Leprosy, a neglected disease that causes a wide variety of clinical conditions in tropical countries.

Abstract:

:Leprosy is an ancient disease that remains endemic and continues to be a major public health problem in some tropical countries, where it has been internationally recognized as being linked to the underdevelopment conditions. The natural course of the disease covers a wide variety of clinical conditions with systemic involvement. In this paper, we review the findings obtained in studies of the pathological mechanisms of leprosy, including a survey of the literature and of our own work. The understanding and control of the wide variety of clinical conditions should help improve patient care and thus prevent the onset of physical impairment and the stigma of the disease.

journal_name

Mem Inst Oswaldo Cruz

authors

Foss NT,Motta AC

doi

10.1590/s0074-02762012000900006

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

28-33

eissn

0074-0276

issn

1678-8060

pii

S0074-02762012000900006

journal_volume

107 Suppl 1

pub_type

杂志文章,评审
  • Life cycle, feeding and defecation patterns of Rhodnius ecuadoriensis (Lent & León 1958) (Hemiptera: Reduviidae: Triatominae) under laboratory conditions.

    abstract::Rhodnius ecuadoriensis is the second most important vector of Chagas Disease (CD) in Ecuador. The objective of this study was to describe (and compare) the life cycle, the feeding and defecation patterns under laboratory conditions of two populations of this specie [from the provinces of Manabí (Coastal region) and Lo...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762008000700011

    authors: Villacís AG,Arcos-Terán L,Grijalva MJ

    更新日期:2008-11-01 00:00:00

  • Molecular epidemiology of methicillin resistant Staphylococcus aureus isolated from newborns in a hospital in Rio de Janeiro, Brazil.

    abstract::Methicillin resistant Staphylococcus aureus (MRSA) is an organism that is frequently transmitted in hospitals and perinatal units. The MRSA is considered a public health problem in neonatology because of its strong potential for dissemination in the wards associated with high rates of morbidity and mortality. In this ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762000000600005

    authors: Loureiro MM,de Moraes BA,Quadra MR,Pinheiro GS,Suffys PN,Asensi MD

    更新日期:2000-11-01 00:00:00

  • Rickettsiae-infected ticks in an endemic area of spotted fever in the State of Minas Gerais, Brazil.

    abstract::A study on tick-borne rickettsiosis was developed in the county of Santa Cruz do Escalvado, State of Minas Gerais, Brazil, where a clinical case of the disease, confirmed by necropsy, had been reported. Of the 1,254 ticks collected, 1,061 belonged to the Amblyomma genus, 57 to the Rhipicephalus sanguineus species, 81 ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761997000400005

    authors: de Lemos ER,Machado RD,Pires FD,Machado SL,da Costa LM,Coura JR

    更新日期:1997-07-01 00:00:00

  • Immuno-epidemiology of Schistosoma mansoni infections in a recently exposed community in Senegal.

    abstract::Schistosoma mansoni was introduced in the Senegal basin around 1988, due to man-made ecological changes. Since 1991, we investigate a recent but very intense focus, Ndombo, a village near the city of Richard Toll where the outbreak was first described. Four cohorts, each a random sample (+/- 400 subjects each) from th...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761995000200025

    authors: Gryseels B,Stelma F,Talla I,Polman K,Van Dam G,Sow S,Diaw M,Sturrock RF,Decam C,Niang M

    更新日期:1995-03-01 00:00:00

  • Chagas disease: national survey of seroprevalence in children under five years of age conducted in 2008.

    abstract:BACKGROUND:Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector contr...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760160407

    authors: Russomando G,Cousiño B,Sanchez Z,Franco LX,Nara EM,Chena L,Martínez M,Galeano ME,Benitez L

    更新日期:2017-05-01 00:00:00

  • Larval dispersal and predation in experimental populations of Chrysomya albiceps and Cochliomyia macellaria (Diptera: Calliphoridae).

    abstract::In this study we investigated the larval dispersal associated with larval predation in experimental populations of Chrysomya albiceps and Cochliomyia macellaria. Frequency distribution of sampling units (G test) in the substrate was used to evaluate variation in larval dispersal. An experimental acrylic channel (1 x 0...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762002000800013

    authors: de Andrade JB,Rocha FA,Rodrigues P,Rosa GS,Faria Ldel B,Von Zuben CJ,Rossi MN,Godoy WA

    更新日期:2002-12-01 00:00:00

  • Hepatitis B and C in the hemodialysis unit of Tocantins, Brazil: serological and molecular profiles.

    abstract::A survey was conducted in the hemodialysis population of the state of Tocantins, Brazil, aiming to assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, to analyze associated risk factors, and also to investigate these viruses genotypes distribution. During January and March 2001, al...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:

    authors: Souza KP,Luz JA,Teles SA,Carneiro MA,Oliveira LA,Gomes AS,Dias MA,Gomes SA,Yoshida CF,Martins RM

    更新日期:2003-07-01 00:00:00

  • Widespread nasal carriage of Mycobacterium lepraeamong a healthy population in a hyperendemic region of northeastern Brazil.

    abstract::A case-control study was conducted to determine the presence ofMycobacterium lepraeDNA in nasal secretions of leprosy cases and nonleprosy individuals in Fortaleza, Brazil. It included 185 cases identified by physicians at the Dona Libânia National Reference Centre for Sanitary Dermatology (CDERM). A control group (Co...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760150178

    authors: Lima LN,Frota CC,Mota RM,Almeida RL,Pontes MA,Gonçalves Hde S,Rodrigues LC,Kendall C,Kerr L

    更新日期:2015-11-01 00:00:00

  • A comparative evaluation of end-emic and non-endemic region of visceral leishmaniasis (Kala-azar) in India with ground survey and space technology.

    abstract::In visceral leishmaniasis, phlebotomine vectors are targets for control measures. Understanding the ecosystem of the vectors is a prerequisite for creating these control measures. This study endeavours to delineate the suitable locations of Phlebotomus argentipes with relation to environmental characteristics between ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000500001

    authors: Kesari S,Bhunia GS,Kumar V,Jeyaram A,Ranjan A,Das P

    更新日期:2011-08-01 00:00:00

  • The depuration dynamics of oysters (Crassostrea gigas) artificially contaminated with hepatitis A virus and human adenovirus.

    abstract::Within the country of Brazil, Santa Catarina is a major shellfish producer. Detection of viral contamination is an important step to ensure production quality and consumer safety during this process. In this study, we used a depuration system and ultraviolet (UV) disinfection to eliminate viral pathogens from artifici...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762012000100002

    authors: Corrêa Ade A,Rigotto C,Moresco V,Kleemann CR,Teixeira AL,Poli CR,Simões CM,Barardi CR

    更新日期:2012-02-01 00:00:00

  • Temporal abundance of Aedes aegypti in Manaus, Brazil, measured by two trap types for adult mosquitoes.

    abstract::A longitudinal study was conducted in Manaus, Brazil, to monitor changes of adult Aedes aegypti (L.) abundance. The objectives were to compare mosquito collections of two trap types, to characterise temporal changes of the mosquito population, to investigate the influence of meteorological variables on mosquito collec...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-0276140234

    authors: Degener CM,Ázara TM,Roque RA,Codeço CT,Nobre AA,Ohly JJ,Geier M,Eiras ÁE

    更新日期:2014-12-01 00:00:00

  • Schistosomiasis mansoni in three localities of western lowland of the state of Maranháo before and after mass treatments.

    abstract::A cross-sectional study for schistosomiasis was carried out in the localities of Aliança, Alegre and Coroatá (districts of Cururupu, São Bento and São João Batista, respectively) in the lowland of the state of Maranhão, after respectively 13, 11 and 4 mass treatments with oxamniquine in the period of ten years (1977-1...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761992000400015

    authors: Cutrim RN,Coura JR

    更新日期:1992-10-01 00:00:00

  • Leishmanial infection: analysis of its first steps. A review.

    abstract::The first steps in leishmaniasis are critical in determining the evolution of the disease. Major advances have recently been done in understanding this crucial moment. Fundamental research in parasite-vector interaction, parasite biology, insect saliva, and vertebrate host response have shed new light and uncovered a ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02762003000700001

    authors: de Almeida MC,Vilhena V,Barral A,Barral-Netto M

    更新日期:2003-10-01 00:00:00

  • Concurrent infection with dengue virus type-2 and DENV-3 in a patient from Ceará, Brazil.

    abstract::Dengue outbreaks have occurred in several regions in Brazil and cocirculating dengue virus type 1 (DENV-1), DENV-2, and DENV-3 have been frequently observed. Dual infection by DENV-2 and DENV-3 was identified by type-specific indirect immunofluorescence assay and confirmed by reverse transcription polymerase chain rea...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762006000800017

    authors: Araújo FM,Nogueira RM,de Araújo JM,Ramalho IL,Roriz ML,de Melo ME,Coelho IC

    更新日期:2006-12-01 00:00:00

  • Benzonidazole levels in blood vary with age in rats.

    abstract::Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the prese...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000300021

    authors: Bulffer RF,Castro JA,Fanelli SL

    更新日期:2011-05-01 00:00:00

  • Intracellular polyamine pools, oligopeptide-binding protein A expression, and resistance to aminoglycosides in Escherichia coli.

    abstract::The role of intracellular free polyamine (putrescine and spermidine) pools in multiple resistance to aminoglycoside antibiotics was investigated among in vitro selected kanamycin-resistant Escherichia coli J53 mutants expressing diminished oligopeptide-binding protein (OppA) levels and/or defective ornithine decarboxy...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762005000700020

    authors: Acosta MB,Ferreira RC,Ferreira LC,Costa SO

    更新日期:2005-11-01 00:00:00

  • Phenotypic and genotypic characteristics of shiga toxin-producing Escherichia coli strains isolated from children in São Paulo, Brazil.

    abstract::The biochemical and serological characteristics, virulence properties, and genetic relatedness of Shiga toxin-producing Escherichia coli (STEC) strains isolated in S o Paulo, from April 1989 through March 1990, were determined. This is also the first report on clinic findings of human STEC infections in Brazil. The on...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762002000800003

    authors: Guth BE,Ramos SR,Cerqueira AM,Andrade JR,Gomes TA

    更新日期:2002-12-01 00:00:00

  • A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information.

    abstract::The current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from the human parasite Trypanosoma cruzi to identify new drug targets and develop appropriate treatments for both acute and chronic Chagas disease. However, the lack...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000800006

    authors: Alves-Ferreira M,Guimarães AC,Capriles PV,Dardenne LE,Degrave WM

    更新日期:2009-12-01 00:00:00

  • Quantitation of HIV-1 RNA viral load using nucleic acid sequence based amplification methodology and comparison with other surrogate markers for disease progression.

    abstract::In this study, HIV-1 viral blood quantitation determined by Nucleic Acid Sequence Based Amplification (NASBA) was compared with other surrogate disease progression markers (antigen p24, CD4/CD8 cell counts and beta-2 microglobulin) in 540 patients followed up at São Paulo, SP, Brazil. HIV-1 RNA detection was statistic...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761998000300027

    authors: Sitnik R,Pinho JR

    更新日期:1998-05-01 00:00:00

  • [Bionomical aspects of the Squamatoides triviattus (Diptera, Sarcophagidae) under laboratory conditions].

    abstract::Experiments with Squamatoides trivitattus were carried out in two different controlled temperatures (16 +/- 1 degree C/50-60% RH and 27 +/- 1 degree C/70-80% RH). The viability of larvae and pupae at 27 degrees C was 89.82% and 92.75% respectively. Larvae did not develop at 16 degrees C. Larval development lasted for ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761996000200024

    authors: Salviano RJ,de Mello RP,Beck LC,d'Almeida JM

    更新日期:1996-03-01 00:00:00

  • Leishmania infections in Lutzomyia longipalpis (Diptera:Psychodidae) on the island of São Luis, Maranhão State, Brazil.

    abstract::Dissection of Lutzomyia longipalpis, captured in the São Luis focus of visceral Leishmaniasis revealed a 1.8% promastigote infection rate. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761984000300016

    authors: Ryan L,Brazil RP

    更新日期:1984-07-01 00:00:00

  • Isolation and identification of 9-methylgermacrene-B as the putative sex pheromone of Lutzomyia cruzi (Mangabeira, 1938) (Diptera: Psychodidae).

    abstract::Lutzomyia (Lutzomyia) cruzi has been named as a probable vector of Leishmania chagasi in Corumbá, Mato Grosso do Sul, Brazil. Taxonomically L. cruzi is closely related to the L. longipalpis species complex. Females of L. cruzi and L. longipalpis are morphologically indistinguishable and associated males must be examin...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762002000300030

    authors: Brazil RP,Hamilton JG

    更新日期:2002-04-01 00:00:00

  • Characteristics of the biological cycle of Lutzomyia evandroi Costa Lima & Antunes, 1936 (Diptera: Psychodidae) under experimental conditions.

    abstract::Lutzomyia evandroi Costa Lima and Antunes, 1936 is found in Rio Grande do Norte, northeastern Brazil, in areas of visceral and mucocutaneous leishmaniasis and follows the same geographic distribution of L. longipalpis. The biological cycle, oviposition, morphological and behavioral characteristics of the species were ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762001000600025

    authors: de Melo Ximenes Mde F,Maciel JC,Jerônimo SM

    更新日期:2001-08-01 00:00:00

  • The balance between the production of tumor necrosis factor-alpha and interleukin-10 determines tissue injury and lethality during intestinal ischemia and reperfusion.

    abstract::A major goal in the treatment of acute ischemia of a vascular territory is to restore blood flow to normal values, i.e. to "reperfuse" the ischemic vascular bed. However, reperfusion of ischemic tissues is associated with local and systemic leukocyte activation and trafficking, endothelial barrier dysfunction in postc...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762005000900011

    authors: Souza DG,Teixeira MM

    更新日期:2005-03-01 00:00:00

  • Abdominal angiostrongyliasis can be diagnosed with a immunochromatographic rapid test with recombinant galactin from Angiostrongylus cantonensis.

    abstract::Angiostrongylus costaricensis is the causative agent of abdominal angiostrongyliasis, a zoonotic infection that may produce severe eosinophilic enterocolitis or hepatitis in humans. Parasites are usually not released in stools and serology has an important role in diagnosis. Since cross-reactivity is demonstrated betw...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760200201

    authors: Graeff-Teixeira C,Pascoal VF,Rodriguez R,Morassutti AL,Intapan PM,Maleewong W

    更新日期:2020-09-21 00:00:00

  • Two years into the Brazilian Reproducibility Initiative: reflections on conducting a large-scale replication of Brazilian biomedical science.

    abstract::Scientists have increasingly recognised that low methodological and analytical rigour combined with publish-or-perish incentives can make the published scientific literature unreliable. As a response to this, large-scale systematic replications of the literature have emerged as a way to assess the problem empirically....

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760200328

    authors: Neves K,Carneiro CF,Wasilewska-Sampaio AP,Abreu M,Valério-Gomes B,Tan PB,Amaral OB

    更新日期:2020-10-23 00:00:00

  • New insights into trypanosomatid U5 small nuclear ribonucleoproteins.

    abstract::Several protozoan parasites exist in the Trypanosomatidae family, including various agents of human diseases. Multiple lines of evidence suggest that important differences are present between the translational and mRNA processing (trans splicing) systems of trypanosomatids and other eukaryotes. In this context, certai...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000200003

    authors: Silva MT,Ambrósio DL,Trevelin CC,Watanabe TF,Laure HJ,Greene LJ,Rosa JC,Valentini SR,Cicarelli RM

    更新日期:2011-03-01 00:00:00

  • Two new Culicoides of the paraensis species group (Diptera: Ceratopogonidae) from the Amazonian region of Peru.

    abstract::Two new species of the Culicoides paraensis species group, C. diversus Felippe-Bauer and C. peruvianus Felippe-Bauer, are described and illustrated based on female specimens from Amazonian region of Peru. A systematic key, table with numerical characters of females, and distribution of species of the C. paraensis grou...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762003000800014

    authors: Felippe-Bauer ML,Cáceres AG,Silva CS,Valderrama-Bazan W,Gonzales-Perez A

    更新日期:2003-12-01 00:00:00

  • Sandfly species diversity in association with human activities in the Kani tribe settlements of the Western Ghats, Thiruvananthapuram, Kerala, India.

    abstract::Sandfly prevalence in the Kani tribe settlements of Western Ghats in India was investigated. A total of 1,279 sandflies comprising 17 species was obtained. Sandfly abundance showed a negative correlation (r = -0.97, p = 0.003) with increase in altitudinal ranges from 0-1,000 m. When sandfly samples were grouped accord...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760140272

    authors: Ranganathan S,Swaminathan S

    更新日期:2015-04-01 00:00:00

  • Isolation and molecular identification of Leishmania chagasi from a bat (Carollia perspicillata) in northeastern Venezuela.

    abstract::This report describes the isolation of a Leishmania chagasi strain from a bat (Carollia perspicillata), and its identification using biological methods and molecular characterization. The parasites were isolated in an artificial culture medium from a blood sample extracted from a bat heart. The isolate was then inocul...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762008000400018

    authors: De Lima H,Rodríguez N,Barrios MA,Avila A,Cañizales I,Gutiérrez S

    更新日期:2008-06-01 00:00:00