Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals.

Abstract:

:Anti-human immunodeficiency virus type 1 (HIV-1) "binding antibodies" (antibodies capable of binding to synthetic peptides or proteins) occur throughout HIV-1 infection, are high-titered and highly cross-reactive, as confirmed in this study by analyzing plasma from B and F genotype HIV-1 infected individuals. Plasma from individuals infected with clade F HIV-1 displayed the most frequent cross-reactivity, in high titers, while Bbr plasma showed much higher specificity. Similarly, neutralization of a reference HIV-1 isolate (HIV-1 MN) was more frequently observed by plasma from F than B genotype infected individuals. No significant difference was seen in neutralization susceptibility of primary B, Bbr or F clade HIV-1 by plasma from individuals infected with the classical B (GPGR) or F HIV-1, but Bbr (GWGR) plasma were less likely to neutralize the F genotype primary HIV-1 isolates. The data indicate that both B and F genotype derived vaccines would be equally effective against B and F HIV-1 infection, with a slightly more probable effectiveness for F than B genotype. Although the Bbr variant appears to induce a much more specific humoral immune response, the susceptibility in neutralizing the Brazilian HIV-1 B genotype Bbr variant is similar to that observed with the classical B genotype HIV-1.

journal_name

Mem Inst Oswaldo Cruz

authors

Bongertz V,Teixeira SL,Grinztejn B,Pilotto JH,Veloso VG,Morgado MG,Bastos FI,Ouverney EP

doi

10.1590/s0074-02762005000100016

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

85-9

issue

1

eissn

0074-0276

issn

1678-8060

pii

S0074-02762005000100016

journal_volume

100

pub_type

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