COVID-19: molecular targets, drug repurposing and new avenues for drug discovery.

abstract：:Thirteen species of helminth parasites were recovered from six species of charadriid shorebirds (Aves: Charadriiformes) from Belize: the ruddy turnstone, Arenaria interpres, the snowy plover, Charadrius alexandrinus, the semipalmated plover, C. semipalmatus, the killdeer, C. vociferus, the white-rumped sandpiper, Cali...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Canaris AG,Kinsella JM

更新日期：2001-08-01 00:00:00

abstract：:It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Costa FT,Lopes SC,Ferrer M,Leite JA,Martin-Jaular L,Bernabeu M,Nogueira PA,Mourão MP,Fernandez-Becerra C,Lacerda MV,del Portillo H

更新日期：2011-08-01 00:00:00

abstract：:This study aimed to analyse changes in the spatial distribution of Lutzomyia longipalpis in Posadas, an urban area located in northeastern Argentina. Data were obtained during the summer of 2007 and 2009 through two entomological surveys of peridomiciles distributed around the city. The abundance distribution pattern ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Fernández MS,Santini MS,Cavia R,Sandoval AE,Pérez AA,Acardi S,Salomón OD

更新日期：2013-11-01 00:00:00

abstract：:From 1970 to 1982, 884 cases of human leptospirosis were serologically diagnosed at the Leptospirosis Laboratory, Fundação Oswaldo Cruz - FIOCRUZ, by means of the microscopic agglutination test. Of these patients, 775 were hospitalized in the city of Rio de Janeiro, and 109 were reported by other Brazilian cities. Ict...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Andrade J,Brandão AP

更新日期：1987-01-01 00:00:00

abstract：:Few studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living in small and medium-sized Brazilian cities. We evaluated the seroprevalence of these viruses in selected individuals from a clinic of infectology, who were referred to...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Portelinha Filho AM,Nascimento CU,Tannouri TN,Troiani C,Ascêncio EL,Bonfim R,D'Andrea LA,Prestes-Carneiro LE

更新日期：2009-11-01 00:00:00

abstract：:The nuclear phenotypes of Malpighian tubule cells in fifth instar nymphs of Triatoma infestans, one of the most important vectors of Chagas disease, were studied following sequential shocks at 0 degrees C, separated by intervals of 8 h and 24 h at 30 degrees C, under conditions of moderate fasting and full nourishment...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Campos SG,Rodrigues VL,Mello ML

更新日期：2002-09-01 00:00:00

abstract：:Direct smear examination using Ziehl-Neelsen staining for pulmonary tuberculosis (PTB) diagnosis is inexpensive and easy to use, but has the major limitation of low sensitivity. Rapid molecular methods are becoming more widely available in centralized laboratories, but they depend on timely reporting of results and st...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Michelon CT,Rosso F,Schmid KB,Sperhacke RD,Oliveira MM,Kritski AL,Rezende L Jr,Costa ER,Ribeiro AW,Verza M,Cafrune PI,Silva MS,Kuhleis D,Zaha A,Rossetti ML

更新日期：2011-03-01 00:00:00

abstract：:In Brazil, carbapenem-resistant Pseudomonas aeruginosa isolates are closely related to the São Paulo metallo-β-lactamase (SPM) Brazilian clone. In this study, imipenem-resistant isolates were divided in two sets, 2002/2003 and 2008/2009, analysed by pulsed field gel electrophoresis and tested for the Ambler class B me...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cavalcanti FL,Almeida AC,Vilela MA,Morais MM,Morais Junior MA

更新日期：2012-05-01 00:00:00

abstract：:Four superoxide dismutase (SOD) activities (SOD I, II, III, and IV) have been characterized in the epimastigote form of Trypanosoma cruzi. The total extract was subjected to two successive ammonium sulphate additions between 35 and 85%, and the resulting fraction was purified using two continuous chromatography proces...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mateo H,Marín C,Pérez-Cordón G,Sánchez-Moreno M

更新日期：2008-05-01 00:00:00

abstract：:As in many areas of Brazil, the AIDS epidemic in Curitiba is relatively stable, but surveillance is important to support public policy. The molecular characteristics of HIV may be instrumental for monitoring epidemic trends. We evaluated plasma HIV-1 RNA (n = 37) from 38 cases presenting with positive serology, who we...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ferreira JL,Thomaz M,Rodrigues R,Harrad D,Oliveira CM,Oliveira CA,Batista JP,Ito TS,Brigido LF

更新日期：2008-12-01 00:00:00

abstract：:In laboratory trials an aqueous solution of Piquerol A from Piqueria trinervia, collected in several regions of Mexico, showed a molluscicide action on the adults of eight different pulmonates snails species: Fossaria (Fossaria) humilis, F. (Bakerilymnaea) sp., Pseudosuccinea columella and Stagnicola attenuata from Me...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cruz-Reyes A,Chavarin C,Campos Arias MP,Taboada J,Jimenez M

更新日期：1989-01-01 00:00:00

abstract：:Integration of human papillomavirus (HPV) DNA into human cells accompanied by the disruption of the viral genome has been described as a prerequisite for cancer development. This study aimed to investigate E2 gene integrity of HPV16 and HPV58 viruses isolated from infected women with cervical lesions. Forty-two HPV16-...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： González-Losa MD,Puerto-Solis M,Tenorio Ruiz J,Rosado-López AI,Hau-Aviles O,Ayora-Talavera G,Cisneros-Cutz I,Conde-Ferráez L

更新日期：2016-12-01 00:00:00

abstract：:Mycobacteria, specially Mycobacterium tuberculosis are among the micro-organisms that are increasing dramatically the number of infections with death, all over the world. A great number of animal experimental models have been proposed to investigate the mechanisms involved in the host response against these intracellu...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Menezes-de-Lima-Júnior O,Henriques M das G

更新日期：1997-01-01 00:00:00

abstract：:In the present study, some morphological structures of antennae, maxillary palps and caudal setae of fourth instar larvae of laboratory-reared phlebotomine sand flies (Lutzomyia longipalpis, L. migonei, L. evandroi, L. lenti, L. sericea, L. whitmani and L. intermedia) of the State of Ceará, Brazil, were examined under...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Pessoa FA,Guerra de Queiroz R,Ward RD

更新日期：2001-11-01 00:00:00

abstract：:Data analysis, presentation and distribution is of utmost importance to a genome project. A public domain software, ACeDB, has been chosen as the common basis for parasite genome databases, and a first release of TcruziDB, the Trypanosoma cruzi genome database, is available by ftp from ftp://iris.dbbm.fiocruz.br/pub/g...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Degrave W,de Miranda AB,Amorim A,Brandão A,Aslett M,Vandeyar M

更新日期：1997-11-01 00:00:00

abstract：:In Brazil, until 2004, the immunization policy against diphtheria involved childhood vaccination with no official routine booster dose administered after 15 years of age. This study assessed functional antibody levels against diphtheria among blood donors. A total of 140 blood samples were collected, and diphtheria an...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Pimenta FP,Damasco PV,Cerbino Neto J,Lopes GS,Hirata R Jr,Milagres LG,Mattos-Guaraldi AL

更新日期：2006-06-01 00:00:00

abstract：:Leishmania braziliensis is the etiological agent of American mucosal leishmaniasis, one of the most severe clinical forms of leishmaniasis. Here, we report the assembly of the L. braziliensis (M2904) genome into 35 continuous chromosomes. Also, the annotation of 8395 genes is provided. The public availability of this ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： González-de la Fuente S,Camacho E,Peiró-Pastor R,Rastrojo A,Carrasco-Ramiro F,Aguado B,Requena JM

更新日期：2018-12-10 00:00:00

abstract：:The aim of the present study was to identify specific markers that mirror liver fibrosis progression as an alternative to biopsy when biopsy is contraindicated, especially in children. After liver biopsies were performed, serum samples from 30 hepatitis C virus (HCV) paediatric patients (8-14 years) were analysed and ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Nassef YE,Shady MM,Galal EM,Hamed MA

更新日期：2013-11-01 00:00:00

abstract：:Visceral leishmaniasis, or kala-azar, is recognised as a serious emerging public health problem in India. In this study, environmental parameters, such as land surface temperature (LST) and renormalised difference vegetation indices (RDVI), were used to delineate the association between environmental variables and Phl...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Kesari S,Bhunia GS,Chatterjee N,Kumar V,Mandal R,Das P

更新日期：2013-04-01 00:00:00

abstract：:We have been interested in identifying genes that play a role in reproduction of the mosquito Aedes aegypti. Our interests are currently focused on the vitellogenin genes which in the mosquito are expressed only in the fat body in response to the insect steroid hormone, 20-hydroxyecdysone. Four of the five vitellogeni...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Hamblin MT,Marx JL,Wolfner MF,Hagedorn HH

更新日期：1987-01-01 00:00:00

abstract：:Multi-resistant gram-negative rods are important pathogens in intensive care units (ICU), cause high rates of mortality, and need infection control measures to avoid spread to another patients. This study was undertaken prospectively with all of the patients hospitalized at ICU, Anesthesiology of the Hospital São Paul...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Martins ST,Moreira M,Furtado GH,Marino CG,Machado FR,Wey SB,Medeiros EA

更新日期：2004-05-01 00:00:00

abstract：:In an endemic area of cutaneous leishmaniasis in Rio de Janeiro State where a mule had been found infected, a systematic search among equines was performed, resulting in the detection of Leishmania parasites in skin lesions of 30.8% of the animals, which included horses and mules. The eventual role of equines in the e...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Aguilar CM,Rangel EF,Deane LM

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Chagas disease is a public health problem caused by infection with the protozoan Trypanosoma cruzi. There is currently no effective therapy for Chagas disease. Although there is some evidence for the beneficial effect of bone marrow-derived cells in chagasic disease, the mechanisms underlying their effects i...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Irion CI,Paredes BD,Brasil GV,Cunha STD,Paula LF,Carvalho AR,Carvalho ACC,Carvalho AB,Goldenberg RCDS

更新日期：2017-08-01 00:00:00

abstract：:This paper presents a list of 131 Mallophaga type specimens deposited in the Werneck Collection of Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil. It includes 69 holotypes, 62 allotypes, 683 paratypes, 1 syntype and 2 neoparatypes, distributed among 6 families and 35 genera. The types are listed with their respect...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cardozo-de-Almeida M,Linardi PM,Costa J

更新日期：2003-03-01 00:00:00

abstract：:Four cross sectional studies on morbidity of schistosomiasis mansoni were carried out respectively in 1973, 1974, 1979 and 1983 in the Village of Capitão Andrade, District of Itanhomi, State of Minas Gerais, Brazil, through clinical and fecal examination of the population. In addition a comparison was made of the dina...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Coura JR,Conceição MJ,Pereira JB

更新日期：1984-10-01 00:00:00

abstract：:This paper examines the distribution and infection of Biomphalaria glabrata with Schistosoma mansoni in all aquatic snail habitats in a rural area in the state of Minas Gerais, Brazil, in relation to physico/biotic and behavioral factors. Snail and environmental surveys were carried out semi-annually between July 2001...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Kloos H,Passos LK,Loverde P,Oliveira RC,Gazzinelli A

更新日期：2004-11-01 00:00:00

abstract：:In the Saimiri monkey, an experimental host for human malaria, acquired protection against Plasmodium falciparum blood stages depends on the IgG antibody populations developed. In vivo protective anti-falciparum activity of IgG antibodies is correlated with the in vitro opsonizing activity promoting phagocytosis of pa...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Gysin J

更新日期：1992-01-01 00:00:00

abstract：:The Brazilian variant of human immunodeficiency virus type 1 (HIV-1) subtype B, (serotype B"-GWGR), has a tryptophan replacing the proline in position 328 the HIV-1 envelope. A longer median time period from infection to acquired immunodeficiency syndrome (AIDS) for serotype B (B"-GWGR) infected subjects compared to t...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Casseb J,Montanheiro P,Komninakis S,Brito A,Duarte AJ

更新日期：2004-02-01 00:00:00

abstract：:Coprolite samples of human and animal origin from the excavations performed at the archaeological site of Furna do Estrago, at Brejo da Madre de Deus in the state of Pernambuco, Brazil and sent to the Paleoparasitology Laboratory at Escola Nacional de Saúde Pública-Fiocruz, Rio de Janeiro, were analyzed for mites. Aft...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Candanedo Guerra Rde M,Gazêta GS,Amorim M,Duarte AN,Serra-Freire NM

更新日期：2003-01-01 00:00:00

abstract：:Lutzomyia evandroi Costa Lima and Antunes, 1936 is found in Rio Grande do Norte, northeastern Brazil, in areas of visceral and mucocutaneous leishmaniasis and follows the same geographic distribution of L. longipalpis. The biological cycle, oviposition, morphological and behavioral characteristics of the species were ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Melo Ximenes Mde F,Maciel JC,Jerônimo SM

更新日期：2001-08-01 00:00:00