right internal carotid artery associated with ipsilateral, congenital Homer's syndrome. DESIGN:Case report. METHODS:A 30-year-old woman, with a past history of migraine headaches, underwent neuro-ophthalmologic and neuroradiologic evaluation for transient visual obsc...

journal_title：Ophthalmology

authors： Ryan FH,Kline LB,Gomez C

更新日期：2000-01-01 00:00:00

abstract：:The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. M...

journal_title：Ophthalmology

authors： Boisjoly HM,Roy R,Bernard PM,Dubé I,Laughrea PA,Bazin R

更新日期：1990-12-01 00:00:00

abstract：:Fifty-eight patients with keratitis sicca were enrolled in a long-term study to test the effectiveness of slow-release artificial tears (SRAT). The average follow up period of 39 weeks, with a range of 9 to 136 weeks. Forty-six (79%) are still being followed. Almost all of these patients have had marked relief from th...

journal_title：Ophthalmology

authors： Werblin TP,Rheinstrom SD,Kaufman HE

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to assess the effect of contact lens wear on the mucosal defenses of the outer eye against infection. DESIGN:A case-controlled study of daily contact lens wearers in their initial 6 months of contact lens wear. PARTICIPANTS:Contact lens wearers (mean age, 23.1 years; 47 subjects) were compa...

journal_title：Ophthalmology

authors： McClellan KA,Cripps AW,Clancy RL,Billson FA

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:To describe the initial experience and to evaluate the safety and feasibility of using the 25-gauge Transconjunctival Sutureless Vitrectomy System (TSV) for a variety of vitreoretinal procedures. DESIGN:Retrospective review of a consecutive interventional case series. PARTICIPANTS:Thirty-five eyes of 33 pat...

journal_title：Ophthalmology

authors： Fujii GY,De Juan E Jr,Humayun MS,Chang TS,Pieramici DJ,Barnes A,Kent D

更新日期：2002-10-01 00:00:00

abstract：:Dr. William O. Coffee was an ophthalmologist who conducted an office and mail-order practice in the Midwest from the 1880s until 1927. His main stock in trade was a self-discovered absorption cure for a variety of ocular diseases, with particular emphasis on the medical cure of cataracts. Dr. Coffee's career was a che...

journal_title：Ophthalmology

authors： Ferry AP

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:To examine the outcomes of vitreoretinal surgery for retinal disorders at Tilganga Eye Centre in Kathmandu, Nepal. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Records of 255 patients undergoing vitreoretinal surgery from December 2000 to January 2003 were reviewed. METHODS:Demographics, dia...

journal_title：Ophthalmology

authors： Paudyal G,Doshi V,Shrestha MK,Kalayoglu MV,Tabin G,Gurung R,Shrestha B,Ruit S

更新日期：2005-02-01 00:00:00

abstract：:The case of a young woman with giant cell polymyositis is described. She had bilateral, severe, midly painful proptosis and ophthalmoplegia. Extensive pharyngeal, laryngeal, and cardiac muscle involvement occurred 18 months later coincident with fatal cardiac arrhythmia. At autopsy, extensive muscle necrosis and giant...

journal_title：Ophthalmology

authors： Kattah JC,Zimmerman LE,Kolsky MP,Chrousos G,Chavis R,Jaffe G,Manz HJ

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:The aim of the study was to determine whether subconjunctival anesthesia is effective at reducing pain associated with laser retinopexy. DESIGN:This was a single-center, prospective, patient-masked, randomized, controlled trial. PARTICIPANTS:In the primary study group, 65 patients were recruited. Thirty-two p...

journal_title：Ophthalmology

authors： Tesha PE,Giavedoni LR,Berger AR,Altomare F,Chow DR,Navajas EV,Yoganathan P,Wong DT,Principe A

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Porous coralline hydroxyapatite orbital implants have gained significant popularity for use in anophthalmic sockets. Several reports have noted increased rates of early implant exposure. METHODS:Six patients with exposure complications of primary hydroxyapatite implants after enucleation or evisceration wer...

journal_title：Ophthalmology

authors： Kim YD,Goldberg RA,Shorr N,Steinsapir KD

更新日期：1994-10-01 00:00:00