Studies on the virulence and attenuation of Trypanosoma cruzi using immunodeficient animals.

Abstract:

:Tissue invasion and pathology by Trypanosoma cruzi result from an interaction between parasite virulence and host immunity. Successive in vivo generations of the parasite select populations with increasing ability to invade the host. Conversely, prolonged in vitro selection of the parasite produces attenuated sublines with low infectivity for mammals. One such subline (TCC clone) has been extensively used in our laboratory as experimental vaccine and tested in comparative experiments with its virulent ancestor (TUL). The experiments here reviewed aimed at the use of immunodeficient mice for testing the infectivity of TCC parasites. It has not been possible to obtain virulent, revertant sublines by prolonged passaged in such mice.

journal_name

Mem Inst Oswaldo Cruz

authors

Basombrío MA,Segura MA,Gómez L,Padilla M

doi

10.1590/s0074-02762000000700029

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

175-8

eissn

0074-0276

issn

1678-8060

pii

S0074-02762000000700029

journal_volume

95 Suppl 1

pub_type

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