An experimental and clinical assay with ketoconazole in the treatment of Chagas disease.

abstract：:In Mexico, despite the relatively high seroprevalence of Trypanosoma cruzi infection in humans in some areas, reported morbidity of Chagas disease is not clear. We determined clinical stage in 71 individuals seropositive to T. cruzi in the state of Puebla, Mexico, an area endemic for Chagas disease with a reported ser...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Sánchez-Guillén Mdel C,López-Colombo A,Ordóñez-Toquero G,Gomez-Albino I,Ramos-Jimenez J,Torres-Rasgado E,Salgado-Rosas H,Romero-Díaz M,Pulido-Pérez P,Pérez-Fuentes R

更新日期：2006-11-01 00:00:00

abstract：:The kidney trematode Paratanaisia bragai is reported for the first time parasitizing the ring-necked pheasant (Phasianus colchicus L., 1758) and the pathological alterations associated to the parasitism are referred on the basis of 50 specimens of this bird from backyard flocks in 11 counties of the state of Rio de Ja...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Gomes DC,Menezes RC,Tortelly R,Pinto RM

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Gene reporter-fluorescent cells have emerged as alternative method for drug screening. OBJECTIVE:Achievement of constitutive expression of fluorescent protein GFP by Leishmania braziliensis as alternative method for drug screening. METHODS:L. braziliensis-GFP was generated using Leishmania tarentolae pLEXS...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bastos MS,Souza LÂ,Onofre TS,Silva A Júnior,Almeida MR,Bressan GC,Fietto JL

更新日期：2017-02-01 00:00:00

abstract：:In many helminth infected hosts the number of eosinophils increases dramatically, often without any concurrent increases in the number of other leukocytes, so that eosinophils become the dominant cell type. Many experimental investigations have shown that the eosinophilia is induced by interleukin-5 (IL-5) but its fun...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ovington KS,Behm CA

更新日期：1997-01-01 00:00:00

abstract：:Given their medical and veterinary relevance, the members of the Pipiens Assemblage are a worldwide target of ecological research. The distribution of Culex pipiens s.s. and Cx. quinquefasciatus converge in Buenos Aires, Argentina, where hybrids have been detected. Each member of the assemblage exhibits a distinct eco...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cardo MV,Rubio A,Junges M,Vezzani D,Carbajo AE

更新日期：2016-11-01 00:00:00

abstract：:Biomphalaria glabrata can react through different pathways to Schistosoma mansoni miracidium penetration, according to the degree of resistance/susceptibility presented by different snail strains, which is a genetically determined character, resistance being the dominant feature. However, it has been observed that pre...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Azevedo CM,Borges CC,Andrade ZA

更新日期：2006-09-01 00:00:00

abstract：:A ribosome association factor (AF) was isolated from the yeast Sacchharomyces cerevisiae. Partial amino acid sequence of AF was determined from its fragment of 25 kDa isolated by treating AF with 2-(2-nitrophenylsulfenyl)-3-methyl-3'-Bromoindolenine (BNPS-skatole). This sequence has a 86% identity to the product of th...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Correia H,Medina R,Hernández A,Bustamante E,Chakraburtty K,Herrera F

更新日期：2004-11-01 00:00:00

abstract：:Results of studies on a larvicidal cyanobacterium that expresses a Bti cryIVD gene fusion are reported. Genetically altered Agmenellum quadruplicatum PR-6 is shown to be toxic to larvae of three major genera of disease-bearing mosquitos. Factors affecting expression of Bti genes in cyanobacteria are discussed. ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Murphy RC,Stevens SE Jr

更新日期：1995-01-01 00:00:00

abstract：:Cutaneous leishmaniasis (CL) is a neglected clinical form of public health importance that is quite prevalent in the northern and eastern parts of Egypt. A comprehensive study over seven years (January 2005-December 2011) was conducted to track CL transmission with respect to both sandfly vectors and animal reservoirs...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Samy AM,Doha SA,Kenawy MA

更新日期：2014-06-01 00:00:00

abstract：:Mitochondrial DNA of Biomphalaria tenagophila, a mollusc intermediate host of Schistosoma mansoni in Brazil, was sequenced and characterised. The genome size found for B. tenagophila was 13,722 bp and contained 13 messenger RNAs, 22 transfer RNAs (tRNA) and two ribosomal RNAs (rRNA). In addition to sequencing, the mit...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Jannotti-Passos LK,Ruiz JC,Caldeira RL,Murta SM,Coelho PM,Carvalho OS

更新日期：2010-07-01 00:00:00

abstract：:In 2008, we have celebrated the centenary of the discovery of Toxoplasma gondii.Although this ubiquitous protozoan can generate devastating damage in foetuses and newborns, its treatment is the only field in which we have made little progress, despite a huge body of research, and has not yet been validated. Pregnant w...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Peyron F

更新日期：2009-03-01 00:00:00

abstract：:While the eosinophil's effector functions clearly can contribute to the pathogenesis of allergic diseases, the evolutionary benefit to having eosinophils as a distinct class of leukocyte is not clear, especially if one must reconsider the nominally beneficial role of eosinophils in parasite host defense, Eosinophils a...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Weller PF,Lim K

更新日期：1997-01-01 00:00:00

abstract：:To analyze whether electrocardiographic alterations (ECGA) in patients with antibodies to Trypanosoma cruzi showed a pattern of familial aggregation, a sample of 379 young adults (166 men and 213 women) distributed in sibships, were assessed for the presence of anti-T. cruzi antibodies, and subjected to a complete cli...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Morini JC,Berra H,Dávila HO,Pividori JF,Bottasso OA

更新日期：1994-07-01 00:00:00

abstract：:From May to August 1999, we evaluated 401 patients from a pediatric hospital of Havana City. One group was composed of 113 patients with diarrhea admitted to the Gastroenterology ward and a second consisted of 288 patients without diarrhea, admitted for other reasons, and hospitalized within the same time period. Thre...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Núñez FA,González OM,González I,Escobedo AA,Cordoví RA

更新日期：2003-06-01 00:00:00

abstract：:The biochemical pathways involved in nicotinamide adenine dinucleotide (NAD) biosynthesis converge at the enzymatic step catalysed by nicotinamide mononucleotide adenylyltransferase (NMNAT, EC: 2.7.7.1). The majority of NMNATs are assembled into homo-oligomeric states that comprise 2-6 subunits. Recently, the NMNAT of...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Contreras-Rodríguez LE,Marin-Mogollon CY,Sánchez-Mejía LM,Ramírez-Hernández MH

更新日期：2018-07-10 00:00:00

abstract：:Mycobacteria, specially Mycobacterium tuberculosis are among the micro-organisms that are increasing dramatically the number of infections with death, all over the world. A great number of animal experimental models have been proposed to investigate the mechanisms involved in the host response against these intracellu...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Menezes-de-Lima-Júnior O,Henriques M das G

更新日期：1997-01-01 00:00:00

abstract：:Facilitated and improved by advances in molecular biology, techniques for the immunodiagnosis of schistosomiasis, including assays based on the detection of antigens circulating in the serum and/or excreted in the urine, have now reached the stage of multi-centre trials. There is a need to complement parasitological t...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bergquist NR

更新日期：1992-01-01 00:00:00

abstract：:A survey was conducted in the hemodialysis population of the state of Tocantins, Brazil, aiming to assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, to analyze associated risk factors, and also to investigate these viruses genotypes distribution. During January and March 2001, al...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Souza KP,Luz JA,Teles SA,Carneiro MA,Oliveira LA,Gomes AS,Dias MA,Gomes SA,Yoshida CF,Martins RM

更新日期：2003-07-01 00:00:00

abstract：:Several genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiquitinating enzymes have been reported to be negative regulators of protein ubiquitination and sh...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Pereira RV,Vieira HG,Oliveira VF,Gomes Mde S,Passos LK,Borges Wde C,Guerra-Sá R

更新日期：2014-02-01 00:00:00

abstract：:In this study, IgA1 levels in the milk and serum of puerperae were compared and a correlation was established between the levels of this immunoglobulin and the occurrence of parasitism. Eighty-three paired milk and serum samples were obtained from puerperal and IgA1 levels were analyzed. In addition, the presence of i...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Manhani MN,Cruz JM,Ferreira DM,Abdallah VO,Souza MA

更新日期：2008-08-01 00:00:00

abstract：:Two essential oils of Lippia alba (Mill.) N.E. Brown (Verbenacea), the carvone and citral chemotypes and 15 of their compounds were evaluated to determine cytotoxicity and antifungal activity. Cytotoxicity assays for both the citral and carvone chemotypes were carried out with tetrazolium-dye, which showed a dose-depe...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mesa-Arango AC,Montiel-Ramos J,Zapata B,Durán C,Betancur-Galvis L,Stashenko E

更新日期：2009-09-01 00:00:00

abstract：:Acoustic signalling has been extensively studied in insect species, which has led to a better understanding of sexual communication, sexual selection and modes of speciation. The significance of acoustic signals for a blood-sucking insect was first reported in the XIX century by Christopher Johnston, studying the hear...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Vigoder Fde M,Ritchie MG,Gibson G,Peixoto AA

更新日期：2013-01-01 00:00:00

abstract：:Patients with acute schistosomiasis were studied before and after oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks before, and presented compatible clinical manifestations, eosinophilia, and high levels of total IgE. Interferon-gamma (IFN-gamma) and interleukin-4 were measured by ELISA in whole b...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Souza JR,Morais CN,Aroucha ML,Miranda PJ,Barbosa CS,Domingues AL,Carvalho Júnior LB,Abath FG,Montenegro SM

更新日期：2007-05-01 00:00:00

abstract：:Prosorhynchoides arcuatus (Linton, 1900) from the intestine of Pomatomus saltator (L.) from the Atlantic coast of the State of Rio de Janeiro is studied by scanning electron microscopy, with detailed description of tegumental spines. Comments on the synonymy of this species with Bucephalopsis callicotyle Kohn, 1962 ar...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Cohen SC,Kohn A,Barth OM

更新日期：1995-01-01 00:00:00

abstract：:Dipteran polytene chromosomes provide an excellent model for understanding in species complexes, as well as for structural and functional cytogenetics. The status of species in the Culex pipiens complex is controversial and the use of polytene chromosomes for cytogenetic analysis in the subfamily Culicinae has been di...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Campos J,Andrade CF,Recco-Pimentel SM

更新日期：2003-04-01 00:00:00

abstract：:Lutzomyia (Lutzomyia) cruzi has been named as a probable vector of Leishmania chagasi in Corumbá, Mato Grosso do Sul, Brazil. Taxonomically L. cruzi is closely related to the L. longipalpis species complex. Females of L. cruzi and L. longipalpis are morphologically indistinguishable and associated males must be examin...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Brazil RP,Hamilton JG

更新日期：2002-04-01 00:00:00

abstract：:A study was undertaken to search for DNA recombinant Schistosoma mansoni proteins responsible for eliciting an antibody response from the host at a very early phase after infection. A S. mansoni adult worm cDNA expression library was screened using pooled sera from baboons with four weeks of infection. Based on their ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Kanamura HY,Hancock K,Rodrigues V,Damian RT

更新日期：2002-07-01 00:00:00

abstract：:The sample consists of 226 skulls from the Atacameño cemetery of Coyo Oriente (639-910 AD), associated with the Tiwanaku period. The authors analyzed signs of acute trauma typically associated with violence, and the results were 12% of men and 9.9% of women displaying any type of lesion related to violence. In males, ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Lessa A,de Souza SM

更新日期：2006-12-05 00:00:00

abstract：:Aedes albopictus was found in six of the 10 departments of Haiti and in 14 of the 35 communes surveyed. The survey found the larvae of Ae. albopictus in 13 different types of containers. Used tires and tins were by far the most common breeding sites used by this mosquito species. At the breeding sites, Ae. albopictus ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Fernández Mdel C,Jean YS,Callaba CA,López LS

更新日期：2012-03-01 00:00:00

abstract：:Rats and mice are among the most susceptible hosts for the helminth Capillaria hepatica. More information on the similarities and differences between the hepatic pathology presented by these two parasite hosts are needed, since they may represent good models for the study of hepatic fibrosis. Early changes are similar...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Andrade SB,Andrade ZA

更新日期：2004-06-01 00:00:00