Changing the epidemiology of carbapenem-resistant Pseudomonas aeruginosa in a Brazilian teaching hospital: the replacement of São Paulo metallo-β-lactamase-producing isolates.

Abstract:

:In Brazil, carbapenem-resistant Pseudomonas aeruginosa isolates are closely related to the São Paulo metallo-β-lactamase (SPM) Brazilian clone. In this study, imipenem-resistant isolates were divided in two sets, 2002/2003 and 2008/2009, analysed by pulsed field gel electrophoresis and tested for the Ambler class B metallo-β-lactamase (MBL) genes blaSPM-1, blaIMP and blaVIM. The results show a prevalence of one clone related to the SPM Brazilian clone in 2002/2003. In 2008/2009, P. aeruginosa isolates were mostly MBL negative, genetically diverse and unrelated to those that had been detected earlier. These findings suggest that the resistance to carbapenems by these recent P. aeruginosa isolates was not due to the spread of MBL-positive SPM-related clones, as often observed in Brazilian hospitals.

journal_name

Mem Inst Oswaldo Cruz

authors

Cavalcanti FL,Almeida AC,Vilela MA,Morais MM,Morais Junior MA

doi

10.1590/s0074-02762012000300019

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

420-3

issue

3

eissn

0074-0276

issn

1678-8060

pii

S0074-02762012000300019

journal_volume

107

pub_type

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