Benzonidazole levels in blood vary with age in rats.

Abstract:

:Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.

journal_name

Mem Inst Oswaldo Cruz

authors

Bulffer RF,Castro JA,Fanelli SL

doi

10.1590/s0074-02762011000300021

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

374-7

issue

3

eissn

0074-0276

issn

1678-8060

pii

S0074-02762011000300021

journal_volume

106

pub_type

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