Two years into the Brazilian Reproducibility Initiative: reflections on conducting a large-scale replication of Brazilian biomedical science.

abstract：:Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objective we have chosen to target the enzymes modifying histones and in part...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Pierce RJ,Dubois-Abdesselem F,Caby S,Trolet J,Lancelot J,Oger F,Bertheaume N,Roger E

更新日期：2011-11-01 00:00:00

abstract：:The association between pyogenic liver abscesses and schistosomiasis has been confirmed by clinical and experimental studies. In this retrospective study of 78 patients with pyogenic liver abscesses the association with schistosomiasis has been investigated. Pyodermitis, a known focus of bacteremia, was observed in 19...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Teixeira R,Pfeilsticker FJ,Santa Cecília GD,Nobre V,Fonseca LP,Serufo JC,Coelho PM,Lambertucci JR

更新日期：2001-01-01 00:00:00

abstract：:Hepatitis E virus (HEV), an emerging virus associated with acute hepatic disease, leads to thousands of deaths worldwide. HEV has already been reported in Brazil; however, there is a lack of epidemiological and molecular information on the genetic variability, taxonomy, and evolution of HEV. It is thus unclear whether...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Oliveira-Filho EF,Dos Santos DR,Durães-Carvalho R,da Silva A,de Lima GB,Batista Filho AFB,Pena LJ,Gil LH

更新日期：2019-01-01 00:00:00

abstract：:This paper presents a list of 131 Mallophaga type specimens deposited in the Werneck Collection of Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil. It includes 69 holotypes, 62 allotypes, 683 paratypes, 1 syntype and 2 neoparatypes, distributed among 6 families and 35 genera. The types are listed with their respect...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cardozo-de-Almeida M,Linardi PM,Costa J

更新日期：2003-03-01 00:00:00

abstract：:This article presents an overview of the currently available drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors (EBI). These comp...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Urbina JA

更新日期：2009-07-01 00:00:00

abstract：:The kidney trematode Paratanaisia bragai is reported for the first time parasitizing the ring-necked pheasant (Phasianus colchicus L., 1758) and the pathological alterations associated to the parasitism are referred on the basis of 50 specimens of this bird from backyard flocks in 11 counties of the state of Rio de Ja...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Gomes DC,Menezes RC,Tortelly R,Pinto RM

更新日期：2005-05-01 00:00:00

abstract：:The biochemical pathways involved in nicotinamide adenine dinucleotide (NAD) biosynthesis converge at the enzymatic step catalysed by nicotinamide mononucleotide adenylyltransferase (NMNAT, EC: 2.7.7.1). The majority of NMNATs are assembled into homo-oligomeric states that comprise 2-6 subunits. Recently, the NMNAT of...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Contreras-Rodríguez LE,Marin-Mogollon CY,Sánchez-Mejía LM,Ramírez-Hernández MH

更新日期：2018-07-10 00:00:00

abstract：:Early Cretaceous flagellates with characters typical of trypanosomatids were found in the gut of sand fly larvae, as well as in surrounding debris, in Burmese amber. This discovery supports a hypothesis in which free-living trypanosomatids could have been acquired by sand fly larvae in their feeding environment and th...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Poinar G Jr

更新日期：2007-08-01 00:00:00

abstract：:Lutzomyia (Lutzomyia) cruzi has been named as a probable vector of Leishmania chagasi in Corumbá, Mato Grosso do Sul, Brazil. Taxonomically L. cruzi is closely related to the L. longipalpis species complex. Females of L. cruzi and L. longipalpis are morphologically indistinguishable and associated males must be examin...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Brazil RP,Hamilton JG

更新日期：2002-04-01 00:00:00

abstract：:Sequences of the cytochrome c oxidase subunit I (COI) mitochondrial gene from adults of 22 Culex (Culex) species from Argentina and Brazil were employed to assess species identification and to test the usefulness of COI for barcoding using the best close match (BCM) algorithm. A pairwise Kimura two-parameter distance ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Laurito M,Oliveira TM,Almirón WR,Sallum MA

更新日期：2013-01-01 00:00:00

abstract：:Six clinical isolates of influenza A viruses were examined for hemagglutinin receptor specificity and neuraminidase substrate specificity. All of the viral isolates minimally passaged in mammalian cells demonstrated preferential agglutination of human erythrocytes enzymatically modified to contain NeuAc alpha 2,6Gal s...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Couceiro JN,Baum LG

更新日期：1994-10-01 00:00:00

abstract：:Two new species of the Culicoides paraensis species group, C. diversus Felippe-Bauer and C. peruvianus Felippe-Bauer, are described and illustrated based on female specimens from Amazonian region of Peru. A systematic key, table with numerical characters of females, and distribution of species of the C. paraensis grou...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Felippe-Bauer ML,Cáceres AG,Silva CS,Valderrama-Bazan W,Gonzales-Perez A

更新日期：2003-12-01 00:00:00

abstract：:We evaluated the potential of Mesocyclops annulatus as a control agent of Aedes aegypti in La Plata city (Argentina). Mosquito larval survivorship due to predation by these copepods was estimated at weekly intervals during the oviposition period of A. aegypti. Mean weekly A. aegypti larval survivorship in cylindrical ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Marti GA,Micieli MV,Scorsetti AC,Liljesthröm G

更新日期：2004-08-01 00:00:00

abstract：:This study updates the geographic distributions of phlebotomine species in Central-West Brazil and analyses the climatic factors associated with their occurrence. The data were obtained from the entomology services of the state departments of health in Central-West Brazil, scientific collections and a literature revie...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Almeida PS,Andrade AJ,Sciamarelli A,Raizer J,Menegatti JA,Hermes SC,Carvalho Mdo S,Gurgel-Gonçalves R

更新日期：2015-06-01 00:00:00

abstract：:Facilitated and improved by advances in molecular biology, techniques for the immunodiagnosis of schistosomiasis, including assays based on the detection of antigens circulating in the serum and/or excreted in the urine, have now reached the stage of multi-centre trials. There is a need to complement parasitological t...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bergquist NR

更新日期：1992-01-01 00:00:00

abstract：:Tungiasis is a parasitic skin disease widespread in resource-poor urban and rural communities in Brazil. Inhabitants of an urban slum in Northeast Brazil were examined for the presence of tungiasis lesions and followed-up twice a week for a period of three weeks. Each time the number, stages, and topographic localizat...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Feldmeier H,Kehr JD,Poggensee G,Heukelbach J

更新日期：2006-02-01 00:00:00

abstract：:In an endemic area of cutaneous leishmaniasis in Rio de Janeiro State where a mule had been found infected, a systematic search among equines was performed, resulting in the detection of Leishmania parasites in skin lesions of 30.8% of the animals, which included horses and mules. The eventual role of equines in the e...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Aguilar CM,Rangel EF,Deane LM

更新日期：1986-10-01 00:00:00

abstract：:The triatomine bug Triatoma infestans probably originated in Bolivia and dispersed passively over wide areas of South America, where it is the principal vector of Trypanosoma cruzi. In the region of its probable origin this species shows colonization in two different ecotopes, so that it may be encountered in sylvatic...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Pires HH,Barbosa SE,Diotaiuti L

更新日期：2000-11-01 00:00:00

abstract：:The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective trea...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Carvalho VF,Barreto EO,Cordeiro RS,Lagente V,Martins MA,e Silva PM

更新日期：2005-03-01 00:00:00

abstract：:Rhodnius ecuadoriensis is the second most important vector of Chagas Disease (CD) in Ecuador. The objective of this study was to describe (and compare) the life cycle, the feeding and defecation patterns under laboratory conditions of two populations of this specie [from the provinces of Manabí (Coastal region) and Lo...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Villacís AG,Arcos-Terán L,Grijalva MJ

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Gene reporter-fluorescent cells have emerged as alternative method for drug screening. OBJECTIVE:Achievement of constitutive expression of fluorescent protein GFP by Leishmania braziliensis as alternative method for drug screening. METHODS:L. braziliensis-GFP was generated using Leishmania tarentolae pLEXS...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bastos MS,Souza LÂ,Onofre TS,Silva A Júnior,Almeida MR,Bressan GC,Fietto JL

更新日期：2017-02-01 00:00:00

abstract：:Trypanosomatids are parasites that cause disease in humans, animals, and plants. Most are non-pathogenic and some harbor a symbiotic bacterium. Endosymbiosis is part of the evolutionary process of vital cell functions such as respiration and photosynthesis. Angomonas deanei is an example of a symbiont-containing trypa...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Penha LL,Hoffmann L,Souza SS,Martins AC,Bottaro T,Prosdocimi F,Faffe DS,Motta MC,Ürményi TP,Silva R

更新日期：2016-11-01 00:00:00

abstract：:Studies on the sandfly fauna to evaluate natural infection indexes are still limited in the Brazilian Amazon, a region with an increasing incidence of cutaneous leishmaniasis. Here, by using a multiplex polymerase chain reaction directed to Leishmania kDNA and hybridisation, we were able to identify L. (Viannia) subge...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Araujo-Pereira T,Pita-Pereira D,Boité MC,Melo M,Costa-Rego TA,Fuzari AA,Brazil RP,Britto C

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Occult hepatitis B virus (HBV) - characterized by the absence of detectable HBsAg in the presence of HBV DNA - represents a potential threat for blood safety. OBJECTIVES:This study was conducted with the aim to investigate the serological and molecular characterization of occult HBV infection (OBI) among bl...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mabunda N,Zicai AF,Ismael N,Vubil A,Mello F,Blackard JT,Lago B,Duarte V,Moraes M,Lewis L,Jani I

更新日期：2020-09-23 00:00:00

abstract：:In 2008, we have celebrated the centenary of the discovery of Toxoplasma gondii.Although this ubiquitous protozoan can generate devastating damage in foetuses and newborns, its treatment is the only field in which we have made little progress, despite a huge body of research, and has not yet been validated. Pregnant w...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Peyron F

更新日期：2009-03-01 00:00:00

abstract：:An unusually high incidence of microcephaly in newborns has recently been observed in Brazil. There is a temporal association between the increase in cases of microcephaly and the Zika virus (ZIKV) epidemic. Viral RNA has been detected in amniotic fluid samples, placental tissues and newborn and fetal brain tissues. H...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Noronha Ld,Zanluca C,Azevedo ML,Luz KG,Santos CN

更新日期：2016-05-01 00:00:00

abstract：:BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Lima LRP,Araújo NA,Guterres A,Pilotto JH,Niel C,Paula VS

更新日期：2018-12-03 00:00:00

abstract：:Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America. Although the pathogenesis of Chagas cardiomyopathy is incompletely understood, it may involve several mechanisms, including parasite-dependent my...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Rassi A Jr,Marin JA Neto,Rassi A

更新日期：2017-03-01 00:00:00

abstract：:Rats and mice are among the most susceptible hosts for the helminth Capillaria hepatica. More information on the similarities and differences between the hepatic pathology presented by these two parasite hosts are needed, since they may represent good models for the study of hepatic fibrosis. Early changes are similar...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Andrade SB,Andrade ZA

更新日期：2004-06-01 00:00:00

abstract：:Ketoconazole, an azole antifungic drug which is already in the market has also been demonstrated to be active against Trypanosoma cruzi experimental infections. In this paper we confirmed the drug effect and investigated its range of activity against different T. cruzi strains naturally resistant or susceptible to bot...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Brener Z,Cançado JR,Galvão LM,da Luz ZM,Filardi Lde S,Pereira ME,Santos LM,Cançado CB

更新日期：1993-01-01 00:00:00