听力与言语-语言病理学

行为科学

医学伦理学

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  • Cellular Therapy in Pediatric Hematologic Malignancies.

    abstract::Advances in cellular therapies for pediatric patients have created many opportunities for improved survival with reduced morbidity. This article reviews current cellular therapies in pediatric hematological malignancy, including the most updated practices in hematopoietic stem cell transplant and the use of chimeric a...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2020.10.008

    authors: Kuldanek S,Pasko B,DomBourian M,Annen K

    更新日期:2021-03-01 00:00:00

  • Modern Blood Culture: Management Decisions and Method Options.

    abstract::The optimal care of septic patients depends on the successful recovery of clinically relevant microorganisms from blood cultures and the timely reporting of organism identification and antimicrobial susceptibility testing (AST) results. Many preanalytic factors play a critical role in culturing microorganisms, and adv...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2020.07.001

    authors: Gonzalez MD,Chao T,Pettengill MA

    更新日期:2020-12-01 00:00:00

  • Fellowship Training for the Future Clinical Microbiology Laboratory Director.

    abstract::Formal medical and public health microbiology (MPHM) fellowship programs play a key role in preparing future clinical microbiology laboratory directors for their leadership and management responsibilities. Given the continually evolving MPHM field, fellowships must remain adaptable to changes in the field, providing t...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2020.08.009

    authors: Pritt BS,Bowler CA,Theel ES

    更新日期:2020-12-01 00:00:00

  • Diagnostic and Prognostic Laboratory Testing for Alzheimer Disease.

    abstract::This article focuses on current clinical laboratory testing to diagnose Alzheimer disease and monitor its progression throughout its disease course. Several clinically available tests focus on analysis of amyloid and tau levels in cerebrospinal fluid as well as autosomal dominant and risk factor genes. Although the cu...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2020.05.003

    authors: Winder Z,Wilcock D,Jicha GA

    更新日期:2020-09-01 00:00:00

  • The Impact of Direct-to-Consumer Genetic Testing on Patient and Provider.

    abstract::Direct-to-consumer genetic testing came on the scene 2 decades ago as a means for allowing consumers to access their genetic information without the involvement of a physician or genetic counselor. Results are delivered directly to the consumer, often leading to misinterpretation and needless medical interventions or ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2019.11.003

    authors: Dinulos MBP,Vallee SE

    更新日期:2020-03-01 00:00:00

  • Diagnostic Pitfalls in Immunology Testing.

    abstract::Immunology testing is relevant for the diagnosis of many autoimmune conditions. However, diagnostic pitfalls arise owing to incorrect interpretation of results and incomplete understanding of the underlying technique or immune-mediated condition. Here, we review the diagnostic considerations related to commonly used i...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2019.07.005

    authors: Maher L,Perugino C

    更新日期:2019-12-01 00:00:00

  • Rapid Susceptibility Testing Methods.

    abstract::With emerging antimicrobial resistance, rapid antimicrobial susceptibility testing (AST) is needed to provide early definitive therapeutic guidance to optimize patient outcome. Genotypic methods are fast, but can identify only a subset of known resistance elements. Phenotypic methods determine clinically predictive mi...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2019.04.001

    authors: Smith KP,Kirby JE

    更新日期:2019-09-01 00:00:00

  • Mapping the Road to the Future: Training the Next Generation of Clinical Microbiologists, from Technologist to Laboratory Director.

    abstract::Rapidly changing technology in the clinical microbiology laboratory requires a highly skilled workforce. The current clinical microbiology workforce is aging with a wave of retirements currently unfolding. Key competencies that will be needed for the next generation of microbiologists include strong analytical skills,...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2019.05.007

    authors: Gilligan PH,McGee MH

    更新日期:2019-09-01 00:00:00

  • Decision Support in Transfusion Medicine and Blood Banking.

    abstract::Clinical decision support (CDS) can greatly enhance patient blood management through optimizing ordering and providing patient-specific information. At present, modeling and prediction have small roles in inventory management; they will likely have increasing applications to help guide donor center collections based o...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2019.01.006

    authors: Shah NK

    更新日期:2019-06-01 00:00:00

  • Genetic Polymorphism in Cytokines and Costimulatory Molecules in Stem Cell and Solid Organ Transplantation.

    abstract::There is growing evidence supporting the genetic variability outside of HLA system that is contributing to the variation in transplant outcomes. Determining novel predictors could help to identify patients at risk and tailor their immunosuppressive regimens. This article discusses the various single nucleotide polymor...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2018.10.002

    authors: Jindra PT,Cusick MF

    更新日期:2019-03-01 00:00:00

  • Biomarkers in Solid Organ Transplantation.

    abstract::After more than 6 decades of clinical practice, the transplant community continues to research noninvasive biomarkers of solid organ injury to help improve patient care. In this review, we discuss the clinical usefulness of selective biomarkers and how they are processed at the laboratory. In addition, we organize the...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2018.11.003

    authors: Choi J,Bano A,Azzi J

    更新日期:2019-03-01 00:00:00

  • Human Leukocyte Antigen Associations in Drug Hypersensitivity Reactions.

    abstract::Severe adverse drug reactions are a common cause of morbidity and mortality. Some of the most severe reactions are immunologically mediated and have been linked to specific HLA alleles. The mechanisms underlying HLA-associated drug hypersensitivity are complex and not fully understood. Recent findings have provided in...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2018.08.002

    authors: Schutte RJ,Sun Y,Li D,Zhang F,Ostrov DA

    更新日期:2018-12-01 00:00:00

  • 25-Hydroxyvitamin D Testing: Immunoassays Versus Tandem Mass Spectrometry.

    abstract::Vitamin D has been associated with many health conditions. Because of widespread deficiency in the general population, laboratory testing of vitamin D has increased exponentially in recent years. Currently, 25-hydroxyvitamin D (25[OH]D) is considered the best marker of vitamin D status. Automated immunoassays and tand...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2018.05.007

    authors: Garg U

    更新日期:2018-09-01 00:00:00

  • Diagnostic Molecular Microbiology: A 2018 Snapshot.

    abstract::Molecular biological techniques have evolved expeditiously and in turn have been applied to the detection of infectious disease. Maturation of these technologies and their coupling with related technological advancement in fluorescence, electronics, digitization, nanodynamics, and sensors among others have afforded cl...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2018.02.004

    authors: Fairfax MR,Bluth MH,Salimnia H

    更新日期:2018-06-01 00:00:00

  • Breast Cancer in Low- and Middle-Income Countries: Why We Need Pathology Capability to Solve This Challenge.

    abstract::Breast cancer is the leading cause of cancer mortality among women in developing countries. Timely and accurate histopathological diagnosis of breast cancer is critical to delivering high-quality breast cancer care to patients in low- and middle-income countries (LMIC). The most important prognostic factors in breast ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2017.10.013

    authors: Martei YM,Pace LE,Brock JE,Shulman LN

    更新日期:2018-03-01 00:00:00

  • Flow Cytometric Assessment of Chronic Myeloid Neoplasms.

    abstract::Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2017.07.006

    authors: Shi M,Nguyen P,Jevremovic D

    更新日期:2017-12-01 00:00:00

  • Primary Cutaneous B-cell Lymphomas.

    abstract::B-cell lymphomas represent approximately 20% to 25% of primary cutaneous lymphomas. Within this group, most cases (>99%) are encompassed by 3 diagnostic entities: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type. In this...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2017.05.009

    authors: Hope CB,Pincus LB

    更新日期:2017-09-01 00:00:00

  • Ebola Virus Disease: An Update on Epidemiology, Symptoms, Laboratory Findings, Diagnostic Issues, and Infection Prevention and Control Issues for Laboratory Professionals.

    abstract::The 2014 to 2016 Ebola virus disease (EVD), through the sheer size of the outbreak and combined experience within both resource-rich and resource-poor settings, allowed for more information to be gained about the clinical and pathologic features of EVD. This review highlights the range of aspects of EVD that the autho...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2017.01.003

    authors: Brown CS,Mepham S,Shorten RJ

    更新日期:2017-06-01 00:00:00

  • Metrological Traceability of Assays and Comparability of Patient Test Results.

    abstract::At the start of the twenty-first century, a dramatic change occurred in the clinical laboratory community. Concepts from Metrology, the science of measurement, began to be formally applied to clinical laboratory field methods, resulting in a new appreciation of metrological calibrator traceability. It is a change beca...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.09.010

    authors: Armbruster D

    更新日期:2017-03-01 00:00:00

  • Understanding the Use of Sigma Metrics in Hemoglobin A1c Analysis.

    abstract::This study uses three unique data sets to show the state of the art of hemoglobin A1c (HbA1c) analyzers in a range of settings and compares their performance against the international guidance set by the International Federation of Clinical Chemistry and Laboratory Medicine task force for HbA1c standardization. The da...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.09.006

    authors: Lenters-Westra E,English E

    更新日期:2017-03-01 00:00:00

  • Otolaryngology Concerns for Illicit and Prescription Drug Use.

    abstract::Concern for illicit and restricted drug use in otolaryngology is similar to other surgical specialties with a few notable exceptions. Many illicit drugs are consumed transnasally. Repeated nasal exposure to stimulants or narcotics can cause local tissue destruction that can present as chronic rhinosinusitis or nasosep...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.07.012

    authors: Gonik NJ,Bluth MH

    更新日期:2016-12-01 00:00:00

  • Extracellular Vesicles Move Toward Use in Clinical Laboratories.

    abstract::Extracellular vesicles (EVs) are membranous particles found in a variety of biofluids that encapsulate molecular information from the cell, which they originate from. This rich source of information that is easily obtained can then be mined to find diagnostic biomarkers. This article explores the current biological un...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.05.004

    authors: Strotman LN,Linder MW

    更新日期:2016-09-01 00:00:00

  • Modifying Risk of Aneuploidy with a Positive Cell-Free Fetal DNA Result.

    abstract::Noninvasive genomic assessments of the fetus while in utero have been made possible by the analysis of cell-free fetal DNA fragments from the serum of pregnant women, as part of a noninvasive prenatal testing screening strategy. Between 7% and 10% of total cell-free DNA in the maternal blood comes from placental troph...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.01.018

    authors: Long AA,Abuhamad AZ,Warsof SL

    更新日期:2016-06-01 00:00:00

  • Screening for Open Neural Tube Defects.

    abstract::Biochemical prenatal screening was initiated with the use of maternal serum alpha fetoprotein to screen for open neural tube defects. Screening now includes multiple marker and sequential screening protocols involving serum and ultrasound markers to screen for aneuploidy. Recently cell-free DNA screening for aneuploid...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.01.004

    authors: Krantz DA,Hallahan TW,Carmichael JB

    更新日期:2016-06-01 00:00:00

  • Laboratory Information Systems.

    abstract::Laboratory information systems (LISs) supply mission-critical capabilities for the vast array of information-processing needs of modern laboratories. LIS architectures include mainframe, client-server, and thin client configurations. The LIS database software manages a laboratory's data. LIS dictionaries are database ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2015.09.002

    authors: Henricks WH

    更新日期:2016-03-01 00:00:00

  • Health Information Systems.

    abstract::This article provides surgical pathologists an overview of health information systems (HISs): what they are, what they do, and how such systems relate to the practice of surgical pathology. Much of this article is dedicated to the electronic medical record. Information, in how it is captured, transmitted, and conveyed...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2015.09.012

    authors: Sirintrapun SJ,Artz DR

    更新日期:2016-03-01 00:00:00

  • Lyme Disease Coinfections in the United States.

    abstract::Lyme disease in North America is caused by infection with the spirochetal bacterium Borrelia burgdorferi and transmitted by Ixodes scapularis and Ixodes pacificus ticks. These ticks also have the potential to transmit a rapidly expanding list of other pathogenic bacteria, viruses, and parasites, including Anaplasma ph...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2015.07.006

    authors: Caulfield AJ,Pritt BS

    更新日期:2015-12-01 00:00:00

  • A Laboratory Diagnostic Approach to Hepatobiliary Disease in Small Animals.

    abstract::Routine biochemical tests generally include serum enzymes, proteins, and other markers useful for identifying hepatobiliary disease in dogs and cats. Obtaining results outside the reference intervals can occur with direct hepatocellular injury, enzyme induction by hepatocytes or biliary epithelium, or decreased hepati...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2015.05.002

    authors: Chapman SE,Hostutler RA

    更新日期:2015-09-01 00:00:00

  • Hematological Assessment in Pet Guinea Pigs (Cavia porcellus): Blood Sample Collection and Blood Cell Identification.

    abstract::Pet guinea pigs are presented to veterinary clinics for routine care and treatment of clinical diseases. In addition to obtaining clinical history and exam findings, diagnostic testing may be required, including hematological assessments. This article describes common blood collection methods, including venipuncture s...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2015.05.012

    authors: Zimmerman K,Moore DM,Smith SA

    更新日期:2015-09-01 00:00:00

  • Salmonella, Shigella, and yersinia.

    abstract::Salmonella, Shigella, and Yersinia cause a well-characterized spectrum of disease in humans, ranging from asymptomatic carriage to hemorrhagic colitis and fatal typhoidal fever. These pathogens are responsible for millions of cases of food-borne illness in the United States each year, with substantial costs measured i...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2015.02.002

    authors: Dekker JP,Frank KM

    更新日期:2015-06-01 00:00:00

  • Infections by Intestinal Coccidia and Giardia duodenalis.

    abstract::The coccidians Cryptosporidium spp, Cyclospora cayetanensis, and Cystoisospora belli and the flagellate Giardia duodenalis are pathogenic protozoa associated with gastrointestinal manifestations. Diagnosis relies heavily on microscopy, and although ova-and-parasite examinations can detect Giardia and Cystoisospora, Cr...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2015.02.010

    authors: Cama VA,Mathison BA

    更新日期:2015-06-01 00:00:00

  • Analysis of bone marrow aspiration fluid using automated blood cell counters.

    abstract::Cytomorphological examination of aspirate smears remains the basic method to diagnose hematologic disorders and to evaluate treatment-related changes. Last-generation hematological analyzers can count, besides cells normally circulating in peripheral blood, some types of immature and abnormal cells, such as erythrobla...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2014.10.001

    authors: d'Onofrio G,Zini G

    更新日期:2015-03-01 00:00:00

  • Hematology testing in urgent care and resource-poor settings: an overview of point of care and satellite testing.

    abstract::The combination of requirements for decreased turnaround time for hematology laboratory results and advances in technology have driven testing closer to the point of patient contact. This article provides an overview of the technologies available to measure hemoglobin, white blood cell counts, differentials, and CD4+ ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2014.10.009

    authors: Sireci AN

    更新日期:2015-03-01 00:00:00

  • The interrelationships of the gut microbiome and inflammation in colorectal carcinogenesis.

    abstract::The cause of colorectal cancer (CRC) is multifactorial, with genetic, molecular, inflammatory, and environmental risk factors. Recently, the gut microbiota has been recognized as a new environmental contributor to CRC in both animal models and human studies. An additional interplay of the gut microbiome with inflammat...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2014.08.002

    authors: Cho M,Carter J,Harari S,Pei Z

    更新日期:2014-12-01 00:00:00

  • Treatment and long-term management of venous thromboembolism.

    abstract::Venous thromboembolism covers a range of conditions from deep vein thrombosis to pulmonary embolism. Treatment aims to alleviate symptoms, minimize acute morbidity and mortality by preventing the extension or potentially fatal embolization of the initial thrombus, and avoid postthrombotic syndrome. Anticoagulant thera...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2014.06.011

    authors: Al-Badri A,Spyropoulos AC

    更新日期:2014-09-01 00:00:00

  • The influence of various patient characteristics on D-dimer concentration in critically ill patients and its role as a prognostic indicator in the intensive care unit setting.

    abstract::This study examines the relationship between D-dimer concentration and patient age, gender, race, and renal function, and the role of D-dimer concentration as a predictor of in-hospital mortality, in a critically ill patient population. The results demonstrate there is a correlation between increased D-dimer concentra...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2014.06.015

    authors: Spring JL,Winkler A,Levy JH

    更新日期:2014-09-01 00:00:00

  • Nonmolecular methods for the diagnosis of respiratory fungal infections.

    abstract::Diagnosis of invasive fungal pneumonias by conventional culture methods is difficult to assess and often delayed. Nonmolecular fungal markers have emerged as an important adjunctive tool to support their diagnosis in combination with other clinical, radiologic, and microbiological criteria of invasive fungal diseases....

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2014.02.006

    authors: Lamoth F,Alexander BD

    更新日期:2014-06-01 00:00:00

  • Cardiac markers following cardiac surgery and percutaneous coronary intervention.

    abstract::Differentiation between procedure-related necrosis and postprocedural myocardial infarction (MI) is challenging because of the inherent association of these procedures to varying levels of myocardial injury. To improve risk stratification of patients at risk of an acute MI, the universal definition of MI implemented c...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2013.11.013

    authors: Grobben RB,Nathoe HM,Januzzi JL Jr,van Kimmenade RR

    更新日期:2014-03-01 00:00:00

  • Molecular diagnostics in the neoplasms of small intestine and appendix.

    abstract::Adenocarcinoma of the small intestine is relatively rare in comparison to colorectal carcinoma. Adenocarcinoma of the small intestine arises through the adenoma-carcinoma sequence in the colon. However, adenocarcinomas arising in the background of inflammatory bowel disease develop through the dysplasia-carcinoma sequ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2013.08.007

    authors: Bhalla A,Zulfiqar M,Weindel M,Shidham VB

    更新日期:2013-12-01 00:00:00

  • Maldi-tof mass spectrometry for microorganism identification.

    abstract::Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2013.03.001

    authors: Dingle TC,Butler-Wu SM

    更新日期:2013-09-01 00:00:00

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