Abstract:
:The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. Most of the recipients under observation (91%) were well matched for HLA-DR. Of 438 recipients, 158 (36%) completed a 3-year follow-up. Three factors were associated with endothelial allograft reactions: 2 to 4+ corneal vascularization (relative risk, 2.2; P = 0.0006), two mismatched antigens at either the HLA-A or HLA-B locus (relative risk, 2.1; P = 0.0009), and recipient wound size of 8 mm or greater (relative risk, 1.5; P = 0.05). Unexpectedly, a strong association between endothelial allograft reactions and HLA-A or HLA-B incompatibility was found in low-risk recipients defined as unvascularized recipients of a small graft (relative risk, 3.2; P = 0.004). A larger sample size is required to determine if HLA matching offers a solution for recipients with corneal vascularization.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Boisjoly HM,Roy R,Bernard PM,Dubé I,Laughrea PA,Bazin Rdoi
10.1016/s0161-6420(90)32360-6subject
Has Abstractpub_date
1990-12-01 00:00:00pages
1689-98issue
12eissn
0161-6420issn
1549-4713pii
S0161-6420(90)32360-6journal_volume
97pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To investigate the incidence and outcomes of retinal detachment (RD) associated with retained lens fragments removed by pars plana vitrectomy (PPV). DESIGN:Retrospective, noncomparative, interventional consecutive case series. PARTICIPANTS:All patients who underwent PPV for retained lens material after catara...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00020-4
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:This study aimed to identify the genetic defects in 2 families with autosomal recessive macular dystrophy with central cone involvement. DESIGN:Case series. PARTICIPANTS:Two families and a cohort of 244 individuals with various inherited maculopathies and cone disorders. METHODS:Genome-wide linkage analysis ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.07.040
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To describe three cases of squamous cell carcinoma of the conjunctiva presenting with corneal and scleral inflammation, thinning, and perforation without any tumor formation. DESIGN:Three case reports. PARTICIPANTS:Three male subjects aged 76, 66, and 61 years. INTERVENTION:The subjects had symptoms of ext...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00585-6
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:To determine the prevalence of and factors associated with diabetic retinopathy (DR) among non-Indigenous and Indigenous Australian adults with self-reported diabetes. DESIGN:Population-based cross-sectional study. PARTICIPANTS:Non-Indigenous Australians (50-98 years of age) and Indigenous Australians (40-92 ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.02.004
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:We examined changes in macular pigment optical density (MPOD) levels after cataract surgery and compared the MPOD between eyes with clear intraocular lenses (IOLs) and yellow-tinted IOLs. DESIGN:Prospective, comparative case series. PARTICIPANTS:The MPOD levels were measured in 480 eyes of 337 patients after ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.02.017
更新日期:2011-09-01 00:00:00
abstract::A 9-year-old boy was diagnosed with fundus flavimaculatus in his left eye. The boy's fellow eye was enucleated at 16 months of age for retinoblastoma. The authors reviewed the material submitted for histopathologic examination and found that the retinal pigment epithelial cells demonstrated increased autofluorescence ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32197-3
更新日期:1991-06-01 00:00:00
abstract:PURPOSE:To present the largest cohort of preschool children screened by the MTI PhotoScreener over a 9-year period from a single, statewide vision screening effort. DESIGN:Cross-sectional study. PARTICIPANTS:We included 147,809 children screened between May 1, 2000, and April 30, 2009 by a photoscreening program. ME...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.03.036
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To estimate the incremental cost-effectiveness of routine glaucoma assessment and treatment under current eye care visit and treatment patterns and different levels of treatment effectiveness (from randomized trials). DESIGN:We compared the costs and benefits of routine glaucoma assessment and treatment comp...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.12.056
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:To investigate the potential contribution of inflammatory and immune-mediated processes contributing to the pathogenesis of proliferative vitreoretinopathy (PVR), an immunohistochemical study was undertaken to characterize the infiltrating inflammatory cells in epiretinal membranes surgically removed from th...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31793-2
更新日期:1992-09-01 00:00:00
abstract::Ten patients, all younger than 50 years of age, had a temporal cilioretinal artery occlusion associated with a nonischemic central retinal vein occlusion. On fluorescein angiography, the cilioretinal artery eventually filled in all but one eye. The cilioretinal artery showed pulsations on fluorescein angiography in fi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32245-0
更新日期:1991-05-01 00:00:00
abstract::The retinal nerve fiber layer is different in normal and glaucomatous eyes. The authors used red-free photographs to examine the retinal nerve fiber layer in 234 normal eyes. The retinal nerve fiber layer was most visible in the inferior temporal arcade, followed by the superior temporal arcade, then by the temporal m...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32838-7
更新日期:1989-05-01 00:00:00
abstract:PURPOSE:To describe the ocular effects associated with the administration of the systemic epidermal growth factor receptor (EGFR) inhibitors panitumumab and erlotinib. DESIGN:Retrospective, noncomparative interventional case series. PARTICIPANTS:Ten eyes of 5 patients in treatment with systemic EGFR inhibitors, 4 pat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.03.002
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of resident participation in cataract surgery on operative time and cost. DESIGN:Retrospective chart review. PARTICIPANTS:All patients who underwent phacoemulsification cataract surgery by an attending or resident surgeon of the Penn State Hershey Eye Center between July 1, 2004, a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.06.026
更新日期:2012-01-01 00:00:00
abstract::The first 290 consecutive eyes (192 patients) to undergo radial keratotomy by one surgeon were evaluated prospectively. All had had complete preoperative evaluation and 269 (93%) were examined one or more years after surgery. Preoperatively, all patients except one had worse than 20/100 uncorrected visual acuity, 65% ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34264-6
更新日期:1984-05-01 00:00:00
abstract::To measure retinal nerve fiber layer (NFL) thickness, three sets of simultaneous stereophotographs of the optic disc, taken with the Donaldson fundus camera, were measured at 5 degrees intervals in a stereoplotter (Kern PG2) at the surface of the internal limiting membrane (ILM) and the retinal pigment epithelium (RPE...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32720-5
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:Newer treatment regimens for age-related macular degeneration have significantly affected traditional and non-traditional retinal services across all types of practice settings around the country as they seek to find a balance among delivering best patient care, keeping operating costs under control, and main...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.04.035
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Several forms of retinal pigment epithelial detachment have been reported. The authors used indocyanine green (ICG) videoangiography, which is useful to study the choroidal vasculature and Bruch membrane, to study pigment epithelial detachments. METHODS:Ninety-eight pigment epithelial detachments in 75 eyes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30990-6
更新日期:1995-04-01 00:00:00
abstract:PURPOSE:To investigate the clinical manifestations and ocular findings in children with ocular myasthenia gravis (MG) that rarely have been reported in the literature. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Twenty-four consecutive patients less than 15 years of age with ocular MG treated betwe...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00460-3
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:To investigate the adherence of one clinically relevant ocular isolate of Staphylococcus epidermidis to polymethyl methacrylate (PMMA) and Acrysof (Alcon Surgical, Fort Worth, TX) intraocular lenses (IOLs). DESIGN:Experimental study. PARTICIPANTS:The authors examined the in vitro adherence of one clinically r...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00080-4
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether artificial tears and cold compress alone or in combination provide a treatment benefit and whether they were as effective as or could enhance topical antiallergic medication. DESIGN:Randomized, masked clinical trial. PARTICIPANTS:Eighteen subjects (mean age, 29.5±11.0 years) allergic ...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2013.08.007
更新日期:2014-01-01 00:00:00
abstract::A 33-year-old man with acquired immune deficiency syndrome (AIDS) was found to have bilateral cytomegalovirus (CMV) retinitis with concomitant unilateral optic neuritis. The patient died and postmortem examination of both eyes disclosed CMV inclusions in all layers of the involved retinas including the retinal pigment...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33261-0
更新日期:1987-12-01 00:00:00
abstract::Iris angiography was performed in 25 cases with unilateral pseudoexfoliation of the lens capsule (PXF) (including two which later became bilateral) to study the development of the microneovascular changes which accompany PXF. Sixteen patients had raised intraocular pressure (IOP) and nine had no rise in IOP in the aff...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33329-9
更新日期:1987-09-01 00:00:00
abstract::Two patients developed proptosis and a slowly enlarging mass with increasing discomfort in the orbital socket 17 and 25 years following enucleation. Preoperative CT scans revealed a single cystic structure within the orbits of each case with distinct soft tissue tumors adjacent to the cysts. The cystic structures and ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34134-3
更新日期:1984-11-01 00:00:00
abstract:PURPOSE:The purpose of this study is to examine the changes of blood-aqueous barrier function in cases of central or branch retinal vein occlusion. METHODS:In addition to fluorophotometry of the aqueous humor and posterior vitreous, the authors used a method that quantifies protein in the aqueous (aqueous flare) by me...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31875-5
更新日期:1992-06-01 00:00:00
abstract:PURPOSE:To evaluate the ability of the GDx Variable Corneal Compensation (VCC) Guided Progression Analysis (GPA) software for detecting glaucomatous progression. DESIGN:Observational cohort study. PARTICIPANTS:The study included 453 eyes from 252 individuals followed for an average of 46+/-14 months as part of the Di...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.08.012
更新日期:2010-03-01 00:00:00
abstract:UNLABELLED:TOPIC/PURPOSE: To assess the clinical usefulness and relevance of indocyanine green angiography (ICG) in the investigation of chorioretinal disorders and assess specifically in what conditions it may add useful information to that obtained using standard fluorescein angiography. CLINICAL RELEVANCE:Many publ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(02)01563-4
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To assess the association of correction of myopia, hyperopia, and astigmatism with self-reported near and distance visual function. DESIGN:Population based, cross-sectional study. PARTICIPANTS:A random sample of 4272 Latinos older than 40 years of age from Arizona with both ophthalmic examination and questi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.03.003
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To describe Descemet's membrane endothelial keratoplasty (DMEK) techniques, perioperative challenges, management, and visual and refractive outcomes. DESIGN:Prospective, multicenter, consecutive case series. PARTICIPANTS:Sixty eyes of 56 patients with Fuchs' endothelial dystrophy, pseudophakic bullous keratop...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2009.07.010
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:To develop a classification of parapapillary atrophy (PPA) based on its relationship with the location of Bruch's membrane (BM) termination in primary open-angle glaucoma (POAG) patients. DESIGN:Cross-sectional observational study. PARTICIPANTS:This study analyzed 161 eyes from 161 POAG patients who had tempo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.02.011
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Earlier studies of subperiosteal abscess secondary to sinusitis showed considerable variation in the clinical course and bacteriology. At one extreme, patients recovered with intravenous antibiotics alone; at the other extreme, complex pathogens persisted despite early surgical drainage and appropriate antib...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(94)31297-8
更新日期:1994-03-01 00:00:00