abstract：BACKGROUND:Intermediate hosts are key organisms in maintaining parasite life cycles, because they can act as amplifiers in the transmission from natural reservoirs to humans. One of the most important groups of intermediate hosts for zoonotic nematode infections are gastropods,slugs and snails. These are essential orga...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Valente R,Robles MDR,Diaz JI

更新日期：2020-11-27 00:00:00

abstract：:Scientists have increasingly recognised that low methodological and analytical rigour combined with publish-or-perish incentives can make the published scientific literature unreliable. As a response to this, large-scale systematic replications of the literature have emerged as a way to assess the problem empirically....

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Neves K,Carneiro CF,Wasilewska-Sampaio AP,Abreu M,Valério-Gomes B,Tan PB,Amaral OB

更新日期：2020-10-23 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Senger MR,Evangelista TCS,Dantas RF,Santana MVDS,Gonçalves LCS,de Souza Neto LR,Ferreira SB,Silva-Junior FP

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Occult hepatitis B virus (HBV) - characterized by the absence of detectable HBsAg in the presence of HBV DNA - represents a potential threat for blood safety. OBJECTIVES:This study was conducted with the aim to investigate the serological and molecular characterization of occult HBV infection (OBI) among bl...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mabunda N,Zicai AF,Ismael N,Vubil A,Mello F,Blackard JT,Lago B,Duarte V,Moraes M,Lewis L,Jani I

更新日期：2020-09-23 00:00:00

abstract：:Angiostrongylus costaricensis is the causative agent of abdominal angiostrongyliasis, a zoonotic infection that may produce severe eosinophilic enterocolitis or hepatitis in humans. Parasites are usually not released in stools and serology has an important role in diagnosis. Since cross-reactivity is demonstrated betw...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Graeff-Teixeira C,Pascoal VF,Rodriguez R,Morassutti AL,Intapan PM,Maleewong W

更新日期：2020-09-21 00:00:00

abstract：:Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/A...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Gama WM,Oliveira LB,Chaves YO,Ribeiro F,Almeida TVR,Baptista BJA,Santana MF,Ferreira LC,Lacerda MVG,Nogueira PA

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Biomphalaria glabrata snails are widely distributed in schistosomiasis endemic areas like America and Caribe, displaying high susceptibility to infection by Schistosoma mansoni. After the availability of B. glabrata genome and transcriptome data, studies focusing on genetic markers and small non-coding RNAs ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Queiroz FR,Portilho LG,Jeremias WJ,Babá ÉH,do Amaral LR,Silva LM,Coelho PMZ,Caldeira RL,Gomes MS

更新日期：2020-07-01 00:00:00

abstract：:Genes associated with wound healing have been shown to be risk factors for cutaneous leishmaniasis (CL) which is caused by Leishmania braziliensis. In this study, we examined whether the genes previously associated with CL influenced the clinical outcome. Patients were genotyped and retrospectively classified as respo...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： da Hora AS,de Almeida LF,do Lago TS,Machado PR,Castellucci LC

更新日期：2020-03-02 00:00:00

abstract：:BACKGROUND Paracoccidioides spp. causes paracoccidioidomycosis (PCM), an important and frequent systemic mycosis that occurs in Latin America. The infectious process begins with contact between the fungus and lung cells, and the molecular pattern of this interaction is currently poorly understood. MicroRNAs (miRNAs) a...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Singulani JL,Silva JFD,Gullo FP,Costa MC,Fusco-Almeida AM,Enguita FJ,Mendes-Giannini MJS

更新日期：2020-01-01 00:00:00

abstract：:BACKGROUND Chagas disease, resulting from Trypanosoma cruzi infections, continues to be a health concern mainly in Latin American countries where the parasite is endemic. The laboratory diagnosis of a chronic infection is determined through serological assays for antibodies against T. cruzi and several tests are avail...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Sáez-Alquezar A,Junqueira ACV,Durans ADM,Guimarães AV,Corrêa JA,Provance DW Jr,Cabello PH,Coura JR,Viñas PA

更新日期：2020-01-01 00:00:00

abstract：:BACKGROUND Fluctuations in climate have been associated with variations in mosquito abundance. OBJECTIVES To analyse the influence of precipitation, temperature, solar radiation, wind speed and humidity on the oviposition dynamics of Aedes aegypti in three distinct environmental areas (Brasília Teimosa, Morro da Conce...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Santos ICDS,Braga C,de Souza WV,de Oliveira ALS,Regis LN

更新日期：2020-01-01 00:00:00

abstract：:Sand fly identification is complex because it depends on the expertise of the taxonomist. The females show subtle morphological differences and the occurrence of the species complexes are usual in this taxon. Therefore, a fragment of the cytochrome c oxidase subunit I (COI) gene is used for taxon barcoding to resolve ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Laurito M,Ontivero IM,Almirón WR

更新日期：2019-11-28 00:00:00

abstract：BACKGROUND:In recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission. OBJECTIVES:In order to improve vector control it is essentia...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Salgueiro P,Restrepo-Zabaleta J,Costa M,Galardo AKR,Pinto J,Gaborit P,Guidez A,Martins AJ,Dusfour I

更新日期：2019-09-23 00:00:00

abstract：BACKGROUND:Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES:We sought to identify the viral etiology of equine encephalitis in Espírito Santo state. METHODS:We performed...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Martins LC,Silva EVPD,Casseb LMN,Silva SPD,Cruz ACR,Pantoja JAS,Medeiros DBA,Martins Filho AJ,Cruz EDRMD,Araújo MTF,Cardoso JF,Cunha MACRD,Almada GL,Romano APM,Santos MGDP,Rodrigues GAP,Chiang JO,Quaresma JAS,Carvalho

更新日期：2019-01-17 00:00:00

abstract：BACKGROUND:Hepatitis delta virus (HDV) infections in hepatitis B virus (HBV) carriers are the most severe form of viral hepatitis. HDV prevalence is high in the Brazilian Amazon, but studies in other regions of the country are still scarce and often underestimated its prevalence by including a small numbers of individu...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Scarponi CF,Kroon EG,Vieira DS,Fernandes AP,Gomes KB,Mota BE

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Dengue virus (DENV) has circulated in Brazil for over 30 years. During this time, one serotype has cyclically replaced the other, until recently, when all four distinct serotypes began to circulate together. Persistent circulation of DENV for long time periods makes sequential infections throughout a person'...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Oliveira RA,de Oliveira-Filho EF,Fernandes AI,Brito CA,Marques ET,Tenório MC,Gil LH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Fibrosis in the peripheral nerve is the end stage of leprous neuropathy and the cause of the resulting permanent neural function impairments. Preventive measures to avoid this irreversible pathological state are a relief strategy for leprosy sufferers. OBJECTIVES:The present study describes the frequency of...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Antunes SLG,Jardim MR,Vital RT,Pascarelli BMO,Nery JADC,Amadeu TP,Sales AM,da Costa EAF,Sarno EN

更新日期：2019-01-01 00:00:00

abstract：:The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Fidelis TAA,Brasileiro-Filho G,Santos HH,Vasconcelos-Santos DV,Parreiras PM,Coelho PMZ,Araujo N,Chaud MV,Lambertucci JR

更新日期：2019-01-01 00:00:00

abstract：:Hepatitis E virus (HEV), an emerging virus associated with acute hepatic disease, leads to thousands of deaths worldwide. HEV has already been reported in Brazil; however, there is a lack of epidemiological and molecular information on the genetic variability, taxonomy, and evolution of HEV. It is thus unclear whether...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Oliveira-Filho EF,Dos Santos DR,Durães-Carvalho R,da Silva A,de Lima GB,Batista Filho AFB,Pena LJ,Gil LH

更新日期：2019-01-01 00:00:00

abstract：:Helmintex is a sensitive method used for detecting Schistosoma mansoni eggs. Here, we describe the observed frequency of six proposed criteria associated with the identification of S. mansoni eggs prepared with the Helmintex method and stained with ninhydrin. The efficacy of these criteria in classifying S. mansoni eg...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Souza RP,Favero V,Pascoal VF,Lindholz C,Bittencourt HR,Graeff-Teixeira C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes a...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ornelas AMM,Xavier-de-Carvalho C,Alvarado-Arnez LE,Ribeiro-Alves M,Rossi ÁD,Tanuri A,de Aguiar RS,Moraes MO,Cardoso CC

更新日期：2019-01-01 00:00:00

abstract：:The presence of tRNA array, a region with high tRNA gene number and density, has been demonstrated in Mycobacterium genus. However, a recent phylogenomic study revealed the existence of five distinct monophyletic groups (genera) within this genus. Considering this new scenario, and based on in-silico analyses, we have...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Morgado SM,Vicente ACP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In Brazil, the Yellow Fever virus (YFV) is endemic in the Amazon, from where it eventually expands into epidemic waves. Coastal south-eastern (SE) Brazil, which has been a YFV-free region for eight decades, has reported a severe sylvatic outbreak since 2016. The virus spread from the north toward the south o...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Abreu FVS,Delatorre E,Dos Santos AAC,Ferreira-de-Brito A,de Castro MG,Ribeiro IP,Furtado ND,Vargas WP,Ribeiro MS,Meneguete P,Bonaldo MC,Bello G,Lourenço-de-Oliveira R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:CD64 (FcγR1) is a high-affinity receptor for monomeric IgG1 and IgG3. Circulating neutrophils express very low amounts of CD64 on their surface. OBJECTIVES:Our primary aim was to investigate the utility of neutrophil CD64 surface expression as a biomarker of active pulmonary tuberculosis (TB). We hypothesis...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Corrêa RDS,Rodrigues LS,Pereira LHL,Nogueira OC,Leung J,Sousa MDS,Hacker MA,Siqueira HR,Capone D,Alves RLR,Pessolani MCV,Schmitz V,Pereira GMB

更新日期：2019-01-01 00:00:00

abstract：:Leishmania braziliensis is the etiological agent of American mucosal leishmaniasis, one of the most severe clinical forms of leishmaniasis. Here, we report the assembly of the L. braziliensis (M2904) genome into 35 continuous chromosomes. Also, the annotation of 8395 genes is provided. The public availability of this ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： González-de la Fuente S,Camacho E,Peiró-Pastor R,Rastrojo A,Carrasco-Ramiro F,Aguado B,Requena JM

更新日期：2018-12-10 00:00:00

abstract：:BACKGROUND The main strategy to control human malaria still relies on specific drug treatment, limited now by Plasmodium falciparum-resistant parasites, including that against artemisinin derivatives. Despite the large number of active compounds described in the literature, few of them reached full development against...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Penna-Coutinho J,Aguiar AC,Krettli\/ AU

更新日期：2018-12-06 00:00:00

abstract：:BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Lima LRP,Araújo NA,Guterres A,Pilotto JH,Niel C,Paula VS

更新日期：2018-12-03 00:00:00

abstract：:Raoultella planticola is an emerging zoonotic pathogen that is associated with rare but life-threatening cases of bacteremia, biliary tract infections, and urinary tract infections. Moreover, increasing antimicrobial resistance in the organism poses a potential threat to public health. In spite of its importance as a ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Huang YT,Chuang WY,Ho BC,Wu ZY,Kuo RC,Ko M,Liu PY

更新日期：2018-08-27 00:00:00

abstract：:The biochemical pathways involved in nicotinamide adenine dinucleotide (NAD) biosynthesis converge at the enzymatic step catalysed by nicotinamide mononucleotide adenylyltransferase (NMNAT, EC: 2.7.7.1). The majority of NMNATs are assembled into homo-oligomeric states that comprise 2-6 subunits. Recently, the NMNAT of...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Contreras-Rodríguez LE,Marin-Mogollon CY,Sánchez-Mejía LM,Ramírez-Hernández MH

更新日期：2018-07-10 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Freire CCM,Palmisano G,Braconi CT,Cugola FR,Russo FB,Beltrão-Braga PC,Iamarino A,Lima Neto DF,Sall AA,Rosa-Fernandes L,Larsen MR,Zanotto PMA

更新日期：2018-05-10 00:00:00

abstract：:Since the 1940s, French Guiana has implemented vector control to contain or eliminate malaria, yellow fever, and, recently, dengue, chikungunya, and Zika. Over time, strategies have evolved depending on the location, efficacy of the methods, development of insecticide resistance, and advances in vector control techniq...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Epelboin Y,Chaney SC,Guidez A,Habchi-Hanriot N,Talaga S,Wang L,Dusfour I

更新日期：2018-03-12 00:00:00

abstract：BACKGROUND:Lutzomyia umbratilis, the vector for Leishmania guyanensis in northern South America, has been found naturally infected with L. guyanensis only in areas north of the Negro and Amazon rivers. While populations of this sand fly species are also found in areas south of these rivers, these populations have never...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Soares RP,Nogueira PM,Secundino NF,Marialva EF,Ríos-Velásquez CM,Pessoa FAC

更新日期：2018-03-01 00:00:00

abstract：:The lack of an experimental animal model for the study of dengue pathogenesis is a limiting factor for the development of vaccines and drugs. In previous studies, our group demonstrated the susceptibility of BALB/c mice to infection by dengue virus (DENV) 1 and 2, and the virus was successfully isolated in several org...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Rasinhas ADC,Silva MAND,Caldas GC,Jácome FC,Leonardo R,Santos FBD,Nunes PCG,Barth OM,Barreto-Vieira DF

更新日期：2018-02-05 00:00:00

abstract：:BACKGROUND Studies on malaria vectors in the Pantanal biome, Central Brazil, were conducted more than half a century ago. OBJECTIVES To update anopheline records and assess receptivity and vulnerability to malaria transmission. METHODS Five-day anopheline collections were conducted bimonthly in Salobra, Mato Grosso do...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Marinho-E-Silva M,Sallum MAM,Rosa-Freitas MG,Lourenço-de-Oliveira R,Silva-do-Nascimento TF

更新日期：2018-02-01 00:00:00

abstract：:[This corrects the article doi: 10.1590/0074-02760180073]. ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors：

更新日期：2018-01-01 00:00:00

abstract：:Acute Chagas disease (ACD) has a distinct epidemiological profile in the Amazon Region, with cases and outbreaks of Trypanosoma cruzi infection being possibly related to the ingestion of contaminated food. Data on ACD in the state of Pará retrieved from 2000 to 2016 from the Brazilian Notifiable Diseases Information S...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Santos VRCD,Meis J,Savino W,Andrade JAA,Vieira JRDS,Coura JR,Junqueira ACV

更新日期：2018-01-01 00:00:00

abstract：:BACKGROUND The genus Flavivirus includes a variety of medically important viruses, including dengue virus (DENV) and Zika virus (ZIKV), which are most prevalent in Brazil. Because the clinical profile of patients affected by different DENV serotypes or ZIKV may be similar, the development of new methods that facilitat...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Nunes AR,Alves BEB,Pereira HW,Nascimento YM,Morais IC,Fernandes JV,Araújo JM,Lanza DC

更新日期：2018-01-01 00:00:00

abstract：:There is a paucity of studies on the cell biology of Sporothrix luriei, the less common of the pathogenic Sporothrix species worldwide. The production of DHN-melanin, eumelanin, and pyomelanin were evaluated on the mycelial and yeast forms of the S. luriei ATCC 18616 strain. The mycelial form of this species produced ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cruz ILR,Figueiredo-Carvalho MHG,Zancopé-Oliveira RM,Almeida-Paes R

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The detection of live Mycobacterium leprae in soil and animals other than humans suggests that the environment plays a role in the transmission of leprosy. OBJECTIVE:The objective of this study was to investigate the presence of viable M. leprae in natural water sources used by the local population in five ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Arraes MLBM,Holanda MV,Lima LNGC,Sabadia JAB,Duarte CR,Almeida RLF,Kendall C,Kerr LRS,Frota CC

更新日期：2017-12-01 00:00:00

abstract：:Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M. tuberculosis knockout strain for cdd gene was obtained by allelic replacement. Evaluation of mRNA expressio...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Villela AD,Rodrigues-Junior VS,Pinto AFM,Falcão VCA,Sánchez-Quitian ZA,Eichler P,Bizarro CV,Basso LA,Santos DS

更新日期：2017-11-01 00:00:00