Understanding the Use of Sigma Metrics in Hemoglobin A1c Analysis.

abstract：:Lyme disease in North America is caused by infection with the spirochetal bacterium Borrelia burgdorferi and transmitted by Ixodes scapularis and Ixodes pacificus ticks. These ticks also have the potential to transmit a rapidly expanding list of other pathogenic bacteria, viruses, and parasites, including Anaplasma ph...

journal_title：Clinics in laboratory medicine

authors： Caulfield AJ,Pritt BS

更新日期：2015-12-01 00:00:00

abstract：:With emerging antimicrobial resistance, rapid antimicrobial susceptibility testing (AST) is needed to provide early definitive therapeutic guidance to optimize patient outcome. Genotypic methods are fast, but can identify only a subset of known resistance elements. Phenotypic methods determine clinically predictive mi...

journal_title：Clinics in laboratory medicine

authors： Smith KP,Kirby JE

更新日期：2019-09-01 00:00:00

abstract：:Disturbed liver parenchymal cell function adversely impacts on the hemostasis system, the extent of which correlates with the degree of liver disease. Because liver parenchymal cells synthesize most factors of the clotting and the fibrinolytic systems, levels of these procoagulant and anticoagulant as well as profibri...

journal_title：Clinics in laboratory medicine

authors： Mammen EF

更新日期：1994-12-01 00:00:00

abstract：:Concern for illicit and restricted drug use in otolaryngology is similar to other surgical specialties with a few notable exceptions. Many illicit drugs are consumed transnasally. Repeated nasal exposure to stimulants or narcotics can cause local tissue destruction that can present as chronic rhinosinusitis or nasosep...

journal_title：Clinics in laboratory medicine

authors： Gonik NJ,Bluth MH

更新日期：2016-12-01 00:00:00

abstract：:This article provides surgical pathologists an overview of health information systems (HISs): what they are, what they do, and how such systems relate to the practice of surgical pathology. Much of this article is dedicated to the electronic medical record. Information, in how it is captured, transmitted, and conveyed...

journal_title：Clinics in laboratory medicine

authors： Sirintrapun SJ,Artz DR

更新日期：2016-03-01 00:00:00

abstract：:A decision model was developed to evaluate the costs and benefits of further reducing the risk of transfusion-transmitted disease. The model addresses recipient risk factors as well as operational considerations. Application of the model to prior risk reduction decisions documents its validity as a decision-making too...

journal_title：Clinics in laboratory medicine

authors： Hanson M

更新日期：1996-12-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is an autoimmune disorder presenting with tissue injury in various organs attributed to large or small vessel thrombosis or, in some instances, possible nonthrombotic inflammatory mechanisms, associated with in vitro evidence of antibodies to certain proteins, or proteinphospholipid...

journal_title：Clinics in laboratory medicine

authors： Eby C

更新日期：2009-06-01 00:00:00

abstract：:Fine needle aspiration biopsy (FNAB) is the diagnostic procedure of choice for evaluation of liver lesions. Although primarily applied to malignant disease, it is also used in the evaluation of benign conditions. Improvements in imaging techniques and advances in cytologic interpretations, as well as production of new...

journal_title：Clinics in laboratory medicine

authors： Pitman MB

更新日期：1998-09-01 00:00:00

abstract：:The clinical diagnosis and management of thyroid hormone excess and deficiency are dependent on accurate laboratory measurements and the interpretation of serum free T4 and TSH values. A variety of free T4 methods are available that perform well in otherwise healthy patients with hypothyroidism or hyperthyroidism and ...

journal_title：Clinics in laboratory medicine

authors： Kaptein EM

更新日期：1993-09-01 00:00:00

abstract：:The search for clinical outcomes associated with antiphospholipid antibodies (aPL) has been ongoing for a decade. This article focuses on the clinical use of tests for the detection of aPL. A review of the current thinking regarding the pathophysiology of antiphospholipid syndromes is relevant to the discussion of dif...

journal_title：Clinics in laboratory medicine

authors： Reyes H,Dearing L,Bick RL,Shoenfeld Y,Peter JB

更新日期：1995-03-01 00:00:00

abstract：:Laboratory information systems (LISs) supply mission-critical capabilities for the vast array of information-processing needs of modern laboratories. LIS architectures include mainframe, client-server, and thin client configurations. The LIS database software manages a laboratory's data. LIS dictionaries are database ...

journal_title：Clinics in laboratory medicine

authors： Henricks WH

更新日期：2016-03-01 00:00:00

abstract：:After more than 6 decades of clinical practice, the transplant community continues to research noninvasive biomarkers of solid organ injury to help improve patient care. In this review, we discuss the clinical usefulness of selective biomarkers and how they are processed at the laboratory. In addition, we organize the...

journal_title：Clinics in laboratory medicine

authors： Choi J,Bano A,Azzi J

更新日期：2019-03-01 00:00:00

abstract：:The interpretation of the total serum testosterone concentration is problematic because it is related directly to the serum SHBG concentration.Frequently, an estimate of the serum free testosterone concentration is obtained to better assess the clinical status of the patient. We reviewed five methods for the determina...

journal_title：Clinics in laboratory medicine

authors： Elin RJ,Winters SJ

更新日期：2004-03-01 00:00:00

abstract：:The red cell indices of mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration have been standard methods of evaluating anemia since they were developed by Wintrobe in the 1930s. This article discusses the technical variabilities that have rendered the classic red cell indi...

journal_title：Clinics in laboratory medicine

authors： Savage RA

更新日期：1993-12-01 00:00:00

abstract：:The subject of this article is privacy and its relationship to the activities of health care organizations. Privacy is a good quality that each individual may possess. The quality of an individual's privacy is a personal determination. Although everyday life requires that we attempt to understand and protect the priva...

journal_title：Clinics in laboratory medicine

authors： Essin DJ

更新日期：1999-06-01 00:00:00

abstract：:The pathologist, by virtue of his or her observations and documentation of injuries with concomitant attempts to discern patterns of injury and correlate autopsy findings with investigative details, will often play an integral and primary role in the death investigation process. The information gleaned during this pro...

journal_title：Clinics in laboratory medicine

authors： Davis GJ

更新日期：1998-06-01 00:00:00

abstract：:Autoimmune aPL are associated with a well-defined clinical syndrome of vascular thromboses, recurrent fetal loss, thrombocytopenia, livedo reticularis, and valvular and neurologic abnormalities. A clinical diagnosis of SLE need not be present, and aPL syndrome in the absence of other well-defined autoimmune disease is...

journal_title：Clinics in laboratory medicine

authors： Sammaritano LR,Gharavi AE

更新日期：1992-03-01 00:00:00

abstract：:Chromosome analysis is the genetic technique useful in evaluating endocrine disease. Indications for cytogenetic studies include suspected sex chromosomal aneuploidies as well as repeated fetal wastage. In patients with ambiguous genitalia, cytogenetic studies are mandatory, not only to provide information for assigni...

journal_title：Clinics in laboratory medicine

authors： Gordon LP

更新日期：1984-12-01 00:00:00

abstract：:Diabetes mellitus affects almost 16 million Americans. It has become a major public health problem and the number one cause of adult blindness, end-stage renal disease, and nontraumatic amputations in the United States. It also markedly increases the risk for cardiovascular, cerebrovascular, and peripheral artery dise...

journal_title：Clinics in laboratory medicine

authors： Kazi AA,Blonde L

更新日期：2001-03-01 00:00:00

abstract：:Processing of specimens for mycobacteria need to proceed as rapidly as possible to provide 24 hour turnaround for smears and 21-day turnaround for the identification of Mycobacterium tuberculosis. If these goals are to be accomplished, a broth culture or microcolony plate method must be part of the media and in the pl...

journal_title：Clinics in laboratory medicine

authors： Hall GS

更新日期：1996-09-01 00:00:00

abstract：:Formal medical and public health microbiology (MPHM) fellowship programs play a key role in preparing future clinical microbiology laboratory directors for their leadership and management responsibilities. Given the continually evolving MPHM field, fellowships must remain adaptable to changes in the field, providing t...

journal_title：Clinics in laboratory medicine

authors： Pritt BS,Bowler CA,Theel ES

更新日期：2020-12-01 00:00:00

abstract：:Several major pet-food and human-food safety incidents occurred worldwide between 2003 and 2008, causing illnesses and deaths in children, cats, dogs, and pigs. During the 2007 outbreak of renal failure in dogs and cats in the United States, veterinary diagnostic laboratories helped identify melamine and melamine anal...

journal_title：Clinics in laboratory medicine

authors： Puschner B,Reimschuessel R

更新日期：2011-03-01 00:00:00

abstract：:There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1...

journal_title：Clinics in laboratory medicine

authors： Laughlin MA,Pomerantz RJ

更新日期：1994-06-01 00:00:00

abstract：:Vitamin D has been associated with many health conditions. Because of widespread deficiency in the general population, laboratory testing of vitamin D has increased exponentially in recent years. Currently, 25-hydroxyvitamin D (25[OH]D) is considered the best marker of vitamin D status. Automated immunoassays and tand...

journal_title：Clinics in laboratory medicine

authors： Garg U

更新日期：2018-09-01 00:00:00

abstract：:One of the most vital functions of the vertebrates is to maintain hemostasis through coagulation and fibrinolysis. This is achieved by the interaction of vascular walls with blood components such as cells and proteins (coagulation factors, immunoglobulins, and complement). Deficiency of coagulation factors results in ...

journal_title：Clinics in laboratory medicine

authors： Saba SR,Domen RE

更新日期：1986-03-01 00:00:00

abstract：:Methodologic aspects including causes of factitious hyperphosphatemia and hypophosphatemia are summarized. The differential diagnosis of hyperphosphatemia is reviewed under its three broad causes: decreased glomerular filtration rate, increased exogenous or endogenous phosphate load, and increased renal tubular phosph...

journal_title：Clinics in laboratory medicine

authors： Bourke E,Yanagawa N

更新日期：1993-03-01 00:00:00

abstract：:This article focuses on current clinical laboratory testing to diagnose Alzheimer disease and monitor its progression throughout its disease course. Several clinically available tests focus on analysis of amyloid and tau levels in cerebrospinal fluid as well as autosomal dominant and risk factor genes. Although the cu...

journal_title：Clinics in laboratory medicine

authors： Winder Z,Wilcock D,Jicha GA

更新日期：2020-09-01 00:00:00

abstract：:Nephroblastoma, or Wilms tumor, is a malignant embryonal neoplasm that is derived from nephrogenic blastemal cells, with variable recapitulation of renal embryogenesis. The pathogenesis of nephroblastoma is complex and has been linked to alterations of several genomic loci, including WT1, WT2, FWT1, and FWT2. Generall...

journal_title：Clinics in laboratory medicine

authors： Khoury JD

更新日期：2005-06-01 00:00:00

abstract：:Technical aspects of rare-event detection are discussed in this article in a practical context, with two real-life examples. A growing number of flow cytometry-based assays depend on rare-event detection for basic science and clinical applications. ...

journal_title：Clinics in laboratory medicine

authors： Donnenberg AD,Donnenberg VS

更新日期：2007-09-01 00:00:00

abstract：:The coccidians Cryptosporidium spp, Cyclospora cayetanensis, and Cystoisospora belli and the flagellate Giardia duodenalis are pathogenic protozoa associated with gastrointestinal manifestations. Diagnosis relies heavily on microscopy, and although ova-and-parasite examinations can detect Giardia and Cystoisospora, Cr...

journal_title：Clinics in laboratory medicine

authors： Cama VA,Mathison BA

更新日期：2015-06-01 00:00:00