Comparison of adverse events following immunization with pandemic influenza A (H1N1)pdm09 vaccine with or without adjuvant among health professionals in Rio de Janeiro, Brazil.

Abstract:

:A vaccination campaign against pandemic influenza A (H1N1)pdm09 was held in Brazil in March 2010, using two types of monovalent split virus vaccines: an AS03-adjuvanted vaccine and a non-adjuvanted vaccine. We compared the reactogenicity of the vaccines in health professionals from a Clinical Research Institute in Rio de Janeiro, Brazil and there were no serious adverse events following immunization (AEFI) among the 494 subjects evaluated. The prevalence of any AEFI was higher in the AS03-adjuvanted vaccine at 2 h and 24 h post-vaccination [preva-lence ratio (PR): 2.05, confidence interval (CI) 95%: 1.55-2.71, PR: 3.42, CI 95%: 2.62-4.48, respectively]; however, there was no difference between the vaccines in the assessments conducted at seven and 21 days post-vaccination. The group receiving the AS03 post-adjuvanted vaccine had a higher frequency of local reactions at 2 h (PR: 3.01, CI 95%: 2.12-4.29), 24 h (PR: 4.57, CI 95%: 3.29-6.37) and seven days (PR: 6.05, CI 95%: 2.98-12.28) post-vaccination. We concluded that the two types of vaccines caused no serious AEFI in the studied population and the adjuvanted vaccine was more reactogenic, particularly in the 24 h following vaccination. This behaviour must be confirmed and better characterised by longitudinal studies in the general population.

journal_name

Mem Inst Oswaldo Cruz

authors

Cerbino-Neto J,Santos AT,Gouvea MI,Pedro RS,Ramos GV,Guaraldo L,Werneck GL

doi

10.1590/s0074-02762012000700014

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

923-7

issue

7

eissn

0074-0276

issn

1678-8060

pii

S0074-02762012000700014

journal_volume

107

pub_type

杂志文章
  • Using immunoglobulin Y as an alternative antibody for the detection of hepatitis A virus in frozen liver sections.

    abstract::An increasing amount of research has been conducted on immunoglobulin Y (IgY) because the use of IgY offers several advantages with respect to diagnostic testing, including its easy accessibility, low cost and translatability to large-scale production, in addition to the fact that it can be ethically produced. In a pr...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760140457

    authors: Bentes GA,Lanzarini NM,Lima LR,Manso PP,da Silva Ados S,Mouta Junior Sda S,Guimarães JR,de Moraes MT,Pelajo-Machado M,Pinto MA

    更新日期:2015-06-01 00:00:00

  • Concurrent infection with dengue virus type-2 and DENV-3 in a patient from Ceará, Brazil.

    abstract::Dengue outbreaks have occurred in several regions in Brazil and cocirculating dengue virus type 1 (DENV-1), DENV-2, and DENV-3 have been frequently observed. Dual infection by DENV-2 and DENV-3 was identified by type-specific indirect immunofluorescence assay and confirmed by reverse transcription polymerase chain rea...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762006000800017

    authors: Araújo FM,Nogueira RM,de Araújo JM,Ramalho IL,Roriz ML,de Melo ME,Coelho IC

    更新日期:2006-12-01 00:00:00

  • Self-fertilization in the freshwater snails Helisoma duryi and Helisoma trivolvis.

    abstract::Fifty specimens of five strains (10 per strain) of Helisoma duryi from Lima (Peru), St. Croix (Virgin Islands), Formosa (Brazil), Cartago (Costa Rica) and St. Vincent (Lesser Antilles), reared in isolation for about 150 days, laid 103 eggs. The numbers of eggs laid by the 10 specimens of each strain were respectively ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761988000400002

    authors: Paraense WL,Corrêa LR

    更新日期:1988-10-01 00:00:00

  • Chagas heart disease: pathophysiologic mechanisms, prognostic factors and risk stratification.

    abstract::Chagas heart disease (CHD) results from infection with the protozoan parasite Trypanosoma cruzi and is the leading cause of infectious myocarditis worldwide. It poses a substantial public health burden due to high morbidity and mortality. CHD is also the most serious and frequent manifestation of chronic Chagas diseas...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000900021

    authors: Rassi A Jr,Rassi A,Marin-Neto JA

    更新日期:2009-07-01 00:00:00

  • Sativa seeds against Schistosoma mansoni different stages.

    abstract::The schistosomicidal properties of Nigella sativa seeds were tested in vitro against Schistosoma mansoni miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In the present work w...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762005000200016

    authors: Mohamed AM,Metwally NM,Mahmoud SS

    更新日期:2005-04-01 00:00:00

  • Bone marrow cell migration to the heart in a chimeric mouse model of acute chagasic disease.

    abstract:BACKGROUND:Chagas disease is a public health problem caused by infection with the protozoan Trypanosoma cruzi. There is currently no effective therapy for Chagas disease. Although there is some evidence for the beneficial effect of bone marrow-derived cells in chagasic disease, the mechanisms underlying their effects i...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760160526

    authors: Irion CI,Paredes BD,Brasil GV,Cunha STD,Paula LF,Carvalho AR,Carvalho ACC,Carvalho AB,Goldenberg RCDS

    更新日期:2017-08-01 00:00:00

  • Isolation and identification of actin-binding proteins in Plasmodium falciparum by affinity chromatography.

    abstract::The invasion of the erythrocyte by Plasmodium falciparum depends on the ability of the merozoite to move through the membrane invagination. This ability is probably mediated by actin dependent motors. Using affinity columns with G-actin and F-actin we isolated actin binding proteins from the parasite. By immunoblottin...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762000000300007

    authors: Forero C,Wasserman M

    更新日期:2000-05-01 00:00:00

  • Recent advances and prospective researches on molecular epidemiology of dengue viruses.

    abstract::The determination of amino acid changes in the envelope protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variation...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02761992000900021

    authors: Deubel V

    更新日期:1992-01-01 00:00:00

  • Larval dispersal and predation in experimental populations of Chrysomya albiceps and Cochliomyia macellaria (Diptera: Calliphoridae).

    abstract::In this study we investigated the larval dispersal associated with larval predation in experimental populations of Chrysomya albiceps and Cochliomyia macellaria. Frequency distribution of sampling units (G test) in the substrate was used to evaluate variation in larval dispersal. An experimental acrylic channel (1 x 0...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762002000800013

    authors: de Andrade JB,Rocha FA,Rodrigues P,Rosa GS,Faria Ldel B,Von Zuben CJ,Rossi MN,Godoy WA

    更新日期:2002-12-01 00:00:00

  • Helicobacter pylori cagA and vacA genotypes in Cuban and Venezuelan populations.

    abstract::The aim of this study was to determine the presence of Helicobacter pylori cytotoxin-associated gene (cagA)/vacuolating cytotoxin gene (vacA) among patients with chronic gastritis in Cuba and Venezuela. Gastric antrum biopsies were taken for culture, DNA extraction and PCR analysis. Amplification of vacA and cagA segm...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762010000300016

    authors: Ortiz-Princz D,Guariglia-Oropeza V,Avila M,Correnti M,Perrone M,Gutierrez B,Torres J,Megraud F,Cavazza ME

    更新日期:2010-05-01 00:00:00

  • Cotylophoron Travassosi sp. n. (Trematoda--Paramphistomidae) from cattle.

    abstract::A new species of the genus Cotylophoron (Trematoda--Paramphistomidae) --Cotylophoron travassosi sp. n.--is described. The measurements of the worm and its structures are compared with the valid known species. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761992000500013

    authors: Costa HM,Guimaráes MP

    更新日期:1992-01-01 00:00:00

  • Faecal examination and PCR to detect Strongyloides venezuelensis in experimentally infected Lewis rats.

    abstract::More sensitive methodologies are necessary to improve strongyloidiasis diagnosis. This study compared the sensitivities of the McMaster modified technique and polymerase chain reaction (PCR) assays, both performed in faecal samples. Lewis rats were subcutaneously infected with 4,000, 400 or 40 infective third-stage la...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762010000100008

    authors: Marra NM,Chiuso-Minicucci F,Machado GC,Zorzella-Pezavento SF,França TG,Ishikawa LL,Amarante AF,Sartori A,Amarante MR

    更新日期:2010-02-01 00:00:00

  • Detection and characterization of rotavirus G and P types from children participating in a rotavirus vaccine trial in Belém, Brazil.

    abstract::This study sought the characterization of rotaviruses in a trial with a tetravalent rhesus-human rotavirus vaccine in Belém, Brazil in children who received three doses of vaccine or placebo in the 1st, 3rd and 5th months of life. Rotavirus electropherotypes, subgroups, G serotypes, G, [P] and [P], G genotypes were de...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1590/s0074-02762002000100020

    authors: Mascarenhas JD,Linhares AC,Gabbay YB,Leite JP

    更新日期:2002-01-01 00:00:00

  • Biology of the first generation of a laboratory colony of Nyssomyia intermedia (Lutz & Neiva, 1912) and Nyssomyia neivai (Pinto, 1926) (Diptera: Psychodidae).

    abstract::The phlebotomine sand flies Nyssomyia intermedia (Lutz & Neiva, 1912) and Nyssomyia neivai (Pinto, 1926) are very close and may be involved in the transmission of Leishmania spp. Ross, 1903 in Brazil. The biology of the first laboratory-reared generations of these species, descended from insects captured in Além Paraí...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762004000600011

    authors: Andrade Filho JD,Galati EA,Falcão AL

    更新日期:2004-10-01 00:00:00

  • Chikungunya virus outbreak in Kerala, India, 2007: a seroprevalence study.

    abstract::India was affected by a major outbreak of chikungunya fever caused by Chikungunya virus (CHIKV) during 2006-2007. Kerala was the worst affected state during 2007 with a contribution of 55.8% suspected cases in the country. However, except for clinically reported case records, no systematic information is available on ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000800003

    authors: Kumar NP,Suresh A,Vanamail P,Sabesan S,Krishnamoorthy KG,Mathew J,Jose VT,Jambulingam P

    更新日期:2011-12-01 00:00:00

  • Sensitivity of a vacuum aspiratory culture technique for diagnosis of localized cutaneous leishmaniasis in an endemic area of Leishmania (Viannia) braziliensis transmission.

    abstract::Sixty eight patients with localized cutaneous leishmaniasis from an area with Leishmania (Viannia) braziliensis transmission had cultures performed with a modified Marzochís vacuum aspiratory puncture technique to establish sensitivity and contamination rate with this new method. Overall sensitivity of three aspirates...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761999000400014

    authors: Romero GA,Sampaio RN,Macedo Vde O,Marsden PD

    更新日期:1999-07-01 00:00:00

  • Veterinary vaccines against Toxoplasma gondii.

    abstract::Toxoplasma gondii has a very wide intermediate host range and is thought to be able to infect all warm blooded animals. The parasite causes a spectrum of different diseases and clinical symptoms within the intermediate hosts and following infection most animals develop adaptive humoral and cell-mediated immune respons...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02762009000200018

    authors: Innes EA,Bartley PM,Maley S,Katzer F,Buxton D

    更新日期:2009-03-01 00:00:00

  • Some coccidial parasites of the lizard Amphisbaena alba (Reptilia: Amphisbaenia: Amphisbaenidae).

    abstract::Five parasites are described in the lizard Amphisbaena alba (Amphisbaenidae) from the state of Par , North Brazil. Mature oocysts of Choleoeimeria amphisbaenae n. sp., are passed already mature in the faeces. They are ellipsoidal-cylindrical, average 33.7 x 22.8 m and are devoid of micropyle, oocyst residuum or polar...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762003000700012

    authors: Lainson R

    更新日期:2003-10-01 00:00:00

  • Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species.

    abstract::Aspartyl proteases are a class of enzymes that include the yeast aspartyl proteases and secreted aspartyl protease (Sap) superfamilies. Several Sap superfamily members have been demonstrated or suggested as virulence factors in opportunistic pathogens of the genus Candida. Candida albicans, Candida tropicalis, Candida...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000300018

    authors: Parra-Ortega B,Cruz-Torres H,Villa-Tanaca L,Hernández-Rodríguez C

    更新日期:2009-05-01 00:00:00

  • Effect of treatment with cyclophosphamide in low doses upon the onset of delayed type hypersensitivity in mice chronically infected with Trypanosoma cruzi: involvement of heart interstitial dendritic cells.

    abstract::Acute infection with Trypanosoma cruzi results in intense myocarditis, which progresses to a chronic, asymptomatic indeterminate form. The evolution toward this chronic cardiac form occurs in approximately 30% of all cases of T. cruzi infection. Suppression of delayed type hypersensitivity (DTH) has been proposed as a...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-0276108062013004

    authors: Thé TS,Portella RS,Guerreiro ML,Andrade SG

    更新日期:2013-09-01 00:00:00

  • Mapping of courses on vector biology and vector-borne diseases systems: time for a worldwide effort.

    abstract::Major emergency efforts are being mounted for each vector-borne disease epidemiological crisis anew, while knowledge about the biology of arthropods vectors is dwindling slowly but continuously, as is the number of field entomologists. The discrepancy between the rates of production of knowledge and its use and need f...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760160295

    authors: Casas J,Lazzari C,Insausti T,Launois P,Fouque F

    更新日期:2016-11-01 00:00:00

  • Two new species of nematodes (Rhabditida: Diplogasteridae and Rhabditidae) parasites of Gryllodes laplatae (Orthoptera: Gryllidae) in Argentina.

    abstract::Cephalobium magdalensis n. sp. (Rhabditida: Diplogasteridae) found in Magdalena, Buenos Aires, and Cruznema lincolnensis n. sp. (Rhabditida: Rhabditidae) found in Lincoln, Buenos Aires, parasitizing the cricket Gryllodes laplatae (Orthoptera: Gryllidae) are described and illustrated. C. magdalensis n. sp. is character...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761998000600013

    authors: Reboredo GR,Camino NB

    更新日期:1998-11-01 00:00:00

  • Chromatin regulation in schistosomes and histone modifying enzymes as drug targets.

    abstract::Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objective we have chosen to target the enzymes modifying histones and in part...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000700003

    authors: Pierce RJ,Dubois-Abdesselem F,Caby S,Trolet J,Lancelot J,Oger F,Bertheaume N,Roger E

    更新日期:2011-11-01 00:00:00

  • Feeding behavior of Triatoma vitticeps (Reduviidae: Triatominae) in the state of Minas Gerais, Brazil.

    abstract::The objective of this study was to evaluate the feeding behavior of Triatoma vitticeps through the identification of its food sources and the characterization of the blood ingestion process. In addition, we aimed to verify if the saliva of this vector interferes with the perception of the host during the feedings by c...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000100003

    authors: Souza Rde C,Soares AC,Alves CL,Lorosa ES,Pereira MH,Diotaiuti L

    更新日期:2011-02-01 00:00:00

  • A comparative study on IgG-ELISA, IgM-IFT and Kato-Katz methods for epidemiological purposes in a low endemic area for schistosomiasis.

    abstract::The high sensitivity and the possibility of automation of the enzyme-linked-immunosorbent-assay (ELISA) has indicated this technique as one of the most useful serological test for epidemiological studies. In the present study, an ELISA for detection of IgG antibodies against adult worm antigens (IgG-ELISA) was investi...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761998000700054

    authors: da Silva RM,Kanamura HY,Camargo ED,Chiodelli SG,Nakamura PM,Gargioni C,Vellosa SA,Antunes JL

    更新日期:1998-01-01 00:00:00

  • Toxoplasma gondii infection induces lipid metabolism alterations in the murine host.

    abstract::Host lipids have been implicated in the pathogenesis of Toxoplasma gondii infection. To determine if Toxoplasma infection influences the lipid status in the normal host, we assessed serum lipids of Swiss-Webster mice during infection with the BGD-1 strain (type-2) at a series of time points. Mice were bled at days zer...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000200008

    authors: Milovanović I,Vujanić M,Klun I,Bobić B,Nikolić A,Ivović V,Trbovich AM,Djurković-Djaković O

    更新日期:2009-03-01 00:00:00

  • From allergy to schistosomes: role of Fc receptors and adhesion molecules in eosinophil effector function.

    abstract::The dual function of eosinophils has been evidenced in protective immunity against parasites as well as in pathological manifestations during allergic disorders. We have demonstrated that a new class of IgE receptors, Fc epsilon RII/CD23, was involved in the functional duality of eosinophils and other proinflammatory ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02761997000800003

    authors: Nutten S,Trottein F,Gounni AS,Papin JP,Capron A,Capron M

    更新日期:1997-01-01 00:00:00

  • Changing the epidemiology of carbapenem-resistant Pseudomonas aeruginosa in a Brazilian teaching hospital: the replacement of São Paulo metallo-β-lactamase-producing isolates.

    abstract::In Brazil, carbapenem-resistant Pseudomonas aeruginosa isolates are closely related to the São Paulo metallo-β-lactamase (SPM) Brazilian clone. In this study, imipenem-resistant isolates were divided in two sets, 2002/2003 and 2008/2009, analysed by pulsed field gel electrophoresis and tested for the Ambler class B me...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762012000300019

    authors: Cavalcanti FL,Almeida AC,Vilela MA,Morais MM,Morais Junior MA

    更新日期:2012-05-01 00:00:00

  • Clinical spectrum of uncomplicated malaria in semi-immune Amazonians: beyond the " symptomatic " vs " asymptomatic " dichotomy.

    abstract::We analyzed prospectively 326 laboratory-confirmed, uncomplicated malarial infections (46.3% due to Plasmodium vivax, 35.3% due to P. falciparum, and 18.4% mixed-species infections) diagnosed in 162 rural Amazonians aged 5-73 years. Thirteen symptoms (fever, chills, sweating, headache, myalgia, arthralgia, abdominal p...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762007005000051

    authors: da Silva-Nunes M,Ferreira MU

    更新日期:2007-06-01 00:00:00

  • Distribution and Schistosoma mansoni infection of Biomphalaria glabrata in different habitats in a rural area in the Jequitinhonha Valley, Minas Gerais, Brazil: environmental and epidemiological aspects.

    abstract::This paper examines the distribution and infection of Biomphalaria glabrata with Schistosoma mansoni in all aquatic snail habitats in a rural area in the state of Minas Gerais, Brazil, in relation to physico/biotic and behavioral factors. Snail and environmental surveys were carried out semi-annually between July 2001...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762004000700002

    authors: Kloos H,Passos LK,Loverde P,Oliveira RC,Gazzinelli A

    更新日期:2004-11-01 00:00:00