Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni).

Abstract:

:Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.

journal_name

Mem Inst Oswaldo Cruz

authors

Thornhill J,Kusel J,Oliviera FA,Ribeiro F,Lima SF,Coelho PM,McVeigh P,Mattos AC

doi

10.1590/s0074-02762010000400007

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

387-90

issue

4

eissn

0074-0276

issn

1678-8060

pii

S0074-02762010000400007

journal_volume

105

pub_type

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