On cytoadhesion of Plasmodium vivax: raison d'être?

Abstract:

:It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.

journal_name

Mem Inst Oswaldo Cruz

authors

Costa FT,Lopes SC,Ferrer M,Leite JA,Martin-Jaular L,Bernabeu M,Nogueira PA,Mourão MP,Fernandez-Becerra C,Lacerda MV,del Portillo H

doi

10.1590/s0074-02762011000900010

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

79-84

eissn

0074-0276

issn

1678-8060

pii

S0074-02762011000900010

journal_volume

106 Suppl 1

pub_type

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