Assessment of immunity induced in mice by glycoproteins derived from different strains and species of Leishmania.

Abstract:

:A comparative study was undertaken on the immunogenic properties of 63kDa glycoproteins obtained from five different strains/species of Leishmania and assessed in C57BL/10 mice. The humoral immune response was assessed by ELISA against the five different antigens of the immunized animals. The cellular immune response was derived from Leishmania. The response was found to be species-specific in all of determined by means of the cytokine profiles secreted by the spleen cells of immunized animals. The presence of gamma-IFN and IL-2, and the absence of IL-4 in the supernatants of cells stimulated by L. amazonensis antigen established that the cellular response is of Th1 type. The five glycoproteins tested were equally effective in protecting C57BL/10 mice against challenge by L. amazonensis. About 50% of the immunized animals were protected for six months.

journal_name

Mem Inst Oswaldo Cruz

authors

Dabés Guimarães TM,de Toledo VD,da Costa CA,da Costa RT,Genaro O,Williams P,Mayrink W

doi

10.1590/s0074-02761996000100010

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

63-70

issue

1

eissn

0074-0276

issn

1678-8060

pii

S0074-02761996000100010

journal_volume

91

pub_type

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