Mechanisms of cell accumulation induced by Mycobacterium bovis BCG.

Abstract:

:Mycobacteria, specially Mycobacterium tuberculosis are among the micro-organisms that are increasing dramatically the number of infections with death, all over the world. A great number of animal experimental models have been proposed to investigate the mechanisms involved in the host response against these intracellular parasites. Studies of airway infection in guinea-pigs and rabbits, as well as in mice intravenously infected with BCG have made an important contribution to our understanding of the virulence, pathogenesis and the immunology of mycobacterial infections. Although, there are few models to study the mechanisms of the initial inflammatory process induced by the first contact with the Mycobacteria, and the relevance of the acute generation of inflammatory mediators, cytokines and leukocyte infiltration to the development of the mycobacterial infection. In this work we reviewed our results obtained with a model of M. bovis BCG-induced pleurisy in mice, describing the mechanisms involved in the leukocyte influx induced by BCG at 24 hr. Different mechanisms appear to be related with the influx of neutrophils, eosinophils and mononuclear cells and distinct inflammatory mediators, cytokines and adhesion molecules are involved in the BCG-induced cell accumulation.

journal_name

Mem Inst Oswaldo Cruz

authors

Menezes-de-Lima-Júnior O,Henriques M das G

doi

10.1590/s0074-02761997000800033

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

227-32

eissn

0074-0276

issn

1678-8060

pii

S0074-02761997000800033

journal_volume

92 Suppl 2

pub_type

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