Present aspects of immunodiagnosis of schistosomiasis.

Abstract:

:Facilitated and improved by advances in molecular biology, techniques for the immunodiagnosis of schistosomiasis, including assays based on the detection of antigens circulating in the serum and/or excreted in the urine, have now reached the stage of multi-centre trials. There is a need to complement parasitological techniques as some national programmes are becoming increasingly successful in establishing control of the disease and the classical approach frequently fails to reveal low-intensity infection. Epidemiological survey teams in some areas have tentatively started to use serology and their experience indicates that antibody detection suffices in eradicated or controlled areas with low expected prevalence but that detection of circulating antigens is needed for assessment of the incidence of infection or reinfection in areas recently brought under control. Before reagents and procedures can be recommended for routine use of national control programmes, the assays must be standardized with sera from clinically well-characterized patients in geographically defined regions, hence emphasizing the need for a reference serum bank. Implementation of serological testing, carried out by national public health laboratories using standardized testing systems, would permit valid comparisons between different areas providing support for decisions regarding national health policies.

journal_name

Mem Inst Oswaldo Cruz

authors

Bergquist NR

doi

10.1590/s0074-02761992000800004

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

29-38

eissn

0074-0276

issn

1678-8060

pii

S0074-02761992000800004

journal_volume

87 Suppl 4

pub_type

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