Cytokine profile associated with human chronic schistosomiasis mansoni.

Abstract:

:This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.

journal_name

Mem Inst Oswaldo Cruz

authors

Magalhães A,Miranda DG,Miranda RG,Araújo MI,Jesus AA,Silva A,Santana LB,Pearce E,Carvalho EM,Jesus AR

doi

10.1590/s0074-02762004000900004

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

21-6

issue

5 Suppl 1

eissn

0074-0276

issn

1678-8060

pii

S0074-02762004000900004

journal_volume

99

pub_type

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